Manganese-coordinated lipid nanoparticles boost VZV antigen delivery and CpG adjuvant response—enhancing vaccine efficacy.
doi.org/10.15212/ZOO...
#LipidNanoparticles #VZV #Adjuvants #Nanomedicine

Big news for LNP development 🧬: ONI’s new LNP PREP on Aplo Flow streamlines single-particle characterization with a fully automated workflow.

Discover how:
zurl.co/jLekN

#Biopharma #DrugDevelopment #LipidNanoparticles #LNP #mRNA #GeneTherapy #Automation

Check out our latest NanoTexh Newsletter, all about #lipidnanoparticles www.linkedin.com/pulse/advanc...

Fast Injections = Massive IV Leak: What 10,000 Simulated Vaccine Shots Reveal on the First 8 Minutes Post-Vaccination Part 1 - My Monte Carlo model shows why rapid delivery sends billions of LNPs straight into the bloodstream — and why slow, gentle injections are dramatically safer

The devil is in the details.

Part 1 - model shows why rapid delivery sends billions of LNPs straight into the bloodstream — and why slow, gentle injections are dramatically safer

covidmythbuster.substack.com/p/fast-injec...

#lipidnanoparticles #mRNA #patientsafety #healthliteracy

A non-invasive intranasal #CancerVaccine comprising #CircularRNA encapsulated in #LipidNanoparticles elicits potent anti-tumor T cell responses in preclinical #LungCancer models, providing a novel approach for treating mucosal malignancies.

#STTT #OpenAccess: doi.org/10.1038/s413...

New work using cGAS #LipidNanoparticles shows how cancer cells can be used to contribute to their own elimination.

Check out the work from Drs. Alexander Cryer and Natalie Artzi at the @wyssinstitute.bsky.social and Brigham and Women’s Hospital: https://bit.ly/49terHm

Lipid Nanoparticles for mRNA Delivery | MedChemExpress Lipid Nanoparticles (LNPs) have emerged as a transformative platform for delivering mRNA therapeutics, enabling the rapid development of COVID-19 vaccines and advancing next-generation cancer vaccines...

🌍LNPs continue to show great promise for next-generation vaccines and gene therapy. 🔗 ow.ly/bReF50Xqrf5

#LipidNanoparticles #GeneTherapy #DrugDelivery #Nanomedicine #Biotech #LifeScience #RNAResearch

"Transfection with LNPs may induce a systemic condition we call lipid-nanoparticle-driven membrane dysfunction (L‑DMD), where transfection results in broader dysregulation of cellular communication, stress response, and energy balance."

#lipidnanoparticles #mRNA

www.preprints.org/manuscript/2...

#mRNA #LNPs #lipidnanoparticles #healthliteracy

Mn-LNP Co-Delivery System Enhances VZV Vaccine Efficacy Mn-coordinated lipid nanoparticles (Mn-LNPs)-encapsulated varicella zoster virus (VZV) glycoprotein E antigen and CpG adjuvant enhances VZV vaccine efficacy.

This study developed manganese-coordinated #LipidNanoparticles to co-deliver #VaricellaZosterVirus (VZV) antigen & CpG #adjuvant, significantly boosting CD4+/CD8+ T cell & IgG2b responses vs aluminum adjuvant, offering a strategy to enhance VZV #vaccine efficacy.

#OpenAccess: tinyurl.com/25eta4n2

ONJCRI researchers and collaborators at @unimelb.bsky.social and RMIT have developed a novel nanomedicine delivery system with highly ordered structures that enhance cargo delivery to their targets.

➡️ Read the paper: ow.ly/XmYX50X1j4I


#LipidNanoparticles #Nanomedicine #CancerResearch

Molecular Therapy podcast: Lipid nanoparticles with Drs. Daniel Stone, Harrison Dulin, and Keith R. Jerome

Check out the latest episode of the #MolecularTherapy podcast on #lipidnanoparticles featuring Drs. Stone, Dulin, and Jerome from Fred Hutchinson Cancer Center. Listen now: http://dlvr.it/TN0b93

The Untold Story of Dr. Chris Shoemaker A Clinician’s Argument on COVID Studies and Outcomes In this in-depth interview, Dr. Chris Shoemaker explains why, based on studies and clinical literature he has reviewed, he came to believe that som

Lear more about #Lipidnanoparticles - flaws and dangers.

#mRNA #healthliteracy #informedconsent #covidvaccines #cancer

rumble.com/v6ybby0-the-...

Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape - Nature Nanotechnology Preventing endosomal damage sensing or using lipids that create reparable endosomal holes reduces inflammation caused by RNA-lipid nanoparticles while enabling high RNA expression.

Translating therapeutic modalities of #LipidNanoparticles to disease indications with pre-existing inflammation www.nature.com/articles/s41... @jakebrenner #LNPs #Nanomedicine #DrugDevelopment #TranslationalScience

Your cell culture might be hiding a secret: This paper reveals how heat-inactivated serum unexpectedly impacts nanoparticle #ProteinCoronas, crucially affecting lipid #nanoparticles #DrugDelivery and potentially skewing in vitro results.
👉 https://tinyurl.com/ek9aucsn
#LipidNanoparticles #BJNANO 💎🔓

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Cardiotropic #DrugDelivery system: Proof-of-concept for #LipidNanoparticles targeting cardiomyocyte-specific SERCA2A to modulate contractility & relaxation www.pnas.org/doi/10.1073/... #siRNA #Myocardium #TranslationalScience

🔬 LNP Webinar Wed, Aug 13th!
"Using single cell RNA sequencing to identify novel LNP candidates"

Explore a powerful approach to overcoming key challenges in lipid nanoparticle delivery.

Save your spot 👉 events.teams.microsoft.com/event/2fa8a4...

