🌾 CHROMOSOME ENGINEERING: #CRISPR targets satellite #DNA repeats to reshape entire #wheat chromosomes
✂️ Achieved:
• Chromosome truncation (9.8% rate)
• Whole #chromosome elimination (25% rate)
• Isochromosome formation
• New telomere addition
doi.org/10.1093/plph...
Explore SMC mechanism and regulation at EMBO Workshop "Threads of life: SMC complexes in #chromosome structure and dynamics" in #Bengaluru, IN, 13–18 Dec 2026.
Registration/Abstract submission by 1 Apr/1 May
https://meetings.embo.org/event/26-smc-complexes
#EMBOThreadsOfLife #genesky #EMBOevents 🧪
PREPRINT ALERT!
Determinants of chromosomal rearrangements in holocentric Leptidea butterflies
www.biorxiv.org/content/10.6...
Massive #chromosome reshuffling in Leptidea #butterflies reveals how satellite DNA, rDNA, and duplications—not #transposons, shape the architecture of #genomeevolution.
#Science The extra #Chromosome.
🥖🧬 De la boulangerie au #génome humain
👉1992 : 150 chercheurs décryptent le génome d’un #chromosome de #levure de boulanger
👉un travail pionnier accompli près de 10 ans avant le séquençage du génome humain
lejournal.cnrs.fr/videos/de-la...
Chromosome de la chatte
Un chromosome est une structure en forme de filament située dans le noyau des cellules qui porte l'information génétique. #Chromosome #Structure #Filament #Information #Genetique
The moment we've been waiting to tell you! We are very proud to present to you our Little Red Book in PRINT and use it to help explain what life is like with a rare #chromosome or #gene disorder.
Buy now on our online shop: https://ow.ly/Rl3G50YhZGI
#RareDiseaseWeek #RareDiseaseDay
Explore SMC mechanism and regulation at EMBO Workshop "Threads of life: SMC complexes in #chromosome structure and dynamics" in #Bengaluru, IN, 13–18 Dec 2026.
Registration/Abstract submission by 1 Apr/1 May
https://meetings.embo.org/event/26-smc-complexes
#EMBOThreadsOfLife #genesky #EMBOevents 🧪
#KnowledgeByte: The Y #Chromosome is shrinking and losing genes over millions of years, a process called genetic degeneration, with estimates suggesting it could vanish in 10-11 million years.
knowledgezone.co.in/posts/Vanish...
(A much younger) Me presenting discovery of CTCF and identification of CTCF Like BORIS at the Nobel Symposium in 2004, while talking of their tentative functions in germline vs. cancer, and of secrets beyond... What a journey in 22 years after that! #Epigenetics #CTCF #BORIS #chromosome
![A figure from Carta et al. (2020) illustrates how n = 7 has been inferred and why this now seems problematic. [Carta, A., G. Bedini, and L. Peruzzi. 2020. A deep dive into the ancestral chromosome number and genome size of flowering plants. New Phytologist 228: 1097–1106.]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:pbn7uj4zr5yukdiqflp3p3n7/bafkreif74wfgug2t3jaseocskeei4d4oeb3vcx625zq5jvqtvjsucgo2ai)
A figure from Carta et al. (2020) illustrates how n = 7 has been inferred and why this now seems problematic. [Carta, A., G. Bedini, and L. Peruzzi. 2020. A deep dive into the ancestral chromosome number and genome size of flowering plants. New Phytologist 228: 1097–1106.]
Why six and seven are implausible ancestral #angiosperm #chromosome numbers
New #AJB research by Susanne Renner
doi.org/10.1002/ajb2... #botany #plantscience
📣 New Podcast! "PGT-A as an IVF Add-On: 25 Years of Controversy" on @Spreaker #aneuploidy #bioethics #chromosomal #chromosome #dna #embryo #embryology #embryos #ethics #fertility #genetic #genetics #infertile #infertility #ivf #law #medicine #miscarriage #regulation #screening
This #MicroscopyMonday shows the synaptonemal complex, which is a multi-protein structure that forms in early #meiosis between the maternal and paternal copy of each #chromosome. Here, we see two such structures in the fruit fly. @sillysciencelady.bsky.social (Hawley Lab & Gibson Lab)
A mid-stage egg chamber taken from a PSR+ female, when hybridized with a PSR probe cognate to the haploidizer gene, reveals the presence of PSR (red) in the polyploid nurse cell nuclei (NCN), the oocyte nucleus (ON) (B′), and somatic follicle cells (FCs) (B″). rDNA is shown in blue, and DNA is gray. Scale bar equals 15 μM. (B′) and (B″) are shown in higher magnification. The white arrow in (B′) indicates the single copy of PSR in the chromatin body of the germinal vesicle.
