His work aims to advance tools for studying antiviral immunity and support the development of Lassa Fever countermeasures.

#ViralImmunology
#LassaFever
#AntibodyResearch
#StructuralBiology
#OxfordScience

Exploring the Human Epigenome: Insights from Professor Jörn Walter on IHEC and the EpiAtlas – EPIVINF

Last week, our project hosted a seminar with Prof Jörn Walter for a deep dive into the world of epigenomics.
📖 Read more about it in our latest post

www.epivinf.eu/2025/06/25/e...

#Epigenetics #ViralImmunology #EpiAtlas #Genomics

Molecular mechanisms adapted by viruses in causing Nds.

#NeuroCovid #viralimmunology
Underestimated virus impaired cognition-more evidence and more work to do . Molecular mechanisms associated with viral infection-related #neurodegeneration
www.frontiersin.org/journals/imm...

#MedSky🧪#IDSky #publichealth #Virology #viralimmunology The virological characteristics of #SARSCoV2 #XEC
To sum up
🦠 #XEC exhibited more robust #immuneresistance to KP.3.3 BTI sera than KP.3.1.1.
🦠XEC exhibited higher #pseudovirus infectivity and higher #immuneevasion than KP.3 .

Delineating sex-specific circulating host response signatures associated with COVID-19 severity and mortality. Male SARS-CoV-2-infected patients have higher hospitalization rates, ICU admissions, and mortality compared to females, yet with unclear underlying mechanisms. We investigated the influence of biologi...

#MedSky🧪#IDSky #Publichealth #Viralimmunology Differential host response biomarker profiles associated with #COVID19 severity.

www.cell.com/iscience/ful...
PDF

www.cell.com/iscience/pdf...

#MedSky🧪 #IDSky #Publichealth The truth in #LongCovid ,Not all symptoms are the same . #Publichealth #Viralimmunology @HeliyonJournal .The primary outcome is the #postacutesequelae of #COVID19 / #LongCovid in the #digestivesystem .
Symptoms incl
- general tiredness,
- fatigue,
- diarrhea,

Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections - Nature Communications Here, the authors isolate a SARS-CoV-2 mutant that has developed decreased sensitivity to Paxlovid and remdesivir from an immunocompromised patient, show that drug resistance can be overcome by simultaneous treatment with both drugs in vitro, and demonstrate that the drug resistant virus can efficiently transmit in the hamster model.

#MedSky🧪#IDSky #publichealth #Viralimmunology the impact of #antiviral treatment on the emergence of #SARSCoV2 resistance during persistent infections in immunocompromised patients

www.nature.com/articles/s41...

#MedSky🧪#IDSky #PublicHealth #ImmunoSky #Viralimmunology #Immunity acquired by vaccination following infection, termed #hybridimmunity, has been shown to confer enhanced protection against severe #COVID by enhancing the breadth & potency of #immuneresponses .

Kidney damage associated with COVID & #LongCOVID : from the acute to the chronic phase.

#MedSky🧪 #IDSky #publichealth #immunoSky #Viralimmunology #Kidney damages associated with #COVID from the acute to the chronic phase. Overview the mechanism in Long-term renal complications of #COVID19 & Kidney function decline #longCovid

www.ncbi.nlm.nih.gov/pmc/articles...

#MedSky🧪#IdSky #Publichealth #Viralimmunology @nejm A phase 2–3 double-blind trial to assess the efficacy and safety of #Paxlovix in asymptomatic, rapid antigen test–negative adults who had been exposed to a household contact with #COVID19 within 96 hours before randomization.

#MedSky🧪 #IDSky #Publichealth #Publichealth #Viralimmunology A recent study analyzed data from more than 200,000 Americans who had #COVID19 twice, revealing that severe #COVID infections tend to predict similarly severe reinfections.

