Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection Neuroimmune interactions shape host responses to infection, but the molecular role of sensory neurons during viral infection remains unclear. Roger et al. show that HSV-1-activated sensory neurons pro...

#EveryCellIsAnImmuneCell! Ugolini, Roger &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 activates sensory #neurons that produce the neuropeptide SP to limit neutrophil influx, & TAFA4 that drives IL-10 by macrophages, overall fostering disease tolerance!

Valentine’s passed… but your lip acting up?

Lip tingling, irritation, or blisters may be signs of a #coldsores (HSV-1). VirtualCare2Go provides convenient telehealth visits with medical evaluation & treatment options to support faster healing.

#HSV1 #Telehealth #VirtualHealthcare #OnlineCare

Valentine’s has passed, but that tingle might not have.

#Coldsores ( #HSV1 ) often begin with tingling or burning before lip blisters appear. Z-2-H provides evaluation & treatment to help shorten outbreaks & ease symptoms. Care early. Heal sooner.

#OralHerpes #LipHealth #TexasHealth#WalkInClinic

Two recent singles by RANCID CHAMBER (aus) 🤮 Youtube link to each single beneath ⬇️ #RancidChamber #deathmetal #deathmetalsky #ResinBomb #brutaldeathmetal #metalsky #Australia #newmusic #art #heavymetal #hsv1 #music

HSV - 1
www.youtube.com/watch?v=048x...

Resin Bomb
www.youtube.com/watch?v=nqdy...

📰New & Featured | A new #Cell study reports how the helicase-primase (H/P) complex of #HSV1 can be structurally inhibited
🧐Explains #antiviral potency and resistance mechanisms
💡Opens new avenues for next-generation anti-HSV therapies
#HelicasePrimaseComplex #UL30

This study shows that novel #NucleotideAnalog #prodrugs—especially ODE-(S)-HPMPA formate—exert markedly stronger anti-orthopoxvirus activity than #Brincidofovir and display differential potency against #HSV1 and #adenovirus. @fudan-university.bsky.social

#STTT: doi.org/10.1038/s413...

One other recent RIP work is www.nature.com/articles/s41..., a paper that describes how viruses like #HSV1 and #InfluenzaA disrupt transcription, resulting in the expression of #ZRNA (a unique form of RNA), and that leads to #CellDeath, which is believed to be an #antiviral mechanism of the host.

Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation Wang et al. find that cell membrane stress upon viral infection induces expression and stabilization of host sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B), which, in turn, degrades cGAMP to s...

#WeekendRead! #FriendOrFoes?! Zhang &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 exploits changes in membrane integrity to activate a GPI-anchored hydrolase which degrades cGAMP preventing #cGAS/#STING activation & favoring virus infection

www.cell.com/immunity/ful...

Client Challenge

#DAMPsPower! Balachandran, Yin &co show @nature.com that upon influenza #IAV or herpes #HSV1 virus infection, ZBP1 induces cell death by sensing #host-derived endogenous retroelement Z-RNAs produced in response to virulence factors! www.nature.com/articles/s41...

Researchers are repurposing the herpes simplex virus (HSV-1)—long associated with cold sores—into a revolutionary oncolytic virus that directly attacks cancer.

#CancerResearch #OncolyticVirus #HSV1 #Immunotherapy #MedicalBreakthrough

Herpes: Alpaka-Nanoteilchen sollen Infektionen verhindern Forschenden in Hamburg und Göttingen ist es gelungen, einen Mini-Antikörper zu finden, mit dem ein Protein ausgeschaltet werden kann, das für die Infektion essenziell ist

Das #Herpes Simplex #Virus Typ 1 kann für immunschwache Menschen durchaus lebensgefährlich sein. Ein von Forschern des @leibnizliv.bsky.social, @uni-hamburg.de, UKE, @cssbhamburg.bsky.social und @mpi-nat.bsky.social neu entdeckter Antikörper könnte die #Infektion verhindern. #HSV1

Uncovering Cryptic Genes: Functional Dissection of HSV-1 UL31.6 as a Neuron-Specific Virulence Factor September 16, 2025 Akihisa Kato, Ph.D., The Institute of Medical Science, University of Tokyo (IMSUT) Yasushi Kawaguchi, Ph.D., The Institute of Medical Science, University of Tokyo (IMSUT) Anna Cliffe, Ph.D. (moderator), University of Virginia School of Medicine Felicia Goodrum, Ph.D. (host), Co-Editor in Chief, Journal of Virology, Geisel School of Medicine at Dartmouth

Think #HSV1 has no more secrets? 🧠 Think again. Join our free #virology webinar Sept. 16 to hear how a “silent” HSV-1 gene—UL31.6—has surprising neurovirulence effects.

