#phage #cycle #defense #response #antiphage #antiviral #differential

N*M210 inhibits SG/RLB formation by sequestering dsRNA. HeLa cells expressing N*M210-FLAG (blue) were transfected with poly (I:C) (pink) and SG/RLB formation was measured using TIAR (yellow). This experiment was conducted and imaged by Rory P Mulloy, who agrees to publish this image under a CC-BY licence.

#SARSCoV2 has optimized its replication fitness in the human host. @rorymulloy.bsky.social @corcoranlab.bsky.social &co show that a #nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness by suppressing #antiviral responses @plosbiology.org 🧪 plos.io/3PIZMjr

Cocrystal Therapeutics Gets FDA Fast Track FDA granted Fast Track on Apr 2, 2026 for Cocrystal's norovirus antiviral; CDC estimates 19–21M US cases annually and global burden ~685M (Lancet).

Cocrystal Therapeutics Gets FDA Fast Track: FDA granted Fast Track on Apr 2, 2026 for Cocrystal's norovirus antiviral; CDC estimates 19–21M US cases annually and global burden ~685M (Lancet). 👈 Read full analysis #CocrystalTherapeutics #FastTrack #FDAApproval #Norovirus #Antiviral

N*M210 inhibits SG/RLB formation by sequestering dsRNA. HeLa cells expressing N*M210-FLAG (blue) were transfected with poly (I:C) (pink) and SG/RLB formation was measured using TIAR (yellow). This experiment was conducted and imaged by Rory P Mulloy, who agrees to publish this image under a CC-BY licence.

#SARSCoV2 has optimized its replication fitness in the human host. @rorymulloy.bsky.social @corcoranlab.bsky.social &co show that a #nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness by suppressing #antiviral responses @plosbiology.org 🧪 plos.io/3PIZMjr

N*M210 inhibits SG/RLB formation by sequestering dsRNA. HeLa cells expressing N*M210-FLAG (blue) were transfected with poly (I:C) (pink) and SG/RLB formation was measured using TIAR (yellow). This experiment was conducted and imaged by Rory P Mulloy, who agrees to publish this image under a CC-BY licence.

#SARSCoV2 has optimized its replication fitness in the human host. @rorymulloy.bsky.social @corcoranlab.bsky.social &co show that a #nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness by suppressing #antiviral responses @plosbiology.org 🧪 plos.io/3PIZMjr

Virologist Finds New Antiviral Strategies in Virus Study Beyond both being viruses, HIV-1 and SARS-CoV-2 don't seem to have a lot in common. HIV-1 is a retrovirus that integrates with its host's DNA for life and can be passed down from mother to child, while SARS-CoV-2 is contagious but temporary and cannot be inherited. And while antivirals can repress the symptoms caused by each infection, effective vaccines exist only for one. But for Rockefeller virologist Theodora Hatziioannou, the viruses have one very important thing in common: They both cause deadly pandemics. Hatziioannou is well known for her pioneering research on the molecular interactions between HIV-1 and its host. Among other insights, she discovered that these interactions were species-specific, which explained why it had been nearly impossible to create an animal model for HIV-1, the human-specific virus-and led her to find a way around it. Researchers have since used her HIV-1 animal model to not only observe the course of infection but also control and manipulate it, as well as to evaluate the effectiveness of HIV-1-specific therapeutics and prevention strategies. So when the SARS-CoV-2 pandemic began, Hatziioannou, in conjunction with Paul Bieniasz, with whom she co-directs the Laboratory of Retrovirology, shifted her focus to bringing her HIV-honed skills and...

Virologist Finds New Antiviral Strategies in Virus Study
->Mirage News | More on "Antiviral strategies HIV SARS-CoV-2" at BigEarthData.ai | #Antiviral #Coronavirus

Prompt and Intensive #Antiviral #Chemoprophylaxis in Nursing Home #Influenza #Outbreaks

Prompt and Intensive #Antiviral #Chemoprophylaxis in Nursing Home #Influenza #Outbreaks, etidiohnew.blogspot.com/2026/03/prom...

