#Fibrinogen–Bmal1 signaling preserves VSMC contractility and limits #AorticDissection progression, offering a promising #TherapeuticTarget to improve vascular stability and patient outcomes.

#STTT #OpenAccess: doi.org/10.1038/s413...

Bijna een week na verwijderden van de bedrade pacemaker en plaatsing van de draadloze...

Tijd zal leren of de vele klachten allemaal samen hingen met de #pacemakerfromhell en het borduursel dat m'n borstkas bij elkaar hield of dat er toch andere dingen aan ten grondslag lagen. #aorticdissection

Aortic arch Height as an independent risk factor for acute type B #AorticDissection
113 case + 113 ctrl

3D CT measurement of Width (not the same as Diameter), Height, Angle of ascending aorta & aortic arch

#AortaEd
#SciRep 2025
www.nature.com/articles/s41...

So happy to meet Robert and Elisabeth in person in Singapore! Robert survived emergency surgery for an #aorticdissection over 17 years ago and has since become a tireless patient advocate for aortic awareness. Thank you both for all you do 🙏🙏🙏

Investigating the role of structural wall stress in aortic growth prognosis in acute uncomplicated type B aortic dissection.
Agarwal, Rishika et al.
Paper
Details
#AorticDissection #StructuralWallStress #VascularMedicine

Blocking Integrin αV (Cilengitide or SB273005) aggravates ascending aortic aneurysm & dissection in 🐭+BAPN

Transcriptional role of STAT1 on SMC contractile proteins

Integrins αV αL ⬇️in👤type A #AorticDissection

Plasma #Proteomics 11 case + 7 ctrl

#JTCVS 2025
www.sciencedirect.com/science/arti...

Deadly and often missed: Aortic dissection demands ED vigilance. Updated Ritter Rules highlight key signs—sudden severe pain, pulse deficits, neuro symptoms. Read more online. #EmergencyMedicine #AorticDissection

https://ow.ly/Uunr50XHuYt

#InterventionalRadiology #AorticDissection #EVAR #StentGraft #VascularSurgery #EndovascularTherapy #Innovation

Exploration of the Causal Roles of Immune Cells and Inflammatory Proteins in Aortic Dissection via Mendelian Randomization Study uncovers immune cell and inflammatory protein links to aortic dissection, revealing potential therapeutic targets for better prevention and treatment.

Using two-step #MendelianRandomization and #GWAS analyses, this #CVIA study identifies immune cell types that promote or protect against #AorticDissection (AD) and highlights #TRAIL as a key mediator linking immune cell activity to AD risk.

#OpenAccess: tinyurl.com/2256u6d5

The Role of Immune Cells and Inflammatory Proteins in Aortic Dissection This editorial uncovers immune and inflammatory pathways driving aortic dissection, highlighting key cell subsets and proteins as potential therapeutic targets.

This editorial uncovers immune and #inflammatory pathways driving #aorticdissection, highlighting key cell subsets and proteins as potential therapeutic targets.
#CardiovascularMedicine.

#OpenAccess: cvia-journal.org/immune-cells...

NRIP2+ #SmoothMuscleCell (likely mediating metabolic resilience by Leptin signaling) #AorticDissection

Leptin antagonist R128Q or AAV9-SM22a-NRIP2
⏬🐭AD #AorticRupture (BAPN)
⏫contractile SMC
⏫SMC mitochondrial ultrastructure & OXPHOS

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Female has a larger (normalized) ascending aorta than male when dissected

146♀️+267♂️ Acute type A #AorticDissection
On average, dissection occurs at < 50 mm diameter

Aortic height index 28.7 vs 27.2 mm/cm
Aortic BSA index 25.7 vs 22.97 mm/m2

#AortaEd
#HeartBMJ 2025
heart.bmj.com/content/earl...

Histone Variants
#SmoothMuscleCell

1⃣H2A.Z
⬇️in #Atherosclerosis
⏫SMC contractile gene
#CircAHA 2018
www.ahajournals.org/doi/10.1161/...
#BMCGenom 2025
bmcgenomics.biomedcentral.com/articles/10....

2⃣H3.3B
⬆️in #AorticDissection
⏫SMC synthetic genes
#Genomics 2023
www.sciencedirect.com/science/arti...

Grateful #hope #aorticdissection #openheartsurgery #aorticvalve #heartvalve

Guest blog by Gareth Owens from Aortic Dissection Awareness UK & Ireland. HSSIB impact: life-saving difference for acute aortic dissection patients.

To mark Global Aortic Dissection Awareness Day, Gareth Owens guest blogs about the impact of two HSSIB reports, with hundreds more people now receiving life-saving emergency aortic surgery every year. Read the blog: buff.ly/r81lr8Z #AorticDissection #ThinkAorta #PatientSafety

Malperfusion in Acute Type A Aortic Dissection: Development of a Predictive Diagnostic Model - Current Medical Science Objective To investigate the clinical predictors of malperfusion in patients with acute type A aortic dissection (ATAAD) and to construct a diagnostic model to identify high-risk individuals. Methods…

This new study examines the clinical predictors of #Malperfusion in ATAAD and develops a diagnostic model using routine biochemical markers for facilitating early management and diagnosis. #AorticDissection #medsky

Read here:

🫀In acute type A aortic dissection surgery, Rh-positive blood type is linked to better in-hospital survival

🩸Could your blood type influence surgical outcomes?

