🌅 #Research #Alert
Single-cell transcriptomics reveals #heterogeneity and #immune #microenvironment in lymphatic #metastasis of head and neck squamous cell #carcinoma

Access here: www.nature.com/articles/s41...
@springernature.com #Genes & #immunity

USP7-mediated deubiquitination and nuclear translocation of PFKM promotes brain tumor development by sensing fructose-2,6-bisphosphate. USP7 interacts with PFKM regulated by F-2,6-BP, resulting in the ubiquitination of PFKM K615 after GD treatment. Deubiquitinated PFKM translocates into nucleus and interacts with c-Myc. PFKM facilitates c-MYC binding to CPT1B promoter and promotes transcription of CPT1B, thereby enhancing FAO and cell survival.

How does nutrient deficiency in the #tumor #microenvironment lead to metabolic reprogramming? This study reveals a mechanism for glioblastoma survival via switching from #glycolysis to #FattyAcid oxidation in mice, with implications for cancer medicine @plosbiology.org 🧪 plos.io/3P6pSg4

USP7-mediated deubiquitination and nuclear translocation of PFKM promotes brain tumor development by sensing fructose-2,6-bisphosphate. USP7 interacts with PFKM regulated by F-2,6-BP, resulting in the ubiquitination of PFKM K615 after GD treatment. Deubiquitinated PFKM translocates into nucleus and interacts with c-Myc. PFKM facilitates c-MYC binding to CPT1B promoter and promotes transcription of CPT1B, thereby enhancing FAO and cell survival.

How does nutrient deficiency in the #tumor #microenvironment lead to metabolic reprogramming? This study reveals a mechanism for glioblastoma survival via switching from #glycolysis to #FattyAcid oxidation in mice, with implications for cancer medicine @plosbiology.org 🧪 plos.io/3P6pSg4

USP7-mediated deubiquitination and nuclear translocation of PFKM promotes brain tumor development by sensing fructose-2,6-bisphosphate. USP7 interacts with PFKM regulated by F-2,6-BP, resulting in the ubiquitination of PFKM K615 after GD treatment. Deubiquitinated PFKM translocates into nucleus and interacts with c-Myc. PFKM facilitates c-MYC binding to CPT1B promoter and promotes transcription of CPT1B, thereby enhancing FAO and cell survival.

How does nutrient deficiency in the #tumor #microenvironment lead to metabolic reprogramming? This study reveals a mechanism for glioblastoma survival via switching from #glycolysis to #FattyAcid oxidation in mice, with implications for cancer medicine @plosbiology.org 🧪 plos.io/3P6pSg4

Schematic overview of the findings of the publication by Suarez-Csrmona et al.

New publication on the role of #macrophages in shaping the tumor #microenvironment in #cancer ... leading to the exploration of #adipose tissue and it's impact on #innateimmunity and #adaptiveimmunity in #ovariancancer to the point where resistancr to […]

[Original post on mstdn.science]

VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement - Nature Communications The SNARE VAMP7 is essential for an unconventional secretory pathway based on late endosomal secretion. Here the authors show that this secretion functions as an organelle quality-control and stress-c...

#VAMP7-dependent late endosomal #secretion of #ER and #mitochondrial proteins impacts the #tumor #microenvironment and #macrophage engagement
www.nature.com/articles/s41...

multiplex IHC using cell signaling, cell proliferation and cell type biomarkers in human GBM tissue (top left); tumorspheres (bottom left) & mouse brain tumor tissue (right)

Spatial organization of the TME explored using #spatialbiology.
Neoplastic cell signaling and TME complexity are not only dependent on cell intrinsic genetics, but also dependent on cell density & stromal interaction. #cellsignaling #microenvironment #brain #GBM

A pan-cancer single-cell transcriptomic atlas of human bone metastases This study constructs a pan-cancer single-cell atlas of human bone metastases, revealing niche-specific stromal and immune programs that drive tumor proliferation and immunotherapy resistance. Combine...

