New research in #GENETICS identifies an important role of the Ess1 prolyl isomerase in regulating #telomere transcription and replication in #yeast. buff.ly/MIkyJsr
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Hashtag
#TELOMERE
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🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5′-cap trimethylation
By Samajdar et al. and Luis Batista
➡️ https://ow.ly/Ko1u50YyStI
Huntsman Cancer Institute
#transcription #telomerase #telomere
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Virtual flyer for a scientific Talk by Dr. Ylli Doksani entitled: Stranger Things at Telomeres Provide Insights into Genome Instability. Part of the DNA dynamics webinar series Social DNAing.
Join us at Social DNAing later today to hear more about telomere biology and genome instability : http://cancer.columbia.edu/dna-webinar
#Telomere #GenomeInstability #Cancer @academicchatter
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TelomereHunter2 Workshop in Heidelberg! 🔬✨
Ready to analyze telomere maintenance mechanisms in cancer, immunology, or aging?
📅 Date: April 14, 2026
🏫 Location: Im Neuenheimer Feld 242, HD
🛠️ Tool: TelomereHunter2
Register here: www.denbi.de/training-cou...
#Bioinformatics #AgingResearch #Telomere
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𝗦𝗰𝗶𝗲𝗻𝘁𝗶𝘀𝘁𝘀 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝘁𝗵𝗮𝘁 𝗿𝗲𝗷𝘂𝘃𝗲𝗻𝗮𝘁𝗲𝘀 𝗮𝗴𝗶𝗻𝗴 𝗯𝗿𝗮𝗶𝗻 𝗰𝗲𝗹𝗹𝘀 [via Science.org] 🧪🥼🧓🧠🩺🧒
"DMTF1 is down-regulated in telomere dysfunctional NSCs and that its up-regulation rescues the defect"
www.science.org/doi/10.1126/...
#telomere #erosion #synaptic #plasticity #aging #brain #health #DMTF1
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fxtwitter.com/nutrition_fa...
"People eating more anti-inflammatory diets tend to have longer telomeres, and the greater the anti-inflammatory potential of the diet over time, the greater the potential to significantly slow down the rate of telomere shortening."
#telomere #anti-inflammation #fiber
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This review highlights the links between #obesity and #aging, noting shared hallmarks like #inflammation, #telomere loss, and #MitochondrialDysfunction, and emphasizes the potential of #AntiObesity therapies to combat age‑related diseases.
#OpenAccess: doi.org/10.1016/j.ge...
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🔑 Findings
-Strong correlations between epigenetic clocks and chronological age (r > 0.8, p < 0.0001) in both healthy & COVID individuals
- Increased acceleration of epigenetic aging & #telomere attrition in patients progressing from healthy to non & severe COVID
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Bei einer #Lungenfibrose vernarbt das zwischen dem Funktionsgewebe der 🫁 Lunge liegende Bindegewebe und führt zu wachsender Atemnot. Ein neuer Behandlungsansatz nimmt die #Telomere der 🧬 DNA in den Fokus. #IPF
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🌟G&D SPOTLIGHT 🌟
REVIEW: CST–Polα/Primase: the second telomere maintenance machine
By Sarah Cai and Titia de Lange
➡️ genesdev.cshlp.org/content/37/13-14/555.abs...
#telomere #telomerase #strandsynthesis #polymerase⍺ #primase
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Throughout #Telomere Biology Disorder #Awareness Month, we are dedicating Fridays to spreading education and awareness. Each “Fact Friday,” we’ll highlight important science and how ongoing #research connects to care and advocacy. Today we are talking about what #telomeres are - check out our video!
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Oxidative-stress-induced #telomere instability drives T cell dysfunction in #cancer
www.sciencedirect.com/science/arti...
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Study Reveals How Telomere Length Is Inherited in Early Embryos
Study finds telomere length in early embryos shows distinct maternal or paternal dominance, uncovered via high‑resolution microscopy and single‑cell genomic analysis. Read more: getnews.me/study-reveals-how-telome... #telomere #embryology #genomics
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Hiroki Shibuya reviews meiotic #chromosome movements, highlighting #telomere and nuclear membrane modifications crucial for accurate sexual reproduction. rupress.org/jcb/article/...
