Neurobehavioral meaning of pupil size Grujic et al. summarize the optical, neural, and behavioral consequences, as well as mechanisms, of pupil-linked arousal. They incorporate novel findings and identify gaps in the literature while prov...

Your Pupils, Your Mind 👁️🧠

Pupil size isn’t just light reflex: it tracks “pupil-linked arousal” shaped by neuromodulators (NA, ACh, 5-HT, orexin). The piece argues pupils are a 1D readout of multidimensional brain states.

#Neuroscience #Arousal #Pupillometry #Orexin
www.cell.com/neuron/fullt...

Current and novel dual orexin receptor antagonists for the treatment of insomnia: the emergence of vornorexant Abstract. Insomnia is a serious public health concern. As the widely prescribed hypnotics that positively modulate gamma-aminobutyric acid (GABA)A receptor

Clinical Perspective: While offering clear mechanistic and safety advantages, the optimization of DORAs continues to evolve around pharmacokinetics and next-day tolerability.
Check more here: doi.org/10.1093/ijnp...
#SleepMedicine #Neuropharmacology #Insomnia #Orexin #DORA #Neurology #Psychiatry

Alkermes’ Alixorexton Shows Positive Phase II Results in Narcolepsy Type 2 | Applied Clinical Trials Online In Vibrance-2, oral alixorexton significantly improved wakefulness and reduced excessive daytime sleepiness with a favorable safety profile, positioning the OX2R agonist for rapid advancement into…

Exciting to see positive results for an orexin agonist in #narcolepsy type 2 (NT2).

This result demonstrates the value of targeting orexin receptor 2 in this poorly understood form of narcolepsy.

#sleep #medicine #orexin #research

www.appliedclinicaltrialsonline.com/view/alkerme...

🔥 Why do some people thrive under #Stress while others collapse? 🤔 The #Orexin system decides who adapts and who breaks! 🧩 @mdpiopenaccess.bsky.social
#Neurobiology #Resilience #Psychiatry
🔗 Read now: www.mdpi.com/2227-9059/12...

Orexin 1-16 as the stable metabolite behind low CSF orexin/hypocretin immunoreactivity in narcolepsy Dear Editor,

#Orexin 1-16 is analyzed to understand its impact on immunoreactivity in #narcolepsy. academic.oup.com/sleep/articl...

🏅Proud “Winner of The Biomedicines Hot Paper #Award!🏆 Shocking fact: #Orexin #Neuropeptides run our #Vigilance, #Stress & #Metabolism!😱🚀Our review unveils their evolution & drug prospects 🧠📈🌟 @mdpiopenaccess.bsky.social
#Neuroscience #HotPaper
Dive in now!
www.mdpi.com/2227-9059/12...

💥 #Orexin system: tiny peptides with HUGE impact! From #Anxiety to #Learning, #Sleep to metabolism—our Hot Paper Award review tells the story + drug advances! 🌍🧠 @mdpiopenaccess.bsky.social #NeuroResearch #HotPaper
www.mdpi.com/2227-9059/12...

New study by Xiang et al. reveals that neural circuits from hypothalamic #orexin neurons to the substantia innominata promote wakefulness and reduces pain under anaesthesia

www.bjanaesthesia.org/article/S000...

🚨 #Orexin: shocking maestros of #Vigilance, #Stress & #Metabolism! 😱🚀Hot Paper #Award🏆 #Winner🏅reveals orexin evolution & drug prospects for brain & metabolic health🧠💊📈🌟 @mdpiopenaccess.bsky.social #Neuroscience #Orexin #HotPaper 👉 Read: www.mdpi.com/2227-9059/12...

#Orexin signalling and modulation in the nucleus accumbens plays a role in #emergence from general anaesthesia, furthering our understanding of the mechanisms by which GA induces reversible loss of consciousness

🚨 #Orexin: shocking maestros of #Vigilance, #Stress & #Metabolism! 😱🚀Hot Paper #Award🏆 #Winner🏅reveals orexin evolution & drug prospects for brain & metabolic health🧠💊📈🌟 @mdpiopenaccess.bsky.social #Neuroscience #Orexin #HotPaper 👉 Read: www.mdpi.com/2227-9059/12...

