MCT4 alleviates #NAFLD by promoting #LipidCatabolism and reducing #steatosis through regulation of metabolic and inflammatory pathways, highlighting its role as a key lactate transporter and promising therapeutic target in #FattyLiverDisease.

#OpenAccess: doi.org/10.1016/j.ge...

Steatosis Paradox:

Unraveling Pathways of Suppressive Effect of Hepatic #Steatosis on #Hepatitis B Virus

www.sciencedirect.com/science/arti... #OpenAccess #HBV #MicroSky #MedSky

Could the #cannabinoids #cannabidiol (#CBD) and #cannabigerol (#CBG) help to treat metabolic dysfunction-associated steatotic #liver disease (#MASLD)? With help from Promethion #Metabolic Cages, scientists combined metabolic, #metabolomics & #lipidomics data to find out.

buff.ly/6UNAVor

#Steatosis

New Research Letter! Prevalence of #hepatic #steatosis and increased #liver stiffness in Chinese children and adolescents.

➡️Steatotic liver disease is a growing pediatric health concern
➡️Its progression is more rapid in children than in adults

🔗 doi.org/10.1111/joim.70069

#MCT4 regulates lipid metabolism and inflammation in #NAFLD, with its overexpression reducing #steatosis while its loss drives #LipidAccumulation, positioning MCT4 as a central regulator of #MetabolicPathways and a promising therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

Today I presented our data on sex differences in experimental #MASH development at the MASLD-EGIR Study group meeting in Pisa showing earlier #steatosis, #inflammation and glucose intolerance in females but more fibrosis in males. Great conference! @gastaldelli-amy.bsky.social

Very excited to have a poster at #BSI25 showing sex-specific #hepatic regulation of #inflammation and #immunity in #liver #steatosis (poster 505)!

@drantonioriva.bsky.social

@britsocimm.bsky.social

#sabv #sexdifferences #liverdisease #masld

Protein kinase A scaffolding by AKAP12 sustains its activation and promotes phosphorylation of its downstream substrates involved in lipid metabolism, thus mitigating #Steatosis & #inflammation in alcohol-associated liver disease.

#STTT #OpenAccess: doi.org/10.1038/s413...

An ethanol-induced loss of the lipid droplet–associated segregase VCP/p97 leads to hepatic #steatosis, say Sandhya Sen, Shaun Weller, Mark McNiven and colleagues @mayoclinic.org: rupress.org/jcb/article/...

#LipidDroplets

New insights into the lipid droplet breakdown in alcohol-associated hepatic #steatosis. Chen Zhang and Wen-Xing Ding @kumedcenter.bsky.social highlight new work from Sen et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...

#CellMetabolism #Disease #LipidDroplets

Spotlight @jcb.org: Zhang and Ding @kumedcenter.bsky.social highlight new work from Sen et al. (rupress.org/jcb/article/...), describing how ethanol impairs hepatocyte #LipidDroplet breakdown via a novel UBXD8-p97/VCP-HSD17β13 axis. rupress.org/jcb/article/...

#Steatosis

Spotlight: Chen Zhang and Wen-Xing Ding @kumedcenter.bsky.social highlight new work from Sen et al. (rupress.org/jcb/article/...), describing how ethanol impairs hepatocyte #LipidDroplet breakdown via a novel UBXD8-p97/VCP-HSD17β13 axis. rupress.org/jcb/article/...

#Steatosis

🎉 Congrats to Jaspreet S. Sandhu of Massachusetts General Hospital, 2025 Pinnacle Research Awardee! His innovative work using in vivo #CRISPR screens to explore #steatosis across metabolic contexts is advancing the future of #liverdisease research. #AASLD #LiverResearch

Waist-to-Height Ratio Better Predicts Liver Outcomes Than BMI Waist-to-height ratio had a better predictive value than BMI in assessing liver fibrosis and steatosis outcomes across ages and racial groups.

Compared with #BMI, waist-to-height ratio offered stronger predictive value for #LiverFibrosis and #steatosis outcomes.

@uniuef.bsky.social

Cause-specific mortality in patients with steatotic liver disease in the United States Causes of death across steatotic liver disease (SLD) subtypes remain incompletely characterized in routine clinical practice. We aimed to quantify and compare cause-specific mortality in SLD.

🚨Check out our new study in @jhepatology.bsky.social ❗️

Using natural language processing to identify >350,000 patients with #steatosis, we demonstrated that cause-specific mortality differs between #MASLD #MetALD and #ALD

www.journal-of-hepatology.eu/article/S016...

At poster WED-503 Dominik Lüttgen presents a clinical decision tree for non-invasive diagnosis of #steatosis at #EASLCongress.

Role of #glucagon in hepatic #lipid #metabolism identified in glucagon-receptor knockout mice. The KO mice on a standard diet showed #hypercholesterolemia and increased #liver fat, yet these changes were masked by fasting-induced #steatosis.

Hepatic #steatosis impacts liver #stiffness measurement (LSM) values in chronic hepatitis B patients, but doesn't affect the diagnostic efficiency of LSM to stage liver fibrosis. Using higher cut-off values can improve LSM's diagnostic accuracy regarding steatosis. (Zhiyuan Chen et al.)

🔗 👇

First ever @bsky.app post🥳!
Very proud to share new results investigating individual metabolic capacity of human primary hepatocytes re #polypharmacy under #ageing & #steatosis conditions🎉 Thanks for your interest, likes, RT’s😉👍🏻
Check summary and #OA article: www.pioneercampus.org/themenmenue-...

Can you say fatty change?
#path101 #pathology #NASH #OilRedO #steatosis