🚀💭Today’s questions!
Swipe to see the answers and explanations!
#CMML #ChronicMyelomonocyticLeukemia #Hematology #HemeOnc #MedEd #MedicalEducation #HematologyEducation #MyeloidNeoplasms #ClonalHematopoiesis #ASXL1 #TET2 #SRSF2 #BoneMarrowFailure #HemeCases #ClinicalHematology #HEMEHUB
🩸🔍First question of the month!
Swipe to see the answer and its explanation.
#CMML #ChronicMyelomonocyticLeukemia #Hematology #MyeloidNeoplasms #ClonalHematopoiesis #CHIP #TET2 #SRSF2 #ASXL1 #BoneMarrow #Monocytosis #FlowCytometry #HematologicMalignancies #HemeEd #HemeHub #BloodCancer
🩸Facts about Chronic Myelomonocytic Leukemia:
Disease Biology & Pathogenesis
#CMML #MDS #MPN #Hematology #HematologicMalignancies #ClonalHematopoiesis #CHIP #TET2 #SRSF2 #ASXL1 #MyeloidNeoplasms #MedEd #HemeEd #HemeHub #BloodCancer #MyeloidDisorders #ClinicalHematology
JAMA Cardiology 'Research Letter' on 'Clonal Hematopoiesis and Risk of Incident Pericarditis and Myocarditis in 2 US Biobank Cohorts' by Yash Pershad@1, Kun Zhao@1, J. Brett Heimlich, et al. Published Online: March 18, 2026.
Among adults in two US biobanks, #ClonalHematopoiesis of indeterminate potential was associated with increased risk of incident #Pericarditis, but not #Myocarditis, supporting gene-driven inflammation as a therapeutic target.
ja.ma/4bw3Pqs
Research co-led by MSK scientists found a gene variant that may reduce the risk of developing certain #bloodcancers associated with #clonalhematopoiesis. Learn more about how @mskcancercenter.bsky.social is leading the way in CH research and treatment.
Also check out our CH clinic: bit.ly/49szicf
🙌 We’re excited to announce Lexicon for #ClonalHematopoiesis in #LiquidBiopsy, the first paper from our CH/CHIP Working Group. This lexicon standardizes terminology to improve communication and consistency in liquid biopsy research and clinical use.
🔗 Read more: bit.ly/BP-CH-lexicon
Wow!! 🔥🔥 CDK4/6 inhibition prevents selection of #ClonalHematopoiesis with DNA-damage repair mutations after chemotherapy! Awesome presentation from Irenaeus Chan from @kellybolton.bsky.social lab! #ASH25
🚨 Excited to share our paper 📢 @natcomms.nature.com
We reveal how inflammation reshapes the human #bonemarrow niche 🦴, home of 🩸 stem cells, in the context of #clonalhematopoiesis and #myelodysplasia
An amazing journey with fantastic colleagues and collaborators, thank you all!
shorturl.at/ad0st
Published in @jci.org, UF Health Cancer Center researchers have found that #ClonalHematopoiesis promotes #obesity and metabolic disease: go.ufl.edu/tbrz64w
Clonal hematopoiesis (CH) is the age-related expansion of mutated blood stem cell clones that increases the risk of blood cancer. A recent publication shows that #IL1RAP isn’t just a marker of CH, it appears to drive it.
lnkd.in/eaCzJUwM
#ClonalHematopoiesis #AML #DrugTarget #CancerPrevention
Co-led with the always awesome @mingxiangteng.bsky.social with data from the #ORIENNetwork #AsterInsights and @moffittnews.bsky.social. #clonalhematopoiesis #CHIPsm
#ClonalHematopoiesis / #CHIP is associated with worse survival in pts treated for solid cancers, but the evolutionary mechanisms driving differential CH dynamics are unknown. To get at this, we calculated therapeutic bottleneck sizes in pts treated for cancer.
1,157 people with TP53-CHIP from BioBankJapan followed over a decade (vs 140,000 controls), TP53-CHIP associated with myeloid, lymphoid neoplasms, respiratory disease mortality. The impact is modulated by lifestyle (smoking and drinking). Stay healthy!
