❤️ Aorta tell you… how much I love you.
Not just the heart—love your arteries & veins too.
Silent risks: aortic aneurysm, stroke, PAD, varicose veins.
Andrew Choong Vascular Surgery, Singapore.
#VascularHealth #AorticAneurysm #VaricoseVeins #SingaporeDoctor #VascularSurgeon

How Smooth Muscle Cells Change Identity in Aortic Aneurysm This story is taken from the paper by Honglin Dong et al. For full details, see below. The aorta is the body’s largest blood vessel, and its strength depends heavily on a special type of cell called v...

New post: How Smooth Muscle Cells Change Identity in Aortic Aneurysm. This piece summarizes recent findings on VSMC phenotypic switching and its role in aortic wall weakening. Read the full article: wix.to/DxHUmQf #vascularmedicine #cardiology #research #aorticaneurysm

Enlarged Human Heart: Effects of Chronic Disease, Atherosclerosis & Aortic Aneurysm
#Cardiology #HumanHeart #Cardiomegaly #Atherosclerosis #AorticAneurysm #HeartDisease #MedicalEducation #Pathology #Anatomy #Healthcare #CardiovascularSystem

JHC's latest article: "CMKLR-1 Expression in Human Aorta Is Dominated by Smooth Muscle Cell Positivity."

Click to read: bit.ly/3Iuw8dX

#aorticaneurysm #hypertension #inflammation

Tie2+ #EndothelialCell- or Col1A2+ fibroblast-derived C-type Natriuretic Peptide protects against #AorticAneurysm in Apoe-/- mice + AngII + AAV-PCSK9 + #WesternDiet

#SmoothMuscleCell & Mφ are responsive to exogenous CNP

#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...

Inhibiting LDHA to prevent Ascending #AorticAneurysm #AorticRupture
🐭BAPN -/+ Oxamate or FX11

Protein/histone lactylation mainly in Mo/Mφ &👤 #ThroacicAorticDissection

Mo/Mφ with high lactylation gene score➡️Angptl4 signals to EC/SMC/fibroblast

#CellSignal 2025
www.sciencedirect.com/science/arti...

JHC's latest article: "CMKLR-1 Expression in Human Aorta Is Dominated by Smooth Muscle Cell Positivity."

Click to read: bit.ly/3Iuw8dX

#aorticaneurysm #hypertension #inflammation

Partial aortic endothelial detachment from disorganized internal elastic lamina, + #EndothelialCell α5⏫ β1⏬ integrin, in a🐭#MarfanSyndrome model mgΔlpn/+ 6-mo♂️ (Already #AorticAneurysm...)

#AortaEd
#SciReports 2025
www.nature.com/articles/s41...

#SmoothMuscleCell-derived #Semaphorin3A protect against🐭thoracic #AorticDissection #AorticAneurysm (BAPN)

Evidence from🐭SM22a-Cre overexpression or KO of Sema3a

SEMA3A ⬇️in🐭👤dissected aortas

Direct impacts on SMC or adventitial #VasaVasorum?

#Angiogenesis 2025
link.springer.com/article/10.1...

JHC's latest article: "CMKLR-1 Expression in Human Aorta Is Dominated by Smooth Muscle Cell Positivity."

Click to read: bit.ly/3Iuw8dX

#aorticaneurysm #hypertension #inflammation

Sex-specific Mortality after Surgery for Acute Type A #AorticDissection
#AortaEd

327♀️+ 551♂️

30-d/In-hosp mortality ♀️20.5% vs ♂️18.5%

Long-term (6.2 y f/up) mortality ♀️4.1% vs ♂️2.6% per patient-year over 10 y
♀️Age COPD CKD #AorticAneurysm
♂️Age MI

#JTCVSOpen 2025
www.jtcvsopen.org/article/S266...

JAK2 #AorticAneurysm

#SmoothMuscleCell CCDC80 KO🐭
⏫Contractile-to-synthetic (prolif, inflam & MMP-hi) phenotypes by Angiotensin II
⏫ #AorticAneurysm Dissection

rescued by JAK2i WP1066

👤 #AorticDissection
⏬CCDC80 ⏫JAK2-STAT3 ⏫MMP2/9

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...

#AorticAneurysm & dissection are major concerns in #vasculitis. This study shows that unlike GCA, PMR isn’t tied to a significantly elevated risk, supporting a more selective screening approach.

More here from Mahmut Kaymakci & colleagues: linkinghub.elsevier.com/retrieve/pii...

AMP published!
"Acute Aortic Dissection in the Third Trimester of Pregnancy as an Initial Presentation of Marfan Syndrome"

Full paper here
www.actamedicaportuguesa.com/revista/inde...

#aorticaneurysm #aorticdissection #marfansyndrome #pregnancycomplications #thirdtrimester #actamedicaportuguesa

💡 Finding a Community When You Have a Health Issue (Issue 122) Seek people who will understand and support you. It helps to know you're not alone. It helps to talk with survivors who tell you everything will be okay.

Coming in my life newsletter tomorrow:

It helps to know you're not alone.