#MedSky🧪#IDSky #Viralimmunology #ImmunoSky #Tlymphocytes play a primary role in the #Adaptiveimmunity .Both #lymphocytosis & #lymphopenia were found to be associated with severe #SARSCoV2

#MedSky🧪#IDSky #NeuroSky #Neuroinflamation #Neuroimmunology #viralimmunology .This is the 1st #Casereport in 🇧🇬 of a patient with imported malaria in the course of #SARSCoV2 infection .

#MedSky🧪 #IDSky #publichealth #Viralimmunology Individuals who completed #Paxlovid treatment for #COVID19 experienced fewer symptoms & lower #ViralLoad but rebound occured more often vs the untreated individuals. Providers should prescribe N/R, when indicated, & communicate rebound risk to patients.

#MedSky🧪 #IDSky #NeuroSky #Viralimmunology #Immunology This study highlights the potential toxicity of the #SARSCoV2 Spike protein for mammalian cells & illustrates the central role for #alveolarmacrophage in pathogenic protein uptake.

#MedSky🧪 #IDSky #Viralimmunology #Immunology Understanding 🔑 contributor to #COVID19 is #SarsCoV2 ’s utilization of “host shutoff” strategies, optimizing viral replication at the expense of host gene expression and delaying the #Innateimmune response.

www.cell.com/cell-reports...

Schematic diagram providing a visual summary of the key findings, including the main miRNAs studied, and their associations with cognitive dysfunction and other diseases and co-existing factors. Parts of this image were derived from the free medical site http://smart.servier.com/ (accessed on November 15, 2023) by Servier, licensed under a Creative Commons Attribution 3.0 Unported Licence. miRNA/miR, microRNA; APOE, apolipoprotein E; CRH, corticotrophin-releasing hormone; AVP, arginine-vasopressin; LC, locus coeruleus; NE, norepinephrine; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Schematic diagram of the main miRNAs studied and their associations with cognitive dysfunction and physiopathological and molecular processes, and other diseases and observations in patients with COVID-19; potential uses as of miRNAs as markers or therapeutic targets.

MedSky🧪 #IDSky #Immunosky #NeuroimmunoSky #Viralimmunology This #Clinicalreviews the main #miRNAs studies & their associations with #cognitivedysfunction & physiopathological in molecular processes, other diseases and observations in #COVID19 Patients.

Assessing antiviral treatment efficacy and risk factors for severe COVID-19 in kidney transplant recipients during the Omicron subvariant-dominant period: a retrospective study - BMC Nephrology Background Kidney transplant recipients (KTRs) are at risk of severe coronavirus disease 2019 (COVID-19), and even now that Omicron subvariants have become dominant, cases of severe disease are certai...

MedSky🧪 #IDsky #ViralImmunology #Immunopharmacology Evaluate the efficacy of #antiviraltreatment for #COVID19 & to identify risk factors for severe #COVID19 in #kidneytransplantrecipients during the #Omicron subvariant-dominant period @BMC_series

link.springer.com/article/10.1...

MedSky🧪 #IDsky #PublicHealth #Viralimmunology Whether pre-exposure prophylaxis (PrEP) with #tixagevimab/#cilgavimab 150mg/150 mg (T/C) in individuals with #hematologicaldiseases may lead to ⏬️risk of Breakthrough #SARSCoV2 infection/hospitalization or death in #Omicron era remains to be established…

MedSky🧪 #IDSky #Viralimmunology #Clinical_ID #Drugsdevelopment perspectives #publichealth @aaas Where do we go wrong ? Pfizer’s antiviral #Paxlovid may not help as many people as hoped. The combo drug was granted emergency use authorization in 2021 in 🇺🇸

Schematic diagram illustrating the hypothesis underlying the study. The SARS-CoV-2 spike protein RBD binds ACE2 on the surface of potential host cells. The RBD has a partial negative image of ACE2. Some antibodies against the RBD may then have a conformation sufficiently like ACE2 to have proteolytic activity similar to the proteolytic activity of ACE2. The hypothesis further suggests that the catalytic activity of some antibodies will have a substrate specificity like ACE2, but because the negative image of RBD present antibodies is imperfect, some antibodies with proteolytic activity will have an altered substrate specificity, potentially affecting multiple proteolytic regulatory cascades.