#clonalhematopoiesis
doi.org/10.1158/2643...
For older males who are frequent #blood donors, the frequency of #ClonalHematopoiesis was not found to differ from that seen in sporadic blood donors, but their #hematopoietic stem cells did show a distinct pattern of mutations in #DNMT3A: ow.ly/xaXZ50VM8WS
#HemeSky
Grateful to @nature.com.web.brid.gy editors & reviewers for valuable guidance 🙏
Special thanks to our fantastic Starczynowski lab team👨🔬👩🔬
#Nature #CincyChildrens #CincyResearch #Aging #Leukemia #AML #MDS #ClonalHematopoiesis #hematopoiesis #Hematology #Oncology #GutHealth #microbiota #microbiome
Excited to see this work on #clonalhematopoiesis in #telomere disorders led by @daria-babushok.bsky.social @pennmedicine.bsky.social in @jclinical-invest.bsky.social - ATM mutations commonly observed. ATM-dependent DDR from telomere dysfunction key in disease pathogenesis www.jci.org/articles/vie...
We integrated data from 713 individuals across 3 longitudinal aging cohorts (2,341 observations total) and developed models to understand the dynamics of CH mutations over time. #CancerResearch #ClonalHematopoiesis
Delighted to share my PhD thesis work is now published in @nature.com! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynmics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis
www.nature.com/articles/s41...
@ganuzalab.bsky.social
Exciting new work from my former trainee, Mikel Ganuza, now running his own excellent team. Congrats!
#HSCs #clonalhematopoiesis
#science
www.nature.com/articles/s41...
Very nice talk from Austin Kulasekararaj from King’s College London on #ClonalHematopoiesis from the the EBMT RACE trial. #BMFsm #ASH24 @ash-hematology.bsky.social
Amazing talk from Fernanda Gutierrez-Rodrigues showing our lab’s work on #ClonalHematopoiesis over 10+ years after IST. We saw long-term clonal persistence of ASXL1 and PIGA. #ASH24 @ash-hematology.bsky.social
A nice commentary in this issue of @bloodjournal.bsky.social for our paper looking at the role of #ClonalHematopoiesis in #TBD from Chris Reilly and Mikko Myllymaki - a somatic symphony; telomeres and CH! ashpublications.org/blood/articl...
First post on BlueSky! We are celebrating a fabulous seed grant Frieda Zimmer MD earned to support her new studies in #clonalhematopoiesis. Excited for the collaborative work to come!
#ClinicalReviews on #ClonalHematopoiesis
www.jci.org/review_serie...
Clonal hematopoiesis is associated with numerous human diseases and conditions. Figure adapted from ref. 3 with permission.
Highlight
#MedSky🧪#ImmunoSky #Cellbiology In #clonalhematopoiesis , HSPCs acquire somatic mutations that drive clone growth. Though CH occurs without overt hematological changes, it influences disease pathogenesis. From #Cancer to #CVD & the ramifications of CH
www.jci.org/articles/vie...
#ClonalHematopoiesis #AorticAneurysm
#AortaEd
CH driver gene JAK2 V617F could be causal to #Aortopathy 😎
Mainly a role in Myeloid cells
See the intriguing Mo/Mφ population shift b/w dilated & aneurysmal LysM-Cre:JAK2 V617F WT/Flex aortas😁
#NatureComms 2022
www.nature.com/articles/s41...
Genetic Architecture of Human #TelomereLength 🤠
N>460K #UKbiobank
TL: qPCR+Telseq (WGS, coverage-adjusted)➡️
PC1 TL surrogate; PC2 artefactual signal➡️
new GWAS common variants
ExWAS rare variants
Plasma Proteomics
#ClonalHematopoiesis driver genes
#NatureGenet 2024
www.nature.com/articles/s41...
Clonal hematopoiesis drives femoral atherosclerosis in middle-aged adults 🔬❤️📊 www.news-medical.net/news/2024090... #CardiovascularResearch #Atherosclerosis #ClonalHematopoiesis #GeneticMutations #DNMT3A #TET2 #Heart #MiddleAge #PreventiveMedicine #Health
