🇬🇧 Congrats to Alexia Kinoo for the SFH 2026 award! 🏆

Her work reveals a key role for ZEB1 in terminal erythroid maturation via the GATA2-KLF1 regulatory switch.

Great team effort from @soler-lab.bsky.social and @herminelab.bsky.social

#hematology #geneRegulation

text "BCBP Seminar Series Presents The RNA Binding protein ZFP36L2 Controls Distinct Gene Programs Across Tissues by Dr. Silvia Ramos who received her MD from the University of Campinas School of Medicine, Campinas, Brazil and completed her residency in Residency Clinical Immunology at the Medical School of Ribeirão Preto. She completed her Masters and Ph.D. in Basic and Applied Immunology at the Medical School of Ribeirão Preto, University of São Paulo, Brazil, and completed her postdoctoral training in mRNA-binding proteins and reproductive biology at the National Institute of Environmental Health Sciences NIEHS-NIH, Research Triangle Park, NC. The Ramos lab’s research is focused on RNA-binding proteins and their physiopathological roles in vivo. Dr. Ramos has a broad medical and biochemical background, with specific training and expertise in RNA-binding proteins and the creation of genetically-engineered mouse models." photo of Dr. Silvia Ramos

Don’t miss this Seminar on March 31, 2026 (11am)!
Silvia Ramos, MD, PhD on "RNA-binding protein ZFP36L2 and gene regulation across tissues"1131 Bioinformatics | Host: Dr. Bill Marzluff #HematoImmunology #GeneRegulation #ReproductiveBiology
@unclineberger.bsky.social @rnadiscoverycenter.bsky.social

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Dive into the full study here: 🔗 doi.org/10.1073/pnas... #Parasitology #GeneRegulation #MolecularBiology #ScienceCommunication #Epigenetics

📚#EpigeneticEditing
Rewires gene expression without altering #DNA—via reversible DNA & histone modifications. Promising for #GeneRegulation in genetic disorders & cancer Challenges: delivery, epigenetic memory, biomarkers. A shift from gene repair → reprogramming beyond #CRISPR
🔗 ow.ly/9JcL50Yw9AT

comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders Shen et al. report comBO, a combined human bone and bone marrow model that integrates osteolineage, vascular, stromal, and hematopoietic compartments in a single hiPSC-derived organoid system. comBO s...

Recent publications:
www.cell.com/cell-stem-ce...
www.nature.com/articles/s41...

#WIMMSpotlight #WIMMCommunity #CancerResearch #BloodCancer #Haematology #StemCellResearch #GeneRegulation #Genomics #DiseaseMechanisms #PrecisionMedicine #iPSC #EarlyCareerResearch #WomenInScience #OxCODE

Unstructured transcription factor interactions enable emergent specificity How intrinsically disordered regions (IDRs) influence chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We employed proximity-assisted photoactivation (PAPA), ...

While #DNAbindingdomains & #IntrinsicallyDisorderedRegions individually do not show binding specificity, "ensembles of diverse, unstructured interactions" collectively enable emergent #TranscriptionFactor specificity ➡️ www.science.org/doi/10.1126/...
#generegulation #IDRs #TFspecificity #chromatin

Redirecting

Really pleased to share the *final* version of @katiegelder.bsky.social's super work, profiling the functional roles of #IDRs in CBP. Published today 🎉

🔗https://doi.org/10.1016/j.celrep.2026.117109

#IDRs #condensates #transcription #CBP #generegulation #enhancers (1/7)

🧬 Epigenetics controls how the same DNA and 46 Chromosome create different cell types in the human body.
It plays a key role in development, health, and disease.

📢 International Epigenetics Conference 2026 | Hybrid Event
🔗 epigenetics-conferences.com

#Epigenetics #GeneRegulation

Thanks for having me @danbose.bsky.social, I had such a wonderful time! Lots of cool questions & great to hear about the exciting research on #condensates and #generegulation @sheffielduni.bsky.social!

Fantastic to welcome @fariatrypslab.bsky.social for our @mcb-sheffield.bsky.social seminar today. So much cool work on #condensates and #generegulation, and can't get over how awesome #trypanosomes are!

An Epigenetic Perspective of Gene Expression: The Regulatory Tools

dl.begellhouse.com/journals/6db...

#EpigeneticsResearch #GeneRegulation #ChromatinBiology #CRE

Connect with researchers in #GeneRegulation, small RNAs, #StructuralBiology and more at the EMBO Workshop "RNA-guided genome protection" in #Caux, CH, 16–20 June 2026.

Deadine: 15 March

https://meetings.embo.org/event/26-genome-protection
#DNAsky #RNAsky #EMBORNAGenomeProtection #EMBOevents 🧪

The mirage of DNA methylation in transcriptional regulation of plants Links between DNA methylation and transcription remain difficult to generalize and are weak on genome-wide scales. Multiple lines of evidence suggest DNA methylation plays only a minor role in the r...

