Strategies to combat multi-drug resistant Mycobacterium focus on novel therapeutics, host-directed approaches, and overcoming resistance mechanisms in persistent infections
doi.org/10.15212/bio...
#Mycobacterium #AntimicrobialResistance #Tuberculosis #DrugResistance #InfectiousDisease

Vault RNAs (vtRNAs): Rediscovered non-coding RNAs with diverse physiological and pathological activities

This review highlights #VaultRNAs as conserved non-coding regulators influencing cellular processes, immunity, viral infections, and #DrugResistance, emphasizing their emerging roles in #cancer and potential involvement in #SARSCoV2 pathogenesis.
Read: doi.org/10.1016/j.ge...

Nanotechnology revolutionizing osteosarcoma treatment: Advances in targeted kinase inhibitors

This study highlights the utility of #Nanotechnology-based delivery of #KinaseInhibitors to enhance targeting, reduce toxicity, and overcome #DrugResistance in #Osteosarcoma, supporting more effective and precise treatment approaches.
Nanotechnology Reviews #OpenAccess: doi.org/10.1515/ntre...

Malaria: past, present, and future

This review outlines the history, biology, and #Epidemiology of #Malaria, and discusses #DrugResistance, immune mechanisms, and advances in therapies, #Vaccines, and control strategies for improved disease management.
#STTT #OpenAccess: doi.org/10.1038/s413...

Pilot study confirms cost-effective way to combat ICU drug-resistant infections A QUT-led pilot study has shown the use of a relatively simple and cost-effective method of monitoring the presence of infectious disease-causing bacteria in intensive care units and their sites of…

Study confirms cost-effective way to combat #ICU #drug-resistant #infections ...

| #microbes | #DrugResistance | #infections | #outbreaks | Via @sciencex.bsky.social

South Africa, Mozambique are global tuberculosis hotspots Africa is making progress in reducing TB. But missed cases and drug-resistant infections are complicating the fight, particularly in South Africa and Mozambique.

South #Africa, #Mozambique are global #tuberculosis hotspots ...

| #TB | #bacteria | #microsky | #infections | #drugresistance | #Mycobacterium | Via @deutschewelle.dw.com

www.dw.com/en/undiagnos...

Learn more about our #malaria research, work to inform optimal malaria treatments, policy and tracking #antimalarial #DrugResistance
Sign up to our newsletter here www.iddo.org/wwarn/wwarn-...

✍️ For The Guardian, Julia Kollewe reports on #AMRB26 findings, highlighting a 35% drop in antimicrobial R&D & uneven industry engagement. With #DrugResistance rising, can #innovation keep up? Read more➡️ https://tinyurl.com/nhcfx7uj #AMR #pharma #HealthEquity #GlobalHealth

SimCells successfully target and kill drug-resistant bacteria We are continually in an evolutionary arms race with bacteria. As we develop new antibiotics, they develop resistance, and so it goes on until some of our treatments no longer work. Superbugs and…

SimCells successfully target and kill #drug-resistant #bacteria ...

| #DrugResistance | #MicroSky | #antibiotics | #Superbugs | #AMR | Via @sciencex.bsky.social

phys.org/news/2026-03...

Exploring advances in Cancer Therapeutics, Targets & Resistance from Acta Materia Medica
Discover cutting-edge research: amm-journal.org
#CancerResearch #CancerTherapeutics #DrugResistance #Oncology

हिंसा समेत अनेक प्रकार की महिला असमानता, एएमआर का खतरा बढ़ाते हैं।

hindi.citizen-news.org/2026/03/blog...

#AntimicrobialResistance #AntibioticResistance #AMR #preventAMR #drugresistance #HealthForAll #WorldHealthDay #WHD2026

AP-1 mediates cellular adaptation and memory formation - Nature Communications Cellular responses to stimuli can involve learned behaviors through memory formation. Here, the authors show that cancer cells encode gene expression into cellular memories during therapy resistance v...

Untangling mechanisms underlying #CancerDrugResistance www.nature.com/articles/s41... @jess_ljx @arjunraj.bsky.social #Cancer #DrugResistance #TranslationalScience

This review shows how #RNAbindingProteins and #circularRNAs form regulatory networks driving #tumor traits like #metastasis & #DrugResistance, offering therapeutic insights via RNA technologies to reshape the #TumorMicroenvironment.

#OpenAccess: doi.org/10.1016/j.ge...

Promising early results for MK-7602, a dual-action #antimalarial from @wehi-research.bsky.social & #MSD (Merck & Co., Inc.) show strong tolerability and potential to tackle #drugresistance. A major step forward in global #malaria #drugdiscovery + #innovation. www.linkedin.com/posts/drmelv...

WWARN Newsletter Signup | Infectious Diseases Data Observatory Subscribe to our mailing list

Learn more about our #malaria research, work to inform optimal malaria treatments, policy and tracking #antimalarial #DrugResistance
Sign up to our newsletter here www.iddo.org/wwarn/wwarn-...

Current therapies and advances in the development pipeline of pre-erythrocytic preventive drugs

This review highlights the urgent need for effective pre-erythrocytic #malaria #prophylactics beyond current #vaccines, addressing partial efficacy and #DrugResistance, and summarizing advances in targeting liver-stage parasites for next-gen therapies.
#MalariaResearch
Read: doi.org/10.1016/j.dc...