It helps to talk with survivors who tell you everything will be okay…

#HealthIssues #AorticAneurysm #support

Aorta Tractography #DiffusionTensorImaging

2 #AorticAneurysm
1 #AorticDissection
1 Control

In chronic type B AD
Dissected aortic media➡️lower Fractional Anisotropy (▶️structural alignment) than thrombus, false lumen septum & intact media🥸

#AortaEd
#JAnat 2025
onlinelibrary.wiley.com/doi/full/10....

SM22α+ #SmoothMuscleCell ATF3 KO🐭➡️ #AorticAneurysm #AorticRupture by AngII or #Aging

ATF3 physically sequestrates MDM2 (E3 ligase for p21)

ATF3 deficiency➡️
⏬p21 protein stability
⏫ds DNA breaks
⏫Micronuclei
⏫cGAS-STING
in SMCs

#AortaEd
Clin Transl Med 2024
onlinelibrary.wiley.com/doi/10.1002/...

1/6 🚨 12.5% 30-day mortality rate in emergency EVAR using the downsizing post-closure technique for access hemostasis in RAAA patients!

Explore the newly published findings from CVIR on this novel approach 👇 🏥🩸

#EVAR #AorticAneurysm #VascularSurgery

#SpatialTranscriptomics #Visium @10xGenomics #AbdominalAorticAneurysm

THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO

Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts

bioRxiv 2024
www.biorxiv.org/content/10.1...

Dose Primer 55 · Introduction To Mayhem · Song · 2000

Getting back into #powerlifting and loving it again

Lived in fear for about a month after my heart diagnosis

F*ck that. I'm gonna lift smart, stay fit, and let the chips fall where they may

If I die, I die

#fitness #AorticAneurysm

open.spotify.com/track/2yNUj5...

Stuck in a cycle of-

Feeling good, catch up on all the things.
&
Feeling crap, doing nothing.

The struggle is real😕

#Aorticaneurysm

Monitoring blood pressure during lifting

Fun fact:
About 2 months ago, I discovered I have an #aorticaneurysm

I don't smoke (never have)
I have a pint of hard cider 1-2 times/week
I've worked out every day for the past 15+ years
I run and hike about 10-15 miles/week

Yet, here I am 🙁🫀

So now I need to be careful with how I #exercise 😐

#ClonalHematopoiesis #AorticAneurysm
#AortaEd

CH driver gene JAK2 V617F could be causal to #Aortopathy 😎

Mainly a role in Myeloid cells

See the intriguing Mo/Mφ population shift b/w dilated & aneurysmal LysM-Cre:JAK2 V617F WT/Flex aortas😁

#NatureComms 2022
www.nature.com/articles/s41...

#AortaOnAChip

Aortic #SmoothMuscleCell grown in a 3-layered PDMS #Microfluidics +#CyclicStrech reveal Notch1 deficiency-induced #MitochondrialDysfunction in #BicuspidAorticValve #AorticAneurysm

Vacuum-induced rhythmic strain😎

#eLife 2021
elifesciences.org/articles/69310

Preprint alert
#AortaEd

A mouse model with FBN1 G234D variant😎
👉Spontaneous lethal Thoracic #AorticAneurysm #AorticDissection (Abdominal aorta not so impacted) 👉Intimomedial tears (synchrotron tomography)

Kenichi Kimura & Hiromi Yanagisawa labs bioRxiv 2024
www.biorxiv.org/content/10.1...

#SmoothMuscleCell #Senescence #AorticAneurysm
Transcriptomics of 3~4 mo FBLN4 (a microfibril protein) hypomorphic (R/R)🐭Aorta

These🐭exhibit
Exaggerated #AscendingAorticAneurysm
Hyper-multilayering of ascending aortas
Aortic tortuosity
SMC senescence

#NPJAging 2024
www.nature.com/articles/s41...

Dietary Selenium protect against #AorticMedialDenegeneration #AorticAneurysm #AorticDissection in🐭+BAPN

Selenium deficient diet < 0.05; adequate 0.2; supplemented 1 mg/kg

Doxycycline-sensitive ECM enzymes

#Ferroptosis GPX4 is a #Selenoprotein
#EJVES_ESVS 2024
www.sciencedirect.com/science/arti...

Prevalence 2.1% of #AorticAneurysm in a general population

#CopenhagenGeneralPopulationStudy 11294👤56%♀️
CT

4%♂️ 0.7%♀️
Ascending 1.8% - Descending thoracic 0.6% -Abdominal 1.6%

#AortaEd
Klaus Fuglsang Kofoed lab #EHJCVI 2024
academic.oup.com/ehjcimaging/...

#VascularEndothelialGrowthFactorReceptor Inhibitors (#Sorafenib #Sunitinib #Pazopanib) & Risk of #AorticAneurysm & #AorticDissection in patients with Cancers (Kidney/Liver/GI/Pancreas)

A retrospective case (n=1461)-control (7198) study

#AortaEd
#JAMANetworkOpen 2024
jamanetwork.com/journals/jam...