🚨 #Orexin: shocking maestros of #Vigilance, #Stress & #Metabolism! 😱🚀Hot Paper #Award🏆 #Winner🏅reveals orexin evolution & drug prospects for brain & metabolic health🧠💊📈🌟 @mdpiopenaccess.bsky.social #Neuroscience #Orexin #HotPaper 👉 Read: www.mdpi.com/2227-9059/12...

🏅Proud “Winner of The Biomedicines Hot Paper #Award!🏆 Shocking fact: #Orexin #Neuropeptides run our #Vigilance, #Stress & #Metabolism!😱🚀Our review unveils their evolution & drug prospects 🧠📈🌟 @mdpiopenaccess.bsky.social
#Neuroscience #HotPaper
Dive in now!
www.mdpi.com/2227-9059/12...

Shocking fact: #Orexin #Neuropeptides run our #Vigilance, #Stress & #Metabolism!😱🚀Our review unveils their evolution & drug prospects 🧠📈🌟 Proud “Winner of The Biomedicines Hot Paper #Award!🏆 @mdpiopenaccess.bsky.social
#Neuroscience #HotPaper
Dive in now!
www.mdpi.com/2227-9059/12...

Low levels of orexin, for example, are associated with excessive daytime sleepiness. High levels may be connected to increased stress.

Given that non-restorative sleep is an important symptom of #MECFS and #LongCOVID, it is hypothesized that #orexin may be disrupted in these diseases. (2/4)

Read these findings by Mélodie Devère et al. supporting the idea that dysfunction of the #orexin system may promote #obesity and #diabetes, and could represent an interesting therapeutic target in the context of ‘diabesity’ 👉 doi.org/10.1530/JOE-...

🔬 Patients & asymptomatic carriers show more wakefulness + reduced deep sleep.
🧪 Our group found key player: orexin-producing neurons in the hypothalamus.
💊 Blocking orexin restored normal sleep—could this be a new treatment target?
#ALS #Neuroscience #SleepResearch #hypothalamus #orexin #sleep

🔬 Patients & asymptomatic carriers show more wakefulness + reduced deep sleep.
🧪 Our group found key player: orexin-producing neurons in the hypothalamus.
💊 Blocking orexin restored normal sleep—could this be a new treatment target?
#ALS #Neuroscience #SleepResearch #hypothalamus #orexin #sleep

#narcolepsy is the inability of regulating the sleep wake cycle, caused by the destruction of #hypocretin #orexin neurons in the hypothalamus. #lifewithnarcolepsy #narcolepsywithcataplexy #cataplexy #sleepparalysis #hypnogagichallucinations

UCLA researchers find new clue to cause of human narcolepsy Narcoleptics have far less hypocretin, a chemical linked to alertness, in their brains than healthy people. A new study zeroes in on just what's killing hypocretin cells off.

So they seem to have figured out that people with more histamine in their brain have less hypocretin aka orexin which is seen as the cause of autoimmune version of narcolepsy (with cataplexy). #narcolepsy #orexin #hypocretin

newsroom.ucla.edu/releases/new...

The microbial metabolite #butyrate can promote #sleep by modulating #orexin neuronal activity in the lateral #hypothalamic area in mice.
www.nature.com/articles/s41...

☀️Good morning #ACNP2024! I’m Ana Pocivavsek from University of South Carolina! Presenting on Tues night: #sleep, #orexin, and #tryptophan metabolism in the #aging 🐀 brain 🧠. I’ve been attending for ~10 years! Happy to answer questions about URM Near-Peer Mentorship Program!

#Orexin receptor antagonist increases fat oxidation and suppresses protein catabolism during #sleep in humans
www.sciencedirect.com/science/arti...

#Ayesart
#Teacup in a teacup
#Orexin 2008 - 2023

Study reveals key brain cells help resist food temptations in favor of exercise Hypocretin/orexin neurons (HONs) are crucial for resisting temptation and choosing exercise over highly palatable foods. This finding highlights potential targets for promoting physical activity and c...

Study reveals key brain cells help resist food temptations in favor of exercise 🧠🏃🍓 www.news-medical.net/news/2024080... #Neuroscience #Obesity #Exercise #Orexin #Hypocretin #BrainHealth #TemptationResistance #HealthyLiving #PhysicalActivity #Research @natureportfolio.bsky.social

New #FDA approval for #sedative that "antagonizes the #orexin receptor" - time to bone up! #belsomra #insomnia

fda.gov/NewsEvents/New…