Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer Overexpression of the proto-oncogene Src is common to a wide variety of cancers. In this work, we found that Src is noncanonically translocated and inverted onto the cell surface in cancer, both in vi...

This week #JournalClub @labsoap.bsky.social
#Src #lysosome #autophagy #exocytosis welcome to the upside-down 😱 @science.org www.science.org/doi/10.1126/...

Check out this animation and thread from @gallegolab.bsky.social on the mechanism of #Exocytosis
Truly remarkable work! They did it all! 😱

🌟 Exo-Endo 2026 • May 27–29, Aussois (FR)
bit.ly/4oEmTHy
We’re excited to gather the membrane trafficking community, with a strong focus on young scientists!
📣 Registration mid-Feb. Stay tuned!!

#ExoEndo2026 #CellBiology #MembraneTrafficking #Endocytosis #Exocytosis #YoungScientists #EVs

28th Meeting of the Club Exo-Endo - Aussois, Savoie Speakers invités: Giovanni D’Angelo (EPFL, Lausanne, Switzerland) Christophe Leterrier (INP, Marseille, France) Miriam Stoeber (University of Geneva, Geneva, Switzerland)

🌟 Exo-Endo 2026 • May 27–29, Aussois (FR)
bit.ly/4oEmTHy
We’re excited to gather the membrane trafficking community, with a strong focus on young scientists!
📣 Registration mid-Feb. Stay tuned!!

#ExoEndo2026 #CellBiology #MembraneTrafficking #Endocytosis #Exocytosis #YoungScientists #EVs

Ren, Fujita et al. reveal that MYO18B, an unconventional #myosin II, positively regulates lysosomal #exocytosis by promoting focal #adhesion maturation. rupress.org/jcb/article/...

📕 Part of The Year In Cell Biology: rupress.org/jcb/collecti...
#CellBio2025

Our Cell Membrane Structure & Transport model was top of the charts last week! Get hands-on to show facilitated #diffusion & co-transport, active transport by ATP, ion channels & bulk transport by #exocytosis & #endocytosis. Learn more here: buff.ly/ufu2jH6

#EduSky #iteachbio #activetransport

This study by Hui-Jing Liu et al. examined activity-induced conversion from #dendritic filopodia to spines mediated by NMDA receptor-dependent calcium transients and vesicular #exocytosis 🔎 ↔️

📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Jinbo Cheng & Meyer B. Jackson of uwmadison.bsky.social examine somatostatin modulation of initial fusion pores in Ca2+-triggered #exocytosis from mouse #chromaffin cells 🔬 💉

📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Male et al show that early during invasion, #Toxoplasma gondii creates a transient perforation pore in the host cell membrane dependent on rhoptry #exocytosis.
#MembraneBiology #apicomplexan

-> www.embopress.org/doi/full/10....

See also Kegawa et al
-> www.embopress.org/doi/full/10....

Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis - Nature Communications Activity recognition in live-cell imaging is laborious. Here, authors present, IVEA, a fully automated AI ImageJ plugin, that efficiently detects and classifies exocytosis events, from synaptic transm...

A fully automated AI ImageJ plugin that detects and classifies #exocytosis events from synaptic transmission to single-vesicle fusion. @alishaib.bsky.social #BiotechNatureComms

doi.org/10.1038/s414...

Welcome to read the article: Intrinsic Disorder and Phase Separation Coordinate #Exocytosis, Motility, and Chromatin Remodeling in the Human Acrosomal #Proteome, by Shivam Shukla et al.

Learn more: mdpi.com/2227-7382/13/2/16

#proteomics #proteomes #proteins #bioinformatics #openaccess #MDPI

A new role of RAB21 and VARP in autophagy and autophagic exocytosis of ATP Autophagy has been implicated in various cellular processes, including non-conventional secretion. Our previous findings suggest that ATP is loaded into amphisomes and secreted upon autophagy stimu...

A new role of #RAB21 and #VARP in #autophagy and autophagic #exocytosis of #ATP
#VAMP7
www.tandfonline.com/doi/full/10....

