Ping Zhong, Tarek Shaker, Pei Li & Zhen Yan from @ubuffalo.bsky.social investigated compromised synaptic signal from prefrontal cortex to mediodorsal thalamus in #Alzheimer's disease models and its rescue by #kinase inhibitors 🧠 🔍️

📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

New data on role of CaM kinase II in #myocardium stretch-induced compliance, independent of protein #kinase G, but likely through shared #phosphorylation targets with PKG, implicating #CaMKII as a possible modulator of diastolic function
doi.org/10.14814/phy...
#Cardiac #Physiology

Modification of PLK1 following the surface-entropy reduction approach yielded a protein which crystallizes readily and forms an excellent new crystallization platform for PLK1–inhibitor co-crystal structures #SurfaceEntropyReduction #SER #Kinase doi.org/10.1107/S205...

RESEARCH PAPER: Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3
By Ji et al., and Feng Cong
➡️ https://genesdev.cshlp.org/content/40/1-2/56.abstract

#development #signaling #kinase #WNT

MultiSearch Tag Explorer MultiSearch Tag Explorer - Explore tags and search results by aéPiot

#MERANTI #MENGKAI
allgraph.ro/advanced-sea...
#TIMIDINA #KINASE
aepiot.ro/advanced-sea...
#MANJALARA
multi-search-tag-explorer.headlines-world.com/advanced-sea...
allgraph.ro

The unique signature of tyrosine kinase inhibitor-induced hypothyroidism Tyrosine kinase inhibitors (TKIs) are anti-cancer agents that inhibit the activity of oncogenic protein kinases. Thyroid hormone abnormalities are common during treatment with TKIs, typically manifest...

The combined action of #TKIs on #thyroid gland function & peripheral deiodinases generates a unique phenotype of primary #hypothyroidism characterised by increased TSH concentrations & a reduced T3 to T4 ratio www.thelancet.com/journals/lan...
#tyrosine #kinase #inhibitors #thyroidcancer
#EndoSky

William J. Evans of @ucberkeleyofficial.bsky.social et al. observed the effects of inhibition of Janus #kinase signalling during controlled mechanical #ventilation on the rate of skeletal muscle protein synthesis in this recent study🔎 🧪

📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Newly discovered host mechanism in coronaviruses A research team at Ruhr University Bochum, Germany, has identified a previously unknown cellular mechanism crucial to the replication of coronaviruses: c-Jun N-terminal kinase (JNK) is activated…

Newly discovered host mechanism in #coronaviruses ...

| #virus | #kinase | #microscopy | #infections | Via eurekalert .org

Meetup with Jim @jwoodgett.bsky.social at @ccralliance.bsky.social conference in Calgary #CCRC2025 Always fun when two kinase scientists get together to discuss research. The conversation was definitely active 🧫🔬⚗️

#ScienceIsFun #Kinase #CancerResearch @terryfoxresearch.bsky.social

Minimal Perturbation of Activation Loop Dynamics Rewires Kinase Signaling Enzymes are central to life, with their catalytic activity often shaped by the dynamic conformations of regulatory loops. In hub enzymes such as tyrosine kinases, the activation loop critically contro...

we just posted our new work on #SRC #kinase led by the superb Prashant Jain 🤩 Inspired by nature, we discover that the length of the catalytic loop and the autophosphorylation site can be engineered to fine-tune downstream pathway activation. 🙏🏻 @oistedu.bsky.social
www.biorxiv.org/content/10.1...

Promega HER2 Kinase Enzyme System - GenomiRX Promega HER2 Kinase Enzyme System

genomirx.com/promega-her2... Promega HER2 Kinase Enzyme System, 1mg baculovirus in Sf9 GST tag @promegacorporation.bsky.social #her2 #kinase #enzyme #baculovirus #sf9 #gst @BPSBioscience @sigmaaldrich.bsky.social @prospec @mybiosource @chemiverseca.bsky.social

The 5th Virtual #ChemBioTalks continue with an insightful talk by @kellychibale.bsky.social. He talked about his group's research into new treatments for #malaria. Great insights into the repurposing of anti #cancer #kinase inhibitors to treat P. falciparum. onlinelibrary.wiley.com/doi/10.1002/...

Who knew the kinome has a dark side? To find out more- check out this new paper from our NSF Biofoundry. #glycotime #kinase 🧪

The Kannan Lab at UGA, with BioF:GREAT, has shown that the “dark kinome” still hides secrets 🔦 Enter DCLK3—a kinase with neuroprotective potential. We found it self-regulates in a brand-new way, and tags Tau as a substrate. A fresh spark for neurodegenerative research! 🧪

#BioFGREAT #NSF #kinase

Kinases contribute to regulation of cellular signalling and drive many diseases when dysregulated. Small molecule kinase inhibitors allow precise control over these enzymes, enabling pathway dissection, biomarker discovery and therapeutic targeting.🧪
#Kinase #MedChem
fluorochem.co.uk/product-cate...