📕 In our Intermediate Filaments collection: rupress.org/jcb/collecti...
#Euro-IF
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The response is evident in tissues with a lot of turnover:
'Here, we show that #telomere shortening triggers the cGAS-STING pathway in skin, testis, kidney marrow (the adult hematopoietic organ in fish), and intestine of zebrafish'
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Telomere: Deine Lebens-Zeitbombe! 🧬 #Telomere #Zellaltern #Lebensdauer 🎥 https://faktaliya.com/de.mp4
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Bí mật tuổi thọ trong ADN hé lộ 🧬 #Telomere #Lãotháiđộ #Chếđộsống 🎥 https://faktaliya.com/vi.mp4
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Proud to contribute to this (Yes!) #Telomere study by Farida Djouad team. Morpholinos against zebrafish #TRF2 induce macrophage #senescence and block fin regeneration. #Parabiosis, #MacrophageTracking & #Transcriptomics show #p16-high, and low pro-inflammation.
Go Fish! 🐟🐟🐟
www.thno.org/v15p7308.htm
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Psilocin treatment extends cellular lifespan. Human lung fibroblasts were treated continuously with vehicle (DMSO 0.02%) or 10 µM psilocin until they reached replicative senescence. Credit: npj Aging (2025). DOI: 10.1038/s41514-025-00244-x
Can #psychedelic #mushrooms turn back the clock? Study suggests #psilocybin preserves #telomere length
medicalxpress.com/news/2025-07...
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Experimental induction of telomeric ncRNA expression & TERRA R-loops in telomerase-expressing cells is sufficient to induce #telomere repair typical for ALT cancer cells, even in the absence of ALT-associated chromatin changes
Suna In, Joachim Lingner and coworkers
www.embopress.org/doi/full/10....
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Excited to see our NHLBI work on infections and immunodeficiency in patients with #telomere biology disorders now published @bloodjournal.bsky.social >1/3 had significant infection history & nearly 1/2 t-lymphopenia. Fernando Catto & Fernanda Gutierrez-Rodrigues. ashpublications.org/blood/articl...
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…women with a chronically ill child had shorter telomeres than those who did not — and that #telomere length correlated with the number of years spent as a carer. These findings suggested that exposure to chronic stress can introduce molecular changes that are important for ageing…
#aging
#medsky
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Here you can see a crystal structure of the hnRNPA1 and telomere-related TERRA RNA complex (PDB code: 8X0N)
Rendering by Francisco J. Enguita made with #ProteinImager
3dproteinimaging.com/protein-imag...
#SciArt #molecularart #telomere #terra #ncRNA #aging #hnRNPA1 #xray
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Individuos con una longitud telomérica leucocitaria corta tienen un riesgo elevado de ictus, demencia y depresión del adulto mayor, y mejorar los factores de riesgo modificables parece mitigar el impacto de esta longitud #telomere #brain www.neurology.org/doi/10.1212/...
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Impacto de desventajas económicas es biológicamente observable en niños a través de longitud de telómeros y producción de cortisol, explica desigualdades de salud en desarrollo infantil y aparición de enfermedad relacionada con la edad #affluence #cortisol #telomere www.thelancet.com/journals/ebi...
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Next up is Victoria Rodriguez Lelis, who has been working with @mgschiavon.bsky.social, and is investigating mathematical models of #telomere homeostasis 🧬💻 #LCGUNAM @liigh-unam.bsky.social
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What is the link between biological #aging and #frailty? In a lung transplant cohort, we found anemia and #telomere dysfunction were more linked to frailty than epigenetic age. www.sciencedirect.com/science/arti...
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#immunosky #pedsky #Publichealth the correlation is revealed from the available data that connect telomere length & #COVID
infection in the fact that the elderly patients & males are more susceptible to
#COVID due to shortening in their #telomere length
www.researchgate.net/profile/Aml-...
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El COVID19 sigue muy presente. Artículo sobre los efectos de la infección en la longitud de los telómeros en los espermatozoides:
link.springer.com/article/10.1...
#bianorbiotech #telomere #spermatozoa #COVID19
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