Colchicine for Atherosclerotic Cardiovascular Disease Prevention TH: Why did you (and your colleagues) write this paper? What was its main purpose? AIMÉE M.H.

Read our interview 🗣️with the lead authors Aimée M.H. van Zelm and Noel C. Chan on their 🆕 article on #Colchicine for #Atherosclerotic Cardiovascular Disease Prevention

👀Read Full text article here 🔗 www.thieme-connect.com/products/ejo...

www.linkedin.com/pulse/colchi...

Comment Mayoly rapatrie en France la production de #colchicine dans l’Yonne, chez les laboratoires Galien

📣 #Colchicine for the prevention and management of Atherosclerotic #Cardiovascular Disease ⬇️

📌 In this review, van Zelm and colleagues review the evidence for the use of colchicine in #ASCVD

🆓 on TH 👉 www.thieme-connect.de/products/ejo...

#CardioEd #CAD #Cardiology #Cardiosky

The December issue is now online!

👉 Read our latest articles!

🚨 Including reviews from the 19th Key Symposium: Planetary Health - What saves the planet saves our health!🍃

🔗onlinelibrary.wiley.com/toc/13652796/2025/298/6

#PlanetaryHealth25 #nature #plastics #ageing #Colchicine #cardiovascular

While this study focused on LC , earlier #clinical trials investigated #colchicine for #COVID with mixed findings
-The RECOVERY trial found no benefit from using colchicine in COVID 🏥 patients
- The COLCORONA trial, which studied outpatient patients with COVID,

#Medsky🧪 #IDsky #pharmsky #immunosky #drugrepurpose #publichealth @jamainternalmed.com
In this RCT #colchicine is not an effective treatment for #LongCOVID. The study found no significant improvement in functional capacity, respiratory function, or other symptoms in treated groups vs placebo group

Efficacy and safety of colchicine in patients with acute coronary syndrome: a systematic review and meta-analysis of randomized controlled trials - BMC Cardiovascular Disorders Background The European Society of Cardiology (ESC) recently endorsed low-dose colchicine for chronic coronary syndrome. However, its role in acute coronary syndrome (ACS) remains uncertain due to inc...

#MetaAnalysis (11 RCTs, n=12,730): #Colchicine shows no cardiovascular benefit in acute coronary syndrome (ACS), though safety remains acceptable. @fadyiskander.bsky.social bmccardiovascdisord.biomedcentral.com/articles/10....

#Colchicine alleviates #AbdominalAorticAneurysm
ApoE−/− mice +ANGII

Effects on Macrophage (down NLRP3 IL-1β TNFα MCP1) & #SmoothMuscleCell (up LOX TIMP1/2)
Unaltered aortic MMP2/9

Yuji Narita lab #CircJ 2025
www.jstage.jst.go.jp/article/circ...

Poisonous Matrimony: From Thallium to Bleach In this episode, we uncover true tales of marriages turned lethal experiments: from the insidious thallium poisonings by Russian engineer Vataslav Solovio—who silently killed his wife, daughter, and partner—to modern cases like the medical resident who murdered his wife with a gout drug (colchicine) and the attempted bleach poisonings via the coffee maker. You’ll hear unique details such as thallium’s symptoms mimicking common illnesses and the digital sleuthing used to trace colchicine. Join us as we explore how investigators pieced together forensic evidence—from hair‐loss patterns and toxicology screens to CCTV footage and metadata—and reveal the warning signs hidden in seemingly normal relationships. Learn critical lessons about domestic vulnerability, the need for routine tests in unexplained illnesses, and the psychology of a killer who treats loved ones as lab subjects.

📣 New Podcast! "Poisonous Matrimony: From Thallium to Bleach" on @Spreaker #bleachattack #colchicine #domesticpoisoning #serialpoisoner #thallium #truecrime #victimandperpetrator

New Brief Report! #Colchicine and #cardiovascular events: An updated meta-analysis of published randomized controlled trials

🔗https://doi.org/10.1111/joim.20107

Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial Background Low-dose colchicine (0.5 mg once daily) reduces the risk of major cardiovascular events in coronary disease, but its mechanism of action is not yet fully understood. We investigated whether...

Dosis bajas de colchicina no alteran la inflamación pericoronaria, pero si puede aumentar el volumen de la placa calcificada, particularmente la densa, lo que se considera un rasgo de estabilidad de la placa #colchicine #coronary heart.bmj.com/content/earl...

#Colchicine rescues #SmoothMuscleCell contractile phenotype & BAPN-induced🐭#AorticDissection

Colchicine restores PDGFBB-downregulated Myocardin but not upregulated KLF4 in primary rat aortic SMC

Role of Microtubule?😁

#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...

Colchicine for preventing stroke in patients with and without intracranial atherosclerotic stenosis: a prespecified analysis of an RCT

Effect of #colchicine on subsequent #stroke within 90 days may differ according to the presence of sICAS

www.thelancet.com/journals/ecl...
#MedSky #NeuroSky

Long-term trials of #colchicine for secondary prevention of vascular events: a meta-analysis

#CardioSky
academic.oup.com/eurheartj/ad...
@escardio.bsky.social @anastasiasmihaili.bsky.social @victoriadelgadomd.bsky.social @gimelliale.bsky.social @load-dependent.bsky.social @dmljmd.bsky.social

Long-term trials of colchicine for secondary prevention of vascular events: a meta-analysis

#Colchicine significantly reduced #MACE in patients with vascular disease: pooled HR 0.75 (95% CI 0.56–0.93) across 6 RCTs (n=21,800).

