👀 In our new application note, we demonstrate how fluorescence cross-correlation spectroscopy (FCCS) can be performed on the EI-FLEX system to characterise the formation of a ternary complex > excitinginstruments.com/resource-lib...

#ternarycomplex #fccs #PROTACs #molecularglues

At the final day of the @novalix.bsky.social conference? If you haven't had chance to meet with Audrey and Jake yet, there's still time to discuss how confocal fluorescence spectroscopy can accelerate your induced-proximity drug screening ⚡
#ternarycomplex #molecularglues #PROTACs #novalix

Targeted protein degradation for cancer therapy - Nature Reviews Cancer Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. In this Review, Hinterndorfer et al. outline the mechanistic bases of TPD and discuss the characteristics, advantages and applications of established compounds as well as upcoming classes of degraders.

🥳 Our 2nd most downloaded article in 2025:

Targeted protein degradation for cancer therapy

#PROTACs #Degraders @NatResCancer
#NRCtop10of2025

A successful PROTAC Hackathon hosted at the@crick.ac.uk:

• 34 participants
• 24 reviews generated
• 100% reported improved understanding

Organised by the Chemical Probes Portal with academic & industry collaboration.

Next Hackathon: EUFEPS–SITELF 2026 in Naples 🇮🇹

#ChemicalProbes #PROTACs #EUFEPS

🇺🇸 Heading to #Novalix? Learn how confocal fluorescence spectroscopy accelerates induced-proximity drug screening. Meet our US team, Audrey & Jake, to discuss #biophysicalscreening, #molecularglues and #PROTACs, #single-molecule #proteindynamics, and more. Look out for their booth and poster!

#NewTeamMembers! Happy to welcome Julia Hierholzer, Dilara Güler, Marcus Kraus and Shipeng Song to our research team!!🎉🎉 We’re thrilled to have them on board. Welcome, Julia, Dilara, Marcus, and Shipeng!! 👩‍🔬🧑‍🔬

#chemistry #photochemistry #electrochemistry #dominoreactions #onepotreactions #PROTACs

This review outlines #ubiquitination as a key regulator of #cellularhomeostasis, its dysregulation in major diseases, and emerging therapeutic strategies including #PROTACs, molecular glues, and clinical advances targeting this pathway.

#OpenAccess in #STTT: doi.org/10.1038/s413...

🔥Tumour-enriched amino acid mimic drives in situ assembly of #PROTACs and immune-engaging #nanoparticles, boosting #Tcell activation 14.8× and causing strong tumour regression with minimal toxicity.
ow.ly/WKzy50XQhjE

#Tumour #CancerResearch #Immunotherapy #Nanomedicine

Reviewing #BCL2 family proteins, their regulation & functions, their role in #Apoptosis, with a discussion on the development & potential of BH3-mimetics, #PROTACs, ADCs and tools targeting the BH4 domain of BCL2. @goetheuni.bsky.social

#OpenAccess: doi.org/10.1038/s413...

Also thanks to @ki.se, @scilifelab.se, @novonordisk.bsky.social, Cancerfonden, and Barncancerfonden for continued support.

#NUDT5 #metabolism #thiopurines #chemotherapy #cancer #biomarker #PROTACs #TPD

4/4

PROTACs: »Entsorgung« als Therapie | Aktuelles aus der Goethe-Universität Frankfurt Der Pharmazeut Manfred Schubert-Zsilavecz erläutert die neuen Wirkstoffe. Bislang greifen fast alle Arzneistoffe in Krankheitsprozesse ein, indem sie entweder fehlende Moleküle ersetzen oder fehlfunkt...

🧪 Die meisten #Medikamente blockieren Proteine bzw. ihre Herstellung. #PROTACs machen es anders: Sie lassen durch zelleigene „Müllschredder“ störende Proteine beseitigen.

🔗 Der Pharmazeut M. Schubert-Zsilavecz erläutert die neuen Wirkstoffe im #UniReport: aktuelles.uni-frankfurt.de/unireport/pr...

The Booming Targeted Protein Degradation Market Expected to Reach $9.85 Billion by 2035 The Targeted Protein Degradation Market is projected to surge to $9.85 billion by 2035, exhibiting a phenomenal CAGR of 35.4%. This report analyzes the factors driving growth in this innovative sector.

The Booming Targeted Protein Degradation Market Expected to Reach $9.85 Billion by 2035 #USA #Delray_Beach #Arvinas #PROTACs #Targeted_Protein_Degradation

Discovery of BMS-986365, a first-in-class dual androgen receptor ligand-directed degrader (AR LDD) and antagonist, for the treatment of advanced prostate cancer Abstract. Purpose: BMS-986365, a heterobifunctional AR LDD, was designed as a potent cereblon-dependent degrader and competitive antagonist of AR to overcome resistance to ARPIs in metastatic prostate...

Discovery of BMS-986365, a first-in-class dual androgen receptor ligand-directed degrader (AR LDD) and antagonist, for the treatment of advanced prostate cancer #proteindegradation #protacs aacrjournals.org/clincancerre...