Drs Jessica Home & Christopher Goodman highlight Nathanael Gray @elizabethwinzeler.bsky.social‬ Debopam Chakrabarti & colleagues’ @cp-cellchembiol.bsky.social‬ article on a #kinase #inhibitor's elusive #antimalarial #modeofaction. #haemoglobin #digestion

authors.elsevier.com/a/1ldhr5Eb1x...

More 🌽🌽 research—Mingliang Xu from China Agricultural University on quantitative resistance in #maize, and the calcium-dependent protein #kinase #QTL

Very much looking forward to the talk by @kellychibale.bsky.social at the 5th Virtual @chembiotalks.bsky.social and to learn more about the repurposing of #anticancer #kinase inhibitors to treat #malaria.

#ChemBio #ChemSky #DrugDiscovery

Want to know which kinase phosphorylates your site of interest in cells, go to kipik.dundee.ac.uk. The patented KiPIK screening method developed in Jon Higgins’ group ‪@medicalsciencesncl.bsky.social is now available as a new service from @mrcppu.bsky.social in Dundee. #kinase #molbiol #chembiol.

49 Take-off projects awarded in spring round 2025 | NWO 38 feasibility studies and 11 vroegefasetrajecten have been awarded in the 2025 spring round of Take-off. The Take-off program gives researchers in phase 1 the opportunity to test the feasibility of commercializing their idea based on innovative research results. In phase 2, knowledge-based, innovative start-ups in the early stages of their development receive a loan to get their business off the ground.

3 projects by the LED3 researchers Nathaniel Martin, Anthe Janssen and Mirjam Huizenga have been awarded NWO Take-off funding to explore commercial development of compounds and technologies with applications in #oncology, #NeuropathicPain treatment and #kinase research!
www.nwo.nl/en/news/49-t...

A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models - Nature Biotechnology An AI-generated small-molecule inhibitor treats fibrosis in vivo and in phase I clinical trials.

Came across this #kinase work, very cool for where in trials the compound is. Interesting commentary noting AI focus on #allosteric sites (notoriously hard to model de novo) although truthfully traditional type I cmpds were extended into a back pocket, so not type III #medchem

rdcu.be/ev0b6

Molecular insight on the role of the phosphoinositide PIP3 in regulating the protein kinases Akt, PDK1, and BTK Protein kinases are master regulators of myriad processes in eukaryotic cells playing critical roles in growth, metabolism, cellular differentiation, and motility. A subclass of protein kinases is reg...

New review out with @jburkevic.bsky.social!
We highlight recent advances in our understanding of the role the phosphoinositide PIP3 plays in regulating the protein kinases Akt, PDK1, and BTK from a structural perspective.
#kinase #phosphoinositides

portlandpress.com/biochemsoctr...

Accelerate kinase research with bioluminescent assays: ADP-Glo™, NanoBRET® TE, Lumit® & HiBiT.

Measure activity, affinity, signalling and degradation with ease

👉 www.promega.co.uk/applications/small-molec...

#kinase #bioluminescent #assays

SciTech Chronicles. . . . . . . . .May 8th, 2025 You've got two good eyes and you still can't see. Vol II No 32 455 links Curated Mission Control RSS Feed Wordpress SubStack Comments Buy...

SciTech Chronicles. . . . . . . . .May 8th, 2025

bit.ly/stc050825

#SIK3 #NSS #profile #kinase #pathogens #intercontinental #balloons #"35 kilometers" #"jurema preta" #dimethyltryptamine #"no ban" #"Mimosa tenuiflora" #TYK2 #psoriasis #inhibitor #Friendship #"Lamprotornis superbus" #reciprocal #DNA

SciTech Chronicles. . . . . . . . .May 6th, 2025 We are Volunteers of America. Vol II No 30 371 links Curated Mission Control RSS Feed Wordpress SubStack Comments Buy Me A Coffee New Mol...

SciTech Chronicles. . . . . . . . .May 6th, 2025

bit.ly/stc050625

#EphB1/2 #tyrosine #kinase #inhibitors #carbene #thiamine #B1 #3D-printable #electroencephalogram #continuously #bioadhesive #AMT #mesothelioma #"low-carbon metal oxides" #CO2 #"digital twin" #"3D digital model" #sonar #Magellan

Faster #kinase research is here! 🧪 Our new curated @SignalChem kinase bundles simplify selection & boost discovery. Explore target family-based kits & accelerate your work: ow.ly/SJgl50VLFRz

💊 Tyrosine kinases have an inevitable role in the proliferation of #tumour cells, hence, #tyrosine #kinase inhibitors are frequently employed as #anti-neoplastic agents in the treatment of #colon, #breast, #kidney, and #lung #cancers

💻 www.thieme-connect.de/products/ejo...

#PcLRR-RK3, an #LRR #receptor #kinase is required for growth and in-planta infection processes in #Phytophthora capsici
doi.org/10.1080/2150...
@tandfresearch.bsky.social

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #ChemSky #ChemBio

#medchem #chembio #chemsky #anthelmintic #drugdiscovery #kinase #parasite