"Low-carb" is not one thing.
Verified ketosis, Mediterranean diet, and unverified carb restriction are three distinct states predicted to produce different immune outcomes in IBD. The middle one — the most studied - may be least informative. Each prediction is falsifiable.
#Immunosky #Gastrosky #IBD

No human study has measured diet, bile acids, and Th17/Treg balance simultaneously in IBD. A 2026 JCC mouse study and a 2022 Nature paper converge on Treg expansion — via BHB, via bile acids. This preprint proposes a cross sectional test of diet on both.
#MucosalImmunology #OpenAccess
#IBD

Graphical abstract: committed diets restore bile acid signaling (FXR/TGR5/RORγt) shifting Th17/Treg toward mucosal tolerance; intermediate restriction predicts uncertain outcome. IBD hypothesis.

Half of “keto diet” IBD trials never confirmed ketosis. No blood BHB — just carb restriction of unknown depth. This preprint proposes why that gap explains contradictory results, and a design to test it.
preprints.org/manuscript/202603.0416/v5
#IBD #GutMicrobiome #BileAcids

Micro- and Nanoplastics: A Paradigm Shift in the Pathogenesis of Inflammatory Bowel Disease Micro- and nanoplastics (MNPs) are pervasive environmental contaminants with growing recognition as potential contributors to human disease. Widespread human exposure occurs primarily through ingestion of contaminated food and water, and MNPs have been detected in multiple human tissues, including the gastrointestinal tract. Experimental evidence provides a plausible biological basis for disease associations, including impairment of intestinal barrier integrity, activation of mucosal immune pathways, and alteration of gut microbial communities caused by MNP exposure. Although human data remain limited, early studies demonstrate MNP detection in stool and suggest potential correlations with inflammatory biomarkers such as fecal calprotectin. These findings, together with mechanistic data from in vitro and animal models, raise concern that MNP exposure represents a paradigm shift in the pathogenesis or modulation of inflammatory bowel disease (IBD); however, methodological variability, small sample sizes, and contamination challenges currently limit definitive conclusions. The aim of this review is to evaluate the current understanding of MNP exposure and its impact on intestinal health, particularly in relation to IBD. We synthesize mechanistic and early clinical evidence linking MNPs to IBD and highlight critical research gaps. Future standardized exposure assessment, mechanistic validation in human systems, and longitudinal studies are essential to clarify causal relationships. Given the modifiable nature of environmental plastic exposure, advancing this field may offer new opportunities for IBD prevention and intervention.

🩺 Could micro- and nanoplastics be part of the IBD story? This review links them to barrier injury, immune shifts, and microbiome disruption. @amergastroassn.bsky.social
#IBD
🔗 www.xiahepublishing.com/2994-8754/JT...

🎧 New Podcast | Blood clots & IBD

Prof Beverley Hunt OBE explains why people with Crohn’s & ulcerative colitis face higher clot risk – and what you can do to protect yourself.

🎧 Listen now thrombosisuk.org/news/

#Thrombosis #IBD #BloodClots #PatientAwareness #ThrombosisUK

Getting immersed in the details of my painting Disruptive Guts. #painting #contemporanyart guts #guthealth disruptive #ibd ibs @gutscharityuk canvas pastel red pink blue red yellow violet silver orange pink #judithwalkerartist

Happy #Vaisakhi! ⚔️✨

We’re celebrating the incredible "warrior spirit" of our Sikh #IBD community today. Whether you’re fighting #Crohns or #Colitis, your resilience is a true inspiration.

What does being a "warrior" mean to you today?

Daily Spoon Count 5/10
Pain Level 3/10
Lousy sleep last night. Got stuff done on the side hustle y'day, that was good. From May to Sept I hand press + sell souvenirs in Shediac. It's nice, I'm on the shore every day all summer. Be a work in progress today and everyday #spoonie #ibd #chronicillness

🚨Spire’s experimental inflammatory bowel drug reduces disease activity in mid-stage trial. #IBD #ClinicalTrial

🚨 Spyre’s experimental IBD drug reduces disease activity in mid-stage trial #IBD #ClinicalTrial

Bright orange clouds from a sunrise over a residential neighborhood.

Daily Spoon Count 5/10
Pain Level 3/10
Had a great time y'day with @runningbackwards.bsky.social and our friend Nancy. But had a lousy sleep last night. I woke up unrested, but I had a nice splash of colour. Be a work in progress today and everyday #ibd #spoonie #chronicillness

I will poop, and then I can be happy
#crohns #ibd

Chronic illness means every day depends on something you can’t control. #ibd

Wearable Technology for IBD Management: Early Insights Into Disease Activity Wearable technology for IBD management includes the ability to detect flares early and support continuous, data-driven disease monitoring.

Wearable devices are emerging as a tool for continuous physiologic monitoring in #IBD, with potential to improve early detection and disease management.

Read More: https://bit.ly/4bQCbpG

🧵3 of 4

It's important for parents/guardians to ask their provider about their child's growth status at every visit!

Check out the multidisciplinary @childrensnational.bsky.social Growth Program for #IBD:

www.childrensnational.org/get-care/dep...

