🩸Facts about Multiple Myeloma:

Adverse Events and Management

#CRS #ICANS #Neurotoxicity #Neutropenia #Teclistamab #MajesTEC3 #Immunotherapy #Tocilizumab #Hematology #RareDiseases #BloodDisorders #ClinicalInsights #MedEd #HEMEHUB

Capecitabine-Carboplatin “Most Favorable” Backbone for Advanced Gastroesophageal Adenocarcinoma Capecitabine plus oxaliplatin (CapOx) does not offer a progression-free survival (PFS) advantage over capecitabine plus carboplatin (CapCar), nor over nanoliposomal irinotecan, leucovorin and fluorour...

#Neurotoxicity rates were 46.3% in patients given CapOx, 2.5% in those treated with CapCar, and 0% in those assigned to F-Nal-IrI.

Read More: https://bit.ly/3Zgl5u7

A new study published in Environmental Chemistry and Ecotoxicology (ENCECO) employs a powerful, integrated strategy to crack this code, offering a blueprint for assessing the neurotoxicity of environmental chemicals.
#Neurotoxicity #Nicotine
Details: doi.org/10.1016/j.en...

BioRxiv Article

[BioRxiv] Aβ-42 sidechain deamidation at Q15 or N27 modulates protein aggregation and alters microglial cytokines and CD68

https://doi.org/10.1101/2025.10.22.684043

#neurodegeneration #biorxiv #neurotoxicity #amyloid

BioRxiv Article

[BioRxiv] Aβ-42 sidechain deamidation at Q15 or N27 modulates protein aggregation and alters microglial cytokines and CD68

https://doi.org/10.1101/2025.10.22.684043

#neurodegeneration #biorxiv #neurotoxicity #amyloid

Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk Copper interferes with tryptophan metabolism and 5-HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coag...

🧠 Copper exposure drives #neurotoxicity through a gut–brain metabolic axis!
🔥 It triggers #gut barrier damage and inflammation, leading to #neural injury.
💊 The #probiotic W. coagulans XY2 counteracts toxicity by targeting a multi-layered network.
onlinelibrary.wiley.com/doi/10.1002/...

BioRxiv Article

[BioRxiv] Mitoxantrone Hydrochloride Targets APP and LRRK2 to Improve Neurodegeneration in Parkinson's Models

https://doi.org/10.1101/2025.10.06.680832

#neurodegeneration #biorxiv #Neurodegeneration #amyloid #neurotoxicity #mitochondrialdysfunction

BioRxiv Article

[BioRxiv] Dual-action peptide shuttles rescue Cu-amyloid-beta-induced neurotoxicity and relocate Cu intracellularly

https://doi.org/10.1101/2024.09.04.611242

#neurodegeneration #biorxiv #amyloidbeta #neurotoxicity #amyloid

Protective effects of alkaloidal fraction of Elaeocarpus angustifolius Blume against AlCl₃-evoked neurotoxicity: insights from an in vivo model of Alzheimer's disease.

https://pubmed.ncbi.nlm.nih.gov/41335145/

#neurodegeneration #neurotoxicity #Alzheimers

📢 Our latest study in the #Wiley Journal of Cellular and Molecular Medicine showed Liposome-Encapsulated Melatonin is a promising therapeutic agent for reducing Amx-induced neurotoxicity in zebrafish. #NIRINepal #CARE #melatonin #Neurotoxicity doi.org/10.1111/jcmm...

This study shows that #ATOX1 overexpression protects #Microglia by sustaining Cu²⁺ #Homeostasis, alleviating #Neurotoxicity, #OxidativeStress, #Apoptosis, & #Neuroinflammation in #Alzheimer’s, opening new avenues for targeted therapies. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

AI & zebrafish data to advance early detection of neurotoxic compounds

We’re using AI and zebrafish data to help detect neurotoxic compounds targeting acetylcholinesterase (AChE) and support defense and public health. #Biodefense #Neurotoxicity #AChE

Neurotoxicity associated with chimeric antigen receptor T-cell therapy Chimeric antigen receptor T cell (CAR-T) therapy involves reengineering patient-derived or donor-derived T cells to express a synthetic CAR that can recognise specific cell-surface antigens, independe...

CAR-T therapy has transformed hematologic cancers, but ICANS remains a major barrier. Diverse neurotoxicities, lack of biomarkers, and unclear mechanisms highlight an urgent unmet need. #CART #Neurotoxicity #crackingICANS

Check out the paper below 👇

www.jni-journal.com/article/S016...

The combined effects of sequestration and collateral degradation trigger a self-amplifying cascade of #neurotoxicity.
-The pool of functional ESCRT-III proteins becomes critically depleted, preventing the cell from properly repairing its endolysosomal membranes.

📌 Conclusion:
Neurotoxicity is a major survivorship challenge → need biomarkers, preventive strategies, multidisciplinary management.

