Findings from the phase 1 HORIZON-X study highlight the robust anti-tumor activity of SHR-A1811 as a novel HER2-targeting antibody-drug conjugate for patients with refractory advanced #SolidTumors.

#STTT #OpenAccess: doi.org/10.1038/s413...

Local gene editing of #fibroblasts in tumors reveals a new cancer-associated fibroblast state. New study from Nicholas F. Kuhn, Matthew F. Krummel @maxkrummel.bsky.social @immunox.bsky.social and colleagues:
rupress.org/jem/article/...

#TumorImmunology #SolidTumors #TME #CAFs

uPAR-targeted CAR T cells shrank solid tumors and cleared metastases in mice Chimeric antigen receptor T-cell therapy—CAR T for short—has been a major advance in treating blood cancers like leukemia and lymphoma. But the immunotherapy has struggled against solid tumors for two...

BREAKING: Scientists at Memorial Sloan Kettering have identified a protein called uPAR that could unlock CAR T cell therapy for solid tumours; lung, pancreatic, ovarian and more. Game-changing research. medicalxpress.com/news/2026-03... #TCSC #CancerResearch #CART #SolidTumors #Oncology

Researchers from @uclacollege.bsky.social use spatiotemporal analyses to compare the #AntiTumor response of CAR-T & CAR-NKT cells in #SolidTumors, revealing differences in immune-cell dynamics, tumor infiltration, and checkpoint regulation.

#OpenAccess: doi.org/10.1038/s413...

This review highlights the role of SUMO #E3Ligase #RANBP2 in cell cycle control and #tumorigenesis, identifying this nuclear pore complex protein as a promising yet underexplored target for #SolidTumors needing clinical validation.

#OpenAccess: doi.org/10.1016/j.ge...

Cancer treatment: Optimization of CAR T-cell therapy – BioNews Central Researchers improve the efficacy of CAR T-cell therapy in solid tumors by modifying T cells to make them resistant to local inhibition within the tumor microenvironment. ...

Researchers improve the efficacy of #CARTCellTherapy in #SolidTumors by modifying #TCells to make them resistant to local inhibition within the #TumorMicroenvironment.
#CancerTreatment

World-First EXO 001 Exosome Platform Enables In Vivo Multi-Target CAR-T for Solid Tumors Jointly developed by China Medical University Hospital and Ever Supreme Bio Technology, the platform demonstrates compelling preclinical tumor clearance across multiple models TAICHUNG, Feb. 13, 2026 /PRNewswire/ — Cancer has long ranked among the leading causes of death in Taiwan, and solid tumors account for more than 90% of cancer cases worldwide—making them the most challenging frontier for CAR-T cell therapy. China Medical University Hospital (CMUH) announced today that, in collaboration with Ever Supreme Bio Technology, it has successfully developed the world’s first EXO 001 targeted exosome platform, a breakthrough technology that enables direct in vivo programming of T cells […]

World-First EXO 001 Exosome Platform Enables In Vivo Multi-Target CAR-T for Solid Tumors #CancerResearch #CAR_Therapy #ExosomeTechnology #SolidTumors #MedicalInnovation

Hypoxia-driven #VEGF secretion promotes resistance to bispecific T-cell engagers by suppressing T-cell function, identifying VEGF inhibition as a viable strategy to enhance #Immunotherapy in #SolidTumors. @harvardmed.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

🔷 Patients were randomized to ultra-low-dose nivolumab 20 mg every 2 weeks versus standard chemotherapy, with median OS of 5.88 vs 4.70 months (HR, 0.80) as the primary endpoint.

🔗 Read more: bit.ly/ONCOnews29J-02

#ONCOnews #OncoAlert #OncEd #SolidTumors #Immunotherapy #ClinicalTrials

This phase 1b #ClinicalTrial revealed that #Olverembatinib demonstrates a tolerable safety profile and antitumor activity by inhibiting pathways associated with #Hypoxia, #Angiogenesis, proliferation, and survival in GIST/other #SolidTumors.

#OpenAccess: doi.org/10.1038/s413...

FDA Accelerated Approval for Oncology Drugs Leads to Improved Patient Survival In this study, researchers sought to determine the impact of the FDA's Accelerated Approval pathway among patients with solid tumors.

The @fda.gov accelerated approval drug pathway has led to significant gains in both progression-free and OS in patients with #solidtumors. Published in @aacrjournals.bsky.social Cancer Research Communications.

https://bit.ly/49fkzRC

#cancerdrugs

Using the SpyTag/SpyCatcher system, researchers developed anti-#Mesothelin (MSLN) uCAR-like NK cells with enhanced tumor penetration, establishing a promising therapeutic strategy for #Immunotherapies targeting MSLN-positive #SolidTumors.

#OpenAccess: doi.org/10.1038/s413...

NRG1 Fusions Across Solid Tumors: Detection Strategies and Distinct Clinical Features in Pancreatic Cancer - OncoDaily NRG1 Fusions Across Solid Tumors: Detection Strategies and Distinct Clinical Features in Pancreatic Cancer / cancer, cancer care, Cancer research, cancer

NRG1 Fusions Across Solid Tumors: Detection Strategies and Distinct Clinical Features in Pancreatic Cancer

oncodaily.com/opinion/nrg1...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #NRG1 #PancreaticCancer #SolidTumors

HIF-1-mediated ISG20 expression promotes #BreastCancer stemness and immune evasion, say Yongkang Yang, Gregg Semenza and colleagues @jhu.edu: rupress.org/jem/article/...