#LipidNanoparticles #RNAtherapeutics #DrugDelivery

🚀 Introducing EVP2 Axis & LNP Axis – ONI’s powerful new open-source tools for streamlined nanoparticle data analysis!

Built for scientists, free to use, and easy to get started.

Dive in now:

🔗 EVP2 Axis: hubs.li/Q03rMNdp0
🔗 LNP Axis: hubs.li/Q03rMJ2b0

#ExtracellularVesicles #LipidNanoparticles

2/9 The COVID vaccine "miracle" wasn't sudden—it built on six decades of Canadian foundational work. UBC's Pieter Cullis invented the "fat bubbles" (lipid nanoparticles) that made mRNA vaccines possible, helping save nearly 10 million lives.
#mRNAHistory #LipidNanoparticles #CanadianScience

Super-resolution imaging reveals new realms in nanoparticle research Nanoparticles are key enablers in modern drug development and show promise in diagnostics. Single-molecule localization microscopy allows researchers to analyse them in a whole new way.

Thrilled to see the article from Nature Custom Media on using #SMLM to study #ExtraCellularVesicles and #LipidNanoparticles!
Whether it's ligand and cargo loading for LNP-#PersonalizedMedicine or EV-based #LiquidBiopsies, #SuperResolution has the answer.
www.nature.com/articles/d42...

Missed our webinar? Watch it here pages.oni.bio/webinar-lnp-....

#LNP #LipidNanoparticles #DrugDiscovery #DrugDevelopment #ResearchAndDevelopment #LifeScience #Nanoimager #LNPProfiler #AutoLNP #SuperResolution #Microscopy #Microscope #SMLM #Innovation #Biotech #Biotechnology #ProductLaunch

New Tools, New Lipids: Joshua Chamberlain Explores Bacterial Sphingolipids for Smarter Drug Delivery At the 2025 Theobald Smith Society Spring Symposium, Joshua Chamberlain, a researcher in the Klein Lab at Rutgers University–Camden, presented a compelling exploration of lipid nanoparticles and the u...

Can bacteria help design better drug delivery systems? Joshua Chamberlain shows how a novel lipid from Caulobacter may unlock new potential for lipid nanoparticles in vaccines and therapies. Learn more here: wix.to/80ZubKQ #Microbiology #DrugDelivery #LipidNanoparticles #Sphingolipids #Rutgers

🔬Did you know that we offer workshops at #ELMI2025? Don't miss our experts ( #ELMI ):
Check out @embl.org website for more details on how to register t.co/3uaJg2gDv4
#SMLM #Microscopy #dSTORM #Nanoimager #DiscoveryKit #TrainingKit #ExtraCellularVesicles #LipidNanoparticles #EMBL #EMBLEvents

THANK YOU FOR making the American Association for Cancer Research® (AACR) Annual Meeting 2025 #AACR25 great!

We’re excited to be part of your research journey!

echelon-inc.com/lipid-nanopa...

#CancerResearch #LipidNanoparticles #Chicago

*Not affiliated with or endorsed by AACR

Can we bring back extinct species using LNPs? 🧬🐘
Full episode on Youtube and Spotify!
#DeExtinction #SyntheticBiology #GeneticEngineering #WoollyMammoth #ColossalBiosciences #SciComm #LipidNanoparticles #ScienceReel #FutureOfMedicine #SciencePodcast #CRISPR #GeneEditing #Biotech #MedicalInnovation

Lipid Nanoparticles for In Vivo Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical Targets In the past 10 years, CRISPR-Cas9 has revolutionized the gene-editing field due to its modularity, simplicity, and efficacy. It has been applied for the creation of in vivo models, to further understa...

Targeting #Lung #EndothelialCells & #EpithelialCells through #LNPtechnology without off-target editing in the liver offers #DrugDevelopment pubs.acs.org/doi/10.1021/... @MJMitchell_Lab #LipidNanoparticles #Nanomedicine #TranslationalScience

Using targeting ligands for specific LNP delivery Loading lipid nanoparticles (LNPs) with ligands can induce tissue specificity. Different categories of ligand are available and studying them is important.

A key consideration for the effective delivery of #LipidNanoParticles ( #LNP ) is the introduction of targeting ligands, like #lipids or #proteins that direct the LNPs to specific tissues.
Read our blog on LNP targeting ligands and the importance of their accurate characterization: hubs.li/Q03k0Qr30

LNPs imaged with the Nanoimager, with and without RNA cargo and ligand.

Did you know that #LNPProfiler uses self-blinking dyes for #dSTORM #imaging of #LipidNanoParticles? No need for imaging buffer, our #PanLNP and ligand reagent are self-blinking and ready for #SuperResolution with a single staining step!

Read more hubs.li/Q03jfNfb0 Join our webinar hubs.li/Q03jfQmV0

Towards gene-targeting drugs capable of targeting brain diseases Getting therapeutic drugs past the blood-brain barrier has long been a major challenge in treating brain diseases. Now, researchers have explored how cholesterol-modified heteroduplex oligonucleotides...

Getting therapeutic drugs past the blood-brain barrier has long been a major challenge in treating brain diseases. Now, researchers have explored how new lipid nanoparticles deliver mRNA to the brain through the blood-brain barrier. #neuroskyence #bloodbrainbarrier #lipidnanoparticles #mRNA

Application Kit: LNP Profiler next to a computer screen showing AutoLNP and next to the Aplo Scope.

Unlock the future of #LipidNanoParticles ( #LNP) #research with #LNPProfiler and #AutoLNP! Each kit includes Assay Chips, SMLM-compatible dyes for #PanLNP and ligands, and a sequence-independent #RNA dye. Find us at the LNP Formulation and Process Development Summit to!
#SMLM #SuperResolution