#Tuberculosis #ScienceSky #DrugResistance

A smart shift toward metabolic vulnerabilities in #tuberculosis #TB - exactly the kind of #innovation needed to tackle #antimicrobialresistance #AMR #drugresistance. Promising research for next-gen antibiotics from @imperialcollegeldn.bsky.social + @lshtm.bsky.social www.linkedin.com/posts/drmelv...

Antimicrobial resistance in India Rejecting ignorance as the cause of antibiotic overuse, a pair of sociologists find more likely explanations

📚💙 A World of Resistance: Antimicrobial resistance in India | Science - Book Review #booksky #antibioticsmisuse #resistance #medicine #drugresistance #bookreviews #sociology #bookrecs

www.science.org/doi/10.1126/...

This review highlights the bidirectional role of FTO in #GastrointestinalCancers, regulating #OncogenicSignaling, immune evasion, and #DrugResistance, while pointing to FTO-targeted regulators and #AI-driven strategies for therapy. #m6A

#OpenAccess: doi.org/10.1016/j.ge...

NOW ONLINE: The 2026 AMR Benchmark #AMRB26 finds pockets of progress in how #pharma companies are tackling #AMR but #DrugResistance continues to outpace industry-wide efforts, underscoring the urgent need for more comprehensive action.
Read the report👉 accesstomedicinefoundation.org/news/tools-t...

Diagnostic Value of Targeted Next-generation Sequencing in Pulmonary Mycobacterial Infections

This retrospective study demonstrates the strong efficacy of tNGS in diagnosing #Mycobacteria, with high sensitivity and specificity, and highlights its promise as a cost-effective approach for comprehensive #DrugResistance testing. #medsky

To read: doi.org/10.1007/s115...

A health worker sits with a patient, giving them treatment. Text reads: 'Project brief: Malaria elimination support to the Uganda Ministry of Health (MOH-UMES).

We’re supporting Uganda's Ministry of Health to develop, approve & disseminate a new #MalariaElimination strategy + costed operational plan. It will address threats incl. #DrugResistance while leveraging opportunities like #malaria #vaccines.

Read more ➡️ www.malariaconsortium.org/resources/ac...

Learn more about our #malaria research, work to inform optimal malaria treatments, policy and tracking #antimalarial #DrugResistance
Sign up to our newsletter here www.iddo.org/wwarn/wwarn-...

Fight against drug-resistant malaria gains momentum in Southern Africa — MARC SE-Africa On 26 February 2026, the Southern African Development Community (SADC) Ministers of Health endorsed the 2025 SADC Malaria Report, a crucial annual brief on the state of the fight against malaria in th...

🦟A milestone in the fight against drug-resistant malaria in Southern Africa

💊SADC health ministers endorsed a malaria report with a dedicated #DrugResistance section and agreed on next steps, including developing a regional strategy.

Read more: tinyurl.com/mpnrcsm3 #MARCSEAfrica

#Review
#Insulin resistance: #mechanisms and therapeutic interventions doi.org/10.1186/s435...

#DrugResistance #Metabolic #dysregulation #HepatocellularCarcinoma #HCC

SIRT7 Orchestrates Ligand‐Dependent ERα Signaling Rewiring to Drive Tamoxifen Resistance in ERα‐positive Breast Cancer In tamoxifen-sensitive breast cancer, SIRT7 deacetylates ERα at lysines 302 and 303, promoting CHIP-mediated, ubiquitin-dependent proteasomal degradation of ERα and thereby restraining estrogen-drive...

#Article in #MedComm_Oncology

Researchers from HunanUniversity find that #SIRT7 Orchestrates Ligand-Dependent ERα Signaling Rewiring to Drive #Tamoxifen Resistance in #ERα-positive #BreastCancer doi.org/10.1002/mog2...

#Deacetylation #DrugResistance

Colourful i-Base graphic. The main text reads: New once-daily HIV pill can reduce pill burden for many people on older complex ART. In the top left is i-Base’s website address: I hyphen base dot info. A smaller rectangle in the bottom right, reads: HIV news. 2026. CROI 2026, is in the top right corner with CROI’s logo, a colourful illustration of the HIV virus. At the bottom, text reads, Denver, Colorado. February 22nd to 25th. Large colourful virus illustrations are faintly seen in the background of the image. The colours used in the image are pale blue, pale green, orange, dark blue, purple, turquoise, yellow, white, pink, green and black.

Once-daily oral BIC/LEN in ARTISTRY studies simplifies #HIVtreatment for those on complex combinations:

i-base.info/htb/53317

Reducing the pill burden for people on several tablets a day due to #DrugResistance will improve quality of life.

#CROI2026 #HIV #HIVsky #Gilead #bictegravir #lenacapavir

EU plans four new health labs as drug-resistant infections soar Drug-resistant bacteria, deadly outbreaks, and diagnostic gaps: Europe may build new labs by 2026 to strengthen its disease-fighting capabilities, according to health experts.

#EU plans four new #health #labs as #drug-resistant #infections soar ...

| #DrugResistance | #bacteria | #Europe | #pathogens | #Clostridioides | #AMR | #gonorrhoea | #tuberculosis | Via @brusselstimes.com

Silencing MFN2 Drives WNT/β-catenin Nucleation to Reduce Sorafenib Sensitivity in Hepatocellular Carcinoma Cells

Low MFN2 in #HepatocellularCarcinoma activates β-catenin/EMT signaling, boosting invasion and #sorafenib resistance; MFN2 overexpression restores drug sensitivity, highlighting MFN2 as a potential therapeutic target to overcome #drugresistance.
Read: doi.org/10.1007/s115...