MultiSearch Tag Explorer MultiSearch Tag Explorer - Explore tags and search results by aéPiot - aéPiot: Independent SEMANTIC Web 4.0 Infrastructure (Est. 2009). High-density Functional Semantic Connectivity with 100/100 Trust...

#ANTIVIRAL #FILM
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#BORAJPUR #KALA
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Use of #baloxavir as adjunctive #antiviral #therapy to neuraminidase inhibitors in severely immunocompromised individuals infected with #influenza

Use of #baloxavir as adjunctive #antiviral #therapy to neuraminidase inhibitors in severely immunocompromised individuals infected with #influenza, etidiohnew.blogspot.com/2026/03/use-...

Multi-specific antiviral PROTAC modality
www.scienceopen.com/hosted-docum...
#PROTAC #Antiviral #TargetedDegradation #DrugDiscovery #ChemicalBiology

Online today! Betrixaban activates #cGAS and ERVs to promote dual nucleic-sensing #antiviral #immunity

By Y. Zhao, X. Wang, X. Guo, F. You & colleagues at Peking University

➡️ doi.org/10.1038/s44321-025-00356-7

Entecavir 0.5 mg | Entecavir Tablet Price - Oddway International
www.oddwayinternational.com/entecavir-ta...

#FotoVorschlag #BBB26 #ForaJonas #ForaJonas #dkpol #fcklive #sldk #FotoVorschlag #TrêsGraças #BVBHSV #health #Entecavir0.5mg #antiviral #HIV #liver #BBB26 #이거 #Jonas #LFI #Lorde #Brasil

New study reveals spleen-to-lung neutrophil axis orchestrates antiviral defense The function of the spleen as an emergency reserve for lung immunity during viral infection has remained obscure. Research led by Professor Xuetao Cao's team at the Chinese Academy of Medical…

#Spleen-to-lung #neutrophil axis orchestrates #antiviral defense ...

| #lungs | #virus | #infection | #respiratory | Via eurekalert .org

Aloe Vera is characterized by increased antiviral properties #aloevera #antiviral #aloeverabenefits Aloe Vera is characterized by increased antiviral properties #aloevera #antiviral #aloeverabenefits

Aloe Vera is characterized by increased antiviral properties #aloevera #antiviral #aloeverabenefits ... Continue to: www.facebook.com/reel/1463668...

Underutilization of Flu Antivirals | Influenza (Flu) - CDC Although the U.S. flu season is winding down, flu activity remains elevated and people are continuing to get sick. Prescription antiviral drugs that can treat flu in children, adults, and pregnant women are available, but those drugs are under-used. Two recent studies found that even patients with flu who are at higher risk of developing severe flu complications are not always being prescribed antiviral drugs as recommended. CDC recommends that people who are very sick with flu (for example, hospitalized) be treated with influenza antiviral medications as soon as possible. CDC likewise recommends that people with suspected or confirmed flu who are not hospitalized but are at higher risk of getting very sick from flu also receive influenza antiviral treatment as soon as possible. The recommendations also allow otherwise healthy people, including children, who have the flu to receive antiviral treatment to shorten the duration of their illness and decrease the risk for some complications. The Data A study in Pediatrics found that, from December 2016 through March 2020, only about half of children hospitalized with flu were treated with antivirals. A report in the Morbidity and Mortality Weekly Report (MMWR) found that use of antivirals in children with flu...

Underutilization of Flu Antivirals | Influenza (Flu) - CDC
->Centers for Disease Control and Prevention | More on "Flu antiviral drugs underutilization" at BigEarthData.ai | #Antiviral #Influenza #BirdFlu #Coronavirus #CDC

14th Meeting of #WHO #Expert Working Group of the Global #Influenza #Surveillance and Response System (GISRS) for Surveillance of #Antiviral Susceptibility (March 20 '26)

14th Meeting of #WHO #Expert Working Group of the Global #Influenza #Surveillance and Response System (GISRS) for Surveillance of #Antiviral Susceptibility (March 20 '26), etidiohnew.blogspot.com/2026/03/14th...

