MCE New Releases | 1,000+ research molecules now available
Expanding coverage across #Oncology, #Neurology, #Immunology, #Metabolism research to support diverse discovery needs. Targets include #BCL2, #KRASG12C, #PPARα, #5HT2A, #JAK/TYK2, and #METTL1—enabling deeper pathway exploration.
🤝MedChemExpress on the Move | #AACR 2026✨
💜Cece and our team had a fantastic time at #AACR26, connecting with researchers and sharing ideas.
Thank you to everyone who stopped by. We’re excited for more discoveries ahead! 🚀
#MedChemExpress @theaacr.bsky.social
#AACR2026 #cancerresearch
🤝MedChemExpress on the Move | #IMMUNOLOGY2026 🌟
🐘The energy here is incredible! A big thank you to everyone who stopped by our booth and shared insightful discussions with us. We truly appreciate the engaging conversations and your continued interest in MedChemExpress. 💜
#AAI2026 #Conference
🚀BRD2 in Transcription Initiation
#BRD2 maintains #RNAPolymeraseII at promoters via TFIID—especially when pause release is impaired. MOF-driven H4 acetylation enhances BRD2 chromatin binding & clustering. Disrupt this axis, and transcription collapses.Acetylation fine-tunes transcription initiation.
🧪Explore shigella-related tools from MedChemExpress: medchemexpress.com/search.html?...
🧪We offer bacterial infection tools for research use only: medchemexpress.com/disease-area...
🎨Science Visuals | #Shigella Infection
🦠Shigella outbreaks can spread quickly due to its very low infectious dose.
🤢Symptoms include #diarrhea, cramps, fever, and dehydration.
⚠️Hygiene, food safety, and early response are critical to limiting spread.
#ShigellaInfection #PublicHealth #Outbreak
📚MedChemExpress Digest | ADCs & Immune Synergy in Cancer Therapy
In this article, we explore:
🔹Evolution of ADCs across three generations
🔹Mechanistic and strategic insights into ADC-based immune combination therapies
🔹Clinical advances & emerging therapeutic approaches
ow.ly/c8W050YJMO0
📚ADCs& Immune Synergy in Cancer Therapy
ADCs are evolving from precision drug delivery to immune-modulating therapies, increasingly integrated with immunotherapy for stronger anti-tumor effects. ADC evolution (3 generations); Immune combination strategies;Emerging clinical advances ow.ly/c8W050YJMO0
🤝MedChemExpress on the Move in the US | Join Us at #Immunology2026
📅 Date: April 15–19, 2026
📍 Venue: Boston Convention & Exhibition Center, Boston, MA, USA
🎪 Booth: #425
Let’s explore the latest in immunology research together! ow.ly/fjPc50YFt0Z
#LifeSciences #Immunology #Biotech
🔸Targeting this pathway or applying senolytic strategies significantly reduces tumor burden in preclinical models
🌟ABT-737, a widely used #BH3 mimetic was cited in this paper
www.medchemexpress.com/abt-737.html
🔗Read the full paper: www.nature.com/articles/s43...
#Bcl2 #CellularSenescence #ABT737
🚀From Bench to Paper | A Nat Aging study reveals the mechanism behind resistance to platinum-based chemotherapy in lung and ovarian cancers
🔸Platinum therapies induce cellular #senescence
🔸Senescent cells secrete a TGFβ-enriched #SASP
⬆️Tumor progression/therapy resistance via #TGFβR1 and #AKT/#mTOR
💊FDA Approval Update | The #FDA has approved the first generics of #dapagliflozin (#FARXIGA)
🔸Reduces glucose/sodium absorption in kidneys
🔸Lowers risk of heart failure hospitalization
🔸Improves blood glucose control
MCE offers dapagliflozin for research use: www.medchemexpress.com/Dapagliflozi...
🐪Hump Day Hack | Guess who’s getting things done… 👀
Counting down to who’s taking on the experiments, the work, the studying… and the suspense is real😅
#LabLife #Experiment #GrindNeverStops #HumpDay
💡At MedChemExpress, we support scientists with reliable reagents and research solutions that accelerate discoveries and improve outcomes.https://www.medchemexpress.com/
🩺World Health Day | Apr 7, 2026
“Together for health. Stand with science.” On this World Health Day, we celebrate the power of science, research, and collaboration in advancing global health.
