🥂Happy to have collaborated on this important #research: The #immunomolecular features & #therapeutic implications of #brain #metastases in #kindey #cancer #patients!

🙏 Congrats Benoit Beuselinck & team.
👉See here: www.nature.com/articles/s41...
@uzleuven.bsky.social @kuleuvenuniversity.bsky.social

MRI features in atypical idiopathic intracranial hypertension - European Radiology Objectives Idiopathic intracranial hypertension (IIH) primarily affects obese women of reproductive age. However, IIH can also occur in individuals outside this typical demographic, where it is…

#MRI #BoneMarrowImaging #Oncology #Metastases #MultipleMyeloma #PracticeRecommendations #EuropeanRadiology

buff.ly/fGSwpa9 (Theresia Knoche et al.)

🤖🫁 Robot-Assisted CT-Guided Cryoablation for Pulmonary Metastases

Robot-assisted CT-guided cryoablation is an evolving approach for treating #pulmonary #metastases, where precise probe placement is critical—especially for complex, multi-probe configurations.

A pan-cancer single-cell transcriptomic atlas of human bone metastases This study constructs a pan-cancer single-cell atlas of human bone metastases, revealing niche-specific stromal and immune programs that drive tumor proliferation and immunotherapy resistance. Combine...

Important insights into the tumor #microenvironment of spinal bone #metastases.

A pan-cancer single-cell transcriptomic atlas of human bone metastases: Cell Reports Medicine

www.cell.com/cell-reports...

The study, published in Science Advances, shows that eliminating these cells at an early stage of tumor growth promotes tumor proliferation and the formation of #metastases
 
By contrast, combining their elimination with an inhibitor of the CCL2 molecule reduces tumor size and eliminates metastases

Stereotactic radiosurgery practice patterns for brain metastases: A survey by the SRS_SBRT_SEOR (Spanish Society of Radiation Oncology) Working Group | Ciérvide | Reports of Practical Oncology and Rad... Reports of Practical Oncology and Radiotherapy

Stereotactic radiosurgery practice patterns for #brain #metastases journals.viamedica.pl/rpor/article... #hvhebron #oncorad [Text complet]

Cancer vaccine stops tumors in mice: "Remarkable survival rates" In the animal-based studies, a nanoparticle-based vaccine shrunk, cleared and prevented cancer growth, including melanoma.

Cancer Vaccine Stops Tumors in Mice: ‘Remarkable Survival Rates’

"Compared to all mice, the nanoparticle-vaccinated mice were also protected against the spread of cancer to the lungs."

#nanotechnology #cancer #metastases #vaccine
www.newsweek.com/cancer-vacci...

Brachytherapy for Brain Metastases As long-term cancer survival outcomes improve, the brain has increasingly become a site of refractory and recurrent disease.

MSK experts are investigating whether #brachytherapy may be an effective treatment option for reducing local recurrence, lowering the risk of #necrosis associated with standard #radiation, and improving the quality of life for patients with brain #metastases. Learn more ⬇️

This study delves into the complex progression of #Neuroblastoma, from primary lesions to #BoneMarrow #Metastases (BMM), & develops a predictive model for BBM status, laying a foundation for early diagnosis & personalized therapies. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Happening tomorrow at #ESMO25: Helena Yu will share preliminary results from the ongoing phase 2b trial of zipalertinib in patients with non-small cell #lungcancer who have central nervous system #metastases. @mskcancercenter.bsky.social @myesmo.bsky.social

Learn more: bit.ly/3W74yY3

#PinkOctober2025: #Leptomeningeal #metastases #LM remain one of the most severe complications in breast cancer, associated with a markedly poorer #prognosis than brain metastases without LM.

This large #registry analysis highlights an urgent unmet clinical need: pmc.ncbi.nlm.nih.gov/articles/PMC...

#PinkOctober 2025 | Spotlight on BMBC Study – Understanding Brain #Metastases in Breast Cancer #BMBC
📰 What’s next: We’re excited to announce that new analyses from the BMBC registry will be presented at #ESMO25 and #SABCS25. Stay tuned for more details in the coming days!
www.gbg.de/en/trials/bmbc

Dr. Alicia L. Bruzos (center), recipient of a Minerva Fast Track Fellowship, with MPG Vice President Dr. Asifa Akhtar (left) and Tobias Erb from the MPI for Terrestrial Microbiology (right) at the award ceremony. (© David Ausserhofer / Max Planck Society)

Hooray, we are growing! 🎉👩‍🔬

We are happy & grateful to welcome #MinervaFastTrack Fellow Alicia L. Bruzos to study how #cancer spreads & forms #metastases in #marine #bivalves.🦪

mpi-bremen.de/en/Page6547....

@bruzos.bsky.social @maxplanck.de
#MaxPlanck #PostDoc #WomeninSTEM #marinescience #Bremen

How do #metastases survive (and thrive!) in the #brain microenvironment?

In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases:
Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠

Dual-mode PET tracer lets surgeons see – and hear – prostate cancer A preclinical evaluation of a new ’dual-mode’ tracer agent shows promise in not only helping surgeons image and plan prostate cancer procedures, but also provide them with much more consistent and tar...

Tracer molecules serve to provide 👁️ visual guidance in #nuclearmedicine, but a new molecule could give surgeons additional 👂 audio cues to help them locate #prostatecancer tumors and #metastases, report researchers from 🇨🇦 @chem.ubc.ca.

