Takeda signs $1.7bn AI alliance with Iambic Iambic bags another pharma partner, Takeda, which plans to use its AI platform to find drugs for cancer, gastrointestinal, and inflammatory disorders

#Takeda #AIalliance #AI #IambicTherapeutics #drugdiscovery #inflammatorydiseases #oncology #NeuralPLexer #smallmoleculetherapeutics #RevolutionMedicines #neurology #Lundbeck #NablaBio #Arzeda #nference #CytoReason #AIStructuralBiology #AISBconsortium #OpenFoldstructure
zurl.co/wMIRf

Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

This review explores proton‑activated #GPCRs, pH‑sensing receptors that modulate #ImmuneResponses, highlighting their roles in #InflammatoryDiseases and future directions for understanding immune regulation under pathological conditions.
Read: doi.org/10.1007/s115...

Fusing future science tech with complex genetic data for faster, more precise diagnostics at the Colonial Foundation Diagnostics Centre with The Royal Melbourne Hospital💡🧬🚀

👇
www.wehi.edu.au/news/ending-...

#Diagnostics #ScienceTech #AI #ML #SpatialOmics #InflammatoryDiseases

MSD advances on a broad front with TL1A drug tulisokibart MSD's confidence in its anti-TL1A drug tulisokibart in inflammatory diseases is made apparent by a decision to start trials in three new diseases.

#MSD's confidence in its anti-TL1A antibody tulisokibart in #inflammatorydiseases has been made apparent by a decision to start trials of the drug in three more indications.

This study shows that PSB-172656, a potent MRGPRX2 #antagonist, blocks Ca²⁺ signaling, β-arrestin recruitment, and #anaphylaxis, demonstrating potential for treating mast cell–mediated #allergic & #InflammatoryDiseases. @unibonn.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

Image shows a square box -the top shows a researcher filling a pipette. The bottom contains a red rectangle with white text that reads: “This research breakthrough highlights the benefit of combining academic expertise with industry to make real-world impact. We hope this discovery will lead to the development of new, targeted anti-inflammatory drugs which will help treat these devastating diseases.” Dr Rebecca Coll, Senior Lecturer in Immunobiology. There is also a photo of Dr Rebecca Coll beside the text in the bottom left-hand corner.

RESEARCH BREAKTHROUGH: Discovery could lead to new drug treatments for #InflammatoryDiseases including #Alzheimers, #asthma, #arthritis and #obesity.

Find out more: ow.ly/LxOx50WQeL9

#LoveQUB #LoveQUBResearch

#ResearchIsKey #EducationsIsKey #FreedomToChoose #NaturalAlternatives #CannabinoidResearch #FundCannabisResearch #CBD #THC #PatientCare #InflammatoryDiseases #Wellness #CannabisScience

#Polyarthritis #SpinalStenosis #Tenosynovitis #InflammatoryDiseases #Ow

Overturning how we think about immune regulation across the body A Fellow at St Catharine’s College has led extensive new research that looks set to overturn the established model about how one type of white blood cell regulates immune responses in tissues – what w...

A poorly regulated or hyperactive immune system can be hugely damaging, as we see in cases of flu, #COVID19, #autoimmunediseases & #inflammatorydiseases…

www.caths.cam.ac.uk/treg

www.biorxiv.org/content/10.1...

A new study found rising rates of rheumatoid arthritis worldwide between 1990 and 2021. And researchers say the autoimmune disease is hitting more younger adults.

youtu.be/ldDvEXiFBqE

#DisabilityStats #RAResearch #GlobalDiseaseTrends #RAandDiet #InflammatoryDiseases #RATreatment #RAinWomen

