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Atmospheric hydrogen consumption is regulated by glycerol-mediated catabolite repression in mycobacteria
#microbiology #hydrogen #mycobacteria #MicroSky
@asm.org
journals.asm.org/doi/full/10....

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Diagnostic Value of Targeted Next-generation Sequencing in Pulmonary Mycobacterial Infections

Diagnostic Value of Targeted Next-generation Sequencing in Pulmonary Mycobacterial Infections

This retrospective study demonstrates the strong efficacy of tNGS in diagnosing #Mycobacteria, with high sensitivity and specificity, and highlights its promise as a cost-effective approach for comprehensive #DrugResistance testing. #medsky

To read: doi.org/10.1007/s115...

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The metallophosphoesterase Rv0805 regulates carbon flux and cell envelope homeostasis during growth of mycobacteria in propionate | Journal of Bacteriology Rv0805 links propionate metabolism with cell envelope homeostasis in mycobacteria, and its loss uncovers a metabolic vulnerability that could be exploited to restrict mycobacterial survival in lipid-r...

I am glad to share our work on mycobacterial metallophosphoesterase Rv0805. Rv0805 functions as a crucial regulator of carbon flux between central carbon metabolism and cell envelope homeostasis.
#mycobacteria #metabolism #metallophosphoesterase
doi.org/10.1128/jb.0...

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🔔 Issue 3 of 2026 is live! Featuring:

🧫 Review: #Helicobacterpylori pathogenesis
🦠 In a Nutshell: Universal stress proteins in #mycobacteria
👨‍🔬: Highlights from the Susan Lindquist School on #Proteostasis
🔬 Research on #enzymology, structural #biology, and gene expression

▶️ tinyurl.com/3yxe4t9b

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Happy our preprint is out🦠:

"Evaluation of an Oxford Nanopore sequencing workflow for mycobacteria from primary MGIT culture"

We developed and tested a workflow for long-read sequencing of #mycobacteria, including optimising DNA extraction and assessing how #ONT performs compared with #Illumina.

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Improving Bacterial Strain Construction with Automation In this webinar, Julia Tenhaef and Tobias Rosch will discuss an automated workflow for transforming Gram-positive bacteria.

How #mycobacteria exploit immune receptors to survive ...

| #bacteria | #infections | #tuberculosis | #pathogen | Via the-scientist .com

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ECDC just updated "Handbook on tuberculosis #laboratory #diagnostic methods in EU". The update includes a new chapter on “The diagnosis of #nontuberculous #mycobacteria (NTM)”, recognising these increasing and difficult-to-treat mycobacteria. Read on in capter 11 from page 126:

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Mycobacterial cell division arrest and smooth-to-rough envelope transition using CRISPRi-mediated genetic repression systems

👉 buff.ly/XjXUefA

#Mycobacteria #Tuberculosis

@pierresantucci.bsky.social

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In vivo antimicrobial activity of engineered mesoporous silica nanoparticles targeting intracellular mycobacteria - Nature Communications Current treatment options for Mycobacterium marinum infections are extensive and challenging. In this work, authors explore the potential of functionalized mesoporous silica nanoparticles as a carrier for delivery of drugs against M. marinum.

In vivo antimicrobial activity of engineered mesoporous silica nanoparticles targeting intracellular #mycobacteria

(doxycycline-loaded nanoparticles, zebrafish model of Mycobacterium marinum #infection)

@lkremer1.bsky.social

#DrugDevelopment

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In vivo antimicrobial activity of engineered mesoporous silica nanoparticles targeting intracellular mycobacteria - Nature Communications Current treatment options for Mycobacterium marinum infections are extensive and challenging. In this work, authors explore the potential of functionalized mesoporous silica nanoparticles as a carrier for delivery of drugs against M. marinum.

In vivo antimicrobial activity of engineered mesoporous silica nanoparticles targeting intracellular #mycobacteria

(doxycycline-loaded nanoparticles, zebrafish model of Mycobacterium marinum #infection)

@lkremer1.bsky.social

#DrugDevelopment

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Toward universal screening for disease-causing alleles: Mendelian susceptibility to mycobacterial disease as a model | Journal of Human Immunity | Rockefeller University Press This Perspective proposes universal genomic screening as a life-course strategy, using Mendelian susceptibility to mycobacterial disease as a model to demo

Toward universal screening for disease-causing alleles: Mendelian susceptibility to mycobacterial disease as a model. A Perspective by Farida Almarzooqi and Ahmed Aziz Bousfiha: rupress.org/jhi/article/...

#Mycobacteria #Tuberculosis #TB

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Toward universal screening for disease-causing alleles: Mendelian susceptibility to mycobacterial disease as a model | Journal of Human Immunity | Rockefeller University Press This Perspective proposes universal genomic screening as a life-course strategy, using Mendelian susceptibility to mycobacterial disease as a model to demo

In this @jhumimmunity.org Perspective, Farida Almarzooqi & Ahmed Aziz Bousfiha propose universal genomic screening as a life-course strategy, using Mendelian susceptibility to #mycobacteria as a model to demonstrate feasibility in high-consanguinity populations

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In this Perspective, Farida Almarzooqi & Ahmed Aziz Bousfiha propose universal genomic screening as a life-course strategy, using Mendelian susceptibility to #mycobacteria as a model to demonstrate feasibility in high-consanguinity populations rupress.org/jhi/article/...

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Expansion of aerobic methanotrophy to the phylum of Actinomycetota and its environmental implications | Applied and Environmental Microbiology The climate crisis is one of the most imminent threats to humanity and all life on our planet. Methane is not only the second most potent greenhouse gas (GHG) and is responsible for approximately 31% ...