#WorldHealthDay #GlobalHealth #LifeScience #DrugDiscovery #HealthcareInnovation #StandWithScience
❓Tech Q&A | #Solubility of #GSK805 in #DMSO/#PEG300/#Tween80 saline
• Vehicle: 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% saline
• Result: clear solution
• Solubility: 2.5 mg/mL
#DrugFormulation #InVivo #LabTips #MouseModel
🎁Free Samples Alert!✨🌎North America 🇺🇸 🇨🇦
Try them for free and unlock your essential MedChemExpress products! 🔬
Unlock 12 categories, including Bioactive Molecules, Natural Products, ADC-Related, Recombinant Proteins, Antibodies, and Kits.
🔗https://ow.ly/lQJN50YCM2o
🐪Hump Day Hack | 😺April Fools' Day
When reality hits back,
the “study all weekend” was just a concept.
📚Plan: “I’ll be productive all weekend”
📱Reality: scroll… snack… nap… repeat
AprilFoolsDay #HumpDay #Reality #PlanvsReality #LabLife
🩺World Autism Awareness Day | April 2
#ASD affects~1% globally, shaped by genetics, environment&early brain development. Key features:Social communication challenges;Repetitive behaviors& focused interests;Atypical sensory processing.
Research: genetics, brain circuits, gut–brain axis, neuroimmune.
🧬ASC Spring 2026
1️⃣IAM1363 – AI-designed #HER2 inhibitor
2️⃣FORX428 – Oral #PARG inhibitor
3️⃣BHV2100 – First-in-class #TRPM3 antagonist
4️⃣BMS986482 – #IKZF 1–4 pan-degrader
5️⃣OP3136 – Selective #KAT6 inhibitor. MCE powers your research with 150,000+ inhibitors and agonists—your trusted science partner.
📚Express Delivery🚚🚢✈️
A little crowded in here📦…
Foam protects, ice packs preserve. Real cold chain delivery keeps every reagent intact, stable, and research-ready.
🔬MedChemExpress Reagents — Cold Chain. Perfect Delivery.
#ColdChain #LabLogistics #LifeScience
💊#FDA Approval Update | #Awiqli (#insulin icodec), the first once-weekly basal insulin approved for #T2D
💉365→52 injections/year
📊To improve long-term glycemic control
🧪We offer insulin icodec for research use only: www.medchemexpress.com/insulin-icod...
www.medchemexpress.com/disease-area...
🔥Hot Off the Press | Can #VitaminC slow biological aging in primates?
A new study in Cell Metabolism defines a conserved “ferro-aging” axis in primates, where iron accumulation drives chronic lipid peroxidation and systemic decline. #ACSL4, acting as a key executor, promoting cellular senescence.
🧬Molecule of the Moment | 🧠New research shows #Metformin doesn’t just act in the liver, it directly affects the #brain, regulating glucose via hypothalamic neurons (#Rap1/#SF1 pathway)
🧪MedChemExpress provides Metformin for research use only: medchemexpress.com/metformin.html
#Type2Diabetes
This study was supported by a range of high-quality reagents from MedChemExpress, including:
#Lecanemab, #BafilomycinA1, #Chloroquine, #Pitstop2, DC-LC3in-D5, as well as multiple antibodies and recombinant proteins. www.medchemexpress.com
#AlzheimersDisease #Neurodegeneration
A recent study reports SPYTACs (synthetic peptide-programmed lysosome-targeting chimeras), a fully synthetic, modular #eTPD platform that leverages LRP1-mediated endocytosis and transcytosis to cross the Blood-Brain Barrier (#BBB) and drive lysosomal degradation of extracellular Aβ.
🚀From Bench to Paper | Efficient amyloid-β degradation in Alzheimer’s disease using #SPYTACs
Alzheimer’s disease (AD) therapy faces a key challenge: clearing pathogenic proteins efficiently while minimizing side effects.
#TargetedProteinDegradation #DrugDiscovery #CNS #TranslationalResearch
💊#FDA Approval Update | #Avlayah: the first therapy targeting neurological symptoms of Hunter syndrome
🧠 Designed to cross the BBB, addressing a major unmet need in this #RareDisease
📉 ~91% reduction in #CSF heparan sulfate in trials
🧪MCE provides tividenofusp alfa for research use
#HunterSyndrome
🧪MedChemExpress continues to support COVID-related research: medchemexpress.com/disease-area...
🔖Read more: pmc.ncbi.nlm.nih.gov/articles/PMC...
#BA32 #COVID19 #SARSCoV2 #Variants #Virology #Immunology #GlobalHealth #NewCOVIDVariant
🔥Hot Off the Press | 🦠A highly mutated COVID-19 variant is under the spotlight: BA 3.2
This study characterizes the COVID-19 BA.3.2 variant, showing:
🔸Extensive spike mutations (>50)
🔸Reduced neutralization by vaccine-elicited antibodies
🔸Ongoing spread
