Protein Termini 2026 – International Society for Protein Termini (ISPT)

8 days left to register | 28 invited speakers | Keynotes from F. Ulrich Hartl, Roland Beckmann and Michael Rapé | #chaperones #degradation #ubiquitin #cryoEM #acetylation #lipidation #ribosomes #proteins
proteintermini.org/meeting/

For certain life-essential proteins in E. coli, repair is more likely A new high-throughput study using preexisting publicly available data shows that E. coli proteins containing a specific structure, called a non-covalent lasso entanglement, are more likely to misfold…

For certain life-essential #proteins in E. coli, repair is more likely ...

| #Ecoli | #bacteria | #chaperones | #aminoacids | Via eurekalert .org

Great talk by Marta Artola at #NWOCHAINS. She talked about the use of modified sugars as inhibitors and molecular #chaperones in #DrugDiscovery. Great insights into the use of cyclic sulfamates and sulfamidates as reactive groups for #CovalentInhibitors
pubs.acs.org/doi/10.1021/...
#ChemSky #ChemBio

Nice new review on #Hsp70 and its network of chaperone friends and clients - by Anne Wentink, Rina Rosenzweig, Harm Kampinga and Bernd Bukau #chaperones #amyloid

Oh this looks good.
#Chaperones #sHSPs

Structural analyses define the molecular basis of clusterin chaperone function Nature Structural & Molecular Biology - The authors reveal a three-domain architecture of glycoprotein clusterin and show that the hydrophobic tails are crucial for clusterin’s functions...

Curious about the structure and functional analysis of one of the most abundant and enigmatic extracellular #chaperones and one of the highest genetic risk factor for developing late onset #Alzheimer’s disease? Check out our paper on Clusterin/ApoJ!
#proteostasis #apolipoprotein
rdcu.be/ezRLv

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

👉 buff.ly/IoEPOTs

🥼 @OscarLlorcaCNIO @CNIOStopCancer

#mTORC1 #CellMetabolism #Chaperones

Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social

Exciting news: DFG funds FOR5872 – Chaperone-mediated regulation of amyloids in condensates!
Led by Prof. Janine Kirstein (FLI), researchers from Germany and Israel will explore how chaperones counteract disease-causing protein misfolding.
Good luck to the team!
#FLI #DFG #FOR5872 #Chaperones

Pathogenic mutation impairs functional dynamics of Hsp60 in mono- and oligomeric states Nature Communications - Mutations cause impairment of function in the chaperone Hsp60. Here, the authors investigate their impact with MD simulations from the monomer to the 28-mer complex, and...

Read our latest #research on #Chaperones, #Mutations, #Function Emergence in large compllexes, published with @SpringerNature in Nature Communications. #CompChem #CompBiol #ChaperoneCode

rdcu.be/ehmjZ

It’s an honor to highlight a groundbreaking work on de novo designed chaperones to target cellular condensates #chaperones #Hsps #proteostasis

Our reseach combines #biochemistry, biophysics, and cell biology to unravel #ProteinInteractions and self-assembly and how #chaperones influence aggregation, #PhaseSeparation and #proteostasis. The image depicts S100B, a chaperone acting on #Tau and #AmyloidBeta, and one of our favorite models 🧪

Now online - the Review "Protein quality control machinery: regulators of condensate architecture and functionality" from Anitha Rajendran and Carlos @castanedalab.bsky.social.

#PQC #condensates #phaseseparation #chaperones #therapeutics

Access here 👉 authors.elsevier.com/a/1kNRo3S6Gf...

Thank god we don't have a black light. #holidayinn #chaperones #omg http://t.co/o8oei4uGe9