Fast-forward a decade (!) of sample collection and analysis, and immune status distinguishes patients compared to healthy controls (AUC 0.83), with CD38+ #Tcells elevated and memory #Bcells way down.

This shared phenotype suggests this *is* a distinct condition, not diverse undiagnosed patients

Historic 1994 influenza vaccine cohorts define breadth of antibody and B cell responses toward future influenza A and B viruses B cell responses that bound to future H1N1 and influenza B virus strains, but not H3N2 strains, were elicited in adults by the 1994 influenza vaccine.

A study from the Doherty Institute has shown that seasonal #influenza vaccination primes the #immune system to respond to future strains, some that emerge decades later. #Antibodies & #Bcells were able to recognize future #viruses including #H1N1 & influenza B.
www.science.org/doi/10.1126/...

Congratulations to Shaila Sachdev for defending her undergraduate Honors Thesis on human early-life B cells and receiving the Highest Honors! @emoryuniversity.bsky.social

Shaila made exciting discoveries about the signaling required to activate or inhibit human #early-life #Bcells.
#BYourCell

Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade Nature Medicine - Transcriptomic and clinical data analyses from multiple cohorts of patients with cancer receiving immunotherapy find that PD-1 blockade potentiates tumor-specific IgG1 plasma cell...

New research in @natmed.nature.com reveals IgG1 producing #Bcells are key to cancer #immunotherapy success. Data from 2k+ patients show these cells coordinate with T-cells to drive anti-tumor immunity. A shift toward humoral-cellular strategies could transform outcomes.

rdcu.be/e90xd

In vivo treatment with 1C5 prolongs skin allograft survival. Left: Schematic representation of the experimental procedures. Right: Wild-type C57BL/6 mice were i.p. injected 4 times with 250 µg 1C5 or C6 once in a week, followed by transplantation of ear skin from BALB/c mice. CyA (20 mg/kg) was injected every day after transplantation until the graft was rejected. Alloreactive IgG in sera was measured by FCM (top right). Mean ± SD are shown (n = 5). Data were analyzed by two-way ANOVA with Šidák multiple comparison test. Bottom right: graft survival curves (n = 20) are shown.

Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @plosbiology.org 🧪 plos.io/41t4KTS

In vivo treatment with 1C5 prolongs skin allograft survival. Left: Schematic representation of the experimental procedures. Right: Wild-type C57BL/6 mice were i.p. injected 4 times with 250 µg 1C5 or C6 once in a week, followed by transplantation of ear skin from BALB/c mice. CyA (20 mg/kg) was injected every day after transplantation until the graft was rejected. Alloreactive IgG in sera was measured by FCM (top right). Mean ± SD are shown (n = 5). Data were analyzed by two-way ANOVA with Šidák multiple comparison test. Bottom right: graft survival curves (n = 20) are shown.

Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @plosbiology.org 🧪 plos.io/41t4KTS

In vivo treatment with 1C5 prolongs skin allograft survival. Left: Schematic representation of the experimental procedures. Right: Wild-type C57BL/6 mice were i.p. injected 4 times with 250 µg 1C5 or C6 once in a week, followed by transplantation of ear skin from BALB/c mice. CyA (20 mg/kg) was injected every day after transplantation until the graft was rejected. Alloreactive IgG in sera was measured by FCM (top right). Mean ± SD are shown (n = 5). Data were analyzed by two-way ANOVA with Šidák multiple comparison test. Bottom right: graft survival curves (n = 20) are shown.

Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @plosbiology.org 🧪 plos.io/41t4KTS

IFN-gene signatures in #Bcells following #influenza A and B virus infection and influenza #vaccination 👉 doi.org/10.1038/s44321-026-00395-8

By W. Zhang, @katherinekedz.bsky.social , T. Nguyen & colleagues @unimelb.edu.au @thedohertyinst.bsky.social

A study, published in 2008, took blood samples from 32 participants 91-102 years old, aged between 2 and 12 during the 1918 #flu #pandemic.
Did they have #antibodies and #Bcells against 1918 pandemic flu?

read this very interesting 🧵⬇️

🩸 Additional insights on myeloma biology and microenvironment

#MultipleMyeloma #EquilibriumPhase #Immunotherapy #HEMEHUB #EscapePhase #PD1 #CTLA4 #BCells #HemeOnc #Hematology

The virus nearly everyone has and its possible role in MS | The-14 Nearly everyone carries Epstein-Barr virus, but research suggests it may trigger multiple sclerosis, opening new paths for prevention and treatment.

The virus nearly everyone has and its possible role in MS
#Health #MultipleSclerosis #MS #EpsteinBarrVirus #EBV #Neurology #Immunology #BrainHealth #Autoimmune #Science #PublicHealth #Inflammation #BCells #TCells #Healthcare #DiseasePrevention
the-14.com/the-virus-ne...

An Anaphylaxis Reaction from Rituximab in Between Shady Years My doctor and I had tried 10 or more immunosuppressants for my Lupus to no avail. Rituximab was next, but I had an anaphylaxis reaction to it.

" #Rituximab is a biological agent (derived from organic sources) that targets #BCells. It was 1st created to treat cancer, namely lymphoma..Now, it is often used off-label to treat other #medical conditions, such as treatment-resistant #Lupus.": buff.ly/6RFNWrx

#AutoimmuneDisease #ChronicIllness

B cells drive CD4 T cell immunosenescence and age-associated health decline B cells promote CD4 T cell aging and decline in health-span parameters through intercellular communication and nutrient sensing.

This Science Immunology article talks about the #aging immune system!

