Antimicrobial peptides in oral medicine: From mechanisms to clinical translation | Newswise Antimicrobial peptides (AMPs) exhibit broad-spectrum antimicrobial activity, low propensity to induce bacterial resistance, and multifunctional properties including immunomodulation and tissue regener...

Antimicrobial peptides in oral medicine: From mechanisms to clinical translation
www.newswise.com/articles/ant...
#antimicrobialpeptides #clinicaltranslation

Experimental mRNA therapy shows potential to combat antibiotic-resistant bacteria – BioNews Central Researchers have reported early success with a novel mRNA-based therapy that slowed bacterial growth, boosted immune response and reduced lung tissue damage in preclinical models of multidrug-resistant pneumonia. ...

Researchers have reported early success with a novel #mRNABasedTherapy that slowed #BacterialGrowth, boosted #ImmuneResponse and reduced #LungDamage in #PreclinicalModels of #MultidrugResistant #Pneumonia.
#AntibioticResistance #Superbugs #AntimicrobialPeptides

📢 Our November issue is now online! Access the full issue 👉 www.cell.com/trends/bioch....

🎨 The cover highlights a Review from Octávio Franco and colleagues describing self-assembling #antimicrobialpeptides.

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Unlocking the specificity of antimicrobial peptide interactions for membrane-targeted therapies. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.04.022

🔗 Unlocking the specificity of antimicrobial peptide interactions for membrane-targeted therapies. doi.org/10.1016/j.cs...

📚 CSBJ Nanoscience & Advanced Materials: csbj.org/nano

#AntimicrobialPeptides #DrugDiscovery #MolecularDynamics #Biophysics #Bioinformatics #PeptideTherapeutics

📝Online now - the Review "Molecular design drives nanoarchitecture in self-assembling antimicrobial peptides" from Octavio Franco and colleagues.

#AntimicrobialPeptides #Nanostructures #PeptideBasedTherapeutics

Read it here: authors.elsevier.com/a/1lhSN3S6Gf...

Overall, TMcin behave in ways like other small #antimicrobialpeptides as a monomer but more like the much larger pore-forming proteins as oligomers.

Novel Synthesis of the Antifungal Cyclic Lipopeptide Iturin A and Its Fluorinated Analog for Structure‐Activity Relationship Studies Iturin A is an antifungal lipopeptide with a wide range of applications. In this study, we present a novel synthesis of iturin A via enantiomeric synthesis of the β-amino fatty acid and on-resin cycl...

Our new paper on the novel synthesis of fluorinated Iturin A analogues is online! Well done to my fantastic PhD student Periklis Karamanis and all other involved! #antimicrobialpeptides

doi.org/10.1002/chem...

Online now - the Review "Proteasome-derived peptides: separating the trash from the recycling" from Anna Brennan, Taylor Church, and Seth Margolis.

#peptides #antimicrobialpeptides #proteasomederivedpeptides #immunoproteasome #neuronalmembraneproteasome

authors.elsevier.com/a/1lQDv3S6Gf...

LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated responses and selectively suppress Lipocalin-2 in bronchial epithelial cells - PubMed Overall, our findings showed that LL-37 and citLL-37 can selectively suppress the abundance of IL-17A/F-mediated LCN-2, a protein that is critical for neutrophil migration in HBEC. These results sugge...

Sharing our latest publication on modulation of IL-17 mediated inflammation by #HostDefencePeptide LL-37 and citrullinated-LL-37 in the context of lung inflammation #Asthma #Immunosky #Immunomodulation #AntimicrobialPeptides pubmed.ncbi.nlm.nih.gov/40410820/

A critical view of antimicrobial peptides: exploring their potential and the barriers to realization Abstract. The global rise of multidrug-resistant infections highlights the urgent need for innovative therapeutic strategies beyond traditional antibiotics

The global rise of multidrug-resistant (MDR) infections highlights the urgent need for innovative strategies beyond traditional antibiotics. A new review in Journal of Applied Microbiology critically evaluates the therapeutic potential of #AntimicrobialPeptides. academic.oup.com/jambio/artic...

Visiting Queens University- Thanks @evakaufmann.bsky.social for the invite! Amazing two days sharing our research on #Asthma #AntimicrobialPeptides #Immunosky & meeting researchers and trainees #WomenInScience

#antimicrobialpeptides

A diagram of Toll and IMD signalling regulation across insect species, with annotations of insect orthologues for their regulation.

A comparison of protein structures for antimicrobial peptides of related gene families across insects, showing commonalities and unifying their naming conventions.

A summary of studies to date detailing the regulation of specific AMPs across insect species.

The mechanisms & regulation of insect #antimicrobialpeptides & #HDPs is of wide interest. We now appreciate their function in vivo is much more complex than what's described in vitro.