#SolidTumors #Hypoxia #Metastasis

Reviewing the role of peripheral nerves in #SolidTumors, with insights into the prevalence & clinical impact of nerve–tumor interactions, their underlying mechanisms, research advancements and therapeutic potential. @pku1898.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

Vivek Subbiah: Targeting the Warburg Effect in Solid Tumors... Nearly a Decade in the Making - OncoDaily Vivek Subbiah: Targeting the Warburg Effect in Solid Tumors... Nearly a Decade in the Making / Allison Klotz, Andrew Hendifer, Arianne Lyng, Can Bruce,

Targeting the Warburg Effect in Solid Tumors… Nearly a Decade in the Making - Vivek Subbiah

@viveksubbiah.bsky.social

oncodaily.com/voices/vivek...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #SolidTumors

Chen, Weichselbaum et al. @ludwigcancer.bsky.social discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy (RT), providing a clinically actionable strategy to overcome RT resistance and #metastasis. rupress.org/jem/article/...

#TumorImmunology #SolidTumors

#Mesothelin-targeted CAR-NK cells secreting the IL-2Rβγ agonist neo-2/15 sustain IL-2 signaling, boost c-Myc/NRF1-driven metabolism, resist TME-induced exhaustion, and exhibit stronger #AntiTumor activity and persistence in #SolidTumors.

#STTT #OpenAccess: doi.org/10.1038/s413...

#Radiotherapy induces YTHDF2 in #DendriticCells impairing cross-presentation and T cell function, say Dapeng Chen, Chuan He, Hua Laura Liang, Ralph Weichselbaum @ludwigcancer.bsky.social and colleagues: rupress.org/jem/article/...

#TumorImmunology #SolidTumors

Immune-Modulatory and mRNA-Based Cancer Vaccines Could Boost Benefit With ICIs Across Solid Tumors | OncLive Three experts spotlight key trials from the 2025 ESMO Congress investigating novel cancer vaccines across solid tumors.

Immune-Modulatory and mRNA-Based #CancerVaccines Could Boost Benefit With ICIs Across #SolidTumors

Watch the full video and read the article here!
www.onclive.com/view/immune-...

Scientists Create "Velcro Bomb" That Enables Immune Cells to Attack Solid Cancer Tumors While it only works on mice for now, it's excitingly promising for humans, too.

#mwgic #2025 #Cancer #SolidTumors #CAR_Tcells

www.zmescience.com/future/scien...

'Weaponised' CAR T-cell therapy shows promise against solid tumours So far, immune cells that have been engineered to kill cancers, known as CAR T-cells, haven’t worked well against solid cancers - but a study in mice suggests that could soon change

'Weaponised' CAR T-cell therapy shows promise against solid tumours #Science #HealthandMedicine #Oncology #CARtherapy #OncologyResearch #SolidTumors

Insights into how nucleus-localized PFKL acts as a key regulator of #HDACi efficacy & intracellular #Epigenetic dynamics, highlighting it as a promising #TherapeuticTarget in #SolidTumors. @fudan-university.bsky.social

#OpenAccess: doi.org/10.1038/s413...

An overview of #CARTcelltherapy, examining applications in #HematologicMalignancies and #SolidTumors, while highlighting ongoing trials and future directions for effective CAR-T therapies in #AML. @idibaps.bsky.social #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Yan Leyfman: γδ T Cells as Scalable “Off-the-Shelf” Therapy for Solid Tumors - OncoDaily Yan Leyfman: γδ T Cells as Scalable “Off-the-Shelf” Therapy for Solid Tumors / Adnan Moinuddin, Ali A. Ashkar, Allyson E. Moore, Ana L. Portilloa, cancer,

γδ T Cells as Scalable “Off-the-Shelf” Therapy for Solid Tumors - Yan Leyfman

@yleyfman.bsky.social

oncodaily.com/voices/yan-l...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #SolidTumors

In Vivo Genome-Wide CRISPR Screens in Human T Cells to Enhance T Cell Therapy for Solid Tumors

oncodaily.com/oncolibrary/...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #SolidTumors #CRISPR

#Photodynamic gel-bombs harness laser-triggered explosive energy & receptor-mediated transcytosis to actively propel therapeutic #nanofragments deep into #SolidTumors, enabling synergistic antitumor effects for #BreastCancerTherapy.

#STTT #OpenAccess: doi.org/10.1038/s413...

Yumei Cheng, Simin Wang, Ming Wang, Yuexiang Wang and colleagues define unique AURKB-ATAD2 dependency in gastrointestinal stromal tumors and identify non-receptor tyrosine kinase therapeutic strategies for clinical translation. rupress.org/jem/article/...

#SolidTumors

Integrated screens identify AURKB dependency in advanced gastrointestinal stromal tumors. New study from Yumei Cheng, Simin Wang, Ming Wang, Yuexiang Wang and colleagues (Shanghai Institute of Nutrition and Health): rupress.org/jem/article/...

#SolidTumors

Yumei Cheng et al. identify AURKB dependency in advanced gastrointestinal stromal tumors (GISTs). AURKB inhibitors demonstrate potent efficacy in various preclinical GIST models at safe doses, overcoming tyrosine kinase inhibitor resistance. rupress.org/jem/article/...

#SolidTumors