Characterizing Patient-Reported Fatigue Using Electronic Diaries in Neurodegenerative and Immune-Mediated Inflammatory Diseases: Observational Study Background: Fatigue is a prevalent and debilitating symptom in many chronic conditions, including immune-mediated inflammatory diseases (IMIDs) and neurodegenerative diseases (NDDs). Fatigue often fluctuates significantly within and between days, yet traditional patient-reported outcomes (PROs) typically rely on recall periods of a week or more, potentially missing these short-term variations. The development of digital tools, such as electronic diaries (eDiaries), offers a unique opportunity to collect granular, real-time data. However, the #feasibility, adherence, and comparability of eDiary-based assessments to established PROs require further investigation. Objective: This study aimed to evaluate the #feasibility and acceptability of using a high-frequency eDiary to capture intra-day variability in fatigue and to compare eDiary data with scores obtained from the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), a validated weekly recall PRO. Methods: Data were collected from 159 participants enrolled in the IDEA-FAST #feasibility Study; a four-week prospective observational study conducted at four European centres. Participants included individuals with NDDs (n=39), IMIDs (n=78), and healthy volunteers (HVs; n=42). Participants used an eDiary to report their physical and mental fatigue levels up to four times daily on a 7-point Likert scale (0 = low, 6 = high). Adherence was calculated as the proportion of completed eDiary entries relative to the total expected entries. Correlations between averaged eDiary scores and weekly FACIT-F scores were analysed. Results: Adherence to the eDiary protocol was 62% overall, varying by cohort, with the highest adherence (93%) observed in the primary Sjögren’s syndrome (PSS) cohort and the lowest adherence in Parkinson’s disease (PD) (43%) and Huntington’s Disease (HD) (44%) cohorts. The average adherence was 44% in the NDD cohorts and 74% in IMID cohorts. Fatigue levels showed clear diurnal variation, with significantly higher fatigue reported in the evening compared to the morning (p

JMIR Formative Res: Characterizing Patient-Reported Fatigue Using Electronic Diaries in Neurodegenerative and Immune-Mediated Inflammatory Diseases: Observational Study #PatientReportedOutcomes #FatigueResearch #NeurodegenerativeDiseases #InflammatoryDiseases #DigitalHealth

Johnson & Johnson shares positive late-stage results for Tremfya in psoriatic arthritis - PMLiVE The inflammatory condition affects approximately 30% of psoriasis patients

#immunology #rheumatology #InnovativeMedicine #jointhealth #JohnsonandJohnson #JandJ #JnJ #Tremfya #guselkumab #psoriaticarthritis #PsA #APEXtrial #activePsA #IL23blocker #pathogenesis #inflammatorydiseases #CD64receptor #CD64receptorbinder #IL23inhibitor #IL23treatment
pmlive.com/pharma_news/...

📣Check out this Masters Program open to international students!
🔬Based in Paris 🇫🇷, taught in English, offers housing for foreign students. More details 👇

#immunology #inflammation #inflammatorydiseases

Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation

This comprehensive review provides an overview of the current knowledge regarding the role of #fucosylation in #InflammatoryDiseases and #cancers, as well as the diagnostic biomarkers and potential therapeutic strategies. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation

This comprehensive review provides an overview of the current knowledge regarding the role of #fucosylation in #InflammatoryDiseases and #cancers, as well as the diagnostic biomarkers and potential therapeutic strategies. #medsky

#OpenAccess: www.sciencedirect.co...

ICONOCLASTIC NEW STUDY BREAKING at @nature.com

#GranzymeK activates the ENTIRE #Complement Cascade

MAJOR Implications for #Inflammation

Novel Mechanism & #Therapeutic Opportunities for #InflammatoryDiseases

www.nature.com/articles/s41...

✅ Inflammation is your immune system's response to injury or infection.

✅ It promotes healing but can harm you if it affects healthy tissues or goes on for too long.🧠🫀

#TheMoreYouKnow #MedX #inflammatorydiseases

Genetic discovery reveals key to inflammatory diseases Researchers discovered that a specific haplotype on chromosome 21 is linked to five inflammatory diseases, offering insights into potential new treatments.

Genetic discovery reveals key to inflammatory diseases 🧬🧪🧠 www.news-medical.net/news/2024060... #InflammatoryDiseases #GeneticResearch #Chromosome21 #AutoimmuneDisorders #CRISPR #FunctionalGenomics #ImmuneSystem @natureportfolio.bsky.social