Proud to share our new preprint on improving DNA-damaging cancer therapies through minor spliceosome inhibition. Treatments must be not only effective, but kinder. Grateful for the support. 🤍 www.biorxiv.org/content/10.6...
#minorspliceosome #breastcancer #prostatecancer #U6atac #RNAsplicing

Poly(A) selection limits detection of long and alternatively spliced transcripts compared with rRNA depletion in RNA-Sequencing The eukaryotic transcriptome diversity arises largely from alternative splicing. One of the widely used high-throughput methods to study this diversity is RNA sequencing. RNA sequencing has become a c...

Our new preprint on the limitations of PolyA+ selection vs rRNA-depleted RNA-seq, especially its effects on analysis of splicing and expression of long transcripts (and on findings of diseases linked to these transcripts), is now out: doi.org/10.21203/rs.... #RNAseq #RNASplicing #Bioinformatics

🌟...let's meet the next #earlycareerresearcher #ECR #postdoc with a big heart for functional genomics 🧬
🥁 ... Dr RICARDO DE PAOLI-ISEPPI from @unimelb.bsky.social #UniMelb will tell us how he uses #longreadsequencing to understand #RNAsplicing.

Our new preprint on the limitations of PolyA+ selection vs rRNA-depleted RNA-seq, especially its effects on splicing and the expression of long transcripts (and diseases linked to them), is now out: doi.org/10.21203/rs....
#RNAseq #RNASplicing #Bioinformatics

Long-read RNA-seq demarcates cis- and trans-directed alternative RNA splicing. #LongRead #RNAseq #Sequencing #RNAsplicing @natcomms.nature.com 🧪🧬 🖥️
www.nature.com/articles/s41...

The AMPK-related kinase NUAK1 regulates neuronal morphogenesis through the RNA splicing co-factor SON In recent years, alternative splicing emerged as a major mechanism controlling gene-regulatory networks during brain development, yet how alternative splicing is tuned to the dynamic alterations under...

I am happy to share our latest work now posted on @biorxiv-neursci.bsky.social
We report that the #AMPK related kinase #NUAK1 teams up with splicing co-factor SON to regulate #RNAsplicing in developing cortical neurons, supporting axon growth and branching

www.biorxiv.org/content/10.1...

🧬 New in NARMME: RNA splicing tweaks rescue tau toxicity in C. elegans. Modifying tri-snRNP proteins rescues tau-induced deficits in transgenic C. elegans, restoring behaviour, neurodegeneration and extending lifespan.
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration

Thank you to the ADAPTAML lab for these incredible years of science, support, and growth! Feeling grateful for everything I’ve learned and excited for what’s next 💫
#PhDDefense #leukemia #RNAsplicing

Congratulations @margauxoberling.bsky.social on your successful PhD defense 🤩! We wish you the best and can't wait to see what you will do next👩‍🔬!
#leukemia #therapeuticresistance #RNAsplicing

Vitamin B12 alleviates Verheij syndrome-like defects via phospholipid remodeling in a C. elegans PUF60 spliceosomopathy model Verheij syndrome (VRJS) is a rare genetic disorder caused by mutations in the poly(U)-binding splicing factor 60 (PUF60), a core component of the spliceosomal complex. VRJS triggers multiple congenita...

🚨New @biorxivpreprint: We model the splicing factor disease Verheij syndrome using C. elegans. Disruption of methionine and phospholipid metabolism drives growth defects; vitamin #B12 restores metabolic balance and rescues development! #metabolism #Celegans #RNAsplicing
doi.org/10.1101/2025...

See also @wojtekgalej.bsky.social and
tinyurl.com/3sfthabb

#MinorSpliceosome #RNAsplicing #snRNP #U12Introns

A group of 9 scientists in casual dress standing having a discussion over cups of tea.

Even during a break the #ScienceChat never stops!
#Unleash #RNASplicing

Alternative RNA Splicing in Cardiac Diseases Explore how RNA Alternative splicing Cardiac Diseases are linked, reshaping gene expression and driving innovative therapies in modern medicine to save lives.

Explore how #RNAsplicing Cardiac Diseases are linked, reshaping gene expression and driving innovative therapies in modern medicine to save lives. @harvardmed.bsky.social

#Openaccess: tinyurl.com/22faf2ut

CETN3 deficiency induces #microcephaly by disrupting neural stem/progenitor cell fate through impaired #CentrosomeAssembly and #RNAsplicing 👉 doi.org/10.1038/s443...

by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University

Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state. #SingleCellProfiling #RNAsplicing #Chromatin #Transcriptome @natbiotech.nature.com 🧬
www.nature.com/articles/s41...