🧬Does DNA methylation really control gene expression in plants?
Our new paper challenges this assumption — showing that methylation and transcription often avoid one another rather than align. Why is that?
acsess.onlinelibrary.wiley.com/doi/10.1002/...
#Epigenetics #DNAmethylation #GeneRegulation

Research topics include:
#EvoDevo #DevelopmentalBiology #Genomics #Genetics #Physiology #FunctionalGenomics #SingleCell #ComparativeGenomics #Regeneration #Aging #Neurobiology #DiseaseModels #HostMicrobe #Immunology #StemCells #CellBiology #CRISPR #GeneRegulation #Epigenomics #Metabolism #Evolution

Gene expression is a finely tuned process — from chromatin remodeling to protein synthesis and degradation. Every step matters in health & disease.

📅 Epigenetics Congress 2026 | Oct 15–16
📍 Boston, USA
🌐 epigeneticscongress.com

#Epigenetics #GeneRegulation

🧬 @danielibrahim.bsky.social, moderated by @stefanschoenfelder.bsky.social, on enhancer-promoter specificity & how promoter-proximal regions act as molecular filters.

Register: us02web.zoom.us/webinar/regi...

March 5, 4PM UK.

#Genomics #GeneRegulation

Epigenetic regulation controls gene activity without changing DNA—through mechanisms like methylation and histone modification. Environment, diet, and stress all matter. 🧬

Join Epigenetics Congress 2026
📅 Oct 15–16, 2026 | 📍 Boston, USA
🔗 epigeneticscongress.com

#Epigenetics #GeneRegulation

In summary, METALoci provides novel insights on #sexdetermination, from fundamental mechanisms of #generegulation to their relevance in vivo. (19/19) These and other interesting observations (as well as many Hi-C maps!) can be found in our paper. 🌀🧬 Have a look!

Cheers, sex & rock and roll. 🍻🤘

But... 🤔💭:
Are conventional tools for Hi-C analysis well suited to identify meaningful changes for #generegulation?

How can such a minor variation in 3D chromatin organization explain a process characterised by major changes in #transcription and cell identity? (5/n)

21/n In summary, METALoci provide novel insights on #sexdetermination, going from fundamental mechanisms of #generegulation to their relevance in vivo.

This highlights the power of integrative genomic approaches to uncover the molecular underpinnings of developmental processes.

a woman says how is that possible in white letters ALT: a woman says how is that possible in white letters

6/n But are conventional tools for Hi-C analysis well suited to identify meaningful changes for #generegulation?

How can such a minor variation in 3D chromatin organization explain a process characterized by major changes in #transcription and cell identity?

A pictographic model of chromatin folding in the nucleus. DNA wrapped around nucleosomes aggregates into nanoscale domains, whilst newly nucleosome depleted DNA that forms after acute degradation of FACT projects from these domains and engages in long-range interactions that can span TAD boundaries

New preprint from @anadopico.bsky.social (who I have had the great pleasure of supervising with Tom Milne) and our fantastic collaborators in the @davieslab.bsky.social

www.biorxiv.org/content/10.6...

#genomics #GeneRegulation #chromatin

Excited to share our newest #SingleCell work on human #AlcoholUseDisorder in #Amygdala out in @natcomms.nature.com
Paper: tinyurl.com/3xh54ath
Data: zenodo.org/records/1765...
Code: github.com/mjgirgenti/A...

#Neuroscience #AlcoholUseDisorder #SingleCell #Epigenomics #GeneRegulation

Discover DNA-protein interactions with Novogene ChIP-Seq. We perform immunoprecipitation, library prep and deep sequencing to map transcription factors, histone modifications and regulatory elements. #ChIPSeq #Epigenomics #GeneRegulation https://bit.ly/4gXbq3G

Switching and Sniffing around the β-globin cluster In this issue of Blood, Bagchi et al1 show how the β-like globin genes may be regulated by “Switch-Sniff” (switch/sucrose nonfermentable) chromatin remodel

#WIMMReads
🧪 #MRCWIMM Professor Doug Higgs authors a commentary in Blood on how chromatin remodeling complexes regulate globin genes and what this could mean for reactivating fetal hemoglobin in beta thalassemia and sickle cell disease.
#Haematology #GeneRegulation #WIMM

Had a fantastic time hosting my friend @husbandslab.bsky.social (an alum of our Plant Biology Graduate program @ucriverside.bsky.social)
Cool talk on paralog-specific regulation of transcription factor families! Exciting discussion on evolutionary and regulatory divergence!
#GeneRegulation

Would you like to join the #PRBBcommunity? Discover an exceptional environment to boost your career 🚀

Check out our #joboffers 👉https://www.prbb.org/carrera.php#Ofertas-empleo

#BiomedicalInformatics #SystemsBiology
#GeneRegulation #Epigenetics #CellBiology #DevelopmentalBiology #Pharmacology

Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!

Poster abstract deadline is Feb 9th for @keystoneSymposia.bsky.social #Epigenetics & #GeneRegulation in Health, Disease & Therapeutics, this March in Geneva - @emboreports.org editor Esther Schnapp will attend!
Details and registration: hubs.la/Q03TCq-r0
#KSEpigenetics26

With 5,565 amiRNAs targeting ~82% of the transportome, mTACT enables spatially resolved genetic screens to uncover hidden regulators of signaling molecule transport.

Published in @plantphys.bsky.social

#PlantPhysiology #Arabidopsis #FunctionalGenomics #Transporters #GeneRegulation #PlantScience

Size matters for gene expression! Our review uncovers how transcription scales with cell size across kingdoms.
Read it here: sciencedirect.com/science/arti...
#GeneRegulation #CellSize #PlantScience