#GrowthStudy #GrowthProgram

Daily Spoon Count 6/10
Pain Level 2/10
It's a beautiful sunny day and I'm going to try to get out and enjoy some of it. Allergies are starting, that's early for me, time to break out the non drowsy meds. Be a work in progress today and everyday #spoonie #ibd #chronicillness #spring

Finished at last my immersive painting Disruptive Guts. #painting #contemporanyart guts #guthealth disruptive #ibd ibs @gutscharityuk canvas pastel red pink blue red yellow violet silver orange pink #judithwalkerartist

"Inspired by an ancient text—the Tao Te Ching—and shaped through the lens of modern life and technology, Smith began rewriting its teachings for life with chronic illness.

A Soft Way is the result of that inquiry."
#TaoTeChing #ChronicIllness #Healing #UlcerativeColitis #IBD
@chris6572.bsky.social

"After living for years with ulcerative colitis, Chris Smith encountered a question that changed everything: What if this experience isn’t something to fight or fix, but something to listen to?"
#UlcerativeColitis #ChronicIllness #Taoism #ASoftWay #IBD #ASoftWay #Taoism
@chris6572.bsky.social

Amazon.com

Chris Smith's new book
A Soft Way: A Taoist Approach for living with Ulcerative Colitis available!
@chris6572.bsky.social @soulinmedicine.bsky.social @miriamcolleran2.bsky.social @crohns-disease.org.uk @crohnsandcolitisau.bsky.social @crohnscolitisfdn.bsky.social
shorturl.at/46ME2
#TaoTeChing #IBD

The Causes and Dangers of Malabsorption, and An Easy Way to Get Your Nutrients via Oral Spray Vitamins

"Whilst #probiotics are generally good for #intestinal flora, some contain #prebiotics ..that..provide food for #GutBacteria. But they can also lead to overgrowth & aggravate #gastrointestinal symptoms.": buff.ly/LnlPpUl

for SpectraSpray
#malabsorption #nutrition #nutrients #ChronicPain #IBD #diet

Gut pathogen Clostridium symbiosum rewires macrophage succinylation to drive enteric neuron loss in inflammatory bowel disease Zhao et al. identify an IBD-enriched gut pathogen, Clostridium symbiosum, that promotes enteric neuron loss and colitis. C. symbiosum-derived succinate rewires macrophage glycolytic metabolism to sustain IL-1β signaling, thereby activating neuronal NLRP3 inflammasomes and driving neuron loss. Targeting C. symbiosum with a phage-derived endolysin preserves enteric neurons and alleviates intestinal inflammation.

#WeekendRead! #EveryCellIsAnImmuneCell! #InflammasomePower! #ImmunometabolismPower! Zhao &co show @cp-cellhostmicrobe.bsky.social that a clostridium enriched in #IBD exacerbates colitis via boosting #glycolysis & IL1b by macrophages & activating NLRP3 in enteric #neurons, causing their loss!

Daily Spoon Count 7/10
Pain Level 2/10
This is my baseline! Yay! I slept like the dead last night, and I really needed it. Got out y'day w/ @runningbackwards.bsky.social and a friend for some time at the Oval. Very nice. Be a work in progress today and everyday #ibd #spoonie #spring #freshair

"Toughing it out" can be common in endurance sports, but it almost cost T.L. Wright her life. After years of undiagnosed Crohn's, she had to completely pivot her diet and athletic goals to heal.
Hear to her journey on the latest #AboutIBDPodcast: bit.ly/AIBD199
#CrohnsDisease #IBD #SCDDiet

Living w/ #IBD can feel isolating. Vivir con la enfermedad de #Crohn o #colitisulcerosa no siempre es fácil-uno se puede sentir muy solo. Por eso existe un #grupodeapoyo virtual en #español para la #EII Si tú, o alguien que quieres, vive con la EII, te invitamos a acompañarnos👇🏼

Daily Spoon Count 6/10
Pain Level 2/10
I survived the stranger in my home*phew* I have a bit of a busy day today, that's not a bad thing. Hopefully it will include some quality outdoor time. Nice to see the warmer weather coming. Be a work in progress today and everyday #ibd #spoonie #chronicillness

Purple banner with text: "June 11, 2026. IBD Pro: Intestinal Ultrasound Educational Webinar." Below, the Crohn's & Colitis Foundation and IBD Pro logos are displayed.

Non-invasive. Radiation-free. Rapidly advancing. #IUS is reshaping #IBD care.
Learn how to use it in practice on June 11.
https://bit.ly/4m6SbHk

#IBD #UltrasoundIBD

A graphic that has an outline of an athlete in the middle. They are stretching and there are colorful spots over certain parts of their body. Each colorful spot corresponds to a category in one of the boxes that surrounds them: Eye, Bone & Joint, Nutrition, Mental Health, and Skin.

Student athletes with inflammatory bowel disease #IBD face challenges that can stand in their way of participation & performance. How can sports medicine professionals help? A multidisciplinary team at @childrensmercy.org outlines practical tips in Current Sports Medicine Reports: cmkc.link/4c3DD84

Infusion day. The most something day every 7 weeks. I'm hoping for a good nap after, at least. #IBD #CrohnsDisease

Daily Spoon Count 6/10
Pain Level 2/10
I have a plumber coming over to replace a faucet and have severe anxiety about strangers coming to my home. Not a fun feeling. Probably that undiagnosed neurodivergent thing. Be a work in progress today and everyday #ibd #spoonie #neurodivergent #chronicillness