📣 New NAR Breakthrough article! 📣

🧬 Cells resist starvation through a nutrient stress splice switch 🧬

👉 Read the free full text here: lnkd.in/eeE8KM8i

#NARBreakthrough #RNAsplicing #YeastGenetics #Introns #Spliceosome

RNA splicing Technological and computational advances in recent years, from cryo-electron microscopy to sequencing technologies and machine learning

RNA splicing is entering a new era. From long-read transcriptomics to cryo-electron microscopy and beyond, we’re finally mapping the real transcriptome. The latest @NaturePortfolio collection dives deep:
🔗 www.nature.com/collections/...
#LongReads #RNAsplicing

Wonderful attendance for Student Research Conference 2025 at St. John's U! My lab presented a poster on #RNAsplicing of voltage-gated #potassium channels Kv7.2 #KCNQ2 and Kv7.3 #KCNC3. Students Amatun Noor Prapty and Chris Beauvil presented the poster. Thank you NIH and NIGMS for funding our work!

Biochemists Uncover How Cells Eliminate RNA Splicing Errors Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA splicing. Two molecular control factors play a key role in splicing, the process...

Biochemists Uncover How Cells Eliminate RNA Splicing Errors #Science #Biology #MolecularBiology #RNAsplicing #CellBiology #BiochemistryResearch

Our manuscript got highlighted with a beautiful infographic!

#TDP43 #PerrySyndrome #Neurodegeneration #RNAsplicing #Biomarkers #Neuroscience #FTLD #ALS #PrudencioLab

DOI: lnkd.in/eXr8te8A

Fragile X syndrome (FXS) is caused by CGG repeat expansion in FMR1, leading to DNA methylation and loss of FMRP. This #RNASpecialIssue paper explores how splice-switching ASOs and kinase inhibition can restore FMR1 expression, offering new therapeutic potential: bit.ly/4i2UpF2 #FragileX #RNAsplicing

Alternative RNA Splicing in Cardiac Diseases Explore how RNA Alternative splicing Cardiac Diseases are linked, reshaping gene expression and driving innovative therapies in modern medicine to save lives.

Explore how #RNAsplicing #CardiacDiseases are linked, reshaping gene expression and driving innovative therapies in modern medicine to #savelives.

Read More: tinyurl.com/bdenfu7z

#CVIAJournal #CVIA #Cardiology #CardioEd @scienceopen.bsky.social
@harvardmed.bsky.social

A Deep Dive into sQTL Modeling – Part 2 In my previous post, I described how, in our recent sQTL preprint, we broke current sQTL pipelines into their basic elements. This led to identifying potential issues/areas we may be able to improv…

📣 Our 2nd Blog post on improving #sQTL modeling and why it matters #RNASplicing #Genetics #Statistics #QTL biociphers.wordpress.com/2025/01/28/a...

🌟 Inverna is heading to San Francisco! 🌟 We’re thrilled to announce that Inverna and our CEO, Poul Sørensen, will be attending the annual JPM Week, one of the most prestigious events in the biotech and healthcare industry. This marks an exciting opportunity for Inverna to share our vision and connect with industry leaders, innovators, and collaborators. As we continue our work in developing disease-modifying therapeutics for Huntington’s disease through our novel RNA splicing modulation platform, we are eager to engage with those who share our passion for groundbreaking science. 📅 If you’re attending the conference and would like to discuss partnerships, innovation, or simply learn more about our journey, we’d love to meet you! Let’s build the future of biotech together.

🌟 Inverna is heading to JPM Week in SF! 🌟
Our CEO, Poul Sørensen, will share our vision for disease-modifying therapies for Huntington’s disease, powered by our RNA splicing platform.
📅 Attending too? Let’s connect to discuss partnerships and innovation!

#jpm2025 #biotech #huntington #rnasplicing

Among so many amazing starter packs, but none focused on RNA splicing - so we made one!

Check out the accounts we’ve included so far, and let us know if you’d like to be added or have suggestions!

go.bsky.app/TigRnmC

#rnasplicing

Our emeritus director Reinhard Lührmann received an honorary doctorate from @UAM_Poznan. Congratulations!
#RNAsplicing twitter.com/NowinyLokalne/status/118...

Our emeritus director Reinhard Lührmann received an honorary doctorate from @UAM_Poznan. Congratulations!
#RNAsplicing twitter.com/NowinyLokalne/status/118...

Our emeritus director Reinhard Lührmann received an honorary doctorate from @UAM_Poznan. Congratulations!
#RNAsplicing twitter.com/NowinyLokalne/status/118...

Our emeritus director Reinhard Lührmann received an honorary doctorate from @UAM_Poznan. Congratulations!
#RNAsplicing twitter.com/NowinyLokalne/status/118...

Our emeritus director Reinhard Lührmann received an honorary doctorate from @UAM_Poznan. Congratulations!
#RNAsplicing twitter.com/NowinyLokalne/status/118...