The Winer lab at @utoronto.ca showed how #Bcells affect #Tcell aging.

📃 https://bit.ly/4aDfEuK
🎤 https://bit.ly/4kEDz1s

natural adenovirus infection
,an adenovirus protein triggers “rogue” antibodies in unlucky people with combination of genetic background a particular mutation in their antibody producing #Bcells. Instead of targeting a viral protein, the rogue antibodies bind to PF4, setting off a dangerous cascade.

T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response - Nature Cell Biology Scourzic et al. show that germinal centre B cells display an enhanced ability to reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher plasticity ...

☕Scourzic et al. showed that germinal centre #Bcells display an enhanced ability to #reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher #plasticity level and is T follicular helper cell-dependent.
👉https://rdcu.be/e2Wxm
bit.ly/4aDyDWY

B Cells and Plasma Cells: Fundamental and Translational Biology | Keystone Symposia Join us at the Keystone Symposia on B Cells and Plasma Cells: Fundamental and Translational Biology, March 2026, in Keystone, with field leaders!

Poster deadline is approaching for @keystoneSymposia.bsky.social #BCells & #PlasmaCells : Fundamental & Translational Biology, this March in Keystone! keysym.us/KSBCells26 #KSBCells26

that uses immune cells from healthy donors to target and destroy EBV-infected #Bcells

🧨Mechanisms Linking EBV, B Cells & Demyelination
- human evidence , myelin-reactive #Bcells in the healthy human repertoire &’ observed LMP1 expression in the brain lesions of a subset of MS patients.
-EBV preferentially infects B lymphocytes,

B-cell antigen presentation in central nervous system autoimmunity The role of B cells in central nervous system (CNS) autoimmunity was initially highlighted by successful clinical trials of anti-CD20 monoclonal antib…

activation antigens,
adhesion molecules & components of the antigen processing pathway,thereby enhancing the antigen-presenting capacity of #Bcells .
This upregulation can lead to increased presentation of self-antigens, including myelin proteins, to T cells

www.sciencedirect.com/science/arti...

which allows these B cells to survive .Once rescued, these B cells initiate inflammatory demyelination through B cell-receptor or antibody-dependent mechanisms & participate in inflammatory demyelination
#Bcells are implicated in the #pathogenesis of MS,

the viral protein latent membrane protein 1 (LMP1) trigger demyelinating lesions . Normally, these antigen-loaded #Bcells do not traffic to draining lymph nodes & without T cell help, die rapidly.
However, this checkpoint can be overridden by CD40L signaling or by the expression of EBV ‘s LMP1 ,

Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation Myelin-reactive B cells entering the central nervous system capture cognate antigen from the parenchyma. Without T cell help, they rapidly die; however, Epstein-Barr virus LMP1 enables them to bypass ...

#Medsky🧪 #IDsky #immunosky #neurosky #publichealth This study established a mechanistic link between #EpsteinBarrvirus (EBV)- #multiplesclerosis (MS), demonstrating how #Bcells expressing
@cellpress.bsky.social

www.cell.com/cell/fulltex...

Multi-omics identifies lipid accumulation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cell lines: a case-control study - Journal of Translational Medicine Background In recent years, evidence has indicated a metabolic shift towards increased demand for lipids in various lymphoid cell populations from people with Myalgic Encephalomyelitis/Chronic Fatigue...

#Medsky🧪 #publichealth @bmc.springernature.com The study found that samples derived from ME/CFS #Bcells hold more fats. The findings suggest a metabolic shift in ME/CFS lymphoid cells towards increased lipid demand or defective degradation.

link.springer.com/article/10.1...

Online today -> A viral glycoprotein targets IgG+ memory #Bcells to mediate humoral #ImmuneEvasion

by P. Cramer, M. Rizzi, H. Hengel and colleagues @uni-freiburg.de @univie.ac.at
🗞️ doi.org/10.1038/s443...

🎆 Happy new year and our first 2026 issue is out!
Cover: #epiblast development

👉Perspective: biological clocks
👉Review: #mitosis #CellDeath #inflammation
🔬 #chromatin #cancer #Bcells #Tcells #autophagy #organoids #mechanobiology #TranscriptionFactors #Xist & more!

www.nature.com/ncb/volumes/...

He later continued with more research into #ClonalSelection of antibodies, the cross-talk between #BCells and #TCells and more. The importance of his discoveries cannot be overstated, and his discoveries laid foundations for modern #immunology.

a process essential for antibody diversification through somatic hypermutation (SHM), class switch recombination (CSR), and gene conversion (GC) in germinal center #Bcells. AID is normally expressed in activated B cells within germinal centers and is tightly regulated to prevent unwanted mutations .

Alzheimer's disease patients have fewer transitional B cells, and in particular they have fewer of the immature transitional B cell compartment.

It does rather seem an emerging theme that #Bcells are associated with #neuroinflammation, such as the huge success of B cell depletion in #MS. 4/8

Watch the Tackling Iron Deficiency video on YouTube: youtu.be/frJ9iCjOYiM?...

#WIMMCommunity #Immunology #IronMetabolism #BCells #AntibodyResponse

Lupus may be triggered by a common virus – new research | The-14 New research suggests Epstein-Barr virus may trigger lupus by reprogramming B cells, increasing autoantibodies, and offering new paths for prevention worldwide.

Lupus may be triggered by a common virus – new research
#Health #Lupus #EBV #EpsteinBarrVirus #BCells #AutoimmuneDisease #HealthNews #MedicalResearch #ImmuneSystem #VirusStudy #ChronicIllness #GlobalHealth #The14 #The14Media
the-14.com/lupus-may-be...