E674Q (Shanghai APP mutant), a novel amyloid precursor protein mutation, in familial late-onset Alzheimer's disease

A novel APP E674Q (“Shanghai APP”) mutation drives late-onset #Alzheimers by enhancing BACE1-mediated #amyloidβ production, showing strong #amyloidogenic effects & pathogenicity comparable to the Swedish mutation, expanding genetic insights into LOAD.
Read: doi.org/10.1016/j.ge...

This study maps spatio-temporal gene interactions during #amyloidβ accumulation using #SpatialTranscriptomics, uncovering ligand–receptor dynamics and transcriptional networks of #AlzheimersDisease etiology. @tulanemedicine.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

LRP1-targeted multivalent #Polymersomes reprogram BBB transport, inducing #Amyloidβ clearance & achieving sustained cognitive recovery in #AlzheimersDisease models by biasing LRP1 trafficking toward #Transcytosis. @ucl.ac.uk @icta-uab.bsky.social

#OpenAccess: doi.org/10.1038/s413...

#LRP1‑targeted #polymersomes reprogram #BloodBrainBarrier trafficking, enabling rapid #Amyloidβ clearance and sustained cognitive recovery in #AlzheimersDisease models. @beppebattaglia.bsky.social @ucl.ac.uk @icta-uab.bsky.social

#CoverPage in #STTT: doi.org/10.1038/s413...

Scientists pioneer BBB-targeted #nanomedicine using #LRP1-polymersomes to boost #Amyloidβ clearance, improve cognition in #AlzheimersDisease mice, and establish LRP1 trafficking as therapy. @beppebattaglia.bsky.social @ucl.ac.uk @icta-uab.bsky.social

#STTT: doi.org/10.1038/s413...

A Cocktail of Two Chelators Is Not Better than One Ligand in Excess to Halt Cu,Zn-(Amyloid-β)-Induced ROS Production in the Context of Alzheimer’s Disease | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Bagrel, Hureau, and Falcone @InorgChem #copper #zinc #amyloidβ #ROS #Alzheimers

#Medsky🧪 #IDsky #Neurosky #virosky #publichealth These results suggest that Spike 1 protein, during infection with #SARSCoV2, can induce #amyloidβ aggregation. This may be associated with neurological symptoms experienced in #NeuroCOVID, such as those seen in #Alzheimer’sdisease.

A novel missense amyloid precursor protein #mutation, APP E674Q (Shanghai APP), promotes #AlzheimersDisease by enhancing BACE1-mediated processing of APP, resulting in increased accumulation & aggregation of #amyloidβ. #medsky
#OpenAccess:

A novel missense amyloid precursor protein #mutation, APP E674Q (Shanghai APP)), promotes #AlzheimersDisease by enhancing BACE1-mediated processing of APP, resulting in increased accumulation & aggregation of #amyloidβ. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

APOE2/3/4 isoforms or APOE KO in #hiPSC-derived isogenic #EndothelialCell #Pericyte & #Amyloidβ

EC
APOE2 ▶️highest transendothelial transport of Aβ42

Pericyte
APOE4 ▶️highest extracellular deposit Aβ42
APOE2 ▶️highest internalized Aβ42

#FBCNS 2024
fluidsbarrierscns.biomedcentral.com/articles/10....