A nature-inspired confined cascade enzyme #Nanoreactor integrating multiple #Nanozyme activities within a #Biomimetic platform modulates inflammatory plaque microenvironments and inhibits #FoamCell formation in #Atherosclerosis.
#STTT #OpenAccess: doi.org/10.1038/s413...
#ApoA #Atherosclerosis
Apolipoprotein A-I Binding Protein deficiency augments #FoamCell formation & TLR4 dimerization on lipid raft/Inflammaraft in hyperlipidemic Ldlr-/-🐭
BODIPY-hi vs -lo lesional macrophage⬅️how much are #SmoothMuscleCell -derived?🧐
bioRxiv 2025
www.biorxiv.org/content/10.1...
#Atherosclerosis #FoamCell heterogeneity 2/2
Meta-analysis 37 scRNAseq libraries + 44 scATACseq datasets->
5 Foam cell states
ICAM1+ inflammatory
FOLR2+ phagocytic
MMP9+ matrix-remodeling
ANGPTL4+ hypoxic
COL1A2+ fibroblastic
#Biomol_MDPI 2024
www.mdpi.com/2218-273X/14...
#Atherosclerosis #FoamCell heterogeneity 1/2
AtheroSpectrum derives 4 transcriptomically distinct Macrophage
Foam cell Non-inflamm, Inflamm
Non-foamy Mφ Inflamm, Non-inflamm
Foam cell hi OXPHOS, Integrin, VEGF, TGFβ, IL-3
#Circ 2022 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
Get your free quote today for #ironman4x4 #foamcell #liftkit at #HawkesOutdoors 210-251-2882
New #liftkit options from #ironman4x4 with #foamcell technology, for a smoother ride. Get your quick free order and install quotes today at #HawkesOutdoors 210-251-2882
My continued biomedical education
Failure of physiological transformation & #SpiralArtery #Atherosis: their roles in #Preeclampsia
Avute Atherosis: #FoamCell lesions at poorly remodeled spiral artery
#SnoothMuscleCell or Macrophage progenies?
#AJOG_thegray 2022
www.ajog.org/article/S000...
FASN/#FattyAcidSynthase #SmoothMuscleCell - #FoamCell transition
Cholesterol->⏫FASN->⏫KLF4->
⏬ABCA1 (cholesterol efflux)
⏫SOAT1 (cholesterol esterification)
Alejandra San Martin lab #Cells_MDPI 2024
www.mdpi.com/2073-4409/13...
#Macrophage #Mitochondria #Atherosclerosis
Macrophage expressing 3β-hydroxysterol Δ24-reductase/DHCR (conv Desmosterol to Cholesterol)⏫Interferon signals, Mito ROS #inflammasome & #FoamCell formation
Myeloid DHCR KI ⏬ IL-10/-12 & LXR/RXR signals in foamy Mφ
#PNAS 2021
www.pnas.org/doi/10.1073/...
Multiplex imaging of human #Atherosclerosis
Frozen section, PhenoCycler, 9-plex imaging
DAPI, CD45, MYH11, CD68, aCasp3, IL1β, TNFα, BODIPY, CD31
Labeling #SmoothMuscleCell derived #FoamCell vs Leukocyte derived FC in🙍♂️coronary arteries Intima
#JAHA_AHA 2024
www.ahajournals.org/doi/10.1161/...
TREM2 as a positive regulator of Macrophage #FoamCell mitochondria, survival & efferocytosis under hypercholesterolemia
Hematopoietic TREM2 KO⏫#NecroticCore formation in early (8~12 wk) #Atherosclerosis in Ldlr-/-🐭
w/o altering lesion or Mφ burden
#NatureCVR 2024
www.nature.com/articles/s44...
#Mechanobiology #SmoothMuscleCell
#Piezo1 & Pressure (hypertensive 180/120 mmHg) ▶️cPLA2-mediated #LipidDroplet formation & #FoamCell phenotype in SMC in 2 h🤠
SMC Epigenetics by 8 h Yoda1 (Piezo1 activator): LAD-heterochromatin, H3K9me3 Cut&Tag
#AdvSci 2023
onlinelibrary.wiley.com/doi/10.1002/...