Important insights into the tumor #microenvironment of spinal bone #metastases.

A pan-cancer single-cell transcriptomic atlas of human bone metastases: Cell Reports Medicine

www.cell.com/cell-reports...

#FollistatinLike1 shapes the fibrotic immune #microenvironment, enabling #MSC‑driven #macrophage recruitment and remodeling to boost #antifibrotic efficacy in #LiverCirrhosis, positioning FSTL1 as a #biomarker of #StemCellTherapy response.

#CoverPage #STTT: doi.org/10.1038/s413...

Compression causes cancer cells to start spreading The switch between proliferation and invasion is triggered by mechanical force.

Turns out #cancer is not driven solely by #DNA #mutations. Physical forces applied by the cells surrounding the tumor (known collectively as the #tumor #microenvironment or #TME) directly influence how aggressive the tumor is and how rapidly it can spread.

www.nature.com/articles/d41...

Climatic and design tipping points in agrivoltaic crop production systems. A meta-analysis - Agronomy for Sustainable Development Amidst global climate change, increasing food demand, and land-use competition between agriculture and energy production, agrivoltaic systems are emerging as a potential solution energy. However, the ...

Zhang, W., Hendriks, PW., Uchanski, M. et al. Climatic and design tipping points in agrivoltaic crop production systems. A meta-analysis. Agron. Sustain. Dev. 45, 69 (2025).
doi.org/10.1007/s135...
#Agrivoltaics #Microclimate #Microenvironment #CropPerformance

Advances in the Application of Living Cells in Tumor Radiosensitization Announcing a new article publication for BIO Integration journal.  Radiation therapy (RT) has a critical role in cancer treatment, yet the efficacy is often limited by tumor resistance mechanisms, suc...

This review highlights how living cells—leveraging #tumor #chemotaxis, #microenvironment modulation, and innate #radiosensitizing abilities—offer innovative solutions to overcome #RadiotherapyResistance and enhance tumor-targeted treatment.

#OpenAccess: bio-integration.org/living-cells...

Immunometabolic Features and Key Biomarkers in Lung Cancer Complicated by Pulmonary Tuberculosis: Insights From Transcriptome and Clinical Cohort Analysis Integrative analysis of LC-PTB patients pinpoints six biomarkers (ANK2, EPB42, CA1, HBB, HBD, MYL4) that reshape the immune microenvironment, offering new targets for diagnosis and treatment of lung ...

🫁Immune–transcriptomic profiling uncovers a four-gene model AUC 0.94 for lung cancer with pulmonary tuberculosis!
💡#MTB remodels #tumor #microenvironment via metabolic-immune crosstalk.
⚡First #immune-transcriptomic map of #lung cancer plus tuberculosis.
onlinelibrary.wiley.com/doi/10.1002/...

This review highlights how #MesenchymalStemCells exert therapeutic effects through #ParacrineSignaling—releasing #GrowthFactors, #cytokines, #chemokines, #ExtracellularMatrix components, & extracellular vesicles shaped by the #microenvironment.

#OpenAccess: doi.org/10.1016/j.ge...

Left: Maximum projection images of elavC155QF>QUAS-prosRi tumor brains stained with Repo and Dpn. The animals were moved from standard food to chemically defined diet (CDD) (top left), CDD minus Leu (top right), CDD minus Ile (bottom left), and CDD minus Met (bottom right) at 72hALH and dissected at 120hALH. Right: Schematic depicting the working model. Nutrient Restriction (NR) inhibits BBB glia expansion, which consequently limits brain tumor growth. The authors show that NR inhibits the expression of fat body and glia-derived Ilp6, causing downregulation of the InR/PI3K pathway in BBB glia. This results in a reduction in Path expression and the downstream mTOR-S6K pathway, causing a slowdown of BBB glial cell cycle progression. Path downregulation and defects in BBB expansion consequently led to a decrease in brain AAs, such as Leu, which hinders brain tumor protein synthesis to slow down tumor growth. Data information: ALH, after larvae hatching.