Particle Metrix booth at the Congress of the Exocytosis-Endocytosis Club in Fort-Mahon

Bertrand Damart is at the 27th @clubexo-endo.bsky.social meeting.
Stop by the @particle-metrix.bsky.social booth to see how our #NTA technology can support your #EVResearch.
Don’t miss our talk on Wednesday at 11:15 a.m.!
exoendo.org/.../27th-con...
#exocytosis #endocytosis #EVs #ZetaView

We kick off a series of events to introduce our latest innovation: 𝗭𝗲𝘁𝗮𝗩𝗶𝗲𝘄® 𝗘𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻!
First stop: The 27th @clubexo-endo.bsky.social meeting.
Visit us at the @particle-metrix.bsky.social booth to see how we are shaping the future of #EVcharacterization.
#exocytosis #endocytosis #EVResearch #NTA

Saffi et al. show that INPP4B promotes #PDAC aggressiveness via PIKfyve and TRPML-1–mediated lysosomal #exocytosis. rupress.org/jcb/article/...

📙 In our #Cancer Cell Biology collection: rupress.org/jcb/collecti...
#AACR25

The registration for the 27th annual meeting of the Exocytosis-Endocytosis Club is open!

6 different sessions:
#Membrane_dynamics
#Exocytosis and #Extracellular_vesicles
#Endocytosis
#Intracellular_Trafficking and #Pathogens

👇👇👇
exoendo.org/evenement/27...

🫧 Is #clathrin involved in the recycling and #exocytosis of endocytosed molecules? Mai Itagaki and Noriyasu Kamei explore this role in a recent article.

➡️ doi.org/10.1002/1873-3468.70016

UNC-31 regulates enhanced spontaneous release in the excitatory synapses of cpx-1 mutants. The image shows representative body bending states (top) and color maps of curvature (bottom) in wild-type, cpx-1(ok1552), cpx-1(ok1552); unc-31(e928), cpx-1(Δ12), and cpx-1(Δ12); unc-31(e928) worms.

How is SNARE-mediated synaptic vesicle release regulated in inhibitory #synapses? This study reveals that the #exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner in #Celegans inhibitory synapses 🧪 @plosbiology.org plos.io/4jRm255

UNC-31 regulates enhanced spontaneous release in the excitatory synapses of cpx-1 mutants. The image shows representative body bending states (top) and color maps of curvature (bottom) in wild-type, cpx-1(ok1552), cpx-1(ok1552); unc-31(e928), cpx-1(Δ12), and cpx-1(Δ12); unc-31(e928) worms.

How is SNARE-mediated synaptic vesicle release regulated in inhibitory #synapses? This study reveals that the #exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner in #Celegans inhibitory synapses 🧪 @plosbiology.org plos.io/4jRm255

UNC-31 regulates enhanced spontaneous release in the excitatory synapses of cpx-1 mutants. The image shows representative body bending states (top) and color maps of curvature (bottom) in wild-type, cpx-1(ok1552), cpx-1(ok1552); unc-31(e928), cpx-1(Δ12), and cpx-1(Δ12); unc-31(e928) worms.

How is SNARE-mediated synaptic vesicle release regulated in inhibitory #synapses? This study reveals that the #exocytosis regulator complexin controls spontaneous synaptic vesicle release in a CAPS-dependent manner in #Celegans inhibitory synapses 🧪 @plosbiology.org plos.io/4jRm255

Sunset showing the sun over a frozen lake huron on tones of red and yellow

Fire 🔥 on Ice 🧊 #sunset #bayfield #exocytosis

Wei-Wei Ren, Morihisa Fujita (Jiangnan University) and colleagues reveal that MYO18B, an unconventional #myosin II, positively regulates lysosomal #exocytosis by promoting focal #adhesion maturation. https://buff.ly/4gMXOXS

📢 2x3-year #PhD positions

within the #MSCA Doctoral Network “ComeInCell"

1) Light-driven #exocytosis of synthetic #cells encapsulating #condensates

tinyurl.com/2s485c2u

2) Exploring the impact of #protein #condensates on #membrane resilience and repair mechanisms

tinyurl.com/39bdbrbr

Mechanisms to separately regulate synaptic #vesicle release and recycling: Interactions of two voltage-gated #calcium channels and a pump enable separate control of #exocytosis and #endocytosis at chemical #synapses www.uni-mainz.de/presse/aktuell/13938_ENG...