PROTAC technology for prostate cancer treatment
www.scienceopen.com/hosted-docum...
#PROTAC #ProstateCancer #TargetedTherapy #ProteinDegradation #Oncology
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Hashtag
#proteindegradation
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PROTACs targeting epigenetic proteins
www.scienceopen.com/hosted-docum...
#PROTAC #Epigenetics #EpigeneticTargets #ProteinDegradation #CancerResearch
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MDM2-BCL-XL PROTACs
www.scienceopen.com/hosted-docum...
#PROTAC #MDM2 #BCLXL #Apoptosis #ProteinDegradation
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Such an exciting opportunity!
Be among the first to join the brand-new @leokiss.bsky.social lab @unidue.bsky.social 🧬✨
#CellularBiochemistry #Ubiquitin #Proteostasis #ProteinDegradation
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Excited to decode the intricate language of ubiquitin chains and unravel their role in protein degradation? 🧬🔬
👉 APPLY NOW to join the lab of Dr. Leo Kiss @leokiss.bsky.social @imprs-lm.bsky.social.
#CellularBiochemistry #Ubiquitin #Proteostasis #ProteinDegradation
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Origami Therapeutics CEO on harnessing autophagy to precisely target disease-causing proteins in the brain.
Link as first comment.
#longevity #biotech #neuro #neurodegeneration #proteindegradation
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#Amgen’s Dark Blue deal (up to $840m) is less about one preclinical asset and more about a trend: pharma is paying to remove proteins, not just block them. Feature: biotech.industryexaminer.com/amgen-dark-b... #Hematology #AML #Oncology #Biotech #Pharma #DrugDevelopment #ProteinDegradation #TechNews
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#ExtracellularVesicle -based targeted #ProteinDegradation platform for multiple extracellular proteins
By B. Tong, L. Tan, Z. Liao, C. Yang & colleagues at Huazhong University of Science and Technology
➡️ doi.org/10.1038/s443...
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Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation
Deol, K. K. et al.
Paper
Details
#ERAD #Ubiquitination #ProteinDegradation
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🗣️ @ptck72.bsky.social: “Recognising protein degradation as part of kinase inhibitor mechanisms expands the possibilities for designing more effective therapies”.
#IRBScience #ProteinDegradation #TPD #DrugDiscovery
@cerca.cat @icreacommunity.bsky.social @bist.eu
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Alexander Varshavsky was born #OTD. He was honored for the discovery and recognition of the significance of the #ubiquitin system for #proteindegradation, a fundamental process that influences a myriad of cellular events. 🧪 California Institute of Technology buff.ly/veT0om9
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I am deeply honored to be supported by the @ekfstiftung.bsky.social in my project on tumor-specific degradation strategies. Together, we will pioneer innovative approaches to selectively eliminate cancer targets
#cancertherapy #funding #proteindegradation
Read more 👉🏻 www.uni-due.de/zmb/novel-ap...
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In TPD, timing is everything.
This blog explores how real-time kinetic data supports more effective degrader optimisation, based on Dr Kristin Riching’s recent webinar.
Read the full blog here: https://tinyurl.com/KineticsBlog
#ProteinDegradation #TPD
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From thalidomide to molecular glues: how targeted protein degradation is reshaping drug discovery.
This blog explores TPD, PROTACs, and the future of eliminating, not just inhibiting, disease-causing proteins.
Read the full blog at: https://tinyurl.com/ThalidomideBlog
#TPD #ProteinDegradation
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Cereblon (CRBN) ligands the most extensively used ligase recruiters in targeted protein degradation. The CRL4 CRBN E3 ligase complex is recruited to tag proteins for ubiquitination & degradation. 🧪
#TargetedMedicine #MedicinalChemistry #ProteinDegradation #PharmaResearch #TranslationalResearch #TPD
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💡 Molecular glues are reshaping drug discovery, unlocking previously untargetable proteins and providing new strategies for oncology, autoimmune, and hematological disorders.
