Short-chain acyl-CoA dehydrogenase promotes antitumor immunity in #ColorectalCancer by initiating #mtDNA demethylation and cytosolic leakage, thereby activating the cGAS–STING pathway, enhancing immune surveillance.

#STTT #OpenAccess: doi.org/10.1038/s413...

Below is a rigorous, explanation that does not pathologize any race, avoids racial essentialism, instead examines systems,
historical conditions, and #psychological mechanisms of the #Savage #Fraud called #whiteness in an era of👉 #mtDNA Science
theorionblogown.blogspot.com/2025/11/my-q...

#biology

We found that physiological and reversible pearling acts simultaneously as a nucleoid spacing ruler and disaggregation mechanism, elegantly establishing the fundamental distribution of #mtDNA nucleoids. [4/6]

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

Study Tracks Genetic Lineages of Europe’s Last Neanderthals TÜBINGEN, GERMANY—According to a Live Science report, a team of researchers including archaeogeneticist Cosimo Posth […] The post Study Tracks Genetic Lineages of Europe’s Last Neanderthals appeared first on Archaeology Magazine.

Report on loss of diversity in #mtDNA lineages of #Neanderthals around 65,000 years ago

archaeology.org/news/2026/03/30/study-tr...

Interested in Pre-clinical Mitochondrial Disease Models?

MRC MitoCluster is delivering a session this May at Queen Square Advances in Mitochondrial Medicine 2026. Register now to join!

#MitochondrialDisease #MitochondrialMedicine #mtDNA #GeneticEngineering #PreclinicalResearch #RareDisease

Lifespan Predicts Mitochondrial Substitution Rates across Vertebrates, but Methodology Matters Abstract. Why do some species live for mere months, while others persist for centuries? A leading explanation implicates mitochondria. The mitochondrial th

Sterling, Zwonitzer & Havird explored the relationship between mtDNA evolution and species' lifespans, showing long-lived vertebrates showed reduced synonymous and nonsynonymous substitution rates, suggesting lower mtDNA mutation.

🔗 doi.org/10.1093/gbe/...

#genome #evolution #mtDNA

Neikirk et al. explore how #mitochondrial epigenetics drives aging, cardiovascular disease, neurodegeneration, and cancer, highlighting new therapeutic avenues and transgenerational effects. doi.org/10.4103/AGIN... #Epigenetics #Aging #Mitoepigenetics #mtDNA #Longevity #MedSky #neuroskyence

In Vitro Assays Fail to Detect mtDNA Depletion for Pathogenic Variants Found in TK2d Patients Researchers developed an in vitro assay for TK2 variants, but mtDNA depletion was minimal, highlighting challenges in modeling TK2d.

#ACMGMtg26: Researchers noted that TK1 may partially compensate for #TK2 deficiency in vitro, although its contribution to #mtDNA maintenance in this system remains unclear. @theacmg.bsky.social

Read more: https://bit.ly/4t0VcLP

#RareDisease #TK2d #MedSky

GBE | Evidence of Relaxed Selection in the Mitochondrial Genomes of Phototrophic Paulinella Lineages

Han et al. studied phototrophic Paulinella amoeba, suggesting that primary endosymbiosis may have left a detectable footprint in host mitochondrial genomes.

🔗 doi.org/10.1093/gbe/evag052

#genome #evolution #mtDNA

@bhattacharyalab.bsky.social

Ancient DNA from Palaeoloxodon naumanni in Japan reveals early evolution of Eurasian Palaeoloxodon Palaeoloxodon, the extinct genus of straight-tusked elephants, originated in Africa and dispersed across Eurasia. We analyzed ancient mitochondrial DN…

Straight-tusked #elephants once roamed across #Eurasia, but one lineage became stranded in Japan?! 🐘🧬 Ancient #mtDNA reveals Palaeoloxodon naumanni as an early-diverging lineage that survived in island isolation.
doi.org/10.1016/j.is...
#MetagenomicsMonday #SPAAM #aDNA #palaeogenetics #ancientDNA

The Osman Lab | LMU Munich Mitochondrial research and genome maintenance at Ludwig-Maximilians-University.

We have officially launched our new lab website. 🥳

The site includes the automated literature curation on #mtDNA quality control and copy number regulation, which will appear on Mondays and Thursdays. Listen to the latest #NotebookLM generated podcast.

🧬 Explore the new site: osman-lab.de

This review highlights #mtDNA leakage as a driver of #CellularSenescence and the SASP, activating cGAS–STING, #TLR9, and #NLRP3, while exploring strategies to block release or downstream sensing to combat #AgingRelatedDiseases.

#OpenAccess: doi.org/10.1016/j.ge...

MBE | Mammalian mitochondrial DNA accumulates insertions and deletions with age in energetically demanding tissues

@edmundotogo.bsky.social et al. studied de novo indel mtDNA mutations across multiple age groups in three mammalian species, showing that indels accumulate rapidly with age in somatic tissues with high energetic demand or high proliferation.

🔗 doi.org/10.1093/molb...

#evobio #molbio #mtDNA

The study discusses how the findings challenge the one specimen–one barcode premise, and the implications of sequence divergence on #metabarcoding-based assessments.

Image credit: Niina Kiljunen and Marko Mutanen.

#COI #mtDNA

GBE Highlight: The “Wild West” of Mitochondrial Genome Evolution in the Gastrotricha

February's article on mitogenome evolution in the Gastrotricha is the focus of this month's GBE Highlight.