Diagram featuring a choloroplast/plastid, ER, cytosol, and nucleus, illustrating how the O-methyltransferases FsE4MT01 and FsE4MT02, and the glycosyltransferase FsP4′GT catalyze the terminal methylation and glycosylation steps in biosynthesis of the unique antiviral lignan phillyrin in Forsythia suspensa.

🧪Phillyrin is a unique #antiviral lignan with potent anti-#flu activity only found in Forsythia suspensa.
Wang et al. reveal key steps in its #biosynthesis, bringing us one step closer to a valuable #drug.
🔗 doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci #JIPB #plant #medicine

Exciting new research from @jacksonlab.bsky.social: PD-L1 can play opposite roles depending on context - suppressing anti-tumor #immunity while enhancing #antiviral defense. Big implications for both #cancer therapy and #infectiousdisease www.linkedin.com/posts/drmelv...

How can we study the function of nucleotide-based #SecondMessengers?

@oliveiramann.bsky.social presented her group's exciting findings in this field at #Biochemistry2026. She e.g. presented the #cryoEM structure of OAS2, which has key #antiviral functions.

linkinghub.elsevier.com/retrieve/pii...

Ordinary differential equation models of SARS-CoV-2 replication dynamics and antiviral drug efficacies - npj Viruses npj Viruses - Ordinary differential equation models of SARS-CoV-2 replication dynamics and antiviral drug efficacies

Ordinary differential equation models of #SARS-CoV-2 replication dynamics and #antiviral #drug efficacies ...

| #COVID | #MicroSky | #SARSCoV2 | #COVID19 | #pathogen | Via @nature.com

Ordinary differential equation models of SARS-CoV-2 replication dynamics and antiviral drug efficacies In this chapter, we examine general viral replication dynamics within the human body without addressing immune response or treatment dynamics. Conceptually, virus replication models focus on three different scales: cell level, tissue level, and population level. For the tissue scale level, within-host models of SARS-CoV-2 focus on the respiratory tract and target cells expressing ACE24,24. Main target sites are the lower respiratory tract (LRT), upper respiratory tract (URT), and nasopharyngeal cells in the nose25,26. Only one study simulates infections in extrapulmonary organs27. For example, Raach et al. developed a tissue-dependent simple TCL model that models various cell populations in the respiratory tract and characterizes different infection dynamics there, leading to the conclusion that ciliated epithelial cells are the main target of SARS-CoV-2 infection based on the concentration of ACE2 receptors24. These tissue-based models indicate how anatomical structures are able to influence parameter estimation and viral kinetics, revealing that whole body dynamics cannot be reliably inferred from single tissue models. To reliably estimate early virus dynamics within patients, several studies have investigated whether the data basis for such estimates is sufficient. They identified that an absence of data prior to the viral peak can lead to unidentifiable model parameters, which in...

Ordinary differential equation models of SARS-CoV-2 replication dynamics and antiviral drug efficacies
->Nature | More on "SARS-CoV-2 viral replication modeling" at BigEarthData.ai | #Antiviral #Coronavirus

TMPRSS2-G4 (Pu23m3) interaction with berberine.

🧪 Targeting viral entry at the DNA level.

A CJNM study reveals the first NMR structure of the TMPRSS2 promoter G-quadruplex. Berberine stabilizes this structure and blocks DNA polymerase progression, potentially reducing TMPRSS2 expression.

doi.org/10.1016/S187...

#Antiviral #Berberine #CJNM

Antiviral use low among older COVID outpatients, despite higher risk for severe disease A University of Calgary–led research team finds that only 7% of children infected with Shiga toxin–producing Escherichia coli (STEC) developed hemolytic uremic syndrome (HUS) during a 395-case outbreak at 11 daycare centers in Alberta, Canada, perhaps partly due to daily lab monitoring for kidney injury. The researchers investigated the outbreak among children and adults related to contaminated food served at the centers in August 2023, publishing the findings yesterday in JAMA Network Open. An estimated 15% to 20% of children infected with STEC develop HUS, more than half of whom require dialysis. “Alberta, Canada, has one of the highest STEC infection rates in North America,” the authors wrote. “Accordingly, the province has developed expertise in diagnostics, public health responses, and care pathways.” Substantial use of health care resources In total, 326 primary and 33 secondary infections occurred among 288 children and 71 adults. Of the 359 infections, 18.4% caused no symptoms. There were 508 and 395 emergency department and STEC clinic visits, respectively, among the 285 children with outcome data. Only 7% of children infected with STEC developed HUS, which is lower than reported in most prior outbreaks and sporadic case series. HUS was documented in 7.4% of children, while...

