Consumo elevado de carne se asocia con mejores trayectorias cognitivas y menor riesgo de demencia en los individuos con genotipos ε3/ε4 y ε4/ε4 de la APOE #meat #cognitive #apoe jamanetwork.com/journals/jam...
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Hashtag
#apoE
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Are you thinking about becoming a #vegetarian or #vegan? Then start by checking your genetic profile for the #APOE genotypes ε3/ε4 and ε4/ε4.
People with these genotypes benefit from eating meat, as it’s associated with slower cognitive decline and a reduced risk of #dementia.
The
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Molecular characterization of humanized #APOE mouse models reveals source and #genotype dependent differences
Na Wang, Gefei Yu, Zhen Wang, Alla Alnobani...Takahisa Kanekiyo & Chia-Chen Liu & Guojun Bu #AlzheimersDisease #lipids
link.springer.com/article/10.1...
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New blog post is out: review of a UBC paper examining the effect of apolipoprotein E (APOE) genotype on a plasma biomarker of Alzheimer's disease. What do these findings mean for early detection?
Read more: wix.to/HTZ0t3d #AlzheimersResearch #Biomarkers #Neurodevelopment #Alzheimer #APOE
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A liver protein (ApoE) that rises with age blocks bone repair by shutting down growth signals. Removing this protein restored fracture healing, suggesting antibody therapies could reverse age-related bone healing decline.😀
#ApoE #bone
@brjournal.bsky.social
www.nature.com/articles/s41...
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Research Discovery: Two variants of the genotype apolipoprotein E (or APOE) may help “super agers” resist Alzheimer’s disease.
Diseases Affected: Alzheimer’s disease
Key Findings: Adults who qualified as “super agers” (people aged 80 or older whose memory and cognitive skills have not declined in 20 or 30 years) tend to have a higher frequency of APOE2 and APOE3 alleles, and a lower frequency of APOE4 alleles. APOE4 appears to be a genetic risk factor for Alzheimer’s.
What's next? While further research on super agers is needed, it’s currently possible to check for APOE variants in a genetic test. A higher APOE4 frequency suggests a higher Alzheimer’s risk, but health care providers can help patients identify and minimize other potential risk factors.
A study recently published in Alzheimer’s & Dementia shares that gene variants APOE2 and APOE3 may help protect “super agers” (people aged 80 or older with the memory and cognitive skills of adults in their 50s o 60s) against #Alzheimers. #SuperAgers #APOE
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Keypoints: Muscularis macrophages express high levels of ApoE after intestinal manipulation, but macrophage-specific deletion of ApoE does not impair gut motility or tissue morphology. While global ApoE deficiency mildly affects intestinal transit and promotes inflammation, macrophage-derived ApoE is dispensable for maintaining normal and postoperative gut motility.
🆕🔥#MuscularisMacrophage-derived #ApoE is dispensable for maintaining #GutMotility 🐭‼️
🎯Global ApoE deficiency delays gut transit & promotes inflammation, while macrophage-specific ApoE deletion does not impair motility #POI👏
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM
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While the assay is effective for ruling out E4 alleles, confirmation via genotyping is still recommended for the most accurate results in the case of E4/E4, especially in individualized interventions contexts. 🧠
📰 pubmed.ncbi.nlm.nih.gov/41512280/
#alzhiemers #endalz #APOE
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New study shows APOE genetics may explain up to 90% of Alzheimer’s risk, which may help in reshaping prevention strategies.
longevity.technology/news/single-...
#longevity #Alzheimers #BrainHealth #Neuroscience #Genetics #APOE #DementiaResearch #PrecisionMedicine #Prevention #HealthyAging
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We need to know more about how best to communicate genetic risk for #AlzheimersDisease and #ApoE. Please circulate this survey that is on the #POPPED website so we can get as many opinions as possible...
popped.org.uk/apoe4/
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🎧 Our podcast, "DNA Dialogues" is almost up to 12,000 downloads!
Here are our top episodes of the year:
Shifting Paradigms: #APOE in Dyslipidemia & Patient Voices in #Neurogenetics
DNA Day: Unexpected DTC Results & Gender Diverse Care
You can find them here:
dnadialogues.podbean.com
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8️⃣ Arrisku-faktoreei dagokienez:
🧬 #APOE ε4 aleloa izateak arriskua handitzen du
🎓 Hezkuntza-maila baxuagoa, patologia gehiago
⚖️ Sexuaren araberako aldeak txikiak dira
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Golden et al. (2025) in Nature Neuroscience reported that APOE4 → APOE2 switch in mice improves AD-related markers! Astrocyte-specific targeting looks promising. Exciting implications for gene editing therapies. Check out the video: youtu.be/I6LuRVE7ygM
#Alzheimers #APOE #Neuroscience #GeneEditing
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Wonderful talk by David Holtzman at the #NIH/#NINDS regarding #APOE and #AD, and Christchurch mutation. #APOE4 #APOE3ch #neurodegeneration
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barplot of number of ancestry-specific DEGs. Venn diagram of overlap between African and European ancestry DEGs in Oligo.3. Scatter plot of DE t-statistics from each ancestry group.
