Are you a DNMT3 enthusiast wondering how they achieve specificity at CpG islands during development? And why is DNMT3B specifically required for methylation on the inactive X?
We set out to dissect the mechanism, now published in Genes & Development
genesdev.cshlp.org/content/earl...
[1/12]
RESEARCH PAPER: Bypass of blocking lesions by RNAPII reveals a novel stress induced by DNA damage
By Bañuelos et al. and Ramiro Verdun
➡️ https://genesdev.cshlp.org/content/40/7-8/538.abstract
#chromatin #histone #epigenetics #cellstress #chemotherapy
🆕 ADVANCE ONLINE 🆕
RESEARCH COMMUNICATION: Nested pediatric low-grade glioma cerebral organoid avatars reveal glutamatergic neuron stromal growth dependency
By Xu et al. and David H. Gutmann
➡️ https://ow.ly/NOzT50YLcgz
David H. Gutmann, MD PhD Gutmann Lab WashU Medicine
#braincancer #organoids
OUTLOOK: It takes two to cleave: the logic of cluster assistance
By Owen Sanborn and Daniel Cifuentes
➡️ https://genesdev.cshlp.org/content/40/7-8/409.full
Also read:
➡️ https://genesdev.cshlp.org/content/40/7-8/517.full
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: The microprotein SMIM26 connects metabolite transporters of the outer & inner mitochondrial membranes and is essential for respiratory chain function
By Heizler et al. and Gunter Meister
➡️ https://ow.ly/mXyg50YLay6
#mitochondria #lncRNA #microprotein #metabolism
A new view of aging: How the immune system rewrites rapid aging.
Read the new #genesdev paper, online now ahead of print:
➡️ https://ow.ly/kCbl50YKyO8
https://ow.ly/NksN50YKyO6
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: A dual role for cGAS in shaping cellular and organismal responses to genomic instability
By Bergman et al. and Itamar Harel
➡️ https://ow.ly/2sZC50YL8CJ
Itamar Harel Hebrew University
#aging #genome #DNArepair #killifish
Delighted to share the lab's latest led by superstar Janith and funded by @snowmedical.bsky.social.
What happens when embryonic factors are reawakened in cancers? We uncovered how DPPA2/4 amplify chromatin states in non-small cell lung cancer 🧬🔬🧪
genesdev.cshlp.org/content/earl...
Tutorial 👇 (1/8)
RESEARCH PAPER: Separable roles for Microprocessor and its cofactors, ERH and SAFB1/2, during microRNA cluster assistance
By Shang et al. and Eric Lai
➡️ https://genesdev.cshlp.org/content/40/7-8/517.full
Memorial Sloan Kettering Cancer Center eric lai
#miRNA #Microprocessor #RNAi
G&D's Editor-In-Chief, Andrew Dillin, will be at CSHL for the Protein Homeostasis in Health and Disease meeting. #cshlprotein
If you’d like to chat about publishing your work with #genesdev, feel free to reach out to dillin@berkeley.edu
RESEARCH COMMUNICATION: A brain-specific microRNA, miR-1000, regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster
By Verma et al. and David Van Vactor
➡️ https://genesdev.cshlp.org/content/40/7-8/444.full
Harvard Medical School
#Drosophila #lipidmetabolism #miRNA
RESEARCH PAPER: Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5′-cap trimethylation
By Samajdar et al. and Luis Batista
➡️ https://genesdev.cshlp.org/content/40/7-8/498.full
#transcription #telomerase #telomere #telomerebiologydisorders
RESEARCH PAPER: The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in S. pombe
By Laffitte et al. and Megan King
➡️ https://genesdev.cshlp.org/content/40/7-8/456.full
Yale School of Medicine
#yeast #DNArepair
RESEARCH COMMUNICATION: Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer
By Garcia-Martinez et al. and Lluis Morey
➡️ https://genesdev.cshlp.org/content/40/7-8/429.full
Lluis Morey
#chromatin #transcription #breastcancer #histone
RESEARCH PAPER: tRNA synthetase activity is required for stress granule and P-body assembly
By Baymiller et al. and Stephanie Moon
➡️ https://genesdev.cshlp.org/content/40/7-8/475.full
Stephanie Moon
#translation #ribosome #granule #stress
RESEARCH PAPER: mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth
By Lin et al. and David P. Bartel
➡️ https://genesdev.cshlp.org/content/40/7-8/586.full
Whitehead Institute Massachusetts Institute of Technology
#miRNA #TDMD #development
REVIEW: Nonhomologous end joining—the importance of end tethering and beyond
By Shan Zha and Geunil Yi
➡️ https://genesdev.cshlp.org/content/40/7-8/411.full
Columbia University
#DNArepair #NHEJ #KuProtein #proteininteractions
RESEARCH PAPER: Multiomic analysis of clonal development reveals new regulators of leukemic cell growth
By Bonilla et al. and Ruslan Sadreyev
➡️ https://genesdev.cshlp.org/content/40/7-8/563.full
@gracia-b.bsky.social Harvard Medical School
#leukemia #AML #evolution
🚨 NEW ISSUE ALERT!!! 🚨
New Research articles and Outlook online now at Genes & Development.