Selfish B chromosomes can spread via super- #Mendelian transmission, but this can be limited by forces like drag. This study shows that jewel #wasp PSR #chromosome spreads via strong paternal drive, hidden female meiotic drag, and restriction to a single copy @plosbiology.org 🧪 plos.io/4r0cJCE
A mid-stage egg chamber taken from a PSR+ female, when hybridized with a PSR probe cognate to the haploidizer gene, reveals the presence of PSR (red) in the polyploid nurse cell nuclei (NCN), the oocyte nucleus (ON) (B′), and somatic follicle cells (FCs) (B″). rDNA is shown in blue, and DNA is gray. Scale bar equals 15 μM. (B′) and (B″) are shown in higher magnification. The white arrow in (B′) indicates the single copy of PSR in the chromatin body of the germinal vesicle.
Selfish B chromosomes can spread via super- #Mendelian transmission, but this can be limited by forces like drag. This study shows that jewel #wasp PSR #chromosome spreads via strong paternal drive, hidden female meiotic drag, and restriction to a single copy @plosbiology.org 🧪 plos.io/4r0cJCE
A mid-stage egg chamber taken from a PSR+ female, when hybridized with a PSR probe cognate to the haploidizer gene, reveals the presence of PSR (red) in the polyploid nurse cell nuclei (NCN), the oocyte nucleus (ON) (B′), and somatic follicle cells (FCs) (B″). rDNA is shown in blue, and DNA is gray. Scale bar equals 15 μM. (B′) and (B″) are shown in higher magnification. The white arrow in (B′) indicates the single copy of PSR in the chromatin body of the germinal vesicle.
Selfish B chromosomes can spread via super- #Mendelian transmission, but this can be limited by forces like drag. This study shows that jewel #wasp PSR #chromosome spreads via strong paternal drive, hidden female meiotic drag, and restriction to a single copy @plosbiology.org 🧪 plos.io/4r0cJCE
Ancestral Sequence Reconstruction Reveals CTP-dependent Loading of the Bacterial Centromere-binding Protein ParB as an Ancient Evolutionary Feature
#microbiology #bacteria #chromosome #evolution #MicroSky
www.sciencedirect.com/science/arti...
bsky.app/profile/did:...
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#SUN #JUN #EASTERN WU
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#MAHANE #YEHUDA #MARKET
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#RING #CHROMOSOME
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#Condensin II collaborates with #cohesin to establish and maintain #interphase #chromosome territories, say Takao Ono, Tatsuya Hirano (Riken) and colleagues: rupress.org/jcb/article/...
#CellCycle #Biochemistry #Chromatin
In @jcb.org, Takao Ono, Tatsuya Hirano et al. show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. rupress.org/jcb/article/...
#CellCycle #Chromatin
Takao Ono, Tatsuya Hirano et al. show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. rupress.org/jcb/article/...
#CellCycle #Biochemistry #Chromatin
Left: Example images of colonies from gain-and-loss rate experiments after 12 days at 25°C. Cells derived from an aneuploid parent (top, green) and colonies derived from a euploid parent (bottom, magenta) each showing one progeny colony (indicated by an arrow) that converted in morphology bias. Bar indicates 10 mm. Conversion in morphology bias was used as a proxy for converting in ploidy. Right: Rapid gain and loss of Chr7 aneuploidy may increase phenotypic diversity. Summary scheme of the authors' data, suggesting that rapid gain and loss of the Chr7 aneuploidy may benefit Histoplasma by rapidly increasing phenotypic diversity, helping populations survive frequent and abrupt transitions between environment and host. Histoplasma grows as yeast in the mammalian body and in the laboratory when grown at 37°C, but as hyphae in the environment or in the laboratory when grown at 25°C. Cells with a second copy of chromosome 7 are biased towards hyphal growth and outcompete euploid cells in the yeast-to-hyphal transition (black arrows). Euploid cells (with one copy of each chromosome) are biased towards yeast growth and outcompete in the hyphal to yeast transition (black arrows). Cells frequently gain and lose a second copy of Chr7 (gray arrows). Cells with one copy of Chr7 have increased virulence in comparison to cells with two copies of the chromosome. Cells with two copies of Chr7 have a hyphal-biased transcriptome as do cells with increased copy number of HYF1, a TF on Chr7.
