Mosaic gastruloids reveal a temporal restriction for developmental cell competition - Nature Cell Biology Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation during which cell competit...

☕ @joshifrenster.bsky.social @amartinezarias.bsky.social & co utilize mosaic mouse #gastruloids as a model of cell fitness & competition, identifying a temporal window between primed pluripotency and early gastrulation during which #CellCompetition occurs in mammalian #embryogenesis.
bit.ly/4cBmfGK

This method to reverse cellular ageing is about to be tested in humans A burgeoning field is launching its first clinical trial to find out whether dialling back cell development can safely refresh aged tissues and organs.

A feature in Nature outlines how a burgeoning field examining a method to reverse cellular aging is launching its first clinical trial to find out if dialling back cell development can safely refresh aged tissues and organs. 🧪

👋Our April issue is out!
Cover: Visualizing #lipids

👉2 Perspectives: #embryo models
👉Comment on #mitochondria DNA
🔬 #telomeres #leukemia #ferroptosis #pyroptosis #PhaseSeparation #CellAdhesion #BreastCancer #lncRNA #metabolism #autophagy #microscopy & more!
www.nature.com/ncb/volumes/...

Visualizing suborganellar lipid distribution using correlative light and electron microscopy - Nature Cell Biology Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...

☕ @mathilda95.bsky.social @nadlerlab.bsky.social & co introduce a correlative light and electron #microscopy workflow, Lipid-CLEM, combining near-native #lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively analyses lipids in membrane nanodomains.
bit.ly/4moYLJH

📰Our editor Zhe Wang will be attending the AACR Annual Meeting in San Diego. Please feel free to reach out to him (zhe.wang@nature.com) if you would like to meet in person to discuss your work and ask questions about Nature Cell Biology.

📣 New Perspective out in @natcellbio.nature.com! With an interdisciplinary team of scientists, ethicists & lawyer we propose embedded ethics as a framework for navigating the complex ethics of human stem cell–based embryo models.

www.nature.com/articles/s41...

Free full text link: rdcu.be/fckmY

🧵

Gene regulatory landscape dissected by single-cell four-omics sequencing - Nature Combining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome pr...

A study published in Nature presents CHARM, a single-cell 'four-omics' sequencing method that profiles genome conformation, histone modifications, chromatin accessibility, and gene expression within the same cell.🧪👇
www.nature.com/articles/s41...

So embarrassing I had no idea 😅 Tasted great! Sweeter than regular potatoes, but not as sweet as sweet potatoes - loved them!

Cooking lunch today, I was shocked: there exist purple potatoes! I ‘d no idea (and didn’t buy them myself; they were sent to me from a company supporting organic local produce & sustainability (by including products super markets would not buy as they ‘re crooked or whatever; highly recommend it!))

☕After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and #ferroptosis sensitivity in #cancer cells.
bit.ly/4t91gm1

Mosaic gastruloids reveal a temporal restriction for developmental cell competition - Nature Cell Biology Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation during which cell competit...

🥳 I am happy to share our latest manuscript published in @natcellbio.nature.com We use #Gastruloids to study #CellCompetition during early mammalian development and find not only that this is highly pronounced in our system but also tightly restricted in time. (1/12) www.nature.com/articles/s41...

Peritumoural adipose tissue promotes ferroptosis resistance by 3-hydroxykynurenine-mediated suppression of ferritinophagy - Nature Cell Biology Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be target...

☕Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoral #adipose tissue is hijacked by #cancer cells to mediate #ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumor growth.
bit.ly/4uWc73X

Amniogenesis in embryos and stem cell models - Nature Cell Biology This Review discusses the mechanisms underlying both cavitation and folding amniogenesis and provides an overview of the various recent stem cell-based human embryo models that have been developed to ...

☕New Review article discussing the mechanisms underlying both cavitation and folding #amniogenesis, as well as various recent stem cell-based human #embryo models developed to elucidate amniotic formation and function.
👉https://rdcu.be/e9wos
bit.ly/4uGeh7v

Happy birthday to him, Jesse! To many more healthy and lovely years 🥂

Thrilled to share that our latest review—led by @aysegulerdemm.bsky.social—synthesizing insights into complex intrinsic and extrinsic metabolic regulation of HSC fate and its implications for leukemogenesis, is published in March 2026 issue of @natcellbio.nature.com.

@nickvangastel.bsky.social

👋Our March issue is out!
Cover: #Adipose – #tumor in #immune escape

👉Reviews on: #metabolism #hematopoiesis ; #amnion ; #brain #lipids
🔬 #mitochondria #LipidDroplets #aging #autophagy #mechanobiology #neurodegeneration #ferroptosis #chromatin #metastasis & more!
www.nature.com/ncb/volumes/...

PML targets and resolves structured protein inclusions to mitigate neurodegeneration - Nature Cell Biology Wang et al. show that promyelocytic leukaemia protein (PML) reduces polyG inclusions via chaperone-mediated disaggregation and proteasome-dependent degradation. This suggests a possible role for PML i...

☕Wang et al. show that promyelocytic leukemia protein (PML) reduces polyG inclusions via chaperone-mediated disaggregation and proteasome-dependent degradation. This suggests a possible role for PML in various neurodegenerative diseases.
👉https://rdcu.be/e7dOe
bit.ly/4ucFCy1

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 - Nature Cell Biology Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1
👉https://rdcu.be/e7dRa
bit.ly/4baJZAO

An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis - Nature Cell Biology Xia, Zhang, Peng, Chen et al. find that Leydig cells and macrophages show bidirectional mitochondrial transfer through extracellular vesicles, ensuring Leydig cells have functional mitochondria. The e...

