Sharma Group: Mechanistic T Cell Genomics Our research team is focused on uncovering the mechanisms that govern T cell signaling, with the goal of precisely engineering immune cells for immunotherapies.

Find out more about the Sharma Group: www.imm.ox.ac.uk/research/res...
#WIMMSpotlight #WIMMCommunity #SystemsBiology #ComputationalBiology #Immunology #TCells #TranslationalResearch

comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders Shen et al. report comBO, a combined human bone and bone marrow model that integrates osteolineage, vascular, stromal, and hematopoietic compartments in a single hiPSC-derived organoid system. comBO s...

Recent publications:
www.cell.com/cell-stem-ce...
www.nature.com/articles/s41...

#WIMMSpotlight #WIMMCommunity #CancerResearch #BloodCancer #Haematology #StemCellResearch #GeneRegulation #Genomics #DiseaseMechanisms #PrecisionMedicine #iPSC #EarlyCareerResearch #WomenInScience #OxCODE

#ScientistSpotlight 🧪

This week we’re featuring Karmella Naidoo, a postdoctoral researcher in the Graham Ogg Group at #MRCWIMM

#WIMMSpotlight #WIMMCommunity #CD1a #cutaneousimmunity #innateimmunology #itch #barriersensing #MRCWIMM #AcademicSky @rdm.ox.ac.uk @medsci.ox.ac.uk

#WIMMSpotlight #WIMMCommunity #IBDResearch #VascularBiology #Inflammation #EndothelialBiology #TranslationalResearch

#ScientistSpotlight 🧪

This week we’re featuring Toby Whitehead, a DPhil student in the Sharma and Davis Labs at the #MRCWIMM.

@rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk

#WIMMSpotlight #WIMMCommunity #Immunology #CancerResearch #Immunotherapy #TCells #CheckpointBiology #AcademicSky

Spatiotemporal analysis of human intestinal development at single-cell resolution Development of the human intestine is not well understood. Here, we link single-cell RNA sequencing and spatial transcriptomics to characterize intest…

📄 Key paper on single cell RNA sequencing and spatial transcriptomics in fetal intestine:
www.sciencedirect.com/science/arti...

#WIMMSpotlight #WIMMCommunity #PaediatricResearch #IntestinalImmunology #SpatialTranscriptomics #SingleCellGenomics #RareDiseaseResearch #MRCWIMM

Katie Croft MPhys (Hons) Katie Croft - DPhil Student

🔗 Learn more about Katie’s work:
www.imm.ox.ac.uk/people/katie...

#WIMMSpotlight #WIMMCommunity #StemCellResearch #Haematopoiesis #AgeingResearch #ComputationalBiology #MRCWIMM

Laura Ciacchi Laura Ciacchi - Postdoctoral Scientist

🔗 Find out more:
RDM profile: www.rdm.ox.ac.uk/people/laura...

#WIMMSpotlight #WIMMCommunity #Immunology #SkinImmunity #TCells #LipidBiology #UVResearch #MRCWIMM

LynchVax A Cancer Prevention Vaccine Programme.

🔗 Learn more about the LynchVax programme:
www.cancer.ox.ac.uk/research/lyn...

#WIMMSpotlight #WIMMCommunity #CancerResearch #Immunotherapy #ClinicalResearch #LynchSyndrome #PreventativeVaccines #MRCWIMM 🧬

Rehwinkel Group: Nucleic Acid Sensing

🔗 Rehwinkel Group lab page:
www.rdm.ox.ac.uk/about/our-di...

#WIMMSpotlight #WIMMCommunity #Immunology #InnateImmunity #AntiviralResearch #Interferon #PhDStudent #MRCWIMM

Through her work, Alison helps ensure that scientific advances are understood not just in the lab, but in the real-world contexts where they matter most.

#WIMMSpotlight #WIMMCommunity #HealthExperienceResearch #GeneticCounselling #PublicEngagement #ScienceAndSociety #MRCWIMM

Through her work, Alison helps ensure that scientific advances are understood not just in the lab, but in the real-world contexts where they matter most.

#WIMMSpotlight #WIMMCommunity #HealthExperienceResearch #GeneticCounselling #PublicEngagement #ScienceAndSociety #MRCWIMM

Through this work, his research sheds light on the mechanisms underlying mutation accumulation with age and its implications for human health and inheritance.

#WIMMSpotlight #WIMMCommunity #Genetics #ReproductiveBiology #Ageing #NextGenerationSequencing #postdoc

Frontiers | Quantifying conformational changes in the TCR:pMHC-I binding interface BackgroundT cells form one of the key pillars of adaptive immunity. Using their surface bound T cell antigen receptors (TCRs), these cells screen millions of...

www.frontiersin.org/journals/imm...

#WIMMSpotlight #WIMMCommunity #Immunology #TCells #MachineLearning #DeepLearning #VaccineResearch #MRCWIMM

We’re incredibly proud of our Sustainability Team for being recognised at the LEAF Oxford Forum yesterday.

#WIMMHighlights #WIMMCommunity #LEAFOxForum
@ox.ac.uk @medsci.ox.ac.uk

#ScientistSpotlight
This week we’re introducing Anna Li, a postdoctoral researcher in the Yin Dong Lab at the #MRCWIMM.

@ndcnoxford.bsky.social @medsci.ox.ac.uk

#WIMMSpotlight #WIMMCommunity #StructuralBiology #CryoEM #IonChannels #Neuroscience

Photo credit: Susan Maxwell

de Bruijn Group: Developmental Haematopoiesis We study the embryonic origins of blood stem cells with the aim to inform the generation of these cells in culture, and ultimate produce clinically relevant blood stem cells for therapeutic purposes.

More about the De Bruijn Group → www.imm.ox.ac.uk/research/res...

#WIMMSpotlight #WIMMCommunity #DevelopmentalBiology #Haematopoiesis #Immunity #EmbryonicDevelopment #MRCWIMM

Assessing Metabolic Ageing via DNA Methylation Surrogate Markers: A Multicohort Study in Britain, Ireland and the USA Metabolomics and epigenomics have been used to develop ‘ageing clocks’ that assess biological age and identify ‘accelerated ageing’. While metabolites are subject to short‐term variation, DNA methylation (DNAm) may capture longer‐term metabolic ...

🔗 Read the full paper 👇

#WIMMcommunity #MachineLearning #AIinBiology #DeepLearning #SpatialTranscriptomics #OxfordScience

Watch the Tackling Iron Deficiency video on YouTube: youtu.be/frJ9iCjOYiM?...

#WIMMCommunity #Immunology #IronMetabolism #BCells #AntibodyResponse

#ScientistSpotlight
This week, we’re featuring Sumana Sharma, one of our newest Group Leaders here at the MRC Weatherall Institute of Molecular Medicine (MRC WIMM).

@rdm.ox.ac.uk @medsci.ox.ac.uk
#WIMMCommunity #Immunology #TCells #SystemsBiology #CRISPR #MRCWIMM