📅 10 a.m. ET / 7:30 p.m. IST

🔗 Register: asm.social/2yH

Cases throughout the year: biphasic 5-30 yo & >50 yo. #HSV1 causes 95% cases. Most sensitive non-invasive test csf PCR (may initially be negative but becomes positive on or after day 4)

Epigenetics News – Herpes virus plays interior designer with human DNA bit.ly/45AApX2

Research from Maria Pia Cosma (CRG, Barcelona) reported in Nat Commun

#Epigenetics #News #HSV1 #Chromatin
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Empower your research with high-res epigenetic insights at epigenometech.com

HSV-1 Reshapes Host Chromatin Architecture Via Transcription Machinery Hijacking - Nature Communications Herpes simplex virus type 1 (HSV-1) remodels the host chromatin structure and induces a host-to-virus transcriptional switch during lytic infection. We combine super-resolution imaging and chromosome-capture technologies to identify the mechanism of remodeling. We show that the host chromatin undergoes massive condensation caused by the hijacking of RNA polymerase II (RNAP II) and topoisomerase I (TOP1). In addition, HSV-1 infection results in the rearrangement of topologically associating domains and loops, although the A/B compartments are maintained in the host. The position of viral genomes and their association with RNAP II and cohesin is determined nanometrically.   We reveal specific host–HSV-1 genome interactions and enrichment of upregulated human genes in the most contacting regions. Finally, TOP1 inhibition fully blocks HSV-1 infection, suggesting possible antiviral strategies. This viral mechanism of host chromatin rewiring sheds light on the role of transcription in chromatin architecture. Here, the authors show how HSV-1 rewires the host cell’s chromatin architecture during lytic infection by hijacking transcription machinery and forming contacts between viral and host genomes.   Published in Nature Comm. (June 19, 2025): https://doi.org/10.1038/s41467-025-60534-6   

The virus hijacks the host RNA polymerase II (RNAP II) and topoisomerase I (TOP1) proteins to condensate host chromatin, shutting down host transcription and promoting transcription of viral genes. #HSV1 #chromatin

#Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types #CMV #HSV1 #VZV #EBV #MECFS #LongCovid

bsky.app/profile/rene...

Repurposing cancer drug to treat neuroinflammation #TOP1 #topotecan #MECFS #LongCovid #HSV #HSV1 #EBV

bsky.app/profile/rene...

Herpes virus reshapes the human genome for its own benefit, but a single enzyme can stop it #HSV #HSV1 #TOP1 #MECFS #LongCovid

bsky.app/profile/rene...

Repurposing cancer drug to treat neuroinflammation The repurposing of FDA-approved drugs for alternative diseases is a faster way of bringing new treatments into the clinic. Researchers at Karolinska Institutet have repurposed a cancer drug for treatm...

Repurposing cancer drug to treat neuroinflammation #TOP1 #topotecan #MECFS #LongCovid #HSV #HSV1 #EBV

news.ki.se/repurposing-...

Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking - Nature Communications Here, the authors show how HSV-1 rewires the host cell’s chromatin architecture during lytic infection by hijacking transcription machinery and forming contacts between viral and host genomes.

www.nature.com/articles/s41...

"Finally, TOP1 inhibition fully blocks #HSV1 infection, suggesting possible antiviral strategies."

"This viral mechanism of host chromatin rewiring sheds light on the role of transcription in chromatin architecture."

Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking - Nature Communications Here, the authors show how HSV-1 rewires the host cell’s chromatin architecture during lytic infection by hijacking transcription machinery and forming contacts between viral and host genomes.

www.nature.com/articles/s41...

"Herpes simplex virus type 1 ( #HSV1) remodels the host chromatin structure and induces a host-to-virus transcriptional switch during lytic infection."

Herpes virus reshapes the human genome for its own benefit, but a single enzyme can stop it Viruses are entirely dependent on their hosts to reproduce. They ransack living cells for parts and energy and hijack the host's cellular machinery to make new copies of themselves. Herpes simplex vir...

Herpes virus reshapes the human genome for its own benefit, but a single enzyme can stop it #HSV #HSV1 #TOP1 #MECFS #LongCovid

medicalxpress.com/news/2025-06...

Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking - Nature Communications Here, the authors show how HSV-1 rewires the host cell’s chromatin architecture during lytic infection by hijacking transcription machinery and forming contacts between viral and host genomes.

✨ I am so happy😊 that we published this amazing project in which we show how HSV-1 rewires the host cell's chromatin by hijacking transcription machinery and forming contacts between viral and host genomes.

www.nature.com/articles/s41...

#HSV1 #chromatin #superresolution #microscopy #HiC #virus

Can You Prevent Alzheimer Disease with L-Lysine? Data linking herpes virus infections (HSV-1) with a higher risk of dementia offer hope that taking L-lysine might prevent Alzheimer disease.

Can You Prevent Alzheimer Disease with L-Lysine? www.peoplespharmacy.com/articles/can... via @peoplespharmacy

#Alzheimers #LLysine #herpes #HSV1 #dementia #health

#MedNews - A large real-world study has found a significant association between #herpes simplex virus type 1 diagnosis and #Alzheimer disease development.

👉 buff.ly/EG331Zj

#NeuroSky #IDSky #HSV1

Herpes virus infection linked to higher Alzheimer’s risk, study shows antiherpetic drugs may help A large US case-control study found that people diagnosed with herpes simplex virus type 1 (HSV-1) had a higher risk of developing Alzheimer’s disease. Use of antiherpetic medications was associated w...

Herpes virus infection linked to higher Alzheimer’s risk, study shows antiherpetic drugs may help www.news-medical.net/news/2025052... #Alzheimers #dementia #HSV1 #herpesvirus #brainhealth #antivirals #research #aging #publichealth #neurology @bmj.com