🔗 Discover more: www.medchemexpress.com/literature/m...
#DrugDiscovery #OncologyResearch #MolecularGlues #ProteinDegradation
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Discovery of BMS-986365, a first-in-class dual androgen receptor ligand-directed degrader (AR LDD) and antagonist, for the treatment of advanced prostate cancer #proteindegradation #protacs aacrjournals.org/clincancerre...
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Excited that Christina Woo (@thewoolab.bsky.social, @harvard.edu) will visit us for a @led3hub.bsky.social Lecture.
Looking forward to hearing more about her group's exciting research in the fields of #ChemBio, #ChemicalProteomics, #ChemSky and #ProteinDegradation.
www.nature.com/articles/s41...
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🎉 2025 DFCI TPD event registration is open!
📆 Sep 11, 11:30 AM–8 PM ET, Boston
🔑 Keynote: Nathanael Gray
📝 Registration link: forms.gle/NLUSa51Btrtf...
#TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI
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Reminder: Our free webinar is tomorrow (18 June at 4.00 p.m. BST).
Discover how live-cell kinetic data drives degrader optimisation and SAR decisions.
Register now: https://bit.ly/3Zei2mE
#ProteinDegradation #LiveCellAnalysis
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Assessing the Suitability of Deubiquitylases As Substrates For Targeted Protein Degradation
Burke, J., Kodadek, T. et al.
Paper
Details
#ProteinDegradation #TargetedTherapy #DeubiquitinasesResearch
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Free Webinar – 18 June, 4.00 p.m. BST
Learn how live-cell kinetic data drives degrader optimisation in drug discovery.
Explore HiBiT-tagged workflows and tools for tracking target degradation in real time.
Register: https://bit.ly/3Zei2mE
#ProteinDegradation #DrugDiscovery
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The presenters explain potential protein degrading drugs called PROTACs.
Our speakers are sharing how #ProteinDegradation works and can be used to treat cancer.
At the ICR we have a Centre for Protein Degradation, where researchers are working to discover new drugs that harness the cell's waste disposal system to defeat cancer. 🗑️💊🧪
#Pint25
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🗺️ Interactive Map Update!
2 new UK-based labs have been added to the global TPD map:
🔹 Kessler Lab @kesslerbenedikt001.bsky.social
🔹 Fletcher Lab
Explore these and many other TPD and ubiquitin labs:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
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🗺️ Interactive Map Update!
The Münch Lab @cmunch.bsky.social has joined the global TPD map! 🎉
Explore their work and discover other labs studying #TPD and #ubiquitin biology.
👉 tpd-community.com
#ProteinDegradation
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🗺️ Interactive Map Update!
The map was just updated with 3 more labs from Germany working on TPD:
🔹 Hausch Lab
🔹 Knapp Lab
🔹 Gersch Lab @maltegersch.bsky.social
Explore these and other labs advancing TPD and ubiquitin biology:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
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Free Webinar – 21 May at 4.00 p.m. BST
Learn how to image NanoLuc® Luciferase assays using the GloMax® Galaxy system for live-cell protein tracking and degradation studies.
Register at: https://bit.ly/4k537mH
#CellularImaging #NanoLuc #ProteinDegradation
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🗺️ TPD Research Map Update!
5 new labs just joined the global TPD map:
🔹 Slabicki Lab
🔹 Kaneko Lab
🔹 Wiener Lab
🔹 Korenblit Lab
🔹 Zhuang Lab
Explore these and many other labs working on targeted protein degradation and ubiquitin biology!
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
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🔬 New from the Itay Koren lab:
💥 TOM20 anchors an E3 ligase to drive UPS-dependent control of mitochondrial fusion/fission via PLD6 degradation.
doi.org/10.1038/s415...
👏 Congrats to all authors!
📍 Find the Koren lab + others on our map: tpd-community.com
#Ubiquitin #ProteinDegradation
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