Exciting new project in our lab @babrahaminst.bsky.social! We are working with @alesdantas.bsky.social at @newcastleuni.bsky.social to understand how extrachromosomal circular DNA mediates drug resistance in fungal pathogens
Funded by @wellcometrust.bsky.social
#ecDNA #eccDNA #Candida #Zymoseptoria
🧬 New #ecDNA @natrevcancer.nature.com review by team #eDyNAmiC @stanfordmedicine.bsky.social @scripps.edu
👉 doi.org/10.1038/s415...
Funded by: @cancerresearchuk.org #TheNationalCancerInstitue, #EmersonCollective and The Kamini & Vindi Banga Family Trust
#CancerResearch #CancerInnovation
Do you want to explore how ecDNA promotes cancers and discover novel ways to regulate ecDNA? Please consider joining my lab! We are hiring a talented postdoc! #ecDNA #postdoc #CancerBiology
➡️ yilaboratory.com
➡️ careers.msu.edu/jobs/postdoc...
Epigenetics Update - Genetic elements promote retention of extrachromosomal DNA in cancer cells go.nature.com/4rqIyWz
Paul S. Mischel and Howard Y. Chang (Stanford University) reporting in Nature
#Epigenetics #ecDNA #DNAm
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Discover the breakthrough at epigenometech.com
The October issue of Cancer Discovery @aacrjournals.bsky.social is now online! The cover features two papers on the role of #ecDNA heterogeneity in tumor evolution and adaptation to therapy - you can find these papers and much more here: aacrjournals.org/cancerdiscov...
📣 New month, new Commentary
Not just a by-product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B-cell leukemia
🔓 buff.ly/hO4fJ9g
🖊️ @andreaventura.bsky.social
#eccDNA #ecDNA
Extrachromosomal DNA Rings Reveal Early Drivers of Glioblastoma
Researchers reported on 8 September 2025 that circular ecDNA bearing EGFR can appear before glioblastoma tumors fully form, offering a potential early blood-test marker. Read more: getnews.me/extrachromosomal-dna-rin... #glioblastoma #ecdna #egfr
Studying or interested in #eccDNA, #ecDNA? Join our Extrachromosomal Circular DNA conference, 31 Oct–03 Nov 2025.
Send in an abstract & explore this dynamic & rapidly evolving field with leaders in ecDNA research➡️ bit.ly/3YmCmBY
💸Grants available for ALL career levels
📆Talk submission: 04 Sep 2025
Findings from @roelverhaak.bsky.social et al. reveal lentiviral transduction + antibiotic selection dramatically ⬇️ ecDNA+ #cancer cells, revealing both a challenge for research and a potential therapeutic clue. #ecdna
aacrjournals.org/cancerrescom...
@aacrjournals.bsky.social
SCI member Paul Mischel & others found that #ecDNA drives evolution & heterogeneity in urothelial carcinoma, playing an early role in tumorigenesis. The study highlights immune evasion mechanisms linked to ecDNA, offering insights for developing targeted therapies. pubmed.ncbi.nlm.nih.gov/40331621/
Rachel Schmargon from #Charité at the #ecDNA session at #EACR2025 shared her great work on neuroblastoma and high-grade glioma. Using chemo and targeted therapy, she showed how ecDNA drives diverse treatment responses in tumor cells. It is impressive translational insight. #Neuroblastoma
Giulia Montuori from #Charité presenting in the #ecDNA session at #EACR2025 :) fantastic talk! 👏 Great work and congrats on the recent Cancer Discovery publication! #CancerGenomics #CancerResearch
A privilege to hear from Paul Salomon Mischel on the history and future of ecDNA research. From discovery to cutting-edge insights .. what a journey. WOW! #EACR2025 #ecDNA #CancerGenomics
A study reveals how hybrid human-HPV ecDNA enhancers fuel tumor growth in #HPV+ #OropharyngealCancer — and how they can be targeted.
Researchers used HPV16 #FISHprobes from @arborbio.bsky.social to visualize key #ecDNA structures driving oncogene expression.
🔗 www.nature.com/articles/s41...
A new therapeutic opportunity in HPV-related cancer: Hybrid ecDNA boosts E6 and E7 expression via viral & host enhancers. Targeting it with CRISPRi or BET inhibition suppresses ecDNA(+) tumors.
Read the paper 👉 bit.ly/42Lk2nl
#CancerResearch #HPV #ecDNA #TargetedTherapy
Now online in Cancer Discovery: Spatial-Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution & Tumor-Immune Microenvironment - by Wei Lv, Yuchen Zeng, Conghui Li, Yuan Liang, Birgitte Regenberg, Yonglun Luo, Chunhua Lin, Peng Han, et al. doi.org/10.1158/2159... #ecDNA
Very excited to share the stellar speaker line-up at our ecDNA conference this June in London! 👇
If you're interested in #ecDNA and want to hear or present groundbreaking research, register now. Abstract submission deadline is 14 March.
Learn more: www.cancergrandchallenges.org/ecDNA-2025
#ecDNA is reshaping biomedical science. Now recognized as a key player in ~30% of cancer patients, understanding its biology could unlock new therapeutic strategies for #cancer & other diseases. Join us at #ecDNA25 for discussions at the forefront of this rapidly advancing field ➡️ bit.ly/XecDNA25
🧬🌟We're excited to add an Extrachromosomal Circular DNA conference to our 2025 calendar!🧬🌟
Chairs Birgitte Regenberg (Univ. of Copenhagen) & Zhao Zhang (Duke Univ.) are bringing a fantastic line up of speakers together in Mexico this year. More details➡️https://bit.ly/4az0PbV #ecDNA25 #eccDNA #ecDNA
New research shows how circular extrachromosomal DNA ( #ecDNA), found in nearly one in five #cancers, co-segregate during mitosis to drive tumor evolution.
1) A trio of Nature research articles examine how ecDNA
www.insideprecisionmedicine.com/topics/oncol...
Coordinated inheritance of extrachromosomal DNAs in cancer cells. #ExtrachromosomalDNA #ecDNA #CancerCells @natureportfolio.bsky.social
www.nature.com/articles/s41...
The papers, published simultaneously in Nature on Nov. 6, detail the prevalence and prognostic impact of the circles, called #ecDNA for extrachromosomal DNA, in nearly 15,000 human #cancers; highlight a novel mode of inheritance that overthrows a fundamental law of genetics; and describe an […]