Highlight: The “Wild West” of Mitochondrial Genome Evolution in the Gastrotricha

🔗 doi.org/10.1093/gbe/evag019

#genome #evolution #mtDNA

Early Bird extended to Feb 27, 2026! Final chance to get the preferential rate.

🔗Register now: www.euromit2026.eu/registration/

EUROMIT 2026 – May 31–June 4, Angers - France

#EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria @chuangers.bsky.social @univangers.bsky.social

STING drives pressure overload–induced #CardiacFibrosis and remodeling by promoting #inflammation, oxidative stress, and fibroblast activation, while #mitophagy limits cytosolic #mtDNA and STING signaling. #HeartFailure

#OpenAccess: doi.org/10.1016/j.ge...

Promotional image announcing the upcoming deadline for the Early Bird rate for EUROMIT 2026. At the top, the text reads “Take advantage before February 17, 2026!”. In the center, two tilted green shapes display the words “Early Bird” and “Rate”. The background features green, mitochondria‑like patterns on a black backdrop. At the bottom, a green band contains the text “EUROMIT 2026

Only a few days left to get the Early Bird rate!

Early Bird registration for EUROMIT 2026 ends on 17 February 2026

👉 Registration : lnkd.in/ecsTM5Gr

👉 Submit your abstract : lnkd.in/ejCS3e4t

#EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria @chuangers.bsky.social @univangers.bsky.social

GBE | From Rigid Order to Radical Variation: Mitogenome Evolution in the Main Lineages of a Lesser-Known Animal Phylum (Gastrotricha)

Kosakyan et al. sequenced mitogenomes of species from the two main lineages of the Gastrotricha; they found stable mitogenomes in the mostly freshwater Chaetonotida, but a dynamic pattern in the the marine Macrodasyida.

🔗 doi.org/10.1093/gbe/evag001

#genome #evolution #mtDNA

Excellent tool! We’ve been testing it all week and it’s already been great for catching every paper. The format makes it much easier to engage with the full daily #mtDNA literature than a standard search! 🧬 Great job @osman-lab.bsky.social

Square, neon-colored illustration announcing a “Daily Briefing” on mtDNA, showing mitochondria, DNA, AI icons, literature stacks, exercise symbols, and a bar graph, in a futuristic purple-pink style.

🧬 Introducing the #mtDNA Lab Intel Pipeline!

Our system daily scans PubMed and bioRxiv to bring you: 📄 #Gemini generated Daily Dossiers (PDF) and 🎙️ #NotebookLM generated Podcasts with a focus on #mtDNA-QC and #mtDNA-copy-number

📂 Full Archive:
drive.google.com/drive/folder...

Signaling Cascade Triggered by Circulating mtDNA May Contribute to Inflammation in TK2d Primary mitochondrial diseases such as TK2d may involve not just energy failure, but also mtDNA-triggered immune activation.

Primary mitochondrial diseases (#PMDs), including thymidine kinase 2 deficiency (#TK2d), may be driven not only by bioenergetic failure but also by activation of innate immunity triggered by mitochondrial DNA release (#mtDNA).

Read here: https://bit.ly/4qlWwao

#RareDisease #MedSky

Genome Biology and Evolution | February 2026 cover

The cover of February's issue of Genome Biology and Evolution features the work of Kosakyan et al. on the evolution of mitochondrial genomes in the Gastrotricha.

🔗 doi.org/10.1093/gbe/evag001

#genome #evolution #mtDNA

Book Early and Maximize Your Benefits

📢 New update on our website!
👉Don't forget : early‑bird rates are available until Februray, 17 !!
👉 : www.euromit2026.eu/article/book...

#EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria @chuangers.bsky.social @univangers.bsky.social

This #STTT study provides mechanistic insights into how arginase1 regulates mitochondrial cristae remodeling and #mtDNA release, triggering the cGAS-STING pathway and #PANoptosis during ischemic/hypoxic #VascularDysfunction.

#OpenAccess: doi.org/10.1038/s413...

Dive into our review of Family Tree DNA!🧬Learn how to trace your ancient haplogroups and use their powerful tools to break genealogical brick walls! → tinyurl.com/y9wejdrc
#FamilyTreeDNA #FTDNA #Genealogy #FamilyHistory #DNATesting #YDNA #MTDNA #Ancestry #GeneticGenealogy #EchoesOfKin

Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number Abstract. Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces c

Our new paper is out 🎉 in @narjournal.bsky.social
A fascinating complex composed of Mrx6, Mam33, and Pim1 controls #mtDNA copy number by regulating Lon-dependent substrate turnover in #yeast.
Congrats to @simonrecyclable.bsky.social, all co-authors and collaborators!
academic.oup.com/nar/article/...

This review describes the relationship between #mtDNA integrity and #CardiacFunction, the associated regulatory pathways and the mechanisms driving #MitochondrialDysfunction and #Ischemia/#Reperfusion-induced cardiomyocyte injury. #medsky

#OpenAccess: doi.org/10.1016/j.ge...

Call for Sponsorship

📢 Call for Sponsorship – Euromit 2026!
Become a sponsor and link your brand to one of the most awaited events in mitochondrial disease research. 👉 www.euromit2026.eu/article/call...

#EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria

@chuangers.bsky.social @univangers.bsky.social