Binary complexes in green and red #Protacs (Turn by 180°)

Happy to share that our project on novel #antiviral #PROTACs has been awarded funding by the #VolkswagenFoundation!🎉 A big thank you to the @volkswagenstiftung.de for supporting our research, and to the #MarschallGroup (Institute of Virology, @fau.de) for the great collaboration!👍

First FRS for Gates Cambridge - Gates Cambridge Professor Alessio Ciulli is the first Gates Cambridge Scholar to be elected a Fellow of the Royal Society.

Big congratulations to Professor Alessio Ciulli, the first Gates Cambridge Scholar to be elected a Fellow of the Royal Society - www.gatescambridge.org/about/news/g...

@uniofcam.bsky.social @gatesfoundation.bsky.social

#chemistry #protacs #impact

Indolequinone-based hypoxia-activated PROTACs (HAP-TACs) selectively degrade BRD4 in hypoxic cancer cells Proteolysis targeting chimeras (PROTACs) have helped to establish proximity induction as an exciting strategy in drug discovery, and there are multiple clinical trials focused on this modality. Howeve...

Cool #TPD concept

Indolequinone-based #hypoxia activated #PROTACs (HAP-TACs) selectively degrade BRD4 in hypoxic cancer cells | ChemRxiv - doi.org/10.26434/che...

🧲 Chemical Inducers of Proximity at #ChemBioParis2025
Explore how small molecules drive protein interactions to rewire biology.
🎙 Featuring Ivan Đikić & Fleur Ferguson
📍 Paris | 🗓 Oct 6-9, 2025
🔗 chembioparis2025.com
#ChemicalBiology #PROTACs #MolecularGlues #DrugDiscovery
#ICBS2025 #ECBS2025

Here’s to decoding the ‘ub-code’, one complex at a time 🔬✨
#CryoEM #CRLs #UbiquitinCode #TPD #PROTACs #glues #MolecularMachines

SciTech Chronicles. . . . . . . . .April 19th, 2025 If you torture data sufficiently, it will confess to almost anything. Vol II No 16 245 links Curated Nutrients strengthen link between pre...

SciTech Chronicles. . . . . . . . .April 19th, 2025

bit.ly/stc041925

#MAP #biomass #grasslands #NutNet #siderite #Sharp #Gale #water #Beekee #microserver #"pop-up digital classroom" #"Raspberry Pi-based" #biomechanical #real-time #dynamic #static #CD36 #uptake #PROTACS #"enhanced uptake"

LinkedIn This link will take you to a page that’s not on LinkedIn

🎧 Listen: lnkd.in/gpK4BkuD

#Degraders #PROTACs #DrugDiscovery #OpenScience #PodcastSeries

Oerth Bio's Innovative PROTAC Technology: Revolutionizing Agriculture with Targeted Protein Degradation Discover how Oerth Bio is leveraging PROTAC technology in agriculture to offer innovative solutions for crop protection and sustainability.

Oerth Bio's Innovative PROTAC Technology: Revolutionizing Agriculture with Targeted Protein Degradation #USA #Durham #Agriculture #Oerth_Bio #PROTACs

This afternoon has been all about the latest techniques - protein degrading #PROTACs, AI support in #drugdiscovery, and small molecules modifying #epigenetics. These techniques have been applied to #cancer #malaria and #antibiotic resistance and demonstrate promising possibilities for the future. 🧪

🧪 Aganitha Igniva™ AI Agents for Molecule & Material Engg.: Balancing novelty with developability

✅ #GenAI for #SMOLs, covalent binders, #PROTACs
✅ De novo #Materials: #Surfactants, fragrance molecules, photoactivators, biopolymers
✅ ADMET, skin sensitization, emulsification

Yesterday's conference was all things #drugdiscovery at AstraZeneca in Cambridge.

From small molecules to PROTACs, researchers are tirelessly streamlining modelling and computational methods to improve the efficiency of candidate discovery.

#MedicinalChemistry #PROTACs #Research #Science

Happy to welcome Julia Ryll & Aya Alfarem to our research team!!🎉🎉 Julia joined us as a PhD student and is developing #anticancer #prodrugs and #PROTACs, while Aya, our new Master's student, is working on #electrochemical #CHfunctionalization! We’re thrilled to have them on board! #Welcome #ChemSky

Next steps for targeted protein degradation Modalities and applications of targeted protein degradation (TPD) have rapidly expanded the therapeutic possibilities of proximity induced pharmacology. Here, Krone et al. spotlight three focal points...

Next steps for targeted protein degradation: Cell Chemical Biology www.cell.com/cell-chemica... #TPD #PROTACs

Aram Davtyan giving an awesome poster presentation about our work modeling protein-small molecule-protein ternary complexes at @keystonesymposia.bsky.social Proximity-Based Therapeutics! #biotech #drugDev #degraders #molecularGlues #PROTACs

Find the poster here: www.deeporigin.com/academic-pos...

Talking about VHL-based #PROTACs: Check out our newest publication from the @proxidrugs.bsky.social consortium in which we propose & exemplify a generalizable workflow for the validation of E3 ligands for developing PROTACs.
pubs.acs.org/doi/10.1021/...

There are many reasons for drug discovery scientists to be interested in #PROTACs. VHL-based PROTACs should not be ignored, there are important use cases for them. @alessiociulli.bsky.social & colleagues now compiled the VHL ligand chemical space in this paper: www.tandfonline.com/doi/pdf/10.1...