Long-term follow-up of dual CD19/CD22 CAR-T-cell therapy, as #Monotherapy and with autologous #StemCellTransplantation, in TP53-altered relapsed/refractory B-cell non-#HodgkinLymphoma patients, reveals clinical benefit & manageable toxicity.

#OpenAccess: doi.org/10.1038/s413...

Patients receiving PER MT were more likely to achieve seizure freedom but had a higher incidence of dizziness than those receiving LEV MT.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #Chinesepatients #focalonsetseizures #Levetiracetam #Perampanel #monotherapy #seizurefreedomrate

First‐Line Third‐Generation EGFR Tyrosine Kinase Inhibitor Monotherapy for Advanced EGFR‐Mutated Non‐Small Cell Lung Cancer: A Systematic Review and Network Meta‐Analysis Third-generation EGFR-TKIs are the current first-line standard for advanced EGFR-mutated NSCLC. While all improve PFS versus first-generation TKIs, no significant PFS or ORR differences exist among t...

#Article in #MedComm

First-Line Third-Generation #EGFR Tyrosine Kinase Inhibitor Monotherapy for Advanced EGFR-Mutated Non-Small Cell Lung Cancer: A Systematic Review and Network Meta-Analysis doi.org/10.1002/mco2...

#MetaAnalysis #NSCLC #TKI #FirstLine #TRAE #Monotherapy

Findings from phase I of two clinical studies demonstrate the promising efficacy and safety profile of IBI351 #monotherapy in KRASG12C inhibitor-naïve Chinese patients with KRASG12C-mutated metastatic #ColorectalCancer (CRC). #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

A total of 70.3% of patients were seizure-free after 12 months on perampanel monotherapy.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #monotherapy #perampanel

Phase I data from clinical studies (NCT05005234 & NCT05497336) revealed that IBI351 #monotherapy shows encouraging efficacy & safety in KRASG12C inhibitor-naïve Chinese patients with KRASG12C-mutated #metastatic #ColorectalCancer. #medsky

#STTT #OpenAccess: www.nature.com/articles/s41...

Finally injecting E again after 6 weeks! Gods I've missed this! Another week of semi-phenomenal nearly-cosmic power! #hrt #monotherapy #transjoy

Teva and Fosun Pharma partner on early-stage oncology drug - PharmaTimes The candidate is being evaluated as both a monotherapy and in combination pembrolizumab

#drugdevelopment #Oncology #FosunPharma #TEV56278 #Teva #monotherapy #combinationtherapy #pembrolizumab #clinicaldatageneration #antiPD1IL2ATTENUKINEtherapy #antitumourTcellactivity #MerckandCo #MSD #enhancedTcellinfiltration #immunememory #preclinicalstudies
pharmatimes.com/news/teva-an...

💊 This review briefly summarises the signalling pathways involved in the #pharmacological activities of #OleanolicAcid as a #monotherapy and in combination with other #drugs.

💻 Read the #FreetoRead #Review on our webpage: www.thieme-connect.com/products/ejo...

Member of CHRI's Pediatric Cancer Research Group, Chittalsinh Raulji, MBBS, recently received funding for a trial of DAY101 #monotherapy for #gliomas and for a study of concizumab prophylaxiss treatment of patients with #haemophilia A or B. Excited to see the results!

VIDEO ABSTRACT
"Indications and Long-Term Outcomes of Using Mycophenolate Mofetil Monotherapy in Substitution for Calcineurin Inhibitors in Liver Transplantation"

The article here: shorturl.at/qumve

#mycophenolate #monotherapy #liver #transplantation #video #abstract
@esottransplant.bsky.social

💊 Several randomized controlled trials (RCTs) have compared the effectiveness, efficacy, and safety of #antipsychotic #monotherapy (APM) versus placebo in patients with major depressive disorder, this #review conducts a meta-analysis to examine this topic.

💻 www.thieme-connect.com/products/ejo...

Key point: A low dose of antiseizure medications may be started in adults with a new diagnosis of focal epilepsy of unknown etiology and low seizure frequency.
doi.org/10.1002/epi4...

#epilepsy #ILAE #efficacy #focalepilepsy #lowdose #monotherapy #newlydiagnosedepilepsy #randomizedtrial

Algiax announces results from phase 2a trial for neuropathic pain treatment - PharmaTimes Study shows AP-325 offers lasting pain relief without central side effects

#AlgiaxPharmaceuticals #SMiPain #painmanagement #nonopioids #neuropathicpain #AP325 #monotherapy #peripheralpostsurgicalneuropathicpain #painrelief #chronicneuropathicpain #allostericGABAAreceptormodulator #GABAAsignalling #neuropathicpainmanagement #painreduction
pharmatimes.com/news/algiax-...

🚀 New Preprint Alert!

Our research shows how #AI #MultiModal #NetworkAnalysis identifies #Monotherapy & #CombinationalTherapy targets for SOX2-driven lung cancer.

A scalable & validated approach for broader disease applications!

🔗 doi.org/10.1101/2025...

#DrugDiscovery #MultiOmics

Key point: LEV is the best choice when combined with antiepileptic clinical guidelines on the basis of its efficacy in decreasing seizure frequency.
doi.org/10.1111/epi....

#epilepsy #ILAE #antiseizuremedication #costeffectiveness #lacosamide #monotherapy #focalepilepsy