ML reveals targets in stress cardiomyopathy.
www.scienceopen.com/hosted-docum...
#MachineLearning #Cardiomyopathy #Targets #AI #CardioSky #MedSky

So I finally found a physio who listened to me. Started last week with five minute daily walks which was shockingly harder than I expected. Probably the least fit I’ve ever been. But it was way easier by the end of the week. Start 7 minutes today. A bit hard but doable. #Cardiomyopathy sux but

Sounds like he had a congenial heart defect (maybe bicuspid aortic valve? Or ASD?) likely exacerbated by chronic #alcoholism, probably has some level of #cardiomyopathy would be my guess

Amazing 3 days of intensive deeping into #Hypertrophic #Cardiomyopathy at @escardio HeartHouse for the #EAPC_ESC #HCM course: Thank you @mauripieroni72 & @gherardobis for inviting me! Great days w @IacopoOlivotto @LuisRLopes77 @chiarabd @VDelgadoGarcia @SSharmacardio Roddy Walsh 🇪🇺 🇺🇦

Madison Clark and colleagues aimed to alleviate #dilated #cardiomyopathy (DCM) in MLPko mice by targeting DCM-linked inflammation by administration of lipoxins, special pro-resolving lipid mediators.

The picture shows some figures from the manuscript

New preprint alert from our lab 🚨
Lipoxins Regulate Intercalated Disk-Associated Signaling and Immune Remodeling in Dilated Cardiomyopathy

www.biorxiv.org/content/10.6...

#dilated #cardiomyopathy #DCM #cardiac #inflammation #sex-specificity #lipoxin #intercalated-disk #myoblue

Atrium Therapeutics Launches with $270 Million Focused on RNA Medicines for Genetic Heart Disorders Atrium Therapeutics, newly launched with $270 million, aims to advance RNA therapeutics designed for rare genetic cardiomyopathies. A transformative step for patients.

Atrium Therapeutics Launches with $270 Million Focused on RNA Medicines for Genetic Heart Disorders #USA #San_Diego #Cardiomyopathy #RNA_Medicines #Atrium_Therapeutics

New Noninvasive Indices Identify Early Myocardial Dysfunction in DMD-Associated Cardiomyopathy Three newly developed noninvasive indices can accurately detect early myocardial dysfunction in patients with DMD-associated cardiomyopathy.

Newly developed noninvasive indices can accurately detect early myocardial dysfunction in patients with Duchenne muscular dystrophy (#DMD)-associated #Cardiomyopathy. Study in Pediatric Cardiology.

Learn more: https://bit.ly/4r0q6m3

#RareDisease #DuchenneMuscularDystrophy #MedSky

KCNA2 variants cause dilated #cardiomyopathy, #obesity and #SleepApnea through RAC-ERK pathway

By P. Chimata, P. Dhandapany & colleagues at Institute for Stem Cell Science and Regenerative Medicine

👉 doi.org/10.1038/s44321-026-00391-y

Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy - Nature Cardiovascular Research Anderson et al. demonstrate that the glucokinase activator AZD1656 reduces inflammation and reverses cardiac dysfunction and metabolic remodeling in mice with diabetic cardiomyopathy.

Excited to share our latest paper in Nature Cardiovascular Research showing #diabetic #cardiomyopathy is driven by aberrant #immunometabolism Enhancing Treg migratory capacity restores immune balance and improves🫀dysfunction a promising new therapeutic direction in T2D
www.nature.com/articles/s44...

#HCM
#Cardiomyopathy
#CardioSky

HCM and Young Black Athletes: Essential Insights for Parents and Coaches Did you know that hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death (SCD) in young athletes? Yup,...

#Hypertrophic #Cardiomyopathy #(HCM)

Origin | Interest | Match

Figure 2: Graphs display the effects of polygenic and monogenic risk on Hypertrophic(HCM) and Dilated(DCM) Cardiomyopathy Probability. Graph A: DCM prediction in carriers. Graph B: HCM prediction in carriers. Lines represent variant status vs PGS, z score.

Polygenic scores for hypertrophic and dilated cardiomyopathies independently and oppositely modified disease risk and penetrance of pathogenic variants, supporting bidirectional genetic influences on #Cardiomyopathy.

ja.ma/4kmmb1k

The figure shows global changes of the left ventricle in modified nephrectomy- and adenine-induced uremic cardiomyopathy. Panel A: volcano plot of upregulated and downregulated differentially expressed genes. Panels B and C: gene ontology circle graphs showing the main changes in biological processes, cellular components and molecular functions in uremic cardiomyopathy developed by both approaches. Panel D: gene set enrichment analysis, which identified the primary differences between these two approaches.

Jing-Fu Bao, Youhua Liu, Aiqing Li & co developed two methods to simulate human uremic #cardiomyopathy, compared these approaches across several #RatModel and#MouseModel, and identified CCR-2 as a potential therapeutic target.

Read doi.org/10.1242/dmm....

FDA Puts Cumberland’s Ifetroban on Fast Track for Cardiomyopathy in DMD The US FDA granted Fast Track designation to ifetroban, an oral thromboxane receptor antagonist, for cardiomyopathy in patients with DMD.

Cumberland Pharmaceuticals announced that the @fda.gov has granted #FastTrack Designation to #Ifetroban (#Dyscorban®), the company’s novel oral therapy for #Cardiomyopathy in patients with #DuchenneMuscularDystrophy (DMD).

