For today’s #FluorescenceFriday, the #rods clearly chose chaos
What you’re looking at are long, beautifully coiled outer segments of rod #photoreceptors… basically the retina showing off its inner spaghetti aesthetic.
Elegant, tangled, and absolutely essential for seeing in low light.

Gaogao He, Lei Zhou et al. demonstrate that #ionchannels from #photoreceptors in the retina are very sensitive to photodynamic modification mediated by singlet oxygen, ¹O2, the molecular oxygen in electronically excited states. rupress.org/jgp/article/...

#Biophysics #MolecularPhysiology

In @jgp.org, Gaogao He, Lei Zhou et al. demonstrate that #ionchannels from #photoreceptors in the retina are very sensitive to photodynamic modification mediated by singlet oxygen, ¹O2, the molecular oxygen in electronically excited states. rupress.org/jgp/article/...

#Biophysics

Delores A. Stacks and colleagues observed that selective knockout of murine glutamic acid-rich protein 2 significantly alters dark continuous noise in rod #photoreceptors 🧠 🔎

📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

No momentum lost as we dazzled with the ciliary necklace, CEP290 and transition zone integrity in #photoreceptors, inner scaffold maintenance & membrane attachment key for gating with the amazing @abimoye.bsky.social (Wensel group and current @carlorivolta.bsky.social ). #IRDs #UKCilia2025 /4

New #organoid research models RPGRIP1-inherited retinal disease; connecting cilium, stress response, and #proteostasis abnormalities to inform variant and therapy assessment. #ciliopathies #AAVtherapy #photoreceptors https://ow.ly/xTwl50Xva6s

University of Sydney (USYD) | ISSCR

Frontiers | AAV-mediated transduction of songbird retina IntroductionGenetic manipulation of murine retinal tissue through ocular administration of adeno-associated viruses (AAVs) has become a standard technique to...

This work opens reliable genetic access to diverse retinal cells, enabling gene delivery, pathway specific manipulation and emerging gene editing strategies.
doi.org/10.3389/fphy...

#AAV #Retina #GeneDelivery #VisionScience #Neuroscience #Songbirds #Photoreceptors

Layers of vision, glowing green #FluorescenceFriday

Here, #photoreceptors expressing a #glutamate biosensor mark the first step in visual processing, with a single inner-retina #neuron (likely amacrine) revealing deeper circuit activity before signals ever reach the brain.
#Neuroscience #Microscopy

🔔 Issue 18 of FEBS Letters features articles on #photoreceptors, #immunology, and more, including:

👁️ Perspective: cGMP and cAMP systems in #RetinitisPigmentosa
🧬 In a Nutshell: #mRNA metabolism in immune cells
🫧 Editor's Choice: Genomic modifiers of #NiemannPick severity

➡️ bit.ly/4mIaSQE

New work from our neighbours @jjfosterlab.bsky.social lab with lead ‪@gkolyfetis.bsky.social‬
- check out their findings on the coupling of #photoreceptors in different #bee species 🐝👇👇

A #fly 's #eye is basically thousands of tiny eyes crammed into one, like having an entire optometrist’s convention on your face.
Each mini-eye, called an #ommatidium, has its own cornea, lens, and #photoreceptors, giving insects a pixelated, wide-angle view of the world, and probably your snack.
🪰

Samantha Thompson, @mrobichaux.bsky.social & co investigate how rod photoreceptor synapses are impacted during diseases like retinitis pigmentosa by using a mouse model where mislocalised rhodopsin can be seen at the synapse. 🐭 👁️ doi.org/10.1242/dmm....

#Rhodopsin #Photoreceptors

📰 Both papers are now out as back-to-back bioRxiv publications, reinforcing the idea that light is more than a trigger.
Thank you very much to everyone involved in this work!
#light #retinalorganoids #maturation #stemcells #photostimulation #development #photoreceptors #iPSC @radboudumc.bsky.social

#MicroscopyMonday
AAV injections in chick retina: #photoreceptors transduced as expected—plus widespread #Müllerglia labeling across layers!
Shows AAV’s promise for multi-cell targeting in vision repair.
📄 doi.org/10.3389/fphy...
#AAV #Retina #GeneTherapy

Bartölke et al, The FASEB journal: Full-Length Cryptochrome 1 in the Outer Segments of the Retinal Blue Cone Photoreceptors in Humans and Great Apes Suggests a Role Beyond Transcriptional Repression

New publication on #cryptochrome 1 by our SFB researchers and colleagues! 👫🦧🦍 #CRY1 in the outer segments of blue cone #photoreceptors might have several different functions including at least one nonclock function. Several versions of CRY1 might exist in humans: doi.org/10.1096/fj.202402614R

#quotes #books #booksky #excerpts #citations #animmenseworld #yong #brittlestar #echinoderm #senses #vision #photoreceptors #eye #compoundeye #sensory #biology

The #phytochromes Agp1 and Agp2 of the soil bacterium #Agrobacterium fabrum control #BacterialConjugation and #GeneTransfer to plants.

This study provides insights into the interactions between Agp1 & Agp2

🖊️ Tilman Lamparter & team

➡️ bit.ly/41vhXLB

#Photoreceptors

Ca²⁺ binding to Esyt modulates membrane contact site density in #Drosophila #photoreceptors, say Vaisaly Nath, Harini Krishnan, Shirish Mishra, and Padinjat Raghu (@rpadinjat.bsky.social) @ncbsbangalore.bsky.social: rupress.org/jcb/article/...

Eyes of Wasp The Megaphragma measure about ⅕ millimeter and do try to catch their prey. They infiltrate thrips bodies to lay their eggs.

Eyes of Wasp

www.linkedin.com/pulse/eyes-w...

#Megaphragma #Ommatidia #wasp #wasps #research #science #photoreceptors #pigmentedgranules #animals #nationalgeographic #lens #photo #vision

Schematic diagram showing the tetrapyrrole biosynthesis pathway starting from 5-aminolevulinic acid and branching at the point of protoporphyrin IX to chlorophyll/bacteriochlorophyll and heme/bilin biosynthetic pathways. Solid and dotted arrows indicate single and multiple enzyme steps, respectively. The chemical structures of representative tetrapyrroles are depicted. The conjugated regions are highlighted. Image taken from Masuda et al. Plant and Cell Physiology, Volume 66, Issue 2, February 2025, Pages 133–135, https://doi.org/10.1093/pcp/pcaf014

📢Special Issue: #Tetrapyrrole #Photoreceptors in Photosynthetic Organisms is now online! @oxunipress.bsky.social
academic.oup.com/pcp/issue/66/2

Organised by:
T. Masuda
R. Narikawa
Y. Saga
H. Yamamoto
M. Terry @mjtplantbiology.bsky.social
Y. Fujita

Editorial: doi.org/10.1093/pcp/...
#PlantScience

Specimen of Graphium sarpedon feeding on a flower. This species, unlike others, has very similar wing uper and undersides. Source: Wikimedia Commons Author: Laitche CC BY-SA 4.0

5️⃣ Graphium sarpedon - This is the top sp. holding the record for eyes with the most diverse #photoreceptors 🌈 among animals.

Its 15 different spectrally sensitive cells integrate in a way that scientists don't yet fully understand (they are most likely #trichromic 🎨!). doi.org/10.3389/fevo...

The beauty of viral transfection in #avianretina 🐔

Here is a transfected #amacrinecell and some #photoreceptors in a cross-section of a #chick #retina.

Great image for #FluorescenceFriday

Sample from
@neurofishh.bsky.social

Green: Viral transfected retina; Red: DAPI for stratification