Thanks @spichaksimon.bsky.social for covering @isabelrb.bsky.social & @tessfalor.bsky.social presenting on our #TheAcidTest research project for #ICanCME2025!
See our March 2025 Roundtable with @sunsopeningband.bsky.social & @ciarawrightphd.bsky.social for more info: www.youtube.com/watch?v=6BUZ...
3) Remember #TheAcidTest? Some people had sky-high lactate and others (including me) had run-of-the-mill lactate.
I think the only 'high' reading I had was when I had a bad reaction to 40mg Prednisolone and it induced lactate/lactic acid in my limbs (like I'd been running the day before).
3/
Not only in the brains. In the blood, I think from muscle mitochondria problems -> anaerobic metabolism. A bunch of us on LC Twitter did some self testing in 2023 for a study we called #TheAcidTest. Many of us have higher than normal levels. There was a recent presentation and video about it.
The recording of #TheAcidTest presentation by @ciarawrightphd.bsky.social and @sunsopeningband.bsky.social is available here ⬇️
#longcovid #mecfs #pem #patient-ledresearch
Hey MECFS Science People, especially those who approve of home DIY experiments whi collaborate on what is learned in hopes of better treatments for all.
This Friday, 1p EDaylightT US @renegaderesearch.bsky.social results of #TheAcidTest.
Register, get reminders:
us06web.zoom.us/webinar/regi...
The Acid Test is a #patient-led study of #lactate in #MECFS and #longCovid Some results from #TheAcidTest will be presented at our research roundtable this month! Register early at https://us06web.zoom.us/webinar/register/3917405199919/WN_K9oQDarhTPeaZAE9Aa3pGw#/registration
The Acid Test is a #patient-led study of #lactate in #MECFS and #longCovid
Some results from #TheAcidTest will be presented at our research roundtable this month!
Register early at
us06web.zoom.us/webinar/regi...
Screenshot from journal article linked in tweet: "This metabolic reprogramming is known as the Warburg effect and is characterized by an increase in the uptake of glucose and the production of lactate, even in the presence of oxygen (aerobic glycolysis).69 mTORC1 enhanced the Warburg effect by increasing the gene expression and catalytic activity of key enzymes required during glycolysis, such as pyruvate kinase muscle isozyme 2, hexokinase 2, and lactate dehydrogenase A, among others. This results in increased flux through the glycolytic pathway, which provides the building blocks and energy required for cell growth and division.69,70,71 Hypoxic stress or anaerobic condition has been found to promote the reduction of pyruvate to lactate by NADH through lactate dehydrogenase that may augment the lactic acid concentration leading to lactic acidosis. Lactic acidosis favors oncogenesis by modulating the tumor microenvironment."
I'm literally on my way to a medical appointment so I can't post much now
but just wondering if anyone is doing research on mTOR signalling pathways and ME, Long COVID, and/or mitochondrial dysfunction?
#NEISvoid
#LongCOVID
Seems relevant to #TheAcidTest also
www.nature.com/articles/s41...
And I am part of the group who set up and run #TheAcidTest, investigating the relationship between lactate levels and symptoms in #MECFS, long COVID, and post-vaccine syndrome
I did this just a few times for #TheAcidTest and me too, was in agony.
#theacidtest 10,9 mmol/l after exertion, but only 1,3 mmol/l two hours later, sober value same day was 2,0 mmol/l.
#MECFS #POTS #LongCovid #Postcovid #Lactat #ascidosis
Vortragsfolie implicaton for physical activity and excercise
2) Long Covid Patienten haben Stoffwechselveränderungen in der Laktat- und Glukoseregulierung. Laktatabbau ist gestört, was als eine Folge zu vermehrter Atmung führt. (Referent: C. Puta) Erhöhte Laktatwerte wurden bereits von Patienten selbst beim #theacidtest berichtet.
Just bought a #lactat messeure device, #AccutrendPlus, to do #theacidtest. 180 Euro incl. 25pcs.
Not that cheap, but a good price including shipping.
I am really interested in the results, my neurologist appointment is January next year, she was stunned when i told her about it on my last visit.
Hat hier jemand schon einmal den #theacidtest probiert? Würde mich gerne dazu austauschen; insbesondere zu den Möglichkeiten, wie man zuviel Laktat im Körper wieder wegbekommt. Habe bisher nur etwas zu Kochsalzlösung Infusionen gefunden, aber sicher gibt es noch mehr Möglichkeiten.