Read more: https://bit.ly/4rTzo4j

#RareDisease #DMD #MedSky

#Cardiomyopathy #HeartHealth #LivingWithCardiomyopathy #PatientExperience #StateOfTheNation #PickerInsights

Cardiomyopathy: Dilated, Hypertrophic & Restrictive Types with Diagnosis & Management
#Cardiomyopathy #HeartFailure #Cardiology #MedicalEducation #VikaasShandily

Could Gene Therapy Treat a Deadly Heart Condition That Targets Young Athletes? A UC San Diego-led team found that gene therapy to restore a single heart protein shows promise for improving multiple forms of arrhythmogenic cardiomyopathy, a deadly condition that targets young…

A @UCSanDiego.bsky.social-led team found that gene therapy to restore a single #heartprotein shows promise for improving multiple forms of #arrhythmogenic #cardiomyopathy, a deadly condition that targets young athletes.

buff.ly/uDcUQhY

Figure: Definition of clusters. Thyroid response and pituitary response curves denote the median of thyroid’s secretory capacity (SPINA-GT) and empirical thyrotropic pituitary response.

Figure: Association of clusters with total fatality (left) and time-course of survival (right).

Table: Characteristics of the three clusters. The figures in the first two lines refer to medoids of TSH and FT4 concentration as identified by the clustering algorithm.

#Takotsubo syndrome (TTS) is a poorly understood life-threatening #cardiomyopathy. With machine learning, we found 3 signatures of #thyroid #homeostasis heralding the prognosis of patients affected by TTS.

pubmed.ncbi.nlm.nih.gov/38502972/
doi.org/10.1016/j.eb...
www.livivo.de/doc/M38502972

Management of hypertrophic cardiomyopathy Cardiomyopathies are primary heart muscle disorders in which the observed structural and functional abnormalities are not explained by coronary artery disease (CAD), hypertension, valvular disease or…

This learning article highlights pharmacological treatment approaches for hypertrophic cardiomyopathy, including pharmacogenomic considerations for first-in-class myosin inhibitors

#ukpharmacy #cardiomyopathy #cardiovasculardiseases

Made it through my epicardial ablation. Apparently I gave the electrophysiologists quite the challenge, but after 6 hours all the faulty circuits had been blocked and no ventricular tachycardia could be induced #arvc #cardiomyopathy 🫀

<em>Journal of Internal Medicine</em> | Wiley Online Library Background Several reports have described Takotsubo syndrome (TTS) secondary to thyrotoxicosis. A complex interaction of central and peripheral catecholamines with thyroid homeostasis has been sugge...

Calculating #SPINA-GT has helped to distinguish two different ways leading to #thyroid-related #Takotsubo #cardiomyopathy.

www.livivo.de/doc/M33179374
pubmed.ncbi.nlm.nih.gov/33179374/
doi.org/10.1111/joim...

Figure showing the effects of polygenic and monogenic risk on Hypertrophic and Dilated Cardiomyopathy probability. It has 4 graphs showing pathogenic variant status with DCM variant and No DCM variant on probability.

Polygenic scores for hypertrophic and dilated cardiomyopathies independently and oppositely modified disease risk and penetrance of pathogenic variants, supporting bidirectional genetic influences on #Cardiomyopathy. ja.ma/4jam5Jx

Cytokinetics Announces FDA Approval of MYQORZO™ (aficamten) for the Treatment of Adults with Symptomatic Obstructive Hypertrophic Cardiomyopathy to Improve Functional Capacity and Symptoms MYQORZO, a Cardiac Myosin Inhibitor, Directly Addresses Underlying Hypercontractility Associated with Obstructive HCM FDA Approval Based on Results of SEQUOIA-HCM MYQORZO is Company’s First FDA-Approv...

FDA approved today! Second in class cardiac myosin inhibitor for obstructive hypertrophic cardiomyopathy.

#HCM
#Cardiomyopathy
#CardioSky
#MedSky

The Future of Gene Therapies for Cardiomyopathies: Market Insights and Innovations from 2025 to 2034 The gene therapies for cardiomyopathies market is on the brink of significant growth, with innovative treatments emerging. This article explores advancements and forecasts for 2025-2034.

The Future of Gene Therapies for Cardiomyopathies: Market Insights and Innovations from 2025 to 2034 #None #gene_therapy #Cardiomyopathy #Lexeo_Therapeutics

In restrictive #cardiomyopathy mice with cTnI R193H mutation, early #DiastolicDysfunction features prolonged relaxation, enhanced #glycolysis, and PI3K/AKT‑driven #glucoseuptake, linking altered energy metabolism to #fibrosis and #HeartFailure.

#OpenAccess: doi.org/10.1016/j.ge...

Persistently increased CaMKIIδ autophosphorylation mediates pathologic SR Ca loss in a murine model of Doxorubicin-induced cardiomyopathy Doxorubicin (DOX)-induced cardiomyopathy (DICM) manifests as left ventricular (LV) systolic dysfunction. DOX triggers oxidative stress and CaMKIIδ act…

🚨 New paper alert! Feder et al. have recently shown that persistently increased #CaMKIIδ autophosphorylation drives pathological sarcoplasmic reticulum #calcium loss in a murine model of #doxorubicin-induced #cardiomyopathy. 💔

➡️📉 Check it out:
www.sciencedirect.com/science/arti...