Circulating tumour cells & ctDNA in patients with resectable colorectal liver #metastases: a prospective observational biomarker study

Postoperative ctDNA and CTC detection are strong, independent predictors for a shorter RFS after local treatment

www.thelancet.com/journals/ecl...
#OncoSky #MedSky

Pressed to the limit: New study explores cancer cell defense mechanism Cancer cells mount an instant, energy‑rich response to being physically squeezed, according to a new study. The surge of energy is the first reported instance of a defensive mechanism which helps the ...

How #cancer cells survive the journey through the body to form #metastases is still poorly understood. New insights from 🇪🇸 @crg.eu,‪ 🇪🇸 @upf.edu, and‪ 🇦🇹 @uniinnsbruck.social.uibk.ac.at.ap.brid.gy, on how cells survive intense physical stress could pave the way for new treatments.

Ammar Omar did an incredible job this summer, working with our own Dr Tatiana Moto to study the establishment of #metastases in #TNBC (breast cancer). Great job Ammar!

"New at JCAT-radiology
'3D Segmentation of Whole Lung and Metastatic Lung Nodules Using Adaptive Region Growing and Shape-based Morphology'
Mul/Aug 25 dlvr.it/TM6NHM Au: Esha Baidya Kayal et al.
#radiology #CAD #lung #metastases

Encorafenib/Binimetinib/Nivolumab Improves PFS in BRAF V600+ Melanoma with Symptomatic Brain Metastases Encorafenib plus binimetinib and nivolumab improved PFS in BRAF V600–mutant melanoma with symptomatic brain metastases.

Encorafenib/Binimetinib/Nivolumab Improves PFS in BRAF V600+ Melanoma with Symptomatic Brain #Metastases

www.onclive.com/view/encoraf...

Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...

🧠 An article discussing the molecular interactions between metastases and immune cells within the leptomeninges is now available in @nature.com.
🔗 www.nature.com/articles/s41...
#EANOessentials #glioblastoma #NeuroOncology #leptomeningeal #metastases

Liquid biopsies for the monitoring of gliomas and brain metastases in adults Liquid biopsies have emerged as a promising candidate for minimally invasive, accurate, and affordable monitoring of disease progression and treatment response in gliomas and brain metastases.

Liquid biopsies have emerged as a promising candidate for minimally invasive, accurate, & affordable monitoring of disease progression & treatment response in #gliomas & brain #metastases.

Find out more in this #EdsChoice review👉 buff.ly/F0KwOcf

#NeuroSky #OncSky #Glioma

Type IV collagen, carcinoembryonic antigen, osteopontin, and hepatocyte growth factor as biomarkers for liver metastatic colorectal cancer - Apr 27, 2025
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#metastases #cancerdiagnostics #oncsky #oncology #openaccess

Routine Surveillance for Cancer Metastases — Does It Help or Harm Patients? | NEJM Research generally suggests that routine surveillance after cancer treatment finds more recurrences — leading to more surgery, chemotherapy, and radiation — without affecting the risk of death.

Routine surveillance for #cancer #metastases — Challenging dogma as results of 12 trials show no survival benefit, despite scans leading to more chemo, radio and surgery #Deescalation www.nejm.org/doi/full/10....

As part of a public event series organised by #TreffpunktScienceCity @ethzurich.bsky.social, Andreas Moor, head of the Systems Physiology Lab, gave a lecture on #liver #metastases (in German) >
youtu.be/Xg22u_l100E?...
Learn about his group's research > bsse.ethz.ch/lsp
#cancer

The local microenvironment suppresses the synergy between irradiation and anti-PD1 therapy in breast-to-brain metastasis Wischnewski et al. demonstrate suppressed CD8+ T cell cytotoxicity in breast cancer brain metastases, contrasting with genetically identical extracranial tumors. Neutrophils and Trem2+ macrophages dri...

🔔🧪 Why do #brain #metastases resist #immunotherapy —even when the same cancer responds outside the brain? 🧠💥

👇Interesting paper from the J. Joyce group in Lausanne

#BreastCancer

www.cell.com/cell-reports...

The local microenvironment suppresses the synergy between irradiation and anti-PD1 therapy in breast-to-brain metastasis Wischnewski et al. demonstrate suppressed CD8+ T cell cytotoxicity in breast cancer brain metastases, contrasting with genetically identical extracranial tumors. Neutrophils and Trem2+ macrophages dri...

🧬 Why do #breast-to-brain #metastases resist treatment?
This study in @cp-cellreports.bsky.social shows how the brain's tumor environment suppresses immune responses and impairs therapy.

🔗 Original paper: www.cell.com/cell-reports...

RBM10 loss promotes #metastases by aberrant splicing of cytoskeletal and extracellular matrix mRNAs, say Gnana Krishnamoorthy, James Fagin and colleagues @mskcancercenter.bsky.social: buff.ly/41bIjCm

Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases - Nature Medicine Multi-omic single-cell and spatial analyses of lung cancer brain metastases from multiple cohorts identify high levels of chromosomal instability and a neural-like profile in brain metastases compared...

🧵(3/3) and last but not least, a large omics study of #LungCancer brain #metastases shows high levels of chromosomal instability and a neural-like profile in brain metastases vs primary tumors. #NatureMedicine #NeuroSky #OncSky #MedSky @natureportfolio.nature.com www.nature.com/articles/s41...

Cerebrospinal fluid circulating tumor DNA profiling for risk stratification and matched treatment of central nervous system metastases - Nature Medicine Cerebrospinal fluid circulating tumor DNA profiling had prognostic value in a cohort of 584 patients with lung cancer and central nervous system metastases, and could be used to inform personalized th...

🧵(2/3) #NatureMedicine ctDNA profiling of CSF is prognostic in patients with #LungCancer and CNS #metastases -- potentially useful for personalizing treatment. #NeuroSky #OncSky #MedSky www.nature.com/articles/s41...