Highlighting the bile acid–#GutMicrobiota crosstalk as a key modulator of the gut–brain axis, regulating #Neuroimmune function, barrier integrity, & #Neurotransmission, with therapeutic implications for neurological & #PsychiatricDisease.
#OpenAccess: doi.org/10.1016/j.ge...
Top: UNC-11 ∆AD synapses exhibit enlarged synaptic vesicles and abnormal endosome-like structures. Representative transmission electron micrographs of synapses from wild-type N2, unc-11 mutants, Full-length UNC-11-rescued, and UNC-11∆AD-rescued unc-11 mutants. Dense projections are highlighted in orange. The arrow marks an endosome-like structure (ELS, >100 nm in diameter). Scale bar, 100 nm. Bottom: UNC-11 condensates promote the growth of F-actin. Full-length UNC-11 (UNC-11 FL) was labeled with Pacific Blue (cyan), and F-actin was visualized using Alexa Fluor 488–phalloidin (yellow). G-actin (2 µM) and phalloidin (0.2 µM) were added to samples containing UNC-11 droplets, and fluorescence images were collected every 3 min for 48 min. Scale bar, 5 µm.
How does AP180 regulate #SynapticVesicles during #neurotransmission? This study shows that AP180's assembly domain regulates #synaptic #vesicle size & release fidelity in #Celegans via actin binding, revealing how vesicle morphology influences neurotransmission @plosbiology.org 🧪 plos.io/3OcO4g4
Top: UNC-11 ∆AD synapses exhibit enlarged synaptic vesicles and abnormal endosome-like structures. Representative transmission electron micrographs of synapses from wild-type N2, unc-11 mutants, Full-length UNC-11-rescued, and UNC-11∆AD-rescued unc-11 mutants. Dense projections are highlighted in orange. The arrow marks an endosome-like structure (ELS, >100 nm in diameter). Scale bar, 100 nm. Bottom: UNC-11 condensates promote the growth of F-actin. Full-length UNC-11 (UNC-11 FL) was labeled with Pacific Blue (cyan), and F-actin was visualized using Alexa Fluor 488–phalloidin (yellow). G-actin (2 µM) and phalloidin (0.2 µM) were added to samples containing UNC-11 droplets, and fluorescence images were collected every 3 min for 48 min. Scale bar, 5 µm.
How does AP180 regulate #SynapticVesicles during #neurotransmission? This study shows that AP180's assembly domain regulates #synaptic #vesicle size & release fidelity in #Celegans via actin binding, revealing how vesicle morphology influences neurotransmission @plosbiology.org 🧪 plos.io/3OcO4g4
Top: UNC-11 ∆AD synapses exhibit enlarged synaptic vesicles and abnormal endosome-like structures. Representative transmission electron micrographs of synapses from wild-type N2, unc-11 mutants, Full-length UNC-11-rescued, and UNC-11∆AD-rescued unc-11 mutants. Dense projections are highlighted in orange. The arrow marks an endosome-like structure (ELS, >100 nm in diameter). Scale bar, 100 nm. Bottom: UNC-11 condensates promote the growth of F-actin. Full-length UNC-11 (UNC-11 FL) was labeled with Pacific Blue (cyan), and F-actin was visualized using Alexa Fluor 488–phalloidin (yellow). G-actin (2 µM) and phalloidin (0.2 µM) were added to samples containing UNC-11 droplets, and fluorescence images were collected every 3 min for 48 min. Scale bar, 5 µm.
How does AP180 regulate #SynapticVesicles during #neurotransmission? This study shows that AP180's assembly domain regulates #synaptic #vesicle size & release fidelity in #Celegans via actin binding, revealing how vesicle morphology influences neurotransmission @plosbiology.org 🧪 plos.io/3OcO4g4
Proteins positioned within the #synapticcleft govern #synapse formation, maintenance and #neurotransmission.
But the exact architecture of this space is still a mystery. IPI’s new #NRXN and #NLGN antibodies could help reveal the blueprint.
Order now: buff.ly/AtBazlt
In this study investigating harnessing #metabolic control for synaptic stability, Daniele Ferrante et al. found that REST/NRSF links glycolytic inhibition to excitatory #neurotransmission 🧠 🔬
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Colin A. Nurse of biomcgill.bsky.social & Erin M. Leonard of laurierbiology.bsky.social offer this #Perspective of Reed et al. (2025)'s research into excitatory #neurotransmission at O2 receptors in zebrafish gill 💭 ✍️
🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...
The acute sleep-inducing effects of light require histamine neurotransmission in mice
Gronfier, C., HOU, Y., TANG, N., WU, S., SHAO, Y., LIN, J.
Paper
Details
#SleepResearch #Neurotransmission #HistamineNeurotransmission
#genetexinc extends its collection of #recombinant monoclonal #antibodies against G-Protein Coupled Receptors #GPCR with the Purinergic P2Y receptors P2Y1,-2,-4,-6,-11,-12,-13,-14R
🔗www.stratech.co.uk/catalogue/
#neurotransmission #neurodegeneration #autoimmune
🧠 Curious how the brain processes thoughts and decisions?
Discover neuronal communication at the chemical synapse, where neurotransmitters bridge gaps between neurons, enabling everything from movement to memory.
#Neuroscience #BrainFunction #Neurotransmission #ChemicalSynapse #Science #Neuron
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Neurons Unplugged: A Fun Journey Through the Brain's Social Network!
#Neuroscience #BrainFunction #Neurons #Synaptogenesis #Glycans #GutHealth #Neurotransmission #BrainAdventure #ScienceFun #LearnWithMe #Neurites #Mitochondria #BrainHealth #CognitiveScience
youtube.com/shorts/EfFMO...
#Cellular structure without a #membrane: Researcher discusses how #synapses use #liquids to create functional separations.
#LLPS #membrane-less_organelles #neurotransmission
phys.org/news/2025-03...
Marveling the Mysteries of Memory: How Our Brain Reactivates and Perceives Sensory Experiences
#MemoryMagic #SensoryPerception #Neuroscience #Hippocampus #CognitiveFunction #Neuroplasticity #PTSD #EmotionalHealth #Neurotransmission #MentalHealthMatters
youtube.com/shorts/1BQGQ...
