This review highlights the role of #DYRK #kinases in #DNADamageResponse, linking their activity to #cancer progression, while evaluating current DYRK inhibitors and positioning DYRK inhibition as a promising #PrecisionOncology strategy.
#OpenAccess: doi.org/10.1016/j.ge...
Left: Virion-associated Vpr proteins induce epigenetic remodeling. Representative fluorescence microscopy images of DDR activation in HeLa and differentiated THP1 cells infected with Vpr or control viruses pre-treated with raltegravir or combination zidovudine/etravirine (n = 50 cells). For these experiments, the mCherry reporter is expressed from the viral promoter instead of being driven by CMV. This allows for tracking infection kinetics in real time to assess DDR activation from virion-associated Vpr. Right: Electrostatic surface potential of a Vpr-DCAF1 co-complex. Surfaces associated with hyperactive or DDR-deficient Vpr mutants are colored in blue and red, respectively.
HIV-1 induces #DNADamageResponse via Vpr, but does this affect the viral cycle? This study shows that Vpr-driven #DNA damage promotes epigenetic remodeling & transcriptional programs to enhance #HIV1 transcription & latency reactivation, with therapeutic potential @plosbiology.org 🧪 plos.io/4c9wVhe
Left: Virion-associated Vpr proteins induce epigenetic remodeling. Representative fluorescence microscopy images of DDR activation in HeLa and differentiated THP1 cells infected with Vpr or control viruses pre-treated with raltegravir or combination zidovudine/etravirine (n = 50 cells). For these experiments, the mCherry reporter is expressed from the viral promoter instead of being driven by CMV. This allows for tracking infection kinetics in real time to assess DDR activation from virion-associated Vpr. Right: Electrostatic surface potential of a Vpr-DCAF1 co-complex. Surfaces associated with hyperactive or DDR-deficient Vpr mutants are colored in blue and red, respectively.
HIV-1 induces #DNADamageResponse via Vpr, but does this affect the viral cycle? This study shows that Vpr-driven #DNA damage promotes epigenetic remodeling & transcriptional programs to enhance #HIV1 transcription & latency reactivation, with therapeutic potential @plosbiology.org 🧪 plos.io/4c9wVhe
Left: Virion-associated Vpr proteins induce epigenetic remodeling. Representative fluorescence microscopy images of DDR activation in HeLa and differentiated THP1 cells infected with Vpr or control viruses pre-treated with raltegravir or combination zidovudine/etravirine (n = 50 cells). For these experiments, the mCherry reporter is expressed from the viral promoter instead of being driven by CMV. This allows for tracking infection kinetics in real time to assess DDR activation from virion-associated Vpr. Right: Electrostatic surface potential of a Vpr-DCAF1 co-complex. Surfaces associated with hyperactive or DDR-deficient Vpr mutants are colored in blue and red, respectively.
HIV-1 induces #DNADamageResponse via Vpr, but does this affect the viral cycle? This study shows that Vpr-driven #DNA damage promotes epigenetic remodeling & transcriptional programs to enhance #HIV1 transcription & latency reactivation, with therapeutic potential @plosbiology.org 🧪 plos.io/4c9wVhe
TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response
TOPK was overexpressed in patients with moderately to poorly differentiated CRC receiving #Radiotherapy, while its knockdown significantly enhanced the #Radiosensitivity of CRC cells by reducing the #DNAdamageResponse.
Read more: doi.org/10.1007/s115...
📝Now online - the Review "Single-stranded DNA-binding proteins at healthy and diseased telomeres" from Stéphane Coulon, Alexandre Maréchal, and colleagues.
#telomeres #SSBPs #ReplicativeStress #DNADamageResponse #telomeropathies #ALT
Read it here 👉 authors.elsevier.com/a/1mPAN3S6Gf...
#DNADamageResponse protein, KIN, drives #ESCC progression by clearing R-loop–associated #DNAdamage, while KIN depletion triggers NFκB–STING activation, improves the #TumorImmuneMicroenvironment, and enhances #immunotherapy response.
#OpenAccess in #STTT: doi.org/10.1038/s413...
📝 Online now - the Review "Emerging functions for nonhistone protein acetylation in budding yeast" from Michael Downey and colleagues.
#PostTranslationalModifications #DNADamageResponse #Proteostasis #Autophagy #MetabolicRegulation
Read it here: authors.elsevier.com/a/1m4nM3S6Gf...
This study identifies KIN as a novel R-loop binding protein in #ESCC, that promotes DNA damage clearance and #ImmuneEvasion, while its depletion triggers R-loop accumulation and STING–NFκB–mediated immune activation. #DNADamageResponse
#STTT #OpenAccess:
TOPK is overexpressed in moderately to poorly differentiated #ColorectalCancer, while its inhibition enhances the sensitivity of CRC cells to #Radiotherapy by suppressing the downstream pathways of #DNADamageResponse. #medsky
Read our #MostDownloaded article: link.springer.com/article/10.1...
TOPK is overexpressed in moderately to poorly differentiated #ColorectalCancer, while its inhibition enhances the sensitivity of CRC cells to #Radiotherapy by suppressing the downstream pathways of #DNADamageResponse. #medsky
Read our #MostDownloaded article: link.springer.com/article/10.1...
We have something for everyone- CSF flow & #neurodegeneration, ciliary trafficking of PKD2 complexes, cilia & #actin dynamics, #DNADamageResponse & multiciliation, cilia & pituitary development & transcriptional control of ciliogenesis... Great breaking science & rising talent to be showcased...🧪
#DoOrDie #DNADamageResponse
Thats a cool story :
When a cells DNA is damaged, and needs a quick reaction, its actually the buildup of (errorenous) RNA that through ribosome confusion and bumping into each other actually signals the quick response for apoptosis. Makes a lot of sense.