How does the #tumor #microenvironment modulate sensitivity to nutrient restriction? @joannaqd.bsky.social @chengflylab.bsky.social &co show that this is regulated by the SCL36 AA transporter Pathetic at #BloodBrainBarrier glial cells in #Drosophila #brain tumors @plosbiology.org 🧪 plos.io/4ibwXWY

Left: Maximum projection images of elavC155QF>QUAS-prosRi tumor brains stained with Repo and Dpn. The animals were moved from standard food to chemically defined diet (CDD) (top left), CDD minus Leu (top right), CDD minus Ile (bottom left), and CDD minus Met (bottom right) at 72hALH and dissected at 120hALH. Right: Schematic depicting the working model. Nutrient Restriction (NR) inhibits BBB glia expansion, which consequently limits brain tumor growth. The authors show that NR inhibits the expression of fat body and glia-derived Ilp6, causing downregulation of the InR/PI3K pathway in BBB glia. This results in a reduction in Path expression and the downstream mTOR-S6K pathway, causing a slowdown of BBB glial cell cycle progression. Path downregulation and defects in BBB expansion consequently led to a decrease in brain AAs, such as Leu, which hinders brain tumor protein synthesis to slow down tumor growth. Data information: ALH, after larvae hatching.

How does the #tumor #microenvironment modulate sensitivity to nutrient restriction? @joannaqd.bsky.social @chengflylab.bsky.social &co show that this is regulated by the SCL36 AA transporter Pathetic at #BloodBrainBarrier glial cells in #Drosophila #brain tumors @plosbiology.org 🧪 plos.io/4ibwXWY

Left: Maximum projection images of elavC155QF>QUAS-prosRi tumor brains stained with Repo and Dpn. The animals were moved from standard food to chemically defined diet (CDD) (top left), CDD minus Leu (top right), CDD minus Ile (bottom left), and CDD minus Met (bottom right) at 72hALH and dissected at 120hALH. Right: Schematic depicting the working model. Nutrient Restriction (NR) inhibits BBB glia expansion, which consequently limits brain tumor growth. The authors show that NR inhibits the expression of fat body and glia-derived Ilp6, causing downregulation of the InR/PI3K pathway in BBB glia. This results in a reduction in Path expression and the downstream mTOR-S6K pathway, causing a slowdown of BBB glial cell cycle progression. Path downregulation and defects in BBB expansion consequently led to a decrease in brain AAs, such as Leu, which hinders brain tumor protein synthesis to slow down tumor growth. Data information: ALH, after larvae hatching.

How does the #tumor #microenvironment modulate sensitivity to nutrient restriction? @chengflylab.bsky.social &co show that this is regulated by the SCL36 amino acid transporter Pathetic at the #BloodBrainBarrier perineural glial cells in #Drosophila #brain tumors @plosbiology.org 🧪 plos.io/4ibwXWY

In this commentary, Fan et al. highlight five recent high-impact studies that collectively construct a multidimensional, cross-system landscape of tumor microenvironment regulation.
doi.org/10.59717/j.x...
#Cancer #Microenvironment #Medicine

This review highlights the diverse roles of #Pdgfrα⁺ stromal cells and their crosstalk with the #Microenvironment across various #Tissues and biological conditions. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

New #hematopoiesis research from UW–Madison: GABA produced by multiple bone marrow cell types regulate hematopoietic stem and progenitor cells. #microenvironment #bonemarrow #Bcells https://ow.ly/kSws50XeaPF

ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation

The Multifaceted Role of Osteopontin in Modulating the Tumor Microenvironment Abstract. Osteopontin, a key structural protein in the extracellular matrix, plays a pivotal role in regulating the local tumor microenvironment and systemic immunity during cancer progression. Recognizing that tumor cells do not exist in isolation but rather interact with a multitude of stromal components that significantly influence patient outcomes and therapy responses, this review focuses on the role of osteopontin in non-tumor cells in the context of solid cancers and the associated phenotypic and mechanistic insights. We explore how osteopontin influences the behavior of various innate and adaptive immune cells, including natural killer cells, neutrophils, macrophages, dendritic cells, myeloid-derived suppressor cells, B cells, T cells, as well as structural stromal cells such as fibroblasts, endothelial cells, and adipocytes. The review highlights the roles of osteopontin in modulating these stromal cells and their multiaxial influence on tumorigenesis and metastasis. These complex interplays offer insights into potential diagnostic and therapeutic strategies around osteopontin/stromal-mediated pathways in cancer progression and recurrence.

(EN) A recent #review from GCI trainee Yu Gu published in Cancer Research (@aacrjournals.bsky.social) brings valuable insights to ongoing conversations in #cancer research. She explores the role of osteopontin in the tumour #microenvironment. Read the full review: doi.org/10.1158/0008...

Just posted (bioRxiv): A novel #mechanobiology model revealing how #immune #Tcells combine a #nucleus as a #piston, an #uropod, and #microenvironment to power #amoeboid #cellmigration in #cellconfinement via a hydraulic cell engine. #CellBiophysics #ImmuneMigration
www.biorxiv.org/content/10.1...

Attend tomorrow's #SITC #NCI Assessing the #Tumor #Microenvironment with Systems #Immunology webinar about cutting-edge #computational tools & analytical approaches that reveal the complexities of the #TME & #tumor #immunobiology!

Register now for this exciting #IO program: sitcancer.org/CompIO

Thanks again to @juliamaxson.bsky.social & Sergei Doulatov for inviting me and #EHA for sposoring an exciting joint session with @faseborg.bsky.social on the #microenvironment shaping normal and malignant #hematopoiesis

✈️Just returned from #FASEB #HMSRC, so many thought provoking data!

Grateful for the chance to spotlight new #organoid technologies & the often overlooked role of the #microenvironment

Proud to be part of a community pushing the boundaries of understanding #leukemia from #clone to #context

🚨June'25 #genes & #Immunity issue! @springernature.com
⏩https://www.nature.com/gene/volumes/26/issues/3
🛜Read: #glioblastoma #immunotherapy #Cancer #hemophilia #antigens #genetics #COVID_19 #lungcancer #lymphocytes #gastriccancer #tumour #microenvironment #Lung #leptin #inflammation #Immunology

7/ Interestingly, disruption of Rab27s opposes EV release from primary tumour cells, but not from micrometastatic cells. Lastly, we show that the switch to nSM2-dependent EV release enables micrometastatic cells to influence #ECM deposition by fibroblasts to foster an invasive #microenvironment.

7/ Interestingly, disruption of Rab27s opposes EV release from primary tumour cells, but not from micrometastatic cells. Lastly, we show that the switch to nSM2-dependent EV release enables micrometastatic cells to influence #ECM deposition by fibroblasts to foster an invasive #microenvironment.

Photo shows three glowing green bottles of chemicals, with a space where a fourth bottle can be placed Text says "New job openings" and "See all recruitment opportunities by visiting cruk.manchester.ac.uk/careers/"

We are recruiting two exciting #Postdoctoral roles:

🧪 Work with @clausjorgensen.bsky.social on targeting the tumour #microenvironment in #PancreaticCancer

🥼 Join @drwilliamhill.bsky.social to study air pollution & #LungCancer

Full details of both positions at:
www.cruk.manchester.ac.uk/careers/

My favorite sessions are yet to come:

Looking forward to Ralf Adams and Christa Maes lectures in just 1h ⏳ & getting ready for my meet-the-expert session 🤓 on high resolution 3D #imaging of #bone

Thank you #ECTS for the invitation!

#passarolab #bone #microenvironment @institutcochin.bsky.social