BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia - Cell Death & Disease Cell Death & Disease - BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia

#BAP1 overexpression induces early onset #preeclampsia–like features in #placental #organoids: ❌blocked extravillous #trophoblast differentiation
❌impaired syncytialization
🔥persistent pro-inflammatory signatures @cbm-csic-uam.bsky.social @csic.es 👏🥳team! www.nature.com/articles/s41...

Placental Steroid Hormones in Preeclampsia: Multilayered Regulation of Endocrine Pathogenesis Abstract. The human placenta serves as the predominant endocrine organ throughout pregnancy, assuming a central role in preserving endocrine homeostasis, f

Placental Steroid Hormones in Preeclampsia: Multilayered Regulation of Endocrine Pathogenesis. Read more in #EndocrineReviews: bit.ly/4usDAtz #placenta #trophoblast #testosterone @endocrinesociety.bsky.social

DOI: https://doi.org/10.1186/s13619-025-00261-x

Cell Regen Research | |✨Primed hPSCs → functional trophoblast stem cells in days?🧬
Transient MEK/ERK inhibition + balanced WNT yields stable hTSCs with strong STB/EVT potential. #StemCells #Trophoblast
🔗 Full paper at: doi.org/10.1186/s136...

Robert Pijnenborg – An appreciation
#Placenta #Trophoblast #ReproSky #Science #Pregnancy
www.sciencedirect.com:5037/science/arti...

Epigenetics Update - VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment bit.ly/3KpCpcc

Francesca Soncin reporting in PNAS

#Epigenetics #Trophoblast
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Perfect for cancer, immunology, and aging research; epigenometech.com

Three-dimensional confocal image of a swine trophoblast organoid immunostained for ZO-1 (green) and actin (purple), with nuclei counterstained using DAPI (grey). ZO-1 highlights tight junctions at the apical borders in the center of the organoids, while actin outlines cellular architecture, revealing organized epithelial polarity within the organoid structure. Image credit: Cole McCutcheon, Duke University.

In vitro model of porcine placental development: @crm110.bsky.social &co develop a swine trophoblast #organoid model that mimics in vivo #trophoblast diversity & gene expression, providing a platform for studying #placental biology & #MaternalFetalInteractions @plosbiology.org 🧪 plos.io/47jf3yd

Three-dimensional confocal image of a swine trophoblast organoid immunostained for ZO-1 (green) and actin (purple), with nuclei counterstained using DAPI (grey). ZO-1 highlights tight junctions at the apical borders in the center of the organoids, while actin outlines cellular architecture, revealing organized epithelial polarity within the organoid structure. Image credit: Cole McCutcheon, Duke University.

In vitro model of porcine placental development: @crm110.bsky.social &co develop a swine trophoblast #organoid model that mimics in vivo #trophoblast diversity & gene expression, providing a platform for studying #placental biology & #MaternalFetalInteractions @plosbiology.org 🧪 plos.io/47jf3yd

Three-dimensional confocal image of a swine trophoblast organoid immunostained for ZO-1 (green) and actin (purple), with nuclei counterstained using DAPI (grey). ZO-1 highlights tight junctions at the apical borders in the center of the organoids, while actin outlines cellular architecture, revealing organized epithelial polarity within the organoid structure. Image credit: Cole McCutcheon, Duke University.

In vitro model of porcine placental development: @crm110.bsky.social &co develop a swine trophoblast #organoid model that mimics in vivo #trophoblast diversity & gene expression, providing a platform for studying #placental biology & #MaternalFetalInteractions @plosbiology.org 🧪 plos.io/47jf3yd

#Pieoz1-TMEM16F ( lipid scramblase)➡️ #Trophoblast Fusion #Polyploidy

Trophoblast Piezo1 KO🐭➡️
👉Embryonic death
👉↔️fetoplacental #Angiogenesis
👉Compromised multi-nucleated Syncytiotrophoblast barrier
⏬MCT4 (maternal-facing BM)
⏬MCT1 (fetal-facing BM)

#NatComm 2025
www.nature.com/articles/s41...

Here is the #MeetourEditorialBoard series!

Spotlight on the Associate Editor Martin Gauster

#MHR #meetthescientist #trophoblast #development #placenta
@ESHRE Oxford University Press @UniGraz

Please add us! #placenta #trophoblast #viralinfections

Would love to be included for our work on #bladder organoids and #trophoblast organoids

A comparative deep dive into marmoset and human trophoblast development! 🧬 Congrats to Dylan and Clara on this exciting study, and thanks for having me on board! Check it out here: doi.org/10.1016/j.st...

#StemCells #Trophoblast #DevBio