Also in this issue, a detailed Review on the molecular and structural mechanisms of non-homologous end joining.
Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/40/7-8.toc
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Multiomic analysis of clonal development reveals new regulators of leukemic cell growth
By Bonilla et al. and Ruslan Sadreyev
➡️ https://ow.ly/Apg850YAPw7
@gracia-b.bsky.social Harvard Medical School
#leukemia #AML #evolution
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Bypass of blocking lesions by RNAPII reveals a novel stress induced by DNA damage
By Bañuelos et al. and Ramiro Verdun
➡️ https://ow.ly/ZfMy50YAOS1
#chromatin #histone #epigenetics #cellstress #chemotherapy
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Separable roles for Microprocessor and its cofactors, ERH and SAFB1/2, during microRNA cluster assistance
By Shang et al. and Eric Lai
➡️ https://ow.ly/XzBb50YyUjb
Memorial Sloan Kettering Cancer Center eric lai
#miRNA #Microprocessor #RNAi
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: A brain-specific microRNA, miR-1000, regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster
By Verma et al. and David Van Vactor
➡️ https://ow.ly/sCFM50YyTsG
Harvard Medical School
#Drosophila #lipid #metabolism #lifespan #miRNA
Register now for On Demand Access to Keystone Symposia #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March to explore emerging research! #KSDiabetes26
For more info:
➡️ https://hubs.la/Q03X7Ckz0
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5′-cap trimethylation
By Samajdar et al. and Luis Batista
➡️ https://ow.ly/Ko1u50YyStI
Huntsman Cancer Institute
#transcription #telomerase #telomere
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: The LINC complex component Kms1 & CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in S. pombe
By Laffitte et al. & Megan King
➡️ https://ow.ly/BRKE50Ywy23
Yale School of Medicine
#yeast #DNArepair
📽️ G&D Tapes 📽️
G&D Author, Jamie Alegrio-Louro, tells us about their work defining conserved nucleosome-binding mechanisms for invertebrate protein Dsup and the vertebrate protein HMGN.
Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1155.full
@jaimealegriolouro.bsky.social
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: tRNA synthetase activity is required for stress granule and P-body assembly
By Baymiller et al. and Stephanie Moon
➡️ genesdev.cshlp.org/content/early/2026/01/13...
Stephanie Moon
#translation #ribosome #granule #stress
🆕 ADVANCE ONLINE 🆕
RESEARCH COMMUNICATION: Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer
By Garcia-Martinez et al. and Lluis Morey
➡️ genesdev.cshlp.org/content/early/2025/12/18...
Lluis Morey
#chromatin #transcription
📽️ G&D Tapes 📽️
G&D Author, Chiara Nicoletti, tells us about how MYOD’s context-dependent role as a transcriptional repressor during skeletal muscle development.
Learn more here:
➡️ genesdev.cshlp.org/content/39/21-22/1299.ab...
Luca Caputo
