Redirecting

🦷🧬 Just published online in JPS❣️
“Orai1- and STIM1-mediated calcium signaling controls PD-L1 expression and modulates antitumor immunity in oral cancer”
— Eriko Yamashita et al.
🔗 doi.org/10.1016/j.jp...
#CalciumSignaling #TumorImmunity #PDL1 #OralCancer #NowOnline #JPhysiolSci

What if cancer immune evasion is driven by metabolites, not mutations?
Tumor-derived metabolites actively suppress immunity and rewire immune cell fate—offering new therapeutic targets.
www.nature.com/articles/s41...
#CancerMetabolism #Immunotherapy #TumorImmunity #TranslationalResearch @nature.com

Epigenetic drugs in cancer therapy: mechanisms, immune modulation, and therapeutic applications - Molecular Biomedicine Epigenetic regulation is a fundamental mechanism controlling gene expression and cellular function, primarily mediated through reversible modifications such as DNA methylation, histone acetylation, an...

#Review
Epigenetic drugs in cancer therapy: mechanisms, immune modulation, and therapeutic applications doi.org/10.1186/s435...

#EpigeneticRegulation #DNAmethylation #HistoneModifications #TumorImmunity #ClinicalTranslation

Reviewing the structure, regulation, and function of RRM2 and its inhibitors, its critical role in promoting tumor malignancy, #TumorImmunity, #TherapyResistance & the #TumorMicroenvironment, with insights into RRM2-targeted therapies. #medsky

#OpenAccess: doi.org/10.1016/j.ge...

This review explores the interplay between the #Nervous and #ImmuneSystems in shaping the #TME, showing how neural activity regulates #TumorImmunity & how tumor-driven immune changes impact neural function, providing insights for new #CancerTherapies.

#STTT: doi.org/10.1038/s413...

This study reveals that #XPR1 can regulate #autophagy and #TumorImmunity through the #lysosomalprotein LAMP1, underscoring XPR1's potential as a promising target for diagnosing and treating #OvarianCancer. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

🧬 Tumor immune evasion:
↓ MHC I (up to 60%)
PD-L1/CTLA-4
TGF-β/Tregs/MDSCs
Warburg/IDO1

⚠️ Only 20–30% of patients respond long-term to ICIs.

🔬 Absea antibodies target these escape routes.

➡️ Which mechanism are you tackling?

Learn more: www.absea.bio

#TumorImmunity #CancerResearch #Immunotherapy

📌 OncoTerm - Word of the Day! 👋 OncoTerm - Günün Kelimesi! 📌

Join us as we break down key terms to empower ourselves with knowledge in the fight against cancer.

#Onco404 #Cancer #Kanser #MedSky #OncSky #CancerAwareness #CancerCare #Chemokine #ImmuneSystem #ImmuneResponse #TumorImmunity #Vocabulary

Featured today by @MSKLibrary: Metabolic engineering to facilitate anti-tumor immunity

#MetabolicEngineering #CancerImmunotherapy #TumorImmunity #BiomedicalResearch #PrecisionMedicine #ImmunoOncology #CancerMetabolism

www.sciencedirect.com/science/arti...

XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagy

XPR1 promotes #OvarianCancer progression and regulates MHC1 expression by suppressing #Autophagy via interacting with LAMP1 and the PI3K/Akt/mTOR pathway. #TumorImmunity

#OpenAccess: https://buff.ly/4aevwD3

This work led by Arja Ray has now been published in @jexpmed.bsky.social!

Read about how “immunosuppressive” CD206 tumor associated macrophages are actually not so immunosuppressive here ➡️ doi.org/10.1084/jem.20240957

#tumorimmunity #macrophage #krummellab

3/4⚙️This strategy bypassed tumor evasion mechanisms and endowed #tumor cells with professional antigen presentation leading to the activation of specific CD8+ T cells (soldiers), and anti-tumor immunity in vivo. #immunity #cancer #tumorimmunity