Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

➡️ buff.ly/ATJrUCp

#Chemokine #CCR5 #BCSM

🖊️ @hkiaris1 @Bernardneuro

TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice Clonal hematopoiesis (CH) is associated with many age-related diseases, but its interaction with Alzheimer’s disease (AD) remains unclear. Here, we sh…

TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice

#neurodegeneration #Alzheimer's #microglia #chemokine #inflammation #phagocytosis 🧪

www.sciencedirect.com/science/arti...

Not all chemokine signaling is about cell migration!

In mouse erythroblasts, CXCL12-bound CXCR4 enters the nucleus to control gene transcription, trigger calcium bursts, and drive red blood cell formation—especially enucleation.

🔗 science.org/doi/10.1126/sc…
#chemokine #CXCR4

New paper alert! Excited to share our latest work on the importance of inflammatory #chemokine receptors (iCCR, aka the best chemokine receptors) in mounting an optimal T cell response to #influenza infection.

Please share, happy to discuss!

📌 OncoTerm - Word of the Day! 👋 OncoTerm - Günün Kelimesi! 📌

Join us as we break down key terms to empower ourselves with knowledge in the fight against cancer.

#Onco404 #Cancer #Kanser #MedSky #OncSky #CancerAwareness #CancerCare #Chemokine #ImmuneSystem #ImmuneResponse #TumorImmunity #Vocabulary

Gerry’s lab developed iCCR mice, these mice lack the chemokine receptors CCR 1,2,3 and 5.

Now they found that after infection with influenza virus, the number of CD4 T cells in the lung was strongly reduced in iCCR mice.

#chemokine

@crgglasgow.bsky.social is on BlueSky 😃 Follow us for all things #chemokine

Our 1st BlueSky post and it's our lab's newest preprint! Please read and share and let us know any of your thoughts 😊 #chemokine #immunosky

While human #proteins span a wide range of molecular weights, from approximately 0.26 to 4000 kDa, human chemokines are restricted to a narrow range of about 8 to 14 kDa. We asked whether there might be an optimality in #cellular #communications.
arxiv.org/abs/2412.00771
#Immunology #Chemokine

Eosinophils promote monocyte to macrophage differentiation and anti-bacterial immunity Chemokine receptors control cell migration within the body. Here we reveal a novel interaction between eosinophils and monocytes in the bone marrow, indirectly controlled by the atypical chemokine rec...

Our new preprint is here! We show eosinophils are retained in the bone marrow by everyone’s (our😊) favourite atypical #chemokine receptor ACKR2.
#Eosinophil education of #monocytes promotes differentiation to #macrophages and bacterial elimination during E.coli #infection. Please read and share.

Platelet factor 4–induced TH1-Treg polarization suppresses antitumor immunity The tumor microenvironment (TME) contains a number of immune-suppressive cells such as T helper 1–polarized regulatory T cells (TH1-Treg cells). However, little is known about the mechanism behind the...

Hot off the presses!

In #ScienceMagazine, the Yamamoto lab reports that #tumor -associated #macrophages ( #TAMs ) polarize #Tregs into a #TH1 – #Treg phenotype via the #chemokine #Platelet Factor 4 (PF4)!

Congrats to Mélanie Bruchard #InsermU1231 for winning the 2022 Amanda Proudfoot Tribute Award for Advances in #Chemokine Biology by a Trainee! See you at the #Cytokines2022 meeting in Hawaii!

Inner Life Of A Cell #HarvardUniversity #CellLife #P-selectin #Leukocytes #LipidRaft #Cholesterol #Chemokine #Proteoglycan #Receptor #SpectrinTetramer #ActinFilaments #SeveringProtein #Microtubules #Vesicle #MotorProtein #Mitochondria #Centrosome #Centriole #Pores #Ribosome #Translocator #EndoplasmicReticulum #PlasmaMembrane #G-protein #Integrin #I-Cam

Inner Life Of A Cell #HarvardUniversity #CellLife #Leukocytes #LipidRaft #Cholesterol #Chemokine #Proteoglycan #Pores

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