Here you have the cryoEM structure of the microbial rhodopsin CryoR1 from Cryobacterium levicorallinum (PDB code: 8R0K)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #rhodopsin #light #activation #cryobacterium #cryoem

mt-EcGAPR, a light-activated #Mitochondrial #Rhodopsin, restores ATP, reduces #ROS and #DNADoubleStrandBreaks, and protects #RetinalGanglionCells in glaucomatous mice by inhibiting ER stress–pyroptosis. @fudan-university.bsky.social

#OpenAccess in #STTT: doi.org/10.1038/s413...

Here you can see a recent cryoEM structure of the light-driven sodium-pumping rhodopsin KR2 (PDB code: 8RQ5)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #pump #ion #sodium #light #rhodopsin #cryoem

Cool preprint: Evidence for the acquisition of a proteorhodopsin-like #rhodopsin by a chrysophyte-infecting giant #virus

www.biorxiv.org/content/10.1...

Samantha Thompson, @mrobichaux.bsky.social & co investigate how rod photoreceptor synapses are impacted during diseases like retinitis pigmentosa by using a mouse model where mislocalised rhodopsin can be seen at the synapse. 🐭 👁️ doi.org/10.1242/dmm....

#Rhodopsin #Photoreceptors

Deletion of Emc6 in rod cells using a rod- and cone-specific Emc6 knockout model led to early-onset #RetinalDegeneration & mislocalization of rhodopsin and other membrane disc proteins, highlighting EMC6’s essential role in the synthesis and transport of #Rhodopsin in retinal

buff.ly/xHQ8Pgu

electron-microscopy picture of rod-shaped single-celled algae

A Most Useful Light Switch schaechter.asmblog.org/schaechter/2... paper from 2023: www.nature.com/articles/s41...

#Diatoms grow well in iron-limited waters. They switch their energy-generating photoreceptor to a proton-translocating #rhodopsin.

#Protists #Algae via @stcmicrobeblog.bsky.social

Defining proteoform-specific interactions for drug targeting in a native cell signalling environment - Nature Chemistry G protein-coupled receptors and their effectors can now be released directly from a lipid bilayer using infrared irradiation for proteoform-level characterization by native top-down mass spectrometry....

#TuesdayReads: Weston Struwe & Carol Robinson groups use #massspectrometry to reveal #rhodopsin proteoforms, lipid mods & PDE5 inhibitor off-target effects in native membranes.
#DrugDiscovery #Proteomics

👉 doi.org/10.1038/s415...

Protective effect of JC3 and JC4 against retinal degeneration in RP. Top: retinal sections treated with vehicle, JC3 and JC4, stained with HE. Middle: retinal cryosections treated with vehicle, JC3 and JC4, stained with 1D4 anti-Rho antibody and peanut agglutinin to detect rods and cones, respectively. Bottom: Structural basis for variant-specific pharmacochaperone effects. Bound state human WT rod opsin models, highlighted with interacting sites for JC3 and JC4 docked models.

#RetinitisPigmentosa is a blinding disease caused by misfolding mutations in #rhodopsin. This study identifies two pharmacologically promising compounds that stabilize misfolded, ligand-free rod opsin and slow down photoreceptor degeneration in a mouse model of RP 🧪 @plosbiology.org plos.io/3DSgI0O

Protective effect of JC3 and JC4 against retinal degeneration in RP. Top: retinal sections treated with vehicle, JC3 and JC4, stained with HE. Middle: retinal cryosections treated with vehicle, JC3 and JC4, stained with 1D4 anti-Rho antibody and peanut agglutinin to detect rods and cones, respectively. Bottom: Structural basis for variant-specific pharmacochaperone effects. Bound state human WT rod opsin models, highlighted with interacting sites for JC3 and JC4 docked models.

#RetinitisPigmentosa is a blinding disease caused by misfolding mutations in #rhodopsin. This study identifies two pharmacologically promising compounds that stabilize misfolded, ligand-free rod opsin and slow down photoreceptor degeneration in a mouse model of RP 🧪 @plosbiology.org plos.io/3DSgI0O

Protective effect of JC3 and JC4 against retinal degeneration in RP. Top: retinal sections treated with vehicle, JC3 and JC4, stained with HE. Middle: retinal cryosections treated with vehicle, JC3 and JC4, stained with 1D4 anti-Rho antibody and peanut agglutinin to detect rods and cones, respectively. Bottom: Structural basis for variant-specific pharmacochaperone effects. Bound state human WT rod opsin models, highlighted with interacting sites for JC3 and JC4 docked models.

#RetinitisPigmentosa is a blinding disease caused by misfolding mutations in #rhodopsin. This study identifies two pharmacologically promising compounds that stabilize misfolded, ligand-free rod opsin and slow down photoreceptor degeneration in a mouse model of RP 🧪 @plosbiology.org plos.io/3DSgI0O

Whales' eyes offer glimpse into their evolution from land to sea: U of T researchers University of Toronto researchers have shed light on the evolutionary transition of whales' early ancestors from on-shore living to deep-sea foraging, suggesting that these ancestors had visual system...

Professor Belinda Chang studies protein evolution, focusing on visual proteins like rhodopsin. One of her studies on evolution of rhodopsin showed that whales evolved swiftly to become deep divers #evolution #photoreceptor #rhodopsin 🧪 www.utoronto.ca/news/whales-...

Picture of a box jellyfish, ghostly white with 4 trailing tentacles, against black background. Pic credit to https://www.asbmb.org/asbmb-today/science/122623/a-jellyfish-model-to-study-optogenetics.

Ooh, cool protein system alert! A rhodopsin from a jellyfish, that participates in signal transduction w G proteins! The biochemistry of visual proteins (not always in vision) continues to amaze.
#proteins #rhodopsin #biochemistry
See www.asbmb.org/asbmb-today/... for the story/link to JBC article.