🔗 doi.org/10.22514/sv....

#AorticDissection #VascularSurgery #Blood #surgery #anesthesia #criticalcare

Wikipedia Edit History entry for Aortic dissection clarify locaiton

Aortic dissection
Edited anonymously from the US Senate on Thursday, Jul 31, 2025 at 9:54 EDT

#Aorticdissection #Wikipedia

#SmoothMuscleCell-derived #Semaphorin3A protect against🐭thoracic #AorticDissection #AorticAneurysm (BAPN)

Evidence from🐭SM22a-Cre overexpression or KO of Sema3a

SEMA3A ⬇️in🐭👤dissected aortas

Direct impacts on SMC or adventitial #VasaVasorum?

#Angiogenesis 2025
link.springer.com/article/10.1...

MSMDS International Conference 2025 - Recordings in Youtube

The 2025 MSMDS Conference recordings are live on YouTube!

📼Watch, learn, and share: bit.ly/2025Conferen...

#ACTA2 #MSMDS #RareDisease #GeneticDisease #VascularDisease #PediatricStroke #AorticDissection #Mydriasis

What are the chances that I’d have both a 3 in every 100,000 persons medical condition *and* a 1 in every 100,000 persons medical condition. I’m too lazy to do the math. I can’t possibly be around much longer #AVM #AorticDissection

Sex-specific Mortality after Surgery for Acute Type A #AorticDissection
#AortaEd

327♀️+ 551♂️

30-d/In-hosp mortality ♀️20.5% vs ♂️18.5%

Long-term (6.2 y f/up) mortality ♀️4.1% vs ♂️2.6% per patient-year over 10 y
♀️Age COPD CKD #AorticAneurysm
♂️Age MI

#JTCVSOpen 2025
www.jtcvsopen.org/article/S266...

Using #CFDsimulations to reveal the mechanisms behind the initiation & progression of #AorticDissection, and identify hemodynamic-based metrics to assess progression risk in type B aortic #IntramuralHematoma patients. #medsky

Read: link.springer.com/article/10.1...

JAK2 #AorticAneurysm

#SmoothMuscleCell CCDC80 KO🐭
⏫Contractile-to-synthetic (prolif, inflam & MMP-hi) phenotypes by Angiotensin II
⏫ #AorticAneurysm Dissection

rescued by JAK2i WP1066

👤 #AorticDissection
⏬CCDC80 ⏫JAK2-STAT3 ⏫MMP2/9

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Genetic Analysis Reveals Key Regulatory Axis in Aortic Dissection: CBL Regulated by HOXB13 and microRNA-1321 Announcing a new article publication for Cardiovascular Innovations and Applications journal. Aortic dissection (AD) is a fatal cardiovascular disease for which the key involved genes are largely unkn...

RNA-seq, enrichment & Cytoscape network analysis identify CBL as a promising AD biomarker (regulated by HOXB13 & miR-1321). Explore #openaccess: tinyurl.com/yn4zglm8

#Cardiology #RNAseq #Biomarkers #AorticDissection #AcademicPublishing

Sex-specific clinical features #ThoracicAorticAneurysm
#AortaEd

1270♂️+ 588♀️ 5.9 y f/up

👉Diagnosis ♀️6.4 y older
👉Aorticφ indexed by BSA/height ♀️>♂️
👉15-y survival ♀️56.1% vs ♂️65.7% (But adj mortality ♀️~♂️
👉Type A #AorticDissection ♀️8.2 vs ♂️2.4 per 1000 pt-y

#EHJ 2025
academic.oup.com/eurheartj/ar...

Guidelines for mouse experiments of thoracic #Aortopathy👹

Great literature synthesis of genetic & chemical models of🐭 #ThoracicAorticAneurysm #AorticDissection

Must-read for all Aorta researchers😎

@alandaugherty.bsky.social #ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/full/10....

Monocyte➡️ #SmoothMuscleCell #EndothelialCell phenotypic shift in #AorticDissection

Lyz2-CreERT2:Basp1 f/f or AAV8-shBasp1🐭+BAPN
👉abrogate thoracic aortic dilation
👉50~80%⏬ #AorticDissection Mortality

In vitro BASP1+ monocyte
⏫ SMC EC Apoptosis

#JAdvRes 2025
www.sciencedirect.com/science/arti...

22/435 #SpontaneousCoronaryArteryDissection 👤also have #AorticDissection in 1st-/2nd-degree relatives

16F+1M probands SCAD+AD families studied

Pathogenic (or likely) variants
SMAD3
COL3A1
CBS H2S synthesis
OAT GABA synthesis
NEXN
DYSF myopathy
CYP7B1

#JAHA 2025
www.ahajournals.org/doi/10.1161/...

March 2025 Update: New Projects, Milestones & Steps Ahead

We’re 4 today! In just four years, we’ve reached 1M people, trained 3,000+ responders & invested £150K+ in #aorticdissection research. Thank you for being part of the journey. Let’s keep driving change for patients. Read our latest update tadct.org/latest-news