#CardioSky @escardio.bsky.social

Gout can affect anyone but affects men more than women because men typically have higher uric acid levels. Those who have a diet that has a lot of red meat are at a higher risk. #Dateline #Gout #Colchicine

Depolymerize microtubules with colchicine. Your heart will thank you. Next, moving onto PAD and AAA… 🫀#MedEd #Colchicine www.sciencedirect.com/science/arti...

#Colchicine stabilizes #SmoothMuscleCell contractile phenotype & alleviates🐭#AbdominalAorticAneurysm (local CaPO4)
ep.2

Colchicine
⏬METTL14-YTHDC1-m6A modification➡️
⏫Sclerostin (BMPi) mRNA stability➡️
⏬Wnt/β-cat

👤#AAA
lesional SMC ⏫METTL14 ⏫β-cat ⏬SOST

#IntJBiolSci 2024
www.ijbs.com/v20p2092.htm

#Colchicine stabilizes #SmoothMuscleCell contractile phenotype & alleviates🐭#AbdominalAorticAneurysm (local elastase + BAPN in water)
ep.1

⏬collagen
↔️elastin
⏬#VascularInflammation
⏬immune cell infiltr
⏬vascular wall #Pyroptosis SMC or immune cells?🤔

#ClinSci 2023
portlandpress.com/clinsci/arti...

Clinical features of the three phases of colchicine poisoning

Colchicine: the good, the bad, the ugly and how to minimize the risks.

academic.oup.com/rheumatology...

#CardioSky #MedSky #Colchicine #Rheumsky

#Forensics #Forensky ⚕️🩺⚖️
#Toxicology
#Colchicine

Pharmacovigilance 51 Hiver 2024 CRPVs Bulletin d'information Nice-Alpes-Côte d’Azur et trimestriel n°51 Marseille-Provence-Corse hiver 2024 harmacovigilance Nice-Alpes-Côte d’Azur-Provence-Corse ABONNEZ -VOUS Nice : 05 pharmaco , 06...

📣 Le nouveau bulletin d'information du CRPV de Nice et de Marseille est en ligne !
⬇️
- #Lecanemab
- #Colchicine
- #Psoriasis et #lithium
- #Hypocalcémie sous #IPP
- #Statines chez les séniors
- Etude #IatrostatEco

@reseaucrpv.bsky.social
@chudenice.bsky.social
@aphm-chu-marseille.bsky.social

Didn’t think to pack my colchicine. And now I need it 😭 Thank you to my speedy health clinic and nearby pharmacy for getting it ready. Now to resume my trip with less pain!

#gout #colchicine #meds
#travel #onemedical #longsdrug

Setback in acute MI, #colchicine does not reduce CV death/recurrent MI, stroke, need for revascularization, which is in contrast with #COLCOT study showing #colchicine resulting in 23% reduction in a similar composite endpoint. #AHA24 #NEJM24

Colchicine in Acute Myocardial Infarction | NEJM Inflammation is associated with adverse cardiovascular events. Data from recent trials suggest that colchicine reduces the risk of cardiovascular events. In this multicenter trial with a 2-by-2 fac...

#Colchicine in Acute Myocardial Infarction

www.nejm.org/doi/full/10....
#AHA24 #NEJM #CardioSky #MedSky
@ahascience.bsky.social

Après #hydroxychloroquine, #ivermectine, #azithromycine on oublie la #colchicine comme traitement de la covidet heureusement car c'est un produit à marge thérapeutique étroite

medrxiv.org/content/10.110…

#Colchicine #COVID
Janvier: BUZZ👍
Mai: FLOP👎In community-treated patients including those without a mandatory diagnostic test, the effect of colchicine on COVID-19-related clinical events was not statistically significant"

Science 👉critique des pairs

thelancet.com/journals/lanre…

RECOVERY trial closes recruitment to colchicine treatment for patients hospitalised with COVID-19 Statement from the RECOVERY trial chief investigators, 5 March 2021

#Colchicine chez les patients hospitalisés #covid inefficace

Le comité indépendant de sécurité a jugé qu’il ne fallait pas continuer car on n’aurait jamais d’effet significatif

⁦@QubRadio⁩ ⁦@SFPT_fr⁩
⁦@Reseau_CRPV⁩ ⁦@ansm⁩

recoverytrial.net/news/recovery-…

[#Santé] #COVID19 et #traitement à la #colchicine : un enthousiasme prématuré.

👉#médicament #interactions #effetsindésirables #pharmacovigilance

ufcqc.link/n87951

L’#hydroxycholoroquine a fait le buzz sur une étude de méthodologie nulle avec des test statistiques présentés significatifs
La #colchicine a fait le buzz avec une bonne méthodologie mais une analyse qui ne permet pas de conclure à la significativite

Science sans conscience