Thermally dimorphic #fungi like #Histoplasma switch between environmental filamentous & host-associated #yeast forms. This study shows that a rapidly reversible duplication of a #chromosome alters the efficiency of this switch, reducing virulence @plosbiology.org 🧪 plos.io/4qCC9Gf
Left: Example images of colonies from gain-and-loss rate experiments after 12 days at 25°C. Cells derived from an aneuploid parent (top, green) and colonies derived from a euploid parent (bottom, magenta) each showing one progeny colony (indicated by an arrow) that converted in morphology bias. Bar indicates 10 mm. Conversion in morphology bias was used as a proxy for converting in ploidy. Right: Rapid gain and loss of Chr7 aneuploidy may increase phenotypic diversity. Summary scheme of the authors' data, suggesting that rapid gain and loss of the Chr7 aneuploidy may benefit Histoplasma by rapidly increasing phenotypic diversity, helping populations survive frequent and abrupt transitions between environment and host. Histoplasma grows as yeast in the mammalian body and in the laboratory when grown at 37°C, but as hyphae in the environment or in the laboratory when grown at 25°C. Cells with a second copy of chromosome 7 are biased towards hyphal growth and outcompete euploid cells in the yeast-to-hyphal transition (black arrows). Euploid cells (with one copy of each chromosome) are biased towards yeast growth and outcompete in the hyphal to yeast transition (black arrows). Cells frequently gain and lose a second copy of Chr7 (gray arrows). Cells with one copy of Chr7 have increased virulence in comparison to cells with two copies of the chromosome. Cells with two copies of Chr7 have a hyphal-biased transcriptome as do cells with increased copy number of HYF1, a TF on Chr7.
Thermally dimorphic #fungi like #Histoplasma switch between environmental filamentous & host-associated #yeast forms. This study shows that a rapidly reversible duplication of a #chromosome alters the efficiency of this switch, reducing virulence @plosbiology.org 🧪 plos.io/4qCC9Gf
Left: Example images of colonies from gain-and-loss rate experiments after 12 days at 25°C. Cells derived from an aneuploid parent (top, green) and colonies derived from a euploid parent (bottom, magenta) each showing one progeny colony (indicated by an arrow) that converted in morphology bias. Bar indicates 10 mm. Conversion in morphology bias was used as a proxy for converting in ploidy. Right: Rapid gain and loss of Chr7 aneuploidy may increase phenotypic diversity. Summary scheme of the authors' data, suggesting that rapid gain and loss of the Chr7 aneuploidy may benefit Histoplasma by rapidly increasing phenotypic diversity, helping populations survive frequent and abrupt transitions between environment and host. Histoplasma grows as yeast in the mammalian body and in the laboratory when grown at 37°C, but as hyphae in the environment or in the laboratory when grown at 25°C. Cells with a second copy of chromosome 7 are biased towards hyphal growth and outcompete euploid cells in the yeast-to-hyphal transition (black arrows). Euploid cells (with one copy of each chromosome) are biased towards yeast growth and outcompete in the hyphal to yeast transition (black arrows). Cells frequently gain and lose a second copy of Chr7 (gray arrows). Cells with one copy of Chr7 have increased virulence in comparison to cells with two copies of the chromosome. Cells with two copies of Chr7 have a hyphal-biased transcriptome as do cells with increased copy number of HYF1, a TF on Chr7.
Thermally dimorphic #fungi like #Histoplasma switch between environmental filamentous & host-associated #yeast forms. This study shows that a rapidly reversible duplication of a #chromosome alters the efficiency of this switch, reducing virulence @plosbiology.org 🧪 plos.io/4qCC9Gf
Counting chromosomes: 1, 2, 3! 🧬 Scientists performed the first #chromosome count for Jaffa Scabious (𝘊𝘦𝘱𝘩𝘢𝘭𝘢𝘳𝘪𝘢 𝘫𝘰𝘱𝘱𝘦𝘯𝘴𝘪𝘴), a cryptogenic #species, and two hawkweeds: 𝘏𝘪𝘦𝘳𝘢𝘤𝘪𝘶𝘮 𝘢𝘤𝘢𝘯𝘵𝘩𝘰𝘥𝘰𝘯𝘵𝘰𝘪𝘥𝘦𝘴 (endemic to Central and Southern Italy) and 𝘏. 𝘱𝘶𝘭𝘤𝘩𝘦𝘭𝘭𝘶𝘮. See the study here:
doi.org/10.3897/ital...
Led by Anthony Barley and co. (not on Bsky?). Some interesting results here from a genomic perspective - (1) tree topology varies spatially across the chromosomes and (2) #chromosome length (macro vs micro) is correlated with magnitude of divergence and introgression level. Lizard genomes are cool!
⏪ G&D RECAP ⏪
🗓️ February 2025
RESEARCH PAPER: LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells
By Ataei et al. and Miguel Ramalho-Santos
➡️ https://genesdev.cshlp.org/content/39/3-4/280.full
#retrotransposons #genome #chromosome
#RING #CHROMOSOME
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#LAURA #AGUILAR
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