Our primer on insect AMP regulation, evolution & function.
Pub: doi.org/10.1016/B978...
🟩OA: bit.ly/MHLH2025

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Drosophila symbionts in infection: when a friend becomes an enemy | Infection and Immunity Occupying the interface between host and environment, host-associated microbes play essential roles in interactions with pathogens and influence disease progression (1–4). Considering that most entry ...

Happy to share our latest minireview on
Drosophila symbionts in infection: when a friend becomes an enemy | Infection and Immunity journals.asm.org/doi/10.1128/...
#immunity #infection #antimicrobialpeptides #microbiome #Drosophila #AcademicSky #insect #endosymbiont #symbiosis

The Drosophila Immunity Handbook cover, showing flies that are either glowing green or not. All flies are infected by a green-expressing bacteria, but only red-eyed flies glow green because those flies are missing immune genes needed for resistance to infection.

Some hashtags:

#immunity #Dros25 #Drosophila #antimicrobialpeptides #NFkB #inflammation #ImmunoSky #Infection #pathogen

And if you want to learn more about these modules and how you could incorporate them in your research, check our our free book: "The Drosophila Immunity Handbook"
bit.ly/3z429p5

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Very interesting #AntimicrobialPeptides #HostDefencePeptides www.nature.com/articles/s41...

Thank you goes out to amazing collaborators Marcus Fletcher, Kareem Al Nahas, John Connolly, Niels Röckendorf, Dominik Schwudke and many more supporters and to the Phospholipid Research Center Heidelberg for funding our project on #liposomes, #antimicrobialPeptides and #microfluidics!

Full list of Antimicrobial Peptide #Feed hashtags:

#AMPs
#HDPs
#AntimicrobialPeptides
#AntimicrobialPeptide
#HostDefensePeptide
#HostDefencePeptide
#HostDefensePeptides
#HostDefencePeptides
#GRCAMP2025

(last updated Feb 27th 2025)

For attendees of #GRCAMP2025, interested in #AntimicrobialPeptides / #AMPs, or #HostDefencePeptides / #HDPs, I've made a Feed to collect posts using these (and other) hashtags! 📣 🧬

bsky.app/profile/hans...

If you use hashtags in the Feed description list, your posts will be included in this Feed 🙂

Adding #GRCAMP2025 which will send this post and replies to my new #AntimicrobialPeptides feed: bsky.app/profile/hans...

Using any of hashtags in Feed description will automatically send those posts to the Feed in the future. And one can reply with any of those hashtags to get a post sent to it.

Thank you @verndolinsky.bsky.social for the invite. It was a wonderful engaging audience at the Pharmacology seminar series - lots of great questions about the utility of #HostDefencePeptides #AntimicrobialPeptides as therapeutics.

Available online - the Spotlight "Journey to the past: #MolecularDeextinction enables the discovery of ancient β-#defensins and highlights their evolutionary history" from @fgosti.bsky.social.

#moleculardynamicsimulation #genomemining #antimicrobialpeptides

authors.elsevier.com/a/1kK%7EK3S6...

🚨 Review Preprint Alert 🚨
Discover how computational and experimental tools are employed in antimicrobial peptide (AMP) research for combating bacteria.
Great Collaboration with Eggeling and Gutsmann Labs
Read now on chemRxiv
#AntimicrobialPeptides #membranes @fau.de
chemrxiv.org/engage/chemr...

Hello all! I am Dr. Neeloffer Mookherjee, research interests include immunity-related functions of #HostDefencePeptides #AntimicrobialPeptides Regulation of Inflammation in chronic disease #Asthma & #Arthritis Let’s talk science!

Emergent conformational and aggregation properties of synergistic antimicrobial peptide combinations Synergy between antimicrobial peptides (AMPs) may be the key to their evolutionary success and could be exploited to develop more potent antibacterial agents. One of the factors thought to be essentia...

Final published version of Miruna and Chris' (and my) first study using machine learning to identify behaviour of #antimicrobialpeptides that only emerges when used in combinations. Is this a key property that keeps AMPs effective throughout evolutionary history? pubs.rsc.org/en/content/a...

A Nonsecretory Antimicrobial Peptide Mediates Inflammatory Organ Damage in Drosophila Renal Tubules bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

New on my "to-read" list: #AntimicrobialPeptides (AMPs or HDPs) are key to fight infections. But there's a building literature on their knock-on effects. This study proposes the AMP "Attacin D" is actually autotoxic, damaging #Drosophila kidneys (MTs) when induced.

www.biorxiv.org/content/10.1...

Stay tuned for more studies as I head into the final year of my PhD! 🎓 #PhD #hostdefencepeptides #antimicrobialpeptides #AcademicTwitter @academic-chatter.bsky.social