✨New issue✨

Check out the latest in #Metabolism research from across all disciplines.

Read about #AdiposeTissue, #EVs, #Incretins, #Immune cells, #LiverMetabolism, #MitochondrialMetabolism, #SpatialOmics, #Tumorbiology and many more topics! 🧪

http://dlvr.it/TRmC3C

Beyond a singular focus on GLP-1: why we need a new nomenclature now www.thelancet.com/journals/lan...
#GLP-1 receptor agonists #incretins
#obesity type 2 #diabetes #T2D

#MedSky #EndoSky

As understanding of the gut–bone axis deepens, there is growing interest in leveraging its effects to develop innovative strategies for preventing & treating #bone fragility in the future www.thelancet.com/journals/lan...
#BoneHealth #osteoporosis #fractures
#incretins #GLP-1 #GLP-2 #GIP

#EndoSky

Incretin hormones—glucagon-like peptide-1 (GLP-1) & glucose-dependent insulinotropic peptide (GIP)—act as a critical link connecting #digestion, #metabolism, & #cardiovascular function, supporting physiological adaptations to nutrient intake thelancet.com/journals/lan...
#incretins

#MedSky #EndoSky

Beyond a singular focus on GLP-1: why we need a new nomenclature now The development of glucagon-like peptide-1 (GLP-1)-based therapies for type 2 diabetes and obesity illustrates a remarkable evolution in scientific understanding and therapeutic innovation.1 As the fi...

Although #GLP-1-based therapy might remain a practical term for the near future, given the central role of GLP-1 in most current molecules and coformulations, there is a clear need for broader, more inclusive terminology thelancet.com/journals/lan...
#incretins #GLP-1 #GIP

#MedSky #EndoSky

The gut–bone axis: implications of gut hormone-based therapies for bone health Historical trends and future projections of the number of people with overweight and obesity suggest alarming parallel increases in serious and potentially fatal comorbidities, particularly type 2 dia...

Cardiometabolic diseases can have detrimental effects on bone health, leading to fractures, morbidity & mortality, & reduced quality of life. Despite these known relationships, bone health is often underestimated & overlooked in this context www.thelancet.com/journals/lan...
#incretins #GLP-1 #GIP

#Incretins could serve as a crucial evolutionary link between digestion & substrate oxidation, orchestrating substrate allocation to optimise the body's fight or flight response www.thelancet.com/journals/lan...
#GLP-1 #GIP #digestion #metabolism #cardiovascular system

#EndoSky #GastroSky

Zealand Pharma logo

Zealand Pharma paused dapiglutide after early data showed no advantage over newer incretin therapies. Focus shifts to programs with stronger potential.

jcst2d.com/index.php/ne...

#ObesityTreatment #GLP1 #Incretins #MetabolicHealth

The gut–bone axis: implications of gut hormone-based therapies for bone health Historical trends and future projections of the number of people with overweight and obesity suggest alarming parallel increases in serious and potentially fatal comorbidities, particularly type 2 dia...

The gut–bone axis: implications of gut hormone-based therapies for bone health thelancet.com/journals/lan...
#GLP-1 #GIP #incretins #weightloss #obesity #overweight #Bonehealth #osteoporosis

#MedSky #EndoSky #RheumSky

Don’t miss this hour of high-impact science.

➡️ FREE to attend
➡️ Open to all

🔗 Register now: tinyurl.com/f8uzk2w2 or use the QR code above.

#CIBER #DZD #Incretins #DiabetesResearch #GLP1 #GIP #ObesityScience

Silhouette of man with gut microbes and brain being shown, surrounded by food

✨New issue!✨

Check out the latest in #metabolism research!

Read about #Cysteine in #WeightLoss, #GutMicrobiome, #Satiety, #Incretins, #Itaconate - and many more topics!

https://bit.ly/44njRQ5

🚨 1st output from @AST_LICOP #obesity & #livertransplant conf!

➡️ anti-obesity meds & surg. underutilized

➡️ #incretins promising pre- & post-txp

➡️ #AOM & #bariatric surg. complementary, not either/or

#liversky #GIsky

journals.lww.com/lt/abstract/99…

The gut–bone axis: implications of gut hormone-based therapies for bone health Historical trends and future projections of the number of people with overweight and obesity suggest alarming parallel increases in serious and potentially fatal comorbidities, particularly type 2 dia...

Advancements in gut–bone axis research could revolutionise treatment approaches for #bone disease, allowing individuals to experience the benefits of weight loss while minimising risks to #skeletal health www.thelancet.com/journals/lan...
#incretins #osteoporosis

#MedSky #EndoSky #RheumSky

Proinflammatory cytokine-induced alpha cell impairment in human islet microtissues is partially restored by dual incretin receptor agonism - Diabetologia Aims/hypothesis In type 1 diabetes, the counterregulatory glucagon response to low plasma glucose is impaired. The resulting increased risk of hypoglycaemia necessitates novel strategies to ameliorate...

New research highlights that inflammation impairs alpha cell function in human islet microtissues and how incretin receptor agonists partially restore glucagon secretion. #alphacells #islets #glucagon #cytokines #T1D #incretins link.springer.com/article/10.1... 🔓

Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s dise...

www.nature.com/articles/s42...

#Neurodegeneration #GLP1 #GIP #Incretins #BrainHealth #Neuroscience #FutureOfMedicine

Text reads: Special Collection Incretins. Pictured: Journal of Endocrinology and Journal of Molecular Endocrinology.

Read the latest article in Journal of Endocrinology's #Incretins Special Collection:
The effects of GIP, GLP-1 and GLP-2 on markers of bone turnover: a review of the gut–bone axis
By Miriam Longo et al.
👉 doi.org/10.1530/JOE-...

As understanding of the gut–bone axis deepens, there is growing interest in leveraging its effects to develop innovative strategies for preventing and treating bone fragility in the future www.thelancet.com/journals/lan...
#osteoporosis #weightloss #incretins
#MedSky #EndoSky #GastroSky #RheumSky

The gut–bone axis: implications of gut hormone-based therapies for bone health Historical trends and future projections of the number of people with overweight and obesity suggest alarming parallel increases in serious and potentially fatal comorbidities, particularly type 2 dia...

New Comment by Marcel H A Muskiet & colleagues:

The gut–bone axis: implications of gut hormone-based therapies for bone health www.thelancet.com/journals/lan... #BoneHealth #osteoporosis #BMD
#incretins #GLP-1 receptor agonists
#MedSky #EndoSky #GastroSky #RheumSky

A 12-Year-Old’s Journey Into the World of Ozempic A mother found success with a weight-loss drug after a lifelong battle. Noticing her young daughter start down the same path, she decided to have her try semaglutide, the active ingredient in Wegovy a...

www.wsj.com/health/pharm...

Fascinating article about pediatric GLP1 usage. Underscores the critical importance of next generation obesity treatments, especially when we see youth begin regular incretin usage. @wsj.com #GLP1 #incretins #obesity #drugdiscovery