#Immunology #Viralimmunology #Publchealth Understanding #COVID19 Abzymes . #ACE2-like enzymatic activity is associated with #immunoglobulin in #COVID19 patients

journals.asm.org/doi/10.1128/...

Abstract

MedSky🧪 #IDSky #Viralimmunology #Immunolgy #Evolutionbiology #Microbiology Following the path of #SARSCoV2 infection from the immune response impairment in #PASC / #LongCovid individuals & the potential contribution of different #COVID19pandemic waves & the consequent effects found after infection :

MedSky🧪 #IDSky #PublicHealth #Covidheart #Viralimmunology Understanding Pathogenesis of long COVID myocarditis: A comprehensive review
🫀#Myocarditis, a long-term complication of #COVID19 an inflammatory condition involving the myocardium of the heart.

Fig. 1: SARS-CoV-2 NSP14 facilitates the activation of NF-κB signalling and inflammatory response.

MedSky🧪 #IDSky #Cellbiology #Clinical_ID #Viralimmunology This findings provide molecular insights into the mechanisms by which strong viral replication but scarce inflammatory response during the early (ACE2-dependent) infection stage,

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MedSky🧪 #IDSky #PublicHealth #Viralimmunology Scientists believe they may have found cause of #longCovid.
Two new studies based on an analysis of blood samples of infected people may pave the way for new treatments…

inews.co.uk/news/health/...

@ImperialImmuno 🔗

x.com/imperialimmu...

Four key pieces of research on Long COVID that have improved our understanding Four years since the start of the pandemic, we now have a good understanding of what Long COVID does. More of a mystery has been why it happens. New research is starting to find answers.

MedSky🧪 #IDsky @gavi #Publichealth #Viralimmunology 4 years since the start of the pandemic, most now have a good understanding of what #LongCOVID does. More of a mystery has been why it happens. New research is starting to find answers…

www.gavi.org/vaccineswork...

Photo

MedSky🧪 #IDsky #Publichealth #Viralimmunology #Immunocardiology Severe lung infection during #COVID19 can cause damage to the heart .Study shows that 🦠 that causes #COVID19 can damage the heart without directly infecting heart tissue.

www.nih.gov/news-events/...

MedSky🧪#IDSky #PublicHealth #Viralimmunology Analysis included 5,793 participants measured from Aug 7, 2020 to April 15, 2023. Hybrid immunity from infection before 1 or 2 vaccine doses elicited modestly superior antibody responses after the 2nd & 3rd events (vs infections or vaccine-doses alone).

Illustration

MedSky🧪 #IDSky #Neuroimmunology #Viralimmunology Unlike the other viral infections #Neurocovid is terrible & #Longcovid can made you forgetful or permanent memory lost…
🧵@danibeckman

x.com/danibeckman/...

Neonatal CD8* T cells have a distinct program of bystander activation. (A) Adult or neonate CD8+ T cells were stimulated overnight with IL-2 ÷ IL-12/18 and gene expression determined by RNA-seq. (B) PCA of samples described in (A); n = 2 or 3 mice. (C) Median innateness score (negative = high adaptiveness, positive = high innateness), including CD4+ T, NKT, and yõ T cells from ImmGen dataset (GSE109125). Error bars represent SD across replicates. (D to F) GSEA running enrichment score plots for three selected Hallmark pathways significantly up-regulated in neonatal cells upon IL-12/18 stimulation compared with that in adults [gene rank expressed as mean log(stim/control)]. TNFa, tumor necrosis factor-a; NES, normalized enrichment score. CFU, colony-forming units. (G to 1) Heatmap visualization of row-scaled gene expression of noteworthy

MedSky🧪#ImmunoSky #Microbiology #viralimmunology Understanding the Innateness profiles of different-aged CD8+ #Tcells are conserved in humans…
www.science.org/doi/10.1126/...