A PTPN23-dependent #ESCRT pathway is essential for constitutive secretion in mammalian cells, say Danièle Stalder, Conceição Pereira, David C. Gershlick @dgershlick.bsky.social and colleagues @thecimr.bsky.social:
rupress.org/jcb/article/...
#Trafficking #Biochemistry #Golgi
Interested in uncovering how the #Golgi reacts to stress? Apply NOW to the @hellerschmiedlab.bsky.social @imprs-lm.bsky.social #chembio #cellbio #biochemistry
If you're interested in our 95th Harden Conference: Linking Golgi trafficking and glycan function, you may be interested in these related articles from our journals 🧪: bit.ly/4uAb2yx #Golgi #glycan
95th Harden Conference: Linking Golgi trafficking and glycan function. Blackburn, UK, 23-26 June 2026. Abstract submissions now open. Super earlybird deadline 23 March 2026. Includes image of delegates networking and Biochemical Society and event logos.
Generate new ideas and collaborations regarding the relationships between #glycan biosynthesis and intracellular organisations, and glycan structures and cell biological functions, at our 95th Harden Conference: Linking #Golgi trafficking and glycan function bit.ly/4cSnxzc
Interested in joining our team? Apply here! #Golgi #proteostasis
Great to see this study from the lab now in print. The differential expression of AXL, and its regulation of Arf1 expression and activation, controls Golgi organization in breast cancer cells in a stiffness-dependent manner.
#matrix #mechanosensing #Golgi
journals.biologists.com/jcs/article/...
CELL BODY MICROTUBULES
Among other things, microtubules are the tracks used by cells to traffic membranes (e.g., next to the nucleus where the #Golgi resides). It takes super-resolution microscopy to resolve and study this complex microtubule-network (image).
#CellBiology
Very happy to share our new preprint on #Golgi #PQC Very grateful to be working at the @hellerschmiedlab.bsky.social and with all the co-authors and colleagues. Special thanks to Sofia- without her, this story wouldn't have #unfolded as it did @unidue-zmb.bsky.social @imprs-lm.bsky.social
Very happy to share our recent preprint describing #Golgi protein quality control #PQC in mammalian cells. #proteasome #ubiquitin #ChemBio Fantastic work by @joaodiamantino.bsky.social and team! #proudPI @unidue-zmb.bsky.social @imprs-lm.bsky.social
Another exciting preprint today about QC mechanism at the Golgy by @hellerschmiedlab.bsky.social #Golgi #membranes
Join us this Thursday (Jan 29) at 5pm CET for the first #MembraneTrafficking seminars of 2026, featuring two outstanding scientists, Giovanni D'Angelo (EPFL) and Sean Munro (@cellbiol-mrclmb.bsky.social), and the shared topic of protein trafficking, retention & sorting at the #Golgi 🥞
The small #GTPase Rab1 is a master regulator of #Golgi traffic and #autophagy. In @jcb.org, van Vliet, Munro et al. @mrclmb.bsky.social performed a proteomic screen to identify novel Rab1 effectors, including a #dynein motor adaptor and cargo receptors for autophagy. rupress.org/jcb/article/...
The small #GTPase Rab1 is a master regulator of #Golgi traffic and #autophagy. van Vliet, Munro et al. @mrclmb.bsky.social performed a proteomic screen to identify novel Rab1 effectors, including a #dynein motor adaptor and cargo receptors for autophagy. rupress.org/jcb/article/...
#Trafficking
@jcb.org's January issue is here! rupress.org/jcb/issue/22...
The cover shows immunofluorescence image of ARPE-19 cells acquired with a Nikon AXR confocal microscope. Short #cilia are observed near the #Golgi in some cells within a confluent culture. See Cao et al. doi.org/10.1083/jcb....
JCB’s January issue is here! rupress.org/jcb/issue/22...
The cover shows immunofluorescence image of ARPE-19 cells acquired with a Nikon AXR confocal microscope. Short #cilia are observed near the #Golgi in some cells within a confluent culture. See Cao et al. doi.org/10.1083/jcb....
Ten more days to apply! We are still looking forward to applications from students eager to study #SPPL3 and other proteases and their role in the regulation of #Golgi #glycosylation. #glycotime
Fig. 1 Iron-catalyzed radical formation and scavenging during lipid peroxidation.
At the (tz) border: glycoprotein trimming in the #Golgi apparatus prevents ferroptotic #CellDeath in #root tips
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
👆 #Commentary by von Schaewen & Koiwa on Li et al. 👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
a colorful graphic showing presence and absence of various genes across the diversity of eukaryotes
New #ISEPpapers! Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in Toxoplasma rupress.org/jcb/article/...
#Toxoplasma #Protists #Parasites #Microbes #Golgi #Evolution
#aiimages #iconoplasm #AIArt #AIArtist #AIArtwork #GenArt #DigitalArt #AIArtGallery #AIGeneratedArt #AIArtCommunity #monster #horrorart #digitalart #synthart #lovecraft #golgi #cyclops #microscopic
Fly-the-Chitin
#aiimages #iconoplasm #AIArt #AIArtist #AIArtwork #GenArt #DigitalArt #AIArtGallery #AIGeneratedArt #AIArtCommunity #monster #horrorart #digitalart #synthart #apicomplexan #jimvarney #golgi #unclassified
Exotic Apicomplexan
Systematic membrane thickness variation across cellular #organelles revealed by cryo-ET. New computational workflow developed by Desislava Glushkova (@deglushk.bsky.social), Stefanie Böhm, & Martin Beck (@becklab.bsky.social) @mpibp.bsky.social: rupress.org/jcb/article/...
#StructuralBiology #Golgi
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from #Golgi to cell surface, say Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University): rupress.org/jcb/article/...
#Biochemistry #Trafficking #CellSignaling #Wnt
In @jcb.org, Li, Hua et al. demonstrate that B4GALT1 and WLS cooperate to retain the canonical #Wnt receptor LRP5/6 on the #Golgi apparatus, leading to specific inhibition of the Wnt/β-catenin signaling in such Wnt-receiving cells that have no expression of Wnt proteins. rupress.org/jcb/article/...
Xinyang Li, Yue Hua et al. demonstrate that B4GALT1 and WLS cooperate to retain the canonical #Wnt receptor LRP5/6 on the #Golgi apparatus, leading to specific inhibition of the Wnt/β-catenin signaling in such Wnt-receiving cells that have no expression of Wnt proteins. rupress.org/jcb/article/...
Host #cytoskeleton and membrane network remodeling in the regulation of #viral replication ...
| #virus | #infections | #Golgi | #endoplasmicreticulum | Via @eurekalert.bsky.social
Excited to share our new paper!
Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in Toxoplasma gondii.
A great collaboration between the Meissner, Jiménez-Ruiz, and Dacks labs 🙌
#Toxoplasma #Apicomplexa #Golgi #CellBiology #Parasites
Cargoes move from cis to trans-Golgi compartments and concentrate in the TGN before exiting
#Golgi #MembraneTrafficking
-> www.embopress.org/doi/full/10....
Multiple golgins are required to support extracellular matrix secretion, modification and assembly, say George Thompson, Nicola Stevenson and colleagues @bristoluni.bsky.social: rupress.org/jcb/article/...
#Organelles #Biochemistry #Trafficking #Golgi