New publication: Expansion of aerobic #methanotrophy to the phylum of #Actinomycetota and its environmental implications. #biodiversity #mycobacteria #methane
doi.org/10.1128/aem....

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🔔 New issue! Articles on #Mycobacteria, gene regulation, and more:

🌐 Scientists' Forum: Recommendations by BioMed Alliance for Framework Programme 10
✳️ Editor's Choice: A novel gain-of-function PC2/PC1 heteromer
🔎 Review: pH homeostasis in Mycobacteria

➡️ bit.ly/3T41t9F

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To start our first full day of #ISBA2025 - Anne Marie Wehenkel (Institut Pasteur) giving a plenary talk on ‘mechanistic insights into polar growth and cell division coordination in Mycobacteriales’ #mycobacteria #actinomycetes

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Super happy to have attended “The Nontuberculous #Mycobacteria Conference 2025” in Fort Collins! Great talks, outstanding science, and a really cool location. Huge thanks to the organizers. Always a pleasure to reconnect with friends and colleagues! #ntm

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#mycobacteria #metabolism #iron

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🔔 Issue 9 is online! ➡️ bit.ly/4mdyPA6

🖊️ Review: NlpC_P60 peptidases from #mycobacteria as targets for #DrugDiscovery
✳️ Editor's Choice: Degradation pathways for the yrzI (spyTA) #mRNA in Bacillus subtilis
🦠 On the Cover: Structures of sheathed and unsheathed #flagella

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Did you know the cell wall of mycobacteria isn’t just for protection? 🧱👀 Here, Mycobacterium marinum sheds its outer capsule right after being eaten by Dicty! A sneaky move that affects even nearby cells… #FluorescenceFriday #Mycobacteria #CellBiology #Infection #3Rmodels #Phagocytosis

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New rifamycin drugs fight antibiotic-resistant lung infections more effectively Researchers have developed next-generation rifamycin analogs that effectively kill both replicating and nonreplicating Mycobacterium abscessus while minimizing drug-drug interactions. Lead candidates ...

New rifamycin drugs fight antibiotic-resistant lung infections more effectively 🧪💊🫁 www.news-medical.net/news/2025050... #Rifamycin #Tuberculosis #DrugResistance #LungInfections #Mycobacteria #Antibiotics #CysticFibrosis #Pharmacology #Microbiology #PrecisionMedicine @pnas.org

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Potency of all-D amino acid antimicrobial peptides derived from the bovine rumen #microbiome on tuberculous and non-tuberculous #mycobacteria
www.sciencedirect.com/science/arti... #OpenAccess #TB #MicroSky #IDSky

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Host invasion by a mycobacteriophage—visualized in action! 🦠✨
Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity 🙌 #CryoEM #CryoET #phage #mycobacteria

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Had an amazing week at the Gordon Research Conference on Biology of Mycobacteria! Great chats, exciting posters and the chance to meet both legends in the field and awesome new peers…
#mycobacteria

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Please go chat with @yushuchen.bsky.social at the Biology of Mycobacteria GRC if you haven't, or missed his Mon poster! Also, Ruby Hao SUN is presenting another interesting poster on Thu! #MicroSky #Mycobacteria #GRCMyco2025

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Happy to share our newest preprint addressing the basis of trehalose essentiality in mycobacteria! This is a story brewing in the lab for the longest time, started by MSc grad Justin Lim, & now completed by the amazing PhD grad-turned-postdoc @yushuchen.bsky.social! #MicroSky #Mycobacteria 1/8

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Symposium: A Dutch Perspective on Mycobacterial Infections On the 24th of March 2025, World TB day, we organize a symposium to connect the Dutch scientific community working on mycobacterial infections. We will cover all aspects of tuberculous or non-tubercul...

Excited for today's symposium "A Dutch Perspective on Mycobacterial Infections" at @leidenscience.bsky.social. I am am looking forward to learning a lot about tuberculosis research in the talks and poster session.
#TB #Mycobacteria #Antibiotics www.universiteitleiden.nl/en/events/20...

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Symposium: A Dutch Perspective on Mycobacterial Infections On the 24th of March 2025, World TB day, we organize a symposium to connect the Dutch scientific community working on mycobacterial infections. We will cover all aspects of tuberculous or non-tubercul...

Looking forward to seeing some excellent talks and posters today: "A Dutch Perspective on Mycobacterial Infections". #Mycobacteria #TB Amazed to learn so much interesting research to understand TB and non-TB mycobacterial infections is going on in NL: www.universiteitleiden.nl/en/events/20...

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Relationship between age, sex, geography and incidence of nontuberculous… | Troels L. In this new nationwide study including all patients with #nontuberculous #mycobacteria (#NTM) isolates in #Denmark over 32 years (n=4,123), we investigated…

New nationwide study including all patients with #nontuberculous #mycobacteria (NTM) isolates in #Denmark over 32 years (n=4,123), investigating age, sex and geographical differences in NTM incidence.

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A potential target for mycobacteria SBGrid member Eilika Weber-Ban study of transcription factor PafBC in mycobacteria reveals it is activated by single-stranded DNA (ssDNA)

A potential target for myobacteria: a publication highlight from Meharry Medical College Ph.D. candidate KeAndreya Morrison featuring a new article from the laboratory of @ewb-lab.bsky.social of @ethzurich.bsky.social .

Read more here: buff.ly/3c27V2w

#SBGrid #MycoBacteria #CryoEM

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