The risk effect of #APOE is ancestry dependent, and the diverse set of donors in our study allowed us to assess this in our data. Oligo.3 was the major source of DEGs in both African and European ancestry, but DEGs were quite different between the two ancestries
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Proposed model for oligodendrocyte subcluster classification and maturation trajectory in APOE E2+ and E4+ carriers
This pattern of downregulation of #oligodendrocyte maturation genes in pre-mylenating Oligo.3’s led us to hypothesize that the maturation of oligos is reduced in the #APOE E4+ ERC, which could lead to reduced myelination, rendering neurons more vulnerable to degradation in #Alzheimers disease
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Volcano plot of Oligo.3, boxplots of select DEGs, heatmap of top up and downregulated DEGs in Oligo subtypes, top DEG enriched GO terms from Oligo.3
Examining the gene expression changes in Oligo.3 between #APOE carriers, genes up-regulated in E4+ were enriched in synaptic signaling & metal ion transport, down-regulated genes enriched in myelination & #oligodendrocyte development
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Design of differential expression analysis in clusters between APOE E4+ and E2+ donors. Bar plot of number of DEGs from each cluster in SRT and snRNA-seq data, subcluster Oligo.3 had the majority of DEGs.
To explore gene expression changes in AD risk, we performed differential expression analysis with #voomLmFit on ERC clusters between high risk #APOE E4+ and low risk E2+. We found a large number of differential expressed genes in an oligodendrocyte subcluster Oligo.3 #edgeR #limma
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'Interplay between #astrocyte reactivity and #APOE ε4 status is associated with accelerated #pTau-related tau pathology in #AlzheimersDisease'
Xiaoxie Mao, Yan Wang, Ying Luan, Ying Wang...Binyin Li, Zijing Li, Qihao Guo, Fang Xie
molecularneurodegeneration.biomedcentral.com/articles/10....
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There is a new PhD in town!
Congratulations Dr. Cruz-Sesé, zorionak Joan!!
#astrocytes #Alzheimers #APOE #Signalling
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🧬 New paper in Stem Cell Reports used EBiSC iPSC lines BIONi037-A (ApoE3/E3) and BIONi037-A-4 (ApoE4/E4) to study how APOE genotype impacts cell biology.
Both lines are available via EBiSC👉
(www.cell.com/stem-cell-re...
#iPSC #EBiSC #APOE #Alzheimers
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#APOE genotype influences on the brain #metabolome of aging mice – role for #mitochondrial energetics in mechanisms of #resilience in APOE2 genotype
Kamil Borkowski, Nuanyi Liang, Na Zhao..Rima Kaddurah-Daouk @dukemedschool.bsky.social @metabolomics-wcmc.bsky.social @mayoclinic.org
bit.ly/4g0otRm
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β-Amyloid induces #microglial expression of GPC4 and #APOE leading to increased neuronal tau pathology and toxicity
Brandon B. Holmes, Thaddeus K. Weigel, Jesseca M. Chung...James A. Wells #AlzheimersDisease #drosophila #amyloid #microglia @ucsanfrancisco.bsky.social
bit.ly/3HXP98J
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Lecanemab vs Donanemab: antiamyloid mAb therapy for #Alzheimers:
🧠 L: lower risk of amyloid-related imaging abnormalities (ARIA)
🧠 D: infused 1x/month, L: 1x/2wks
🧠 Both: out-of-pocket ~$30k/yr
🧠 “No head-to-head study... need more randomized data"
#AlzSky #NeuroSky
#dementia #amyloid #APOE
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A manifesto for #AlzheimersDisease drug discovery in the era of disease-modifying #therapies
Heike Hering, Thierry Bussiere, Chia-Chen Liu...Dominic M. Walsh #amyloid #alphasynuclein #APOE
molecularneurodegeneration.biomedcentral.com/articles/10....
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Cold exposure promotes the progression of #osteoarthritis through downregulating #APOE in cartilage
By Y Zhang, M Fu, C Zhou, S An, X Wang, Z Wang & colleagues
➡️ doi.org/10.1038/s443...
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#Medsky🧪 #publichealth In this cohort study that evaluated 2038 patients who had atrial fibrillation on #apixaban & no history of #stroke, carriers vs noncarriers of 1 or 2 #APOE epsilon ε4 alleles exhibited a 3-fold increase in intracranial hemorrhage risk over a median follow-up of 2.9 years.
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Why Alzheimer’s DNA tests don’t treat all populations equally www.news-medical.net/news/2025061... #Alzheimers #Genomics #GWAS #PolygenicRisk #Diversity #PrecisionMedicine #Neurodegeneration #APOE
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