#NeuroOncology #Neurotoxicity #CancerSurvivorship #MedEd

🧠 GAIKER's iCARE team developed human in vitro models to evaluate nanomaterial neurotoxicity. Their work includes blood-brain barrier models and 2D/3D co-culture systems using graphene materials. Check out their poster → tinyurl.com/n8c4su8r 🔬 #iCAREproject #neurotoxicity #nanomaterials

Understanding the toxicity induced by radiation-triggered neuroinflammation and the on-demand design of targeted peptide nanodrugs - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Understanding the toxicity induced by radiation-triggered neuroinflammation and the on-demand design of targeted peptide nanodrugs

This study shows that radiation-generated mitochondrial ROS-induced #mtDNA leakage activates the cGAS-STING pathway, resulting in microglia-mediated #neuroinflammation. #neurotoxicity #medsky

#OpenAccess:

Chronic exposure to microplastics impairs blood-brain barrier and damages neurons A study on rats suggests that exposure to microplastics may impair the blood–brain barrier, induce oxidative stress in the brain, and damage neurons. The microplastic exposure involved oral administration...

Chronic exposure to microplastics impairs blood-brain barrier and damages neurons #Science #HealthandMedicine #Neurology #Microplastics #Neurotoxicity #PublicHealth

Arndt Vogel Highlights Key Findings on ICI-Related Neurotoxicity - OncoDaily Arndt Vogel Highlights Key Findings on ICI-Related Neurotoxicity / Arndt Vogel, Bianca Denise Santomasso, cancer, Carsten Bagh Juhl, Dorte Lisbet Nielsen,

Arndt Vogel Highlights Key Findings on ICI-Related Neurotoxicity
@arndtvogel.bsky.social

oncodaily.com/science/arnd...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #ICIs #IO #Neurotoxicity

🧠 GAIKER’s iCARE poster introduces new in vitro ecotox models for neurotoxicity: shifting from gill to brain cell models, using high-throughput 96-well formats, and developing 3D co-cultures mimicking real exposures. Download full poster : tinyurl.com/23z5aem2

#iCARE #neurotoxicity #ecotox

🧠 New insights raise concerns about CAR-T cell therapy and its possible link to mild cognitive impairment.
Could a treatment designed to fight cancer also affect the brain?
🌐 Visit: mciandbeyond.org

#CAR_T #CognitiveImpairment #BrainHealth #DementiaAwareness #Neurotoxicity #MCIandBeyond

Lets lear more about dolphin's 🐬 brain 🧠
#cetacean #pathologies
#neurodegeneration
#neurotoxicity
#OneHealth

#SAREUS
@ehu.eus @ztffct.bsky.social

Rapidly progressive dementia in tacrolimus neurotoxicity: rare but reversible.

https://pubmed.ncbi.nlm.nih.gov/40407992/

#neurodegeneration #neurotoxicity

Neurological Side Effects of Chemotherapy - OncoDaily Explore neurological side effects of chemotherapy, including neuropathic pain and chemobrain, multidisciplinary approach to manage neurotoxicity.

Neurological Side Effects of Chemotherapy

oncodaily.com/oncolibrary/...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Chemotherapy #Chemobrain #PeripheralNeuropathy #CIPN #NeuroprotectiveDrugs #Neurotoxicity #Duloxetine

🔬 Curious about nanomaterial safety?

Stay updated with the iCARE Project!
Subscribe to our newsletter for the latest on brain health, research, and events.

👉 Sign up now: t.co/ucWMWqROr3

#brainhealth #neurotoxicity #SaferChemicals
#nanomaterials

👏 Congratulations to Aline Hajj (@ulaval.ca, #QPRNmember) for winning the prestigious Samuel-De Champlain funding for her project on the neurotoxic effects of #chemotherapy, in collaboration with Bruno Mégarbane (@upcite.bsky.social )! 🌍

👉 qprn.ca/en/2025/04/1...

#Research #Neurotoxicity

Key point: Prenatal VPA exposure is associated with teratogenicity, rendering it contraindicated for women of childbearing potential.
onlinelibrary.wiley.com/doi/full/10....

#epilepsy #ILAE #epilepsia #neurotoxicity #stemcell #teratogenicity #valproate #VPA

Montelukast's potential as a neuroprotective agent against acrylamide induced neurotoxicity: In vivo and computational modelling.

https://pubmed.ncbi.nlm.nih.gov/40222648/

#neurodegeneration #neurotoxicity #neuroprotective

Melatonin protects mouse hippocampal neurons from neurotoxicity induced by amyloid β-peptide(25-35).

https://pubmed.ncbi.nlm.nih.gov/40222698/

#neurodegeneration #amyloid #neurotoxicity

Amyloid-β-Induced Neurotoxicity Modulates miR-98 and miR-200 Expression in SH-SY5Y Cells: A Step Toward Alzheimer's Biomarker Discovery.

https://pubmed.ncbi.nlm.nih.gov/40195218/

#neurodegeneration #Alzheimers #neurotoxicity