Antiviral use low among older COVID outpatients, despite higher risk for severe disease
->CIDRAP | More info at BigEarthData.ai | #Antiviral #Coronavirus #Disease #Covid #Health

Rice ARGONAUTE 2 (AGO2) binds the small RNA miR167g-3p and facilitates its repression of the target gene SNAP32 during rice ragged stunt virus infection. AGO2 also associates with virus-derived small RNAs. miR167g-3p accumulation and SNAP32 suppression correspond with reduced viral levels, whereas decreased miR167g-3p or elevated SNAP32 increases susceptibility.

😎Because when it comes to #PlantSci, you can't have too much of a good thing!
💪In this #FreeToRead paper, Zhao et al. report on an AGO2–miR167g-3p–SNAP32 module that confers #antiviral immunity in #rice. 🪴
🌾 doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantScience #agriculture #RNA

Pictured on a wooden counter, a pink N95 mask is missing two rectangles, which have been cut out for use as air-intake filters for a CPAP machine.

🚨PSA🚨
Instantly turn your CPAP into an air purifier:
1. Cut a filter-sized chunk of N95 mask
2. Replace your CPAP air intake particulate filter with a superior anti-viral filter!

You can get at least 3 filters out of a standard mask.

#CPAP #Covid #AntiViral

A potential broad coronavirus drug target: Blocking tRNA-modifying enzymes slows viral proteins Coronaviruses not only use the machinery of the human cells they infect: they modify them to achieve optimal conditions to produce viral proteins and thus spread more quickly. This is the main…

Potential broad #coronavirus #drug target ...

| #infections | #RNA | #tRNA | #antiviral | #drugs | Via @sciencex.bsky.social

Graphic to illustrate the role of Argonaute proteins (components of the RNA silencing machinery) in plant antiviral defenses. In this figure, OsAGO2 is significantly induced by infection with rice stripe virus and rice dwarf virus. Loss-of-function ago2 mutant lines lack antiviral activity, and AGO2 over-expression lines show increased antiviral activity.

🌾#Rice...

✅ Crucial #food source
✅ Monocot model #plant
☠️ Vulnerable to #viral pathogens

🎉But there's hope!

📢Li et al. report ARGONAUTE 2 plays essential roles in a broad-spectrum #antiviral defense.

🔗 doi.org/10.1111/jipb...
💕
@wileylifesci.bsky.social
#PlantSci #FoodSecurity

Frontiers | Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Pteropus alecto) Bats are natural reservoir of viruses that cause severe disease in livestock and humans. Recent high-profile spillover events have directed significant atten...

Excited to share our new paper on producing recombinant bat antibodies! 🦇🧬

Out now in Frontiers in Immunology:
www.frontiersin.org/journals/imm...

#bat #antibodies #immunoglobulin #chiroptera #antiviral

An overview of the landscape of #Antiviral #DrugDiscovery and challenges like viral resistance & delivery barriers, while identifying AI-driven design & host-targeting strategies as future development trajectories. @shandonguniversitysdu1901

#OpenAccess: doi.org/10.1038/s413...

HIV can develop resistance to blockbuster antiviral lenacapavir—but at a cost to the virus Long-acting antiviral medications are transforming HIV prevention and care, requiring only minimalistic dosing. But as the use of lenacapavir expands, scientists are probing a critical question: If…

#HIV can develop resistance to blockbuster #antiviral #lenacapavir ...

| #virus | #AIDS | #Mutations | #fullerene | Via @sciencex.bsky.social