☕Xia, Zhang, Peng, Chen et al. find that #Leydig cells and macrophages show bidirectional mitochondrial transfer through #ExtracellularVesicles, ensuring Leydig cells have functional #mitochondria. The exchange is needed for testosterone production.
bit.ly/40US4Vy

Cellular mechanisms of brain lipid metabolism in health and disease - Nature Cell Biology This Review discusses brain lipid metabolism from a cellular perspective, focusing on lipid uptake, de novo synthesis, storage, breakdown and intercellular transfer, and highlights its emerging implic...

☕New Review discusses #brain #lipid #metabolism from a cellular perspective, focusing on lipid uptake, de novo synthesis, storage, breakdown and intercellular transfer, and highlights its emerging implications for brain health and disease.
👉Read here: rdcu.be/e8rlJ
bit.ly/4rxWpJm

THY1+ cancer stem cells drive metastasis through a pseudohypoxic state shaped by neutrophil-derived mitochondria - Nature Cell Biology Wan, Li, Cao and colleagues report a feedback crosstalk between THY1+ cancer stem cells and neutrophils via migrasome-mediated release of mitochondria, which induces a pseudohypoxic state and promotes...

☕Wan, Li, Cao et al report a feedback crosstalk between THY1+ #cancer #StemCells and neutrophils via #migrasome - mediated release of #mitochondria, which induces a pseudohypoxic state and promotes metastasis.
👉https://rdcu.be/e51HE
bit.ly/3ZZRw0q

Defining the reference proteomes for small extracellular vesicles and non-vesicular components - Nature Cell Biology Morales-Sanfrutos, Etxeberria-Ugartemendia, Barroso-Gomila and colleagues map the elution profiles of small extracellular vesicles along density gradients from human biofluids and cell lines, distingu...

☕Morales-Sanfrutos, Etxeberria-Ugartemendia, Barroso-Gomila et al map the elution profiles of small #ExtracellularVesicles along density gradients from human biofluids and cell lines, distinguishing extracellular vesicle content from co-isolation components.
bit.ly/3ZWmeHJ

Graphic promoting the Springer Nature “Opening Doors Internship Programme 2026.” The design features bold, colorful abstract shapes in purple, orange, and blue. On the left, logo for “Be part of progress.” On the right, text states “Opening Doors Internship Programme 2026 – Accepting applications,” alongside the Springer Nature logo and the “Stretch Your Horizons” branding. A young woman is seated in the foreground.

Our Opening Doors Internship Programme is open for applications! #BePartOfProgress and join one of our teams to gain hands-on experience working on impactful projects and benefit from the expertise of our talented colleagues.
spklr.io/63327DL797

#Publishing #WorkInPublishing

Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice - Nature Communications Exposure to inflammation drives hematopoietic stem cells (HSC) aging, limiting their self-renewal capacity and differentiation. Here, the authors explore the mechanistic link between inflammation and ...

Our work is out www.nature.com/articles/s41...

👋Our February issue is out!
Cover: spatial #transcriptomics

👉Review: telomeric #chromatin
🔬 #mitochondria #mitophagy #senescence #p53 #epigenetics #glioblastoma #IDR #immunotherapy #cGASSTING #apoptosis #lysosomes & more!

www.nature.com/ncb/volumes/...

Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis - Nature Cell Biology Bång-Rudenstam et al. report that the acidic tumour microenvironment facilitates the assembly of chondroitin sulfate-enriched glycocalyx to disrupt lipid scavenging and prevent ferroptosis, thereby pr...

☕Bång-Rudenstam et al. report that the acidic #tumor microenvironment facilitates the assembly of chondroitin sulfate-enriched glycocalyx to disrupt lipid scavenging and prevent #ferroptosis, thereby providing an adaptive mechanism upon tumor acidosis.
bit.ly/3Mvuvz1

Thank you for your contribution!

The interpretable multimodal dimension reduction framework SpaHDmap enhances resolution in spatial transcriptomics - Nature Cell Biology Tang, Chen, Qian et al. present a multimodal, interpretable dimension reduction framework called SpaHDmap, which leverages histology images and enhances the resolution of spatial transcriptomics, thus...

☕Tang, Chen, Qian et al. present a multimodal, interpretable dimension reduction framework called SpaHDmap, which leverages #histology images and enhances the resolution of spatial #transcriptomics, thus enabling the dissection of complex tissue structures.
bit.ly/4chkfoD

T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response - Nature Cell Biology Scourzic et al. show that germinal centre B cells display an enhanced ability to reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher plasticity ...

☕Scourzic et al. showed that germinal centre #Bcells display an enhanced ability to #reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher #plasticity level and is T follicular helper cell-dependent.
👉https://rdcu.be/e2Wxm
bit.ly/4aDyDWY

Bring structure to your research - protocols.io A secure platform for developing and sharing reproducible methods.

Join Springer Nature editors and the protocols.io team for an exciting event as part of #LoveMethods26!
🔮Gain insight on methods publishing at our Methods Mythbusting on Jan 22. Our editor Sabrya Carim will be there!
👉FREE registration